Chemical Reviews最新文献_第9页

Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease 外周髓鞘蛋白22及其在腓骨-玛丽-牙病中的作用。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-05-20 DOI: 10.1021/acs.chemrev.6c00096

Charles R. Sanders*, Bruce D. Carter, Mason C. Wilkinson, Geoffrey C. Li and Katherine M. Stefanski,

{"title":"Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease","authors":"Charles R. Sanders*, Bruce D. Carter, Mason C. Wilkinson, Geoffrey C. Li and Katherine M. Stefanski, ","doi":"10.1021/acs.chemrev.6c00096","DOIUrl":"10.1021/acs.chemrev.6c00096","url":null,"abstract":"Charcot-Marie-Tooth disease (CMT) is an often-debilitating peripheral neuropathy that is a top-10 most prevalent human genetic disorder. However, there is currently no effective treatment. Over half of diagnosed CMT cases in western populations are caused by genetic variations that alter the expression levels or sequence of peripheral myelin protein 22 (PMP22). PMP22 is a tetraspan membrane glycoprotein that is most highly expressed in Schwann cells (SCs) of the peripheral nervous system (PNS) under conditions of myelination, where it plays multiple important roles. These functions are reduced in humans with only a single PMP22 allele, resulting in a common and usually mild form of CMT, hereditary neuropathy with liability to pressure palsies (HNPP). The rare type 1E CMT (CMT1E) is caused by amino acid variations in PMP22. The most common form of CMT (CMT1A) is caused by a third wild type (WT) allele of PMP22. The disease mechanisms of CMT1A are still incompletely understood, but there is much evidence that a major driver is proteostasis stress caused by WT PMP22 overexpression upon induction of myelination in SCs, possibly compounded by gain-of-function effects. Here, we explore PMP22’s structure, functions, trafficking, role in CMT, and prospects for successful therapeutic intervention.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"7165–7206"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.6c00096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shape-Conserving Atom Replacements 保持形状的原子替换。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-02 DOI: 10.1021/acs.chemrev.5c01009

Mikus Puriņš, Cecile Elgindy and Mark D. Levin*,

引用次数: 0

The Shape of Things to Come: α-Helical Membrane Protein Folding on the Ribosome 未来的形态：α-螺旋膜蛋白在核糖体上的折叠。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-05-18 DOI: 10.1021/acs.chemrev.6c00236

Edward Lambden, Benjamin Russell Lewis, Zadie L. R. Baker, Marvin V. Dilworth, Erin C. Johnston, Juan Palacios-Ortega, Kaylee Patel, Colin P. Pilkington, Heather E. Findlay, Paula J. Booth* and Grant A. Pellowe*,

{"title":"The Shape of Things to Come: α-Helical Membrane Protein Folding on the Ribosome","authors":"Edward Lambden, Benjamin Russell Lewis, Zadie L. R. Baker, Marvin V. Dilworth, Erin C. Johnston, Juan Palacios-Ortega, Kaylee Patel, Colin P. Pilkington, Heather E. Findlay, Paula J. Booth* and Grant A. Pellowe*, ","doi":"10.1021/acs.chemrev.6c00236","DOIUrl":"10.1021/acs.chemrev.6c00236","url":null,"abstract":"Understanding how membrane proteins insert into and fold within cell membranes is critical for explaining the molecular basis of many diseases. It also underpins advances in biotechnology, including the development of therapies for protein misfolding disorders and improved methods for producing membrane proteins at high yield. In cells, nearly all α-helical membrane proteins are synthesized and inserted cotranslationally, folding sequentially as they emerge from the ribosome. This process occurs under spatial constraints imposed by the translational machinery and in membranes with complex physicochemical properties. These processes are vastly different from classical in vitro refolding studies of full-length purified proteins, highlighting a critical need to alter our experimental approach to understand de novo membrane protein folding. The mechanisms driving membrane protein folding remain elusive, largely due to the limited availability of approaches that can probe these processes both in real-time and in their native context. Here, we discuss recent progress in uncovering how membrane proteins fold during synthesis and insertion, and highlight how established and emerging biophysical and structural tools are beginning to resolve cotranslational events with greater mechanistic detail than has been previously possible. Together, these advances are reshaping our understanding of membrane protein biogenesis far beyond traditional refolding models.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"7303–7337"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.6c00236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147961297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relay Catalysis in Selective Transformations of C1 into C2+ Molecules C1选择性转化为C2+分子的接力催化。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-01 DOI: 10.1021/acs.chemrev.6c00026

Yubing Li, Suhan Liu, Yu Xie, Kang Cheng*, Qinghong Zhang, Jincan Kang and Ye Wang*,

{"title":"Relay Catalysis in Selective Transformations of C1 into C2+ Molecules","authors":"Yubing Li, Suhan Liu, Yu Xie, Kang Cheng*, Qinghong Zhang, Jincan Kang and Ye Wang*, ","doi":"10.1021/acs.chemrev.6c00026","DOIUrl":"10.1021/acs.chemrev.6c00026","url":null,"abstract":"C1 molecules (e.g., CO, CO2, CH4, and CH3OH) are pivotal platforms for synthesizing fuels and chemicals from nonpetroleum resources. However, the selective activation of C–O and C–H bonds, precise control of C–C formation, and preservation of functional groups are tough challenges in catalysis. Traditional routes like Fischer–Tropsch synthesis and methanol conversion often suffer from limited selectivity or require multiple processing steps. By using a relay catalysis strategy, a series of bifunctional or multifunctional catalysts composed of metals and acidic zeolites has been developed for the selective hydrogenation of CO to hydrocarbon fuels. Recently, this methodology has also been successfully applied for the precise synthesis of high-value chemicals, such as lower olefins, aromatic hydrocarbons, and higher alcohols from not only CO but also CO2 and CH4. The core of relay catalysis is integrating sequential reactions within one multifunctional catalyst or in a single reactor and providing controllable product selectivity. This review will analyze recent advances in C1 chemistry using relay catalysis as well as tandem catalysis for the selective synthesis of hydrocarbon fuels and chemicals. We also detail the design principles of relay pathways, outlining the strengths, applications, and future potential of relay catalysis in C1 chemistry.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"7112–7164"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148141908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling Targeted Mechanochemistry in Polymeric Solids 聚合物固体中定向机械化学建模。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-05-12 DOI: 10.1021/acs.chemrev.6c00110

Brandon C. Jeong, and , Antonia Statt*,

引用次数: 0

Topological Data Analysis in Materials Science: Principles, Machine Learning Integration, and Application Landscapes 材料科学中的拓扑数据分析：原理、机器学习集成和应用前景。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-09 DOI: 10.1021/acs.chemrev.5c01098

Shisheng Zheng, Bingxu Wang, Mengmeng Zhang, Jiawei Tan, Hang-Biao Lv, Ran Liu, Zhong-Zhang Shi, Xin Li, Ruoxuan Wang, Siwang Zhang, Jingyan Li, Yingru Zhao*, Jie Wu*, Jian-Feng Li*, Shing-Tung Yau* and Feng Pan*,

{"title":"Topological Data Analysis in Materials Science: Principles, Machine Learning Integration, and Application Landscapes","authors":"Shisheng Zheng, Bingxu Wang, Mengmeng Zhang, Jiawei Tan, Hang-Biao Lv, Ran Liu, Zhong-Zhang Shi, Xin Li, Ruoxuan Wang, Siwang Zhang, Jingyan Li, Yingru Zhao*, Jie Wu*, Jian-Feng Li*, Shing-Tung Yau* and Feng Pan*, ","doi":"10.1021/acs.chemrev.5c01098","DOIUrl":"10.1021/acs.chemrev.5c01098","url":null,"abstract":"The data-driven paradigms are reshaping materials science, placing unprecedented emphasis on the digital characterization and representation of the material data. Topological Data Analysis (TDA) methods offer a promising and innovative approach to uncovering data patterns in complex material systems from a topological perspective. By focusing on topological invariants across multiscale resolution, TDA offers unique robustness, interpretability, and universality for the discovery of structure–property relationships. This review presents the mathematical foundations of TDA, with a focus on key methodologies such as persistent homology, persistent GLMY homology, and Euler characteristic curves. We further introduce the emerging field of topological learning, which integrates TDA with machine learning to enhance the development of predictive models. Representative applications of TDA are discussed in diverse material systems. In addition, we briefly highlight its emerging applications in related domains such as molecular science and biochemistry. Building on these examples, we summarize the unique advantages TDA offers in materials informatics, along with the critical challenges that remain. This review aims to provide a practical guide for materials scientists seeking to apply TDA in data-driven research, and to highlight its growing potential in advancing materials discovery and design.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"7029–7067"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Additive Manufacturing Electrochemistry 增材制造电化学研究进展。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-05 DOI: 10.1021/acs.chemrev.5c00984

Robert D. Crapnell, Elena Bernalte and Craig E. Banks*,

{"title":"Advances in Additive Manufacturing Electrochemistry","authors":"Robert D. Crapnell, Elena Bernalte and Craig E. Banks*, ","doi":"10.1021/acs.chemrev.5c00984","DOIUrl":"10.1021/acs.chemrev.5c00984","url":null,"abstract":"Fused filament fabrication (FFF) has rapidly evolved from a prototyping tool into a powerful platform for electrochemical device innovation. Its accessibility, design freedom, and compatibility with diverse polymers have enabled breakthroughs in sensor architectures, energy storage components, and wearable systems. However, works using currently available commercial filament lack the required conductivity or functionality to create impactful devices. Recent advances in conductive composites, surface functionalization strategies, and multimaterial printing have transformed FFF from a low-resolution technique into a versatile manufacturing approach capable of integrating complex geometries with tailored electrochemical properties with the potential to of achieve real impact. While challenges remain in realizing microscale resolution and consistentency in conductivity between filament batches and in printing across different devices, emerging solutions are pushing the boundaries of what is possible. This review highlights the progress that has positioned FFF at the forefront of additive manufacturing for electrochemistry and outlines the innovations that will drive the next generation of scalable, high-performance devices.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"6963–7003"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.5c00984","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wired and Wireless Photosynthetic Biohybrids: Design, Materials, and Mechanisms 有线和无线光合生物杂交体：设计、材料和机制。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-03 DOI: 10.1021/acs.chemrev.6c00116

Lihini Jayasinghe, Wonseok Lee, Andrew Liu, Elizabeth Lineberry, Jiaxi Wei and Peidong Yang*,

{"title":"Wired and Wireless Photosynthetic Biohybrids: Design, Materials, and Mechanisms","authors":"Lihini Jayasinghe, Wonseok Lee, Andrew Liu, Elizabeth Lineberry, Jiaxi Wei and Peidong Yang*, ","doi":"10.1021/acs.chemrev.6c00116","DOIUrl":"10.1021/acs.chemrev.6c00116","url":null,"abstract":"Photosynthetic biohybrid systems (PBSs) integrate semiconductor light harvesters with microbial metabolism to enable solar-driven chemical synthesis, yet the chemical principles governing their performance remain dispersed across two distinct architectures: wired biohybrids, which rely on photoelectrode–microbe interfaces, and wireless systems, where microbes are photosensitized by colloidal or molecular catalysts. This review examines the materials chemistry, interfacial electron transfer mechanisms, and biological constraints that define each approach. We evaluate the stability and biocompatibility of semiconductor photoelectrodes, charge transfer pathways across abiotic/biotic interfaces, microbial community dynamics, and photoelectrochemical operational parameters central to wired systems. For wireless platforms, we analyze design rules for whole-cell photosensitization, including semiconductor selection, cellular uptake, redox coupling, and mechanistic probes of electron delivery. By comparing both architectures, we identify unifying chemical principles and key bottlenecks that limit efficiency, providing a framework for the predictive design of next-generation PBSs for sustainable solar-to-chemical conversion.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"7249–7302"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methods toward Single-Cell Total-Analysis 单细胞全量分析方法。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-03 DOI: 10.1021/acs.chemrev.5c01127

Qiang Zhang, Wenjun Liao, Ling Lin*, XiuJun James Li, Jiaxu Lin, Yang Song, Ying Hou and Jin-Ming Lin*,

{"title":"Methods toward Single-Cell Total-Analysis","authors":"Qiang Zhang, Wenjun Liao, Ling Lin*, XiuJun James Li, Jiaxu Lin, Yang Song, Ying Hou and Jin-Ming Lin*, ","doi":"10.1021/acs.chemrev.5c01127","DOIUrl":"10.1021/acs.chemrev.5c01127","url":null,"abstract":"Single-cell total-analysis aims to bridge the gap between cellular molecular makeup and functional phenotype, deciphering how genomic, transcriptomic, proteomic, and metabolic networks orchestrate phenotypic outcomes. Despite rapid omics advances, a critical disconnect persists: nucleic acid-based analyses (genomics, epigenomics, transcriptomics) are mature, while proteomic/metabolomic profiling is incomplete, and comprehensive phenomics (the direct readout of cellular function) lags due to dynamic cellular complexity. This raises a core question: how to transcend isolated molecular layers to capture the ″molecular-phenotypic correlation″ in single cells? Multimodal integration progresses but is constrained by technical incompatibilities, throughput-depth trade-offs, and poor temporal resolution. This review examines advances in five core omics domains, identifies bottlenecks, analyzes multiomics coanalysis strategies, and outlines a roadmap for true single-cell total-analysis, emphasizing breakthrough approaches to unify molecular and phenotypic landscapes. We propose that true single-cell total-analysis is defined not by the accumulation of multiomic molecular layers, but by the direct establishment of phenotype–component correlations within the same individual cell.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"7068–7111"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic Reduction–Oxidation System for Synergistic Utilization of Photogenerated Electrons and Holes 协同利用光生电子和空穴的光催化还原氧化系统。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-06-24 Epub Date: 2026-06-08 DOI: 10.1021/acs.chemrev.5c00766

Boxin Liu, Xin Tan, Tao Yu* and Jinlong Gong*,

{"title":"Photocatalytic Reduction–Oxidation System for Synergistic Utilization of Photogenerated Electrons and Holes","authors":"Boxin Liu, Xin Tan, Tao Yu* and Jinlong Gong*, ","doi":"10.1021/acs.chemrev.5c00766","DOIUrl":"10.1021/acs.chemrev.5c00766","url":null,"abstract":"The efficient and simultaneous utilization of photogenerated electrons and holes in photocatalytic reduction–oxidation (redox) reactions is currently an important trend in photocatalysis. This review systematically describes photocatalytic redox systems involving H2 evolution, H2O2 evolution, CO2 reduction, and NO3– reduction coupled with key oxidation reactions, respectively, to meet economic and sustainable goals. The general background and fundamental principles of photocatalytic coupled reactions are first introduced to provide a systematic understanding of the field. Thereafter, the research progress of H2 evolution, H2O2 evolution, CO2 reduction, and NO3– reduction coupled with various oxidation reactions, including H2O oxidation, biomass and its derived platform molecules valorization, organics conversion, and pollutants treatment, respectively, is highlighted. Moreover, the commonalities and differences among photocatalytic coupled reactions are briefly summarized. Finally, the remaining challenges and future prospects of photocatalytic coupled reactions are critically discussed.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 12","pages":"6899–6962"},"PeriodicalIF":64.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0