Chemical ReviewsPub Date : 2025-03-31DOI: 10.1021/acs.chemrev.4c00906
Jiangtao Su, Ke He, Yanzhen Li, Jiaqi Tu, Xiaodong Chen
{"title":"Soft Materials and Devices Enabling Sensorimotor Functions in Soft Robots","authors":"Jiangtao Su, Ke He, Yanzhen Li, Jiaqi Tu, Xiaodong Chen","doi":"10.1021/acs.chemrev.4c00906","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00906","url":null,"abstract":"Sensorimotor functions, the seamless integration of sensing, decision-making, and actuation, are fundamental for robots to interact with their environments. Inspired by biological systems, the incorporation of soft materials and devices into robotics holds significant promise for enhancing these functions. However, current robotics systems often lack the autonomy and intelligence observed in nature due to limited sensorimotor integration, particularly in flexible sensing and actuation. As the field progresses toward soft, flexible, and stretchable materials, developing such materials and devices becomes increasingly critical for advanced robotics. Despite rapid advancements individually in soft materials and flexible devices, their combined applications to enable sensorimotor capabilities in robots are emerging. This review addresses this emerging field by providing a comprehensive overview of soft materials and devices that enable sensorimotor functions in robots. We delve into the latest development in soft sensing technologies, actuation mechanism, structural designs, and fabrication techniques. Additionally, we explore strategies for sensorimotor control, the integration of artificial intelligence (AI), and practical application across various domains such as healthcare, augmented and virtual reality, and exploration. By drawing parallels with biological systems, this review aims to guide future research and development in soft robots, ultimately enhancing the autonomy and adaptability of robots in unstructured environments.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"50 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-31DOI: 10.1021/acs.chemrev.4c0086810.1021/acs.chemrev.4c00868
Helies Hyrondelle, Alexandre Terry, Jérôme Lhoste, Sophie Tencé, Kevin Lemoine, Jacob Olchowka, Damien Dambournet, Cédric Tassel, Jacinthe Gamon and Alain Demourgues*,
{"title":"Fluorine as a Key Element in Solid-State Chemistry of Mixed Anions 3d Transition Metal-Based Materials for Electronic Properties and Energy","authors":"Helies Hyrondelle, Alexandre Terry, Jérôme Lhoste, Sophie Tencé, Kevin Lemoine, Jacob Olchowka, Damien Dambournet, Cédric Tassel, Jacinthe Gamon and Alain Demourgues*, ","doi":"10.1021/acs.chemrev.4c0086810.1021/acs.chemrev.4c00868","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00868https://doi.org/10.1021/acs.chemrev.4c00868","url":null,"abstract":"<p >Mixed anion compounds containing fluorine and based on 3d transition elements represent a class of materials with significant interest in solid-state chemistry. Indeed, their highly varied chemical composition, structural diversity, and the resulting electronic properties provide a rich playground for imagining new applications in the field of energy. The anions and the chemical bonds they form with the 3d transition elements are at the heart of this review. Key parameters such as electronegativity, hardness, and polarizability are introduced and discussed to better understand the charge capacity of the anion and the bonds formed in the solid. Oxyfluorides represent the most studied family due to the size similarity of the two anions, and part of the review is dedicated to the specific synthesis of these materials by systematically adjusting the fluorine content within various structures and analyzing the electronic and electrochemical properties of these compositions. The final sections focus on materials with structures often exhibiting a two-dimensional character, where ionic blocks coexist with covalent layers, such as fluorochalcogenides, fluoropnictides, and fluorotetrelides. The compositions and structures are systematically correlated with the electronic properties.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 8","pages":"4287–4358 4287–4358"},"PeriodicalIF":51.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-31DOI: 10.1021/acs.chemrev.4c00868
Helies Hyrondelle, Alexandre Terry, Jérôme Lhoste, Sophie Tencé, Kevin Lemoine, Jacob Olchowka, Damien Dambournet, Cédric Tassel, Jacinthe Gamon, Alain Demourgues
{"title":"Fluorine as a Key Element in Solid-State Chemistry of Mixed Anions 3d Transition Metal-Based Materials for Electronic Properties and Energy","authors":"Helies Hyrondelle, Alexandre Terry, Jérôme Lhoste, Sophie Tencé, Kevin Lemoine, Jacob Olchowka, Damien Dambournet, Cédric Tassel, Jacinthe Gamon, Alain Demourgues","doi":"10.1021/acs.chemrev.4c00868","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00868","url":null,"abstract":"Mixed anion compounds containing fluorine and based on 3d transition elements represent a class of materials with significant interest in solid-state chemistry. Indeed, their highly varied chemical composition, structural diversity, and the resulting electronic properties provide a rich playground for imagining new applications in the field of energy. The anions and the chemical bonds they form with the 3d transition elements are at the heart of this review. Key parameters such as electronegativity, hardness, and polarizability are introduced and discussed to better understand the charge capacity of the anion and the bonds formed in the solid. Oxyfluorides represent the most studied family due to the size similarity of the two anions, and part of the review is dedicated to the specific synthesis of these materials by systematically adjusting the fluorine content within various structures and analyzing the electronic and electrochemical properties of these compositions. The final sections focus on materials with structures often exhibiting a two-dimensional character, where ionic blocks coexist with covalent layers, such as fluorochalcogenides, fluoropnictides, and fluorotetrelides. The compositions and structures are systematically correlated with the electronic properties.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"183 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-26DOI: 10.1021/acs.chemrev.4c00785
Ronald H. Heisser, Maheera Bawa, Jessica Shah, Angel Bu, Ritu Raman
{"title":"Soft Biological Actuators for Meter-Scale Homeostatic Biohybrid Robots","authors":"Ronald H. Heisser, Maheera Bawa, Jessica Shah, Angel Bu, Ritu Raman","doi":"10.1021/acs.chemrev.4c00785","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00785","url":null,"abstract":"Skeletal muscle’s elegant protein-based architecture powers motion throughout the animal kingdom, with its constituent actomyosin complexes driving intra- and extra-cellular motion. Classical motors and recently developed soft actuators cannot match the packing density and contractility of individual muscle fibers that scale to power the motion of ants and elephants alike. Accordingly, the interdisciplinary fields of robotics and tissue engineering have combined efforts to build living muscle actuators that can power a new class of robots to be more energy-efficient, dexterous, and safe than existing motor-powered and hydraulic paradigms. Doing so ethically and at scale─creating meter-scale tissue constructs from sustainable muscle progenitor cell lines─has inspired innovations in biomaterials and tissue culture methodology. We weave discussions of muscle cell biology, materials chemistry, tissue engineering, and biohybrid design to review the state of the art in soft actuator biofabrication. Looking forward, we outline a vision for meter-scale biohybrid robotic systems and tie discussions of recent progress to long-term research goals.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"183 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-26DOI: 10.1021/acs.chemrev.5c00158
Bryan C. Dickinson
{"title":"Introduction: Synthetic Biology","authors":"Bryan C. Dickinson","doi":"10.1021/acs.chemrev.5c00158","DOIUrl":"https://doi.org/10.1021/acs.chemrev.5c00158","url":null,"abstract":"Published as part of <i>Chemical Reviews</i> special issue “Synthetic Biology”. The 21st century is undeniably the century of biology, with scientific advancements accelerating at an unprecedented pace due to our growing ability to manipulate, reprogram, and engineer biological systems. At the heart of many groundbreaking discoveries in biotechnology over the past 25 years are chemists─driven by a deep-rooted desire to understand molecules and design new ones. Chemists are, by nature, builders. Whether synthesizing complex natural products, constructing entire proteins and nucleic acids, or assembling novel biomolecular systems, we learn by creating and refining the very molecules that shape life. In this spirit, synthetic biology─a field dedicated to harnessing and engineering biological systems─has become a natural extension of chemical biology, offering vast opportunities for innovation. This special issue, <i>Synthetic Biology</i>, highlights recent contributions by chemists in engineering biological systems to develop tools and technologies that deepen our understanding of nature while enabling new applications in both basic research and medicine. The selected works span multiple scales, from small molecules to biological macromolecules to entire organisms, illustrating how synthetic biology serves both as a means to answer fundamental biological questions and as a platform for groundbreaking biotechnological and therapeutic advancements. Collectively, this collection reflects the fearless, inventive spirit of chemists as they continue to push the boundaries of what is possible in synthetic biology. Starting with small molecule discovery, synthetic biology has revolutionized natural product research in the postgenomics era, enabling the discovery, characterization, and engineering of bioactive compounds with unprecedented precision. <i>Tang and colleagues</i> review key advancements in the field of natural products research from a synthetic biology perspective, focusing on three major aspects. First, they explore the integration of bioinformatics and analytical tools in identifying natural products through biosynthetic gene clusters (BGCs), enhancing the efficiency of natural product discovery. Second, they examine the heterologous expression of natural product biosynthetic pathways across various host organisms, such as bacteria, fungi, and plants, allowing researchers to bypass native-host limitations. Finally, they discuss strategies for modifying and diversifying natural product structures, including innovations in megasynthase engineering, precursor-directed synthesis, and combinatorial biosynthesis. These developments are expanding the chemical diversity of bioactive molecules, driving applications in drug discovery, biotechnology, and metabolic engineering. Moving from small molecules to fundamental cell biology, this collection features two reviews on using synthetic biology approaches to understand lipids. Lipid biology plays a fund","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"21 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-26DOI: 10.1021/acs.chemrev.4c0078510.1021/acs.chemrev.4c00785
Ronald H. Heisser, Maheera Bawa, Jessica Shah, Angel Bu and Ritu Raman*,
{"title":"Soft Biological Actuators for Meter-Scale Homeostatic Biohybrid Robots","authors":"Ronald H. Heisser, Maheera Bawa, Jessica Shah, Angel Bu and Ritu Raman*, ","doi":"10.1021/acs.chemrev.4c0078510.1021/acs.chemrev.4c00785","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00785https://doi.org/10.1021/acs.chemrev.4c00785","url":null,"abstract":"<p >Skeletal muscle’s elegant protein-based architecture powers motion throughout the animal kingdom, with its constituent actomyosin complexes driving intra- and extra-cellular motion. Classical motors and recently developed soft actuators cannot match the packing density and contractility of individual muscle fibers that scale to power the motion of ants and elephants alike. Accordingly, the interdisciplinary fields of robotics and tissue engineering have combined efforts to build living muscle actuators that can power a new class of robots to be more energy-efficient, dexterous, and safe than existing motor-powered and hydraulic paradigms. Doing so ethically and at scale─creating meter-scale tissue constructs from sustainable muscle progenitor cell lines─has inspired innovations in biomaterials and tissue culture methodology. We weave discussions of muscle cell biology, materials chemistry, tissue engineering, and biohybrid design to review the state of the art in soft actuator biofabrication. Looking forward, we outline a vision for meter-scale biohybrid robotic systems and tie discussions of recent progress to long-term research goals.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 7","pages":"3976–4007 3976–4007"},"PeriodicalIF":51.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-21DOI: 10.1021/acs.chemrev.4c00567
Kaushik Seshadri, Abner N. D. Abad, Kyle K. Nagasawa, Karl M. Yost, Colin W. Johnson, Moriel J. Dror, Yi Tang
{"title":"Synthetic Biology in Natural Product Biosynthesis","authors":"Kaushik Seshadri, Abner N. D. Abad, Kyle K. Nagasawa, Karl M. Yost, Colin W. Johnson, Moriel J. Dror, Yi Tang","doi":"10.1021/acs.chemrev.4c00567","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00567","url":null,"abstract":"Synthetic biology has played an important role in the renaissance of natural products research during the post-genomics era. The development and integration of new tools have transformed the workflow of natural product discovery and engineering, generating multidisciplinary interest in the field. In this review, we summarize recent developments in natural product biosynthesis from three different aspects. First, advances in bioinformatics, experimental, and analytical tools to identify natural products associated with predicted biosynthetic gene clusters (BGCs) will be covered. This will be followed by an extensive review on the heterologous expression of natural products in bacterial, fungal and plant organisms. The native host-independent paradigm to natural product identification, pathway characterization, and enzyme discovery is where synthetic biology has played the most prominent role. Lastly, strategies to engineer biosynthetic pathways for structural diversification and complexity generation will be discussed, including recent advances in assembly-line megasynthase engineering, precursor-directed structural modification, and combinatorial biosynthesis.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-21DOI: 10.1021/acs.chemrev.4c0056710.1021/acs.chemrev.4c00567
Kaushik Seshadri, Abner N. D. Abad, Kyle K. Nagasawa, Karl M. Yost, Colin W. Johnson, Moriel J. Dror and Yi Tang*,
{"title":"Synthetic Biology in Natural Product Biosynthesis","authors":"Kaushik Seshadri, Abner N. D. Abad, Kyle K. Nagasawa, Karl M. Yost, Colin W. Johnson, Moriel J. Dror and Yi Tang*, ","doi":"10.1021/acs.chemrev.4c0056710.1021/acs.chemrev.4c00567","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00567https://doi.org/10.1021/acs.chemrev.4c00567","url":null,"abstract":"<p >Synthetic biology has played an important role in the renaissance of natural products research during the post-genomics era. The development and integration of new tools have transformed the workflow of natural product discovery and engineering, generating multidisciplinary interest in the field. In this review, we summarize recent developments in natural product biosynthesis from three different aspects. First, advances in bioinformatics, experimental, and analytical tools to identify natural products associated with predicted biosynthetic gene clusters (BGCs) will be covered. This will be followed by an extensive review on the heterologous expression of natural products in bacterial, fungal and plant organisms. The native host-independent paradigm to natural product identification, pathway characterization, and enzyme discovery is where synthetic biology has played the most prominent role. Lastly, strategies to engineer biosynthetic pathways for structural diversification and complexity generation will be discussed, including recent advances in assembly-line megasynthase engineering, precursor-directed structural modification, and combinatorial biosynthesis.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 7","pages":"3814–3931 3814–3931"},"PeriodicalIF":51.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-03-19DOI: 10.1021/acs.chemrev.4c0078610.1021/acs.chemrev.4c00786
Hongwei Ming, Zhong-Zhen Luo*, Zhigang Zou and Mercouri G. Kanatzidis*,
{"title":"Strategies and Prospects for High-Performance Te-Free Thermoelectric Materials","authors":"Hongwei Ming, Zhong-Zhen Luo*, Zhigang Zou and Mercouri G. Kanatzidis*, ","doi":"10.1021/acs.chemrev.4c0078610.1021/acs.chemrev.4c00786","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00786https://doi.org/10.1021/acs.chemrev.4c00786","url":null,"abstract":"<p >Thermoelectric materials hold great potential for direct conversion of ubiquitous waste heat into electricity. However, their commercialization is hindered by low efficiency, reliance on rare and expensive Te, and limited stability under operating conditions. This review explores recent advances in novel strategies for achieving high thermoelectric performance and stability in Te-free inorganic bulk materials. First, we discuss diverse innovative techniques aimed at substantially enhancing electrical transport properties. These methods encompass strategies such as charge carrier engineering, band convergence, band inversion, valley anisotropy, multiband synglisis, and the incorporation of resonant levels or midgap states. Then we focus on strategies to reduce lattice thermal conductivity, including phonon scattering induced by multidimensional defects, off-center doping, resonance scattering, and lattice softening. Additionally, this review presents strategies for decoupling electron and phonon transport to enhance the thermoelectric performance of materials further. The strategies include interface engineering, crystal symmetry manipulation, high-entropy engineering and nanostructuring, high-pressure technology, and magnetically enhanced thermoelectrics. Moreover, we highlight novel strategies for improving the chemical and thermal stability of materials under operating conditions. Last, we discuss current controversies and challenges and suggest future directions for further research to improve the thermoelectric performance of Te-free bulk materials.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 7","pages":"3932–3975 3932–3975"},"PeriodicalIF":51.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}