Chemical ReviewsPub Date : 2025-07-23DOI: 10.1021/acs.chemrev.4c00989
Lucia Lombardi,Valentina Del Genio,Fernando Albericio,Daryl R Williams
{"title":"Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications.","authors":"Lucia Lombardi,Valentina Del Genio,Fernando Albericio,Daryl R Williams","doi":"10.1021/acs.chemrev.4c00989","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00989","url":null,"abstract":"Over the past two decades, peptide drug discovery has experienced a remarkable renaissance, with organic chemistry and biotechnology emerging as pivotal tools for developing peptidomimetics that exhibit improved stability, specificity, and bioavailability compared to conventional peptides. This review systematically examines methodologies for modifying peptide backbones to achieve targeted properties, highlighting recent advances facilitated by modern biotechnological innovations for novel molecular transformations. Additionally, the review emphasizes the practical applications of peptides and peptidomimetics, showcasing their successful integration into medicine and pharmacology. This manuscript evaluates achievements and challenges in the field and identifies critical areas for further research. Its overarching aim is to synthesize current knowledge and propose strategic directions for advancing peptide-based therapeutics.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"667 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Ziyang Zhang*, and , Kevan M. Shokat, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":51.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.5c00246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-07-23Epub Date: 2025-06-27DOI: 10.1021/acs.chemrev.5c00025
Zhuyuan Wang, Jindi Yang, Ming Yong, Xiangkang Zeng, Mike Tebyetekerwa, Kaige Sun, Chuanbiao Bie, Chao Xing, Huanting Wang, Daria V Andreeva, Kostya S Novoselov, Xiwang Zhang
{"title":"From Layered Crystals to Permselective Membranes: History, Fundamentals, and Opportunities.","authors":"Zhuyuan Wang, Jindi Yang, Ming Yong, Xiangkang Zeng, Mike Tebyetekerwa, Kaige Sun, Chuanbiao Bie, Chao Xing, Huanting Wang, Daria V Andreeva, Kostya S Novoselov, Xiwang Zhang","doi":"10.1021/acs.chemrev.5c00025","DOIUrl":"10.1021/acs.chemrev.5c00025","url":null,"abstract":"<p><p>Membranes are crucial in permselective processes, such as water purification, gas sequestration, ion separation, membrane distillation and pervaporation, and energy conversion and storage. The two-decade development of two-dimensional (2D) membranes has shifted the membrane transport from solution-diffusion in the polymer matrix to size-dependent migration in Ångström-to-nanoscale slit-like channels, delivering distinctive fundamentals within nanoconfinements and potential implementations. In this review, we delve into the comprehensive information that facilitates the transformation of layered crystals into continuous thin-film architectures boasting well-defined nanopores. We trace the evolutionary history of these technologies, engage in debates on their underlying principles, and reveal obstacles that demand attention. Starting with the preparation of \"single-layer carbon,\" we explore an array of protocols designed for the sizable production of 2D nanosheets. Our focus then shifts toward unveiling the solutions available for membrane fabrication and control, specifically focusing on the chemical and structural properties of 2D membranes that dictate their mass transportation behaviors in various scenarios. This is followed by a brief comparative discussion on the development of atomically thin and 2D-based mixed matrix membranes. Finally, we conclude by outlining the challenges and limitations associated with streamlining the interlocked exfoliation-reconstruction-control processes to consolidate their practicalities for use in environment and energy-related applications.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":" ","pages":"6753-6818"},"PeriodicalIF":51.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seong Ho Hong, Thu Nguyen, Joseph F. Ongkingco, Alex Nazzaro and Paramjit S. Arora*,
{"title":"","authors":"Seong Ho Hong, Thu Nguyen, Joseph F. Ongkingco, Alex Nazzaro and Paramjit S. Arora*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":51.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.5c00046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
