细菌天然产物生物合成中的脂肪酰基- amp连接酶。

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2025-01-03 DOI:10.1039/d4np00073k

Anne Liong , Pedro N. Leão

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引用次数: 0

摘要

覆盖范围：覆盖范围达2024脂酰amp连接酶（FAALs）属于腺苷酸形成酶家族，通过腺苷化激活脂酰底物。FAALs在各种天然产物的生物合成途径中发挥着关键作用，特别是在聚酮和非核糖体肽的组装中。这些酶表现出一种保守的结构结构，将它们与它们的近亲脂肪酰基辅酶a连接酶区分开来。FAALs在多种天然产物的生物合成中发挥着启动单位作用，它们将脂肪酰基底物转移到次级代谢中，以进一步延长链和/或修饰。本文综述了FAALs的发现、分布、结构及其在天然产物生物合成中的作用。此外，我们概述了它们的基因组和生物合成背景，并总结了用于分析FAAL活性，预测其底物特异性以及发现涉及这些酶的生物合成的新化合物的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fatty acyl-AMP ligases in bacterial natural product biosynthesis

查看原文本刊更多论文

Fatty acyl-AMP ligases in bacterial natural product biosynthesis

Covering: covering up to 2024

Fatty Acyl-AMP Ligases (FAALs) belong to the family of adenylate-forming enzymes and activate fatty acyl substrates through adenylation. FAALs were discovered as key players in various natural product biosynthetic pathways, particularly in the assembly of polyketides and non-ribosomal peptides. These enzymes exhibit a conserved structural architecture that distinguishes them from their close relatives, the Fatty Acyl-CoA Ligases. FAALs display the starter unit in the biosynthesis of diverse natural products where they shuttle fatty acyl substrates into secondary metabolism for further chain elongation and/or modification. In this review, we cover the discovery, distribution and structure of FAALs as well as their role in natural product biosynthesis. In addition, we provide an overview about their genomic and biosynthetic contexts and summarize approaches used to analyze FAAL activity, predict their substrate specificity and to discover new compounds whose biosyntheses involve these enzymes.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.