Bi- and tricyclic diterpenoids: landmarks from a decade (2013–2023) in search of leads against infectious diseases

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2024-10-07 DOI:10.1039/D4NP00021H

Olha Antoniuk, Ana Maranha, Jorge A. R. Salvador, Nuno Empadinhas and Vânia M. Moreira

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Abstract

Covering: 2013 to 2023

In an era where antimicrobial resistance severely threatens our ability to treat infections, the discovery of new drugs that belong to different chemical classes and/or bear original modes of action is urgently needed. In this case, diterpenoids comprise a productive field with a proven track record in providing new anti-infectives to tackle bacterial infections and malaria. This review highlights the potential of both naturally occurring and semi-synthetic bi- and tricyclic diterpenoids to become leads in search of new drugs to treat infections caused by bacteria, fungi, viruses and protozoan parasites. The literature from the last decade (2013–2023) is covered, focusing on naturally occurring and semi-synthetic bicyclic (labdanes and labdane-type) and tricyclic (all classes) diterpenoids, detailing their relevant biological activities in the context of infection, which are explained through structure–activity relationships.

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双环和三环二萜类化合物：寻找抗传染病线索十年（2013-2023 年）的里程碑。

覆盖时间：2013 年至 2023 年在抗菌药耐药性严重威胁我们治疗感染能力的时代，迫切需要发现属于不同化学类别和/或具有独创作用模式的新药。在这种情况下，二萜类化合物是一个富有成效的领域，在提供新的抗感染药物以应对细菌感染和疟疾方面有着良好的记录。本综述强调了天然和半合成的双环和三环二萜类化合物在寻找治疗细菌、真菌、病毒和原生动物寄生虫引起的感染的新药方面的潜力。本研究涵盖了过去十年（2013-2023 年）的文献，重点关注天然和半合成的双环（拉布丹类和拉布丹类）和三环（所有类别）二萜类化合物，详细介绍了它们在感染方面的相关生物活性，并通过结构-活性关系对这些活性进行了解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.