Natural Product Reports最新文献_第2页

The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture. I 型多酮类天然产物的化学生态学和生理功能：初露端倪。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-18 DOI: 10.1039/d4np00046c

Romain M M François, Jean-Malo Massicard, Kira J Weissman

引用次数: 0

Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides 真菌：发现葡聚糖合成酶抑制剂enfumafungin和开发新型抗真菌三萜糖苷。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-18 DOI: 10.1039/D4NP00044G

Francisca Vicente, Fernando Reyes and Olga Genilloud

{"title":"Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides","authors":"Francisca Vicente, Fernando Reyes and Olga Genilloud","doi":"10.1039/D4NP00044G","DOIUrl":"10.1039/D4NP00044G","url":null,"abstract":"Covering: up to 2024Fungal pathogens are a major threat to public health, with emerging resistance to all three classes of antifungals that are currently available and increased incidence of invasive fungal infections among hospitalized patients. Ibrexafungerp is a semi-synthetic analog of enfumafungin and the first antifungal agent approved in more than 20 years since the launch of caspofungin, the first of echinocandins. This new drug approval was made possible after a long arduous journey lasting 25 years by dedicated and talented medicinal chemists from two companies that undertook tedious atom-by-atom chemical modification of the natural product enfumafungin, a glycosylated fernane-type triterpenoid isolated from the fungus Hormonema carpetanum. This highlight will cover the discovery of enfumafungin, its biosynthesis and the characterisation of its antifungal profile and mode of action that led to the development of ibrexafungerp. We will discuss the challenges encountered during this long preclinical program and the clinical trial validation of this first-in-class oral antifungal approved to treat vulvovaginal candidiasis with an enormous therapeutic potential to treat future major threatening drug-resistant fungal pathogens.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 12","pages":" 1835-1845"},"PeriodicalIF":10.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Debottlenecking cytochrome P450-dependent metabolic pathways for the biosynthesis of commercial natural products 去瓶颈化细胞色素 P450 依赖性代谢途径，促进商业天然产品的生物合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-18 DOI: 10.1039/D4NP00027G

Susanne M. Germann, Maxence Holtz, Michael Krogh Jensen and Carlos G. Acevedo-Rocha

{"title":"Debottlenecking cytochrome P450-dependent metabolic pathways for the biosynthesis of commercial natural products","authors":"Susanne M. Germann, Maxence Holtz, Michael Krogh Jensen and Carlos G. Acevedo-Rocha","doi":"10.1039/D4NP00027G","DOIUrl":"10.1039/D4NP00027G","url":null,"abstract":"Covering: 2016 to the end of 2024This highlight article aims to provide a perspective on the challenges that novel biotechnological processes face in the biomanufacturing of natural products (NPs) whose biosynthesis pathways rely on cytochrome P450 monooxygenases. This enzyme superfamily is one of the most versatile in the biosynthesis of a plethora of NPs finding use across the food, nutrition, medicine, chemical and cosmetics industries. These enzymes often exhibit excellent regio- and stereoselectivity, but they can suffer from low activity and instability, which are serious issues impairing the development of high performing bioprocesses. We start with a brief introduction to industrial biotechnology and the importance of looking for alternative means for producing NPs independently from unsustainable fossil fuels or plant extractions. We then discuss the challenges and implemented solutions during the development of commercial NP processes focusing on the P450-dependent steps primarily in yeast cell factories. Our main focus is to highlight the challenges often encountered when utilizing P450-dependent NP pathways, and how protein engineering can be used for debottlenecking them. Finally, we briefly touch upon the importance of artificial intelligence and machine learning for guiding engineering efforts.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 12","pages":" 1846-1857"},"PeriodicalIF":10.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human microbiota peptides: important roles in human health 人类微生物群肽：在人类健康中的重要作用。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-15 DOI: 10.1039/D4NP00042K

Abdul Bari Shah and Sang Hee Shim

{"title":"Human microbiota peptides: important roles in human health","authors":"Abdul Bari Shah and Sang Hee Shim","doi":"10.1039/D4NP00042K","DOIUrl":"10.1039/D4NP00042K","url":null,"abstract":"Covering: 1974 to 2024Human microbiota consist of a diverse array of microorganisms, such as bacteria, Eukarya, archaea, and viruses, which populate various parts of the human body and live in a cooperatively beneficial relationship with the host. They play a crucial role in supporting the functional balance of the microbiome. The coevolutionary progression has led to the development of specialized metabolites that have the potential to substitute traditional antibiotics in combating global health challenges. Although there has been a lot of research on the human microbiota, there is a considerable lack of understanding regarding the wide range of peptides that these microbial populations produce. Particularly noteworthy are the antibiotics that are uniquely produced by the human microbiome, especially by bacteria, to protect against invasive infections. This review seeks to fill this knowledge gap by providing a thorough understanding of various peptides, along with their in-depth biological importance in terms of human disorders. Advancements in genomics and the understanding of molecular mechanisms that control the interactions between microbiota and hosts have made it easier to find peptides that come from the human microbiome. We hope that this review will serve as a basis for developing new therapeutic approaches and personalized healthcare strategies. Additionally, it emphasizes the significance of these microbiota in the field of natural product discovery and development.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 1","pages":" 151-194"},"PeriodicalIF":10.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical diversity of cyanobacterial natural products† 蓝藻天然产品的化学多样性。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-14 DOI: 10.1039/D4NP00040D

Márcio B. Weiss, Ricardo M. Borges, Peter Sullivan, João P. B. Domingues, Francisco H. S. da Silva, Victória G. S. Trindade, Shangwen Luo, Jimmy Orjala and Camila M. Crnkovic

引用次数: 0

Small animals with unique chemistry - the natural product chemistry of Collembola. 具有独特化学性质的小动物--鞘翅目动物的天然产品化学。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-12 DOI: 10.1039/d4np00049h

Anton Möllerke, Stefan Schulz

引用次数: 0

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-04 DOI: 10.1039/D4NP00025K

Shengxin Sun, Xia Wang, Nvdan Hu, Shiqi Fu and Shengkun Li

{"title":"Siccanin-related drimane meroterpenoids: biological activities and synthesis†‡","authors":"Shengxin Sun, Xia Wang, Nvdan Hu, Shiqi Fu and Shengkun Li","doi":"10.1039/D4NP00025K","DOIUrl":"10.1039/D4NP00025K","url":null,"abstract":"Covering: 1962 to 2023Drimane (hydro)quinones biosynthetically arise from the combination of drimane-type terpenoids with phenols or equivalents. Since the isolation of siccanin in 1962 (structure identified in 1967), over 200 natural drimane (hydro)quinones have been reported. They are widespread with remarkably diverse architectures and biological functions, which are achieved by varying either the drimane subunit, hydroquinone segment, or the fusion types of drimane and hydroquinone segment both of them. This type of natural products has drawn increasing attention in the discovery of novel pharmaceutical leads. Enormous efforts have been devoted to developing efficient and divergent synthesis approaches to facilitate the SAR study of drimane (hydro)quinones, aiming for more promising functional leads. This review is arranged mainly in terms of scaffold types of drimane (hydro)quinones and further categorized on the basis of biological functions. The mechanisms of action are also briefly discussed. Synthetic methods are categorized according to the strategies forging the Csp2–Csp3 linker between drimane segments and (hydro)quinone subunits.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 1","pages":" 113-150"},"PeriodicalIF":10.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic-bioinformatic natural product-inspired peptides† 合成生物信息学天然产品启发肽。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-30 DOI: 10.1039/D4NP00043A

Samantha Nelson and Elizabeth I. Parkinson

{"title":"Synthetic-bioinformatic natural product-inspired peptides†","authors":"Samantha Nelson and Elizabeth I. Parkinson","doi":"10.1039/D4NP00043A","DOIUrl":"10.1039/D4NP00043A","url":null,"abstract":"Covering: 2016 to 2024Natural products, particularly cyclic peptides, are a promising source of bioactive compounds. Nonribosomal peptide synthetases (NRPSs) play a key role in biosynthesizing these compounds, which include antibiotic and anticancer agents, immunosuppressants, and others. Traditional methods of discovering natural products have limitations including cryptic biosynthetic gene clusters (BGCs), low titers, and currently unculturable organisms. This has prompted the exploration of alternative approaches. Synthetic-bioinformatic natural products (syn-BNPs) are one such alternative that utilizes bioinformatics techniques to predict nonribosomal peptides (NRPs) followed by chemical synthesis of the predicted peptides. This approach has shown promise, resulting in the discovery of a variety of bioactive compounds including peptides with antibacterial, antifungal, anticancer, and proteasome-stimulating activities. Despite the success of this approach, challenges remain especially in the accurate prediction of fatty acid incorporation, tailoring enzyme modifications, and peptide release mechanisms. Further work in these areas will enable the discovery of many bioactive peptides that are currently inaccessible.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 1","pages":" 50-66"},"PeriodicalIF":10.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth 陆地极端环境中的挥发性有机化合物（VOCs）：对地球以外生命探测的影响。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-21 DOI: 10.1039/D4NP00037D

Claire A. Batty, Victoria K. Pearson, Karen Olsson-Francis and Geraint Morgan

{"title":"Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth","authors":"Claire A. Batty, Victoria K. Pearson, Karen Olsson-Francis and Geraint Morgan","doi":"10.1039/D4NP00037D","DOIUrl":"10.1039/D4NP00037D","url":null,"abstract":"Covering: 1961 to 2024Discovering and identifying unique natural products/biosignatures (signatures that can be used as evidence for past or present life) that are abundant, and complex enough that they indicate robust evidence of life is a multifaceted process. One distinct category of biosignatures being explored is organic compounds. A subdivision of these compounds not yet readily investigated are volatile organic compound (VOCs). When assessing these VOCs as a group (volatilome) a fingerprint of all VOCs within an environment allows the complex patterns in metabolic data to be unravelled. As a technique already successfully applied to many biological and ecological fields, this paper explores how analysis of volatilomes in terrestrial extreme environments could be used to enhance processes (such as metabolomics and metagenomics) already utilised in life detection beyond Earth. By overcoming some of the complexities of collecting VOCs in remote field sites, a variety of lab based analytical equipment and techniques can then be utilised. Researching volatilomics in astrobiology requires time to characterise the patterns of VOCs. They must then be differentiated from abiotic (non-living) signals within extreme environments similar to those found on other planetary bodies (analogue sites) or in lab-based simulated environments or microcosms. Such an effort is critical for understanding data returned from past or upcoming missions, but it requires a step change in approach which explores the volatilome as a vital additional tool to current ‘Omics techniques.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 1","pages":" 93-112"},"PeriodicalIF":10.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/np/d4np00037d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerating enzyme discovery and engineering with high-throughput screening. 通过高通量筛选加速酶的发现和工程化。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-15 DOI: 10.1039/d4np00031e

Eray U Bozkurt, Emil C Ørsted, Daniel C Volke, Pablo I Nikel

{"title":"Accelerating enzyme discovery and engineering with high-throughput screening.","authors":"Eray U Bozkurt, Emil C Ørsted, Daniel C Volke, Pablo I Nikel","doi":"10.1039/d4np00031e","DOIUrl":"10.1039/d4np00031e","url":null,"abstract":"Covering: up to August 2024Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable resources, biocatalysis offers a pathway to an efficient bioeconomy with reduced environmental footprint. However, enzymes have evolved over millions of years to meet the needs of their host organisms, which often do not align with industrial requirements. As a result, enzymes frequently need to be tailored for specific industrial applications. Combining enzyme engineering with high-throughput screening has emerged as a key approach for developing novel biocatalysts, but several challenges are yet to be addressed. In this review, we explore emergent strategies and methods for isolating, creating, and characterizing enzymes optimized for bioproduction. We discuss fundamental approaches to discovering and generating enzyme variants and identifying those best suited for specific applications. Additionally, we cover techniques for creating libraries using automated systems and highlight innovative high-throughput screening methods that have been successfully employed to develop novel biocatalysts for natural product synthesis.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0