Natural Product Reports最新文献_第2页

The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives. 红藻萜烯生物合成的分子复杂性：现状与未来展望。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-24 DOI: 10.1039/d4np00034j

Wanessa Francesconi Stida Peixoto, Renato Crespo Pereira, Esthfanny Dos Santos Souza Azevedo, Fernando Martins Dos Santos, Ricardo Coutinho, Louisi Souza de Oliveira

{"title":"The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives.","authors":"Wanessa Francesconi Stida Peixoto, Renato Crespo Pereira, Esthfanny Dos Santos Souza Azevedo, Fernando Martins Dos Santos, Ricardo Coutinho, Louisi Souza de Oliveira","doi":"10.1039/d4np00034j","DOIUrl":"https://doi.org/10.1039/d4np00034j","url":null,"abstract":"<p><p>Covering the period 1998-2024Red algae are the largest group of seaweeds and rich sources of bioactive terpenes with broad and significant biotechnological potential. However, the main obstacle to the economic exploitation of these compounds is the difficulty of obtaining them on an industrial and sustainable scale. Genetic engineering and heterologous biosynthesis are promising tools for overcoming this limitation, but little is known about red algal terpene biosynthetic routes. In general, terpene biosynthesis relies on complex mechanisms that produce a wide array of chemically diverse compounds. In this article, we review the main processes that contribute to such chemical diversity of terpenes, which are divided into four biosynthetic steps: (i) biosynthesis of isoprenoid precursors, (ii) linear condensation of precursors to produce polyisoprenyl diphosphate intermediary molecules, (iii) terpene synthase-catalyzed chemical/structural modifications, and (iv) additional chemical/structural modifications on the basic terpene carbon skeleton. Terpene synthase evolution in algae and topics that have only recently been explored, such as terpene synthase catalytic and substrate promiscuity, have also been analyzed in detail. We present a detailed analysis of terpenoid metabolism in red algae, highlighting the mechanisms that generate their chemical diversity and identifying knowledge gaps. Additionally, we provide perspectives to guide future studies, aiming to advance the heterologous biosynthesis of terpenes from red algae for biotechnological development and application.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cytochalasans: potent fungal natural products with application from bench to bedside. 细胞分裂素：从工作台到床边都可应用的强效真菌天然产品。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-24 DOI: 10.1039/d4np00076e

Mohamed A Tammam, Florbela Pereira, Elizabeth Skellam, Stefan Bidula, A Ganesan, Amr El-Demerdash

引用次数: 0

Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics. 描述底栖海水的复杂化学：从外代谢物取样策略到基于质谱的代谢组学。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-20 DOI: 10.1039/d4np00064a

Morgane Mauduit, Stéphane Greff, Marie Derrien, Charlotte Simmler

引用次数: 0

Marine natural products† 海洋天然产品。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-06 DOI: 10.1039/D4NP00067F

Anthony R. Carroll, Brent R. Copp, Tanja Grkovic, Robert A. Keyzers and Michèle R. Prinsep

引用次数: 0

Hot off the press 刚印出来的。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-04 DOI: 10.1039/D5NP90004B

Robert A. Hill and Andrew Sutherland

引用次数: 0

Sesterterpenoids: sources, structural diversity, biological activity, and data management† 酯萜类：来源、结构多样性、生物活性和数据管理。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-01-20 DOI: 10.1039/d4np00041b

Valeria Iobbi , Valentina Parisi , Mauro Giacomini , Francesco De Riccardis , Paola Brun , Laura Núñez-Pons , Giuliana Drava , Paolo Giordani , Maria Chiara Monti , Roberto Poggi , Ylenia Murgia , Nunziatina De Tommasi , Angela Bisio

引用次数: 0

Harnessing microbial co-culture to increase the production of known secondary metabolites† 利用微生物共培养来增加已知次生代谢物的产量。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-01-20 DOI: 10.1039/d4np00052h

Yu-Zhen Li , Wan-Qi Zhang , Peng-Fei Hu , Qiong-Qiong Yang , István Molnár , Peng Xu , Bo-Bo Zhang

{"title":"Harnessing microbial co-culture to increase the production of known secondary metabolites†","authors":"Yu-Zhen Li , Wan-Qi Zhang , Peng-Fei Hu , Qiong-Qiong Yang , István Molnár , Peng Xu , Bo-Bo Zhang","doi":"10.1039/d4np00052h","DOIUrl":"10.1039/d4np00052h","url":null,"abstract":"<div><div>Covering: 2019 to 2024</div></div><div><div>Secondary metabolites (SMs) are naturally occurring defense or signaling molecules that are also utilized as human and animal drugs, crop protection agents, and fine chemicals. Currently, SMs are primarily produced in monoculture settings, devoid of the intricate microbial interactions found in natural environments. Monoculture may lead to the silencing of gene clusters, requiring various genetic or bioprocess strategies to activate the biosynthesis of the corresponding metabolites. Less considered is the effect of monoculture on the efficiency of the production of important, known SMs during microbial fermentations. Co-culturing aims to mimic the complexity of natural microbial habitats, thus may increase the titer, the rate and/or the yield of fermentations. This review summarizes the progress in utilizing co-culture to promote the synthesis of known SMs by describing the types of various microbial co-cultures, listing the mechanisms for enhancing the biosynthesis of SMs, and navigating the challenges and strategies for applying such an approach in the biotechnology industries.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 3","pages":"Pages 623-637"},"PeriodicalIF":10.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced crystallography for structure determination of natural products 用于天然产物结构测定的先进晶体学。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-01-20 DOI: 10.1039/d4np00071d

Jian-Guo Song , Wen-Cai Ye , Ying Wang

{"title":"Advanced crystallography for structure determination of natural products","authors":"Jian-Guo Song , Wen-Cai Ye , Ying Wang","doi":"10.1039/d4np00071d","DOIUrl":"10.1039/d4np00071d","url":null,"abstract":"<div><div>Covering: up to 2025</div></div><div><div>Crystallographic analysis has become the most reliable method for elucidating the structures of natural products, as it can provide absolute configurations with precise spatial arrangement information at the molecular level. However, obtaining high-quality and suitable-sized single crystals can be challenging for many natural products, making their structure determination difficult through traditional crystallography techniques. Recent advancements in this field have introduced innovative strategies to overcome the obstacle. These cutting-edge strategies include post-orientation of organic molecules within pre-prepared porous crystals (crystalline sponge method), co-crystallization of organic molecules with a crystalline mate through supramolecular interactions (crystalline mate method), encapsulation of organic molecules within inert oil nanodroplets (encapsulated nanodroplet crystallization method), and the use of electron diffraction and microscopy for nanocrystals (microcrystal electron diffraction method). This highlight delves into the fundamental principles, key characteristics, and representative applications of each strategy, as well as their respective advantages and limitations, aiming to guide researchers in choosing the most suitable crystallography approach for analyzing the structures of natural products.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 3","pages":"Pages 429-442"},"PeriodicalIF":10.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/np/d4np00071d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery 地下奇迹：洞穴和地下矿井中的微生物群落及其对天然产物发现的承诺。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-01-20 DOI: 10.1039/d4np00055b

Paris S. Salazar-Hamm , Frances E. Homan , Shyleigh A. Good , Jennifer J. M. Hathaway , Ashley E. Clements , Evelyn G. Haugh , Lindsay K. Caesar

{"title":"Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery","authors":"Paris S. Salazar-Hamm , Frances E. Homan , Shyleigh A. Good , Jennifer J. M. Hathaway , Ashley E. Clements , Evelyn G. Haugh , Lindsay K. Caesar","doi":"10.1039/d4np00055b","DOIUrl":"10.1039/d4np00055b","url":null,"abstract":"<div><div>Covering: 2014 to 2024</div></div><div><div>Since the dawn of human history, caves have played an intimate role in our existence. From our earliest ancestors seeking shelter from the elements to more recent generations harnessing cave substances for medicinal purposes, caves have served as essential resources and havens. The last 40 years of geomicrobiology research has replaced the outdated perception of subterranean environments as lifeless and unchanging with the realization that vibrant microbial communities have adapted to thrive in extreme conditions over millions of years. The ability of subterranean microbial communities to withstand nutrient deprivation and darkness creates a unique reservoir of untapped biosynthetic potential. These communities offer exciting prospects for medicine (<em>e.g.</em>, antimicrobial and antitumor therapies) and biotechnology (<em>e.g.</em>, redox chemical properties and biomineralization). This article highlights the significance of caves and mines as reservoirs of microbial diversity, the potential impact of their bioactive compounds on the fields of healthcare and biotechnology, and the significant challenges that must be overcome to access and harness the biotechnological potential of subterranean microbial communities. Additionally, it emphasizes the conservation efforts needed to protect these delicate ecosystems, ensuring the preservation of both ancient traditions and tomorrow's medicines.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 3","pages":"Pages 592-622"},"PeriodicalIF":10.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/np/d4np00055b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products. 解锁隐藏的宝藏：高通量质谱法在筛选神秘天然产物中的演变。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-01-20 DOI: 10.1039/d4np00026a

Brett C Covington, Mohammad R Seyedsayamdost

引用次数: 0