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Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae). 薄荷科生物活性萜类化合物的生物合成。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-27 DOI: 10.1039/d5np00026b
Maximilian Frey, Sandra T Gohr, Tobias G Köllner, Ulschan Bathe, Nathalie D Lackus, Federico Padilla-Gonzalez, Dae-Kyun Ro, Sarah E O'Connor, Jörg Degenhardt, Alain Tissier
{"title":"Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae).","authors":"Maximilian Frey, Sandra T Gohr, Tobias G Köllner, Ulschan Bathe, Nathalie D Lackus, Federico Padilla-Gonzalez, Dae-Kyun Ro, Sarah E O'Connor, Jörg Degenhardt, Alain Tissier","doi":"10.1039/d5np00026b","DOIUrl":"https://doi.org/10.1039/d5np00026b","url":null,"abstract":"<p><p>Covering: 2000 to 2025The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including anti-inflammatory, psychoactive, anti-cancer, and antiviral effects. Notable examples with fully elucidated biosynthetic pathways include menthol from peppermint, forskolin from blue spur flower, and carnosol from rosemary. For other key Lamiaceae terpenes-such as the anti-cancer oridonin, the psychoactive salvinorin A, and bioactive marrubiin and vitexilactone-significant progress has been made. This review explores the bioactivity and biosynthesis of Lamiaceae terpenes, with a focus on mono- and diterpenes, while highlighting future research directions.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144936756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural products influence bacteriophage infectivity. 天然产物影响噬菌体的感染性。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-18 DOI: 10.1039/d5np00014a
Zhiyu Zang, Joseph P Gerdt
{"title":"Natural products influence bacteriophage infectivity.","authors":"Zhiyu Zang, Joseph P Gerdt","doi":"10.1039/d5np00014a","DOIUrl":"10.1039/d5np00014a","url":null,"abstract":"<p><p>Covering: 1942-2025Bacteriophages (phages) are obligate viruses that infect bacteria. The antibacterial effects of both phages and natural products shape microbial ecosystems and have yielded competing antibiotic strategies. Phages have also intersected many times with natural products research throughout the past century. To discover antiviral leads, natural products were screened for anti-phage activity. To discover new anti-cancer drugs, natural products were screened for the ability to trigger lysis by the λ prophage-indicating DNA damage. Now, the antibiotic resistance crisis motivates the study of natural products that can synergize with phages to improve antibacterial therapies. Beyond applications, these parallel natural \"chemical\" and \"biological\" antibacterial factors combine to shape microbial communities across our planet. Here, we provide a comprehensive overview of natural products that modulate phage activities. We discuss their mechanisms of action, and we present opportunities for future research.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis. 天然三环和超多环芳烃：结构、生物合成、生物活性和合成。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-15 DOI: 10.1039/d5np00032g
Yujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan Zhang
{"title":"Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis.","authors":"Yujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan Zhang","doi":"10.1039/d5np00032g","DOIUrl":"https://doi.org/10.1039/d5np00032g","url":null,"abstract":"<p><p>Covering: 1950 to up to the end of 2024Natural products containing polycyclic aromatic hydrocarbons (PAHs) feature at least two fused aromatic ring systems, conforming to Hückel's rule and representing an important class of secondary metabolites with a wide range of biological activities. Among them, the subtype of natural products containing tricyclic and greater than tricyclic systems has been neglected for a long time. This review summarizes the isolation, structural features, bioactivities, biosynthetic pathways, and chemical synthesis of this special subtype reported over the past decades. This review provides a current understanding of the tricyclic and hyper-PAHs represented by anthracene, phenanthrene, acenaphthalene, pyrene, fluoranthene, and tetraphene from organic, biosynthetic, and pharmacological perspectives.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coprophilous fungi in the search for new antimicrobials and other beneficial natural products. 在寻找新的抗菌剂和其他有益的天然产物的亲性真菌。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-08 DOI: 10.1039/d5np00015g
Esteban Charria-Girón, Joseph Tchamgoue, Marc Stadler, Yasmina Marin-Felix
{"title":"Coprophilous fungi in the search for new antimicrobials and other beneficial natural products.","authors":"Esteban Charria-Girón, Joseph Tchamgoue, Marc Stadler, Yasmina Marin-Felix","doi":"10.1039/d5np00015g","DOIUrl":"https://doi.org/10.1039/d5np00015g","url":null,"abstract":"<p><p>Covering: up to 2025Microbial interactions involve complex processes shaped by their ecological contexts. Herbivore animal dung denotes an interesting ecological niche for the study of interorganism communication and competition mediated by small molecules. Coprophilous organisms, which inhabit or are associated with animal dung, have developed resourceful defense mechanisms to survive in this competitive environment. Fungi, in particular, are renowned for their ability to produce biologically active secondary metabolites, a chemical arsenal that fosters successful colonization of the dung substrate. With recent advancements in OMICs technologies and our extensive knowledge of coprophilous fungi diversity, we can now delve into the biosynthetic machinery of these organisms and explore the opportunities they offer for discovering new antimicrobials and other beneficial natural products. This review explores the potential of coprophilous fungi in the context of the intricate microbial dynamics of this substrate, particularly the biosynthetic and chemical diversity that make this environment especially promising for natural product discovery. Notably, taxa spanning multiple families within the Sordariomycetes, Dothideomycetes, and Eurotiomycetes have been reported to thrive in dung, highlighting their potential as a reservoir of unique metabolic capabilities. Indeed, 198 secondary metabolites, derived from polyketide, amino acid derived, terpene, and hybrid pathways, have been reported from these fungi, underscoring the remarkable scope of their biosynthetic potential.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis. 天然和非天然糖胺聚糖生物合成的微生物工程。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-05 DOI: 10.1039/d5np00043b
Chunlei Zhao, Jinyi Qian, Xiulai Chen
{"title":"Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis.","authors":"Chunlei Zhao, Jinyi Qian, Xiulai Chen","doi":"10.1039/d5np00043b","DOIUrl":"https://doi.org/10.1039/d5np00043b","url":null,"abstract":"<p><p>Covering: up to 2025Microbial synthesis of glycosaminoglycans (GAGs) facilitates sustainable biomanufacturing using cost-effective carbon feedstocks. This transformative framework is driven by three core innovations: <i>de novo</i> GAGs biosynthesis, sulfation engineering, and new-to-nature GAGs analogs creation. Despite these advances, critical challenges hinder industrial-scale efficiency, such as suboptimal distribution of metabolic flux, insufficient sulfation environments, and host incompatibility with unnatural analogs. In this review, we present a systematic analysis of microbial hosts, biosynthetic pathways, and microbial engineering strategies for GAGs production. We first describe how strategic host optimization and pathway manipulation can tap the full potential of microorganisms for efficient GAGs biosynthesis. Then, we analyze the development of microbial cell factories (MCFs) for GAGs biosynthesis from the simple pathway transplantation to systemic <i>de novo</i> construction of metabolic systems, thereby establishing programmable platforms to surpass natural biosynthesis limits. Next, we present a tripartite engineering framework for GAGs sulfation that integrates precursor synthesis modules, sulfate donor accumulation systems, and sulfotransferase networks, thereby progressing sulfation control from biomimetic mechanisms to programmable artificial systems. Further, we discuss the microbial synthesis of new-to-nature GAGs analogs through the incorporation of unnatural precursors or the reprogramming of natural precursors, thereby enabling MCFs to construct non-canonical glycopolymers with designed function. Finally, we prospect the development of multifunctional customized MCFs to drive breakthroughs in industrial-scale GAGs bioproduction.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
para-Quinone methides in natural product biosynthesis. 天然产物生物合成中的对醌类化合物。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-01 DOI: 10.1039/d5np00044k
Jie Gao, Qibin Chen, Qi Zhang
{"title":"<i>para</i>-Quinone methides in natural product biosynthesis.","authors":"Jie Gao, Qibin Chen, Qi Zhang","doi":"10.1039/d5np00044k","DOIUrl":"https://doi.org/10.1039/d5np00044k","url":null,"abstract":"<p><p>Covering: up to 2025<i>para</i>-Quinone methides (<i>p</i>-QMs) are highly reactive Michael acceptors with broad applications in organic synthesis, drug development, and materials science. Nature ingeniously harnesses these intermediates for diverse biochemical processes, ranging from melanization to the biosynthesis of bioactive natural products. While some natural products incorporate stable <i>p</i>-QM moieties, most <i>p</i>-QMs are transient, serving as pivotal intermediates in various metabolic pathways. This highlight examines <i>p</i>-QM-mediated enzymatic transformations in natural product biosynthesis, emphasizing catalytic mechanisms, substrate flexibility, and engineering potential. Understanding these biosynthetic strategies would advance enzyme discovery, inspire biomimetic synthesis, and guide rational enzyme design efforts.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products. 光/电化学催化：含烯烃天然产物后期功能化的有前途的工具。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-08-01 DOI: 10.1039/d5np00030k
Ji-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong Zhang
{"title":"Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products.","authors":"Ji-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong Zhang","doi":"10.1039/d5np00030k","DOIUrl":"https://doi.org/10.1039/d5np00030k","url":null,"abstract":"<p><p>Covering: 2013 to 2024Alkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms. Strategic alkene modification of NPs not only generates diverse chemical libraries, enriching scaffold, stereochemistry and appendage variations but also aids in unraveling the intricate mechanisms and cellular targets of NPs. Over the past 15 years, visible-light photocatalysis and electrochemical catalysis have emerged as two highly promising approaches for novel chemical transformations. It is worth emphasizing that these radical-mediated strategies have indeed altered the conventional transformation patterns of alkenes. These electronic or energy supply methods reduce dependence on stringent reaction conditions, showcasing more green and efficient characteristics. Over the years, numerous articles have been published, providing concise summaries of remarkable advancements in the fields of photo-organic synthesis, electro-organic synthesis, and late-stage functionalization (LSF). These contributions have predominantly centered on mechanistic explorations of chemical reactivity, with comparatively less emphasis on leveraging these transformations for the LSF of NPs to probe their biological functions. This review is organized according to the reaction types of alkenes, and we aim to elucidate the pathways for the LSF of NPs, exploring their synthetic potential and delineating the limitations of specific reaction classes. Through this overview, we expect that function-oriented synthetic methodologies will drive future research directions, facilitating mutual feedback and collaboration between synthetic chemistry, medicinal chemistry and chemical biology.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semi-synthesis in the exploration of opioid-targeting natural products. 半合成在阿片类药物靶向天然产物探索中的应用。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-07-30 DOI: 10.1039/d5np00029g
Andrew P Riley
{"title":"Semi-synthesis in the exploration of opioid-targeting natural products.","authors":"Andrew P Riley","doi":"10.1039/d5np00029g","DOIUrl":"10.1039/d5np00029g","url":null,"abstract":"<p><p>Covering: up to May 2025Since the isolation of morphine from opium, chemists have sought to modify its chemical structure in hopes of developing a safer, less addictive pain killer. At the same time, these novel morphine derivatives have provided new chemical tools to study the opioid receptors. In this way, the field of semi-synthesis, that is, the synthetic modification of isolated natural products, has co-evolved alongside the field of opioid pharmacology. This review summarizes recent semi-synthetic studies of the opioid-targeting natural products mitragynine, akuammine, akuammicine, and salvinorin A. These studies have resulted in novel opioid ligands with improved affinity and potency, differing signaling profiles, and increased effects in animals. In addition to offering new tools to study the opioid receptors, these natural product analogues represent promising steps towards developing safer opioid analgesics.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis. 天然产物合成中[5 + 2]环加成反应的研究进展。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-07-28 DOI: 10.1039/d5np00023h
Nan Wang, Yu Bai, Qingyi Zeng, Tao Zhang, Jun Deng
{"title":"Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis.","authors":"Nan Wang, Yu Bai, Qingyi Zeng, Tao Zhang, Jun Deng","doi":"10.1039/d5np00023h","DOIUrl":"https://doi.org/10.1039/d5np00023h","url":null,"abstract":"<p><p>Covering: 2013 to 2024Cycloaddition reactions, which efficiently construct polycyclic ring systems and stereocenters, are powerful tools in the total synthesis of natural products. Given the significant progress and numerous elegant applications of [5 + 2] cycloaddition reactions over the past decade, this review systematically summarizes the advances in three major types of [5 + 2] cycloaddition reactions in natural product synthesis from 2013 to 2024. The advantages of [5 + 2] cycloadditions in constructing complex natural product frameworks are illustrated through comparisons with alternative strategies for the same targets. Additionally, trends and future prospects for [5 + 2] cycloadditions are discussed, offering valuable insights for further research and broader applications.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering. 迈向天然产物发现的统一管道：NRPS和PKS途径探索和工程的工具和策略。
IF 10.6 1区 化学
Natural Product Reports Pub Date : 2025-07-28 DOI: 10.1039/d5np00041f
Biyan Chen, Emre F Bülbül, SeoungGun Bang, Hannah A Minas, Kenan A J Bozhüyük
{"title":"Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering.","authors":"Biyan Chen, Emre F Bülbül, SeoungGun Bang, Hannah A Minas, Kenan A J Bozhüyük","doi":"10.1039/d5np00041f","DOIUrl":"https://doi.org/10.1039/d5np00041f","url":null,"abstract":"<p><p>Covering: up to 2025.Non-ribosomal peptide synthetases and polyketide synthases are modular biosynthetic systems that produce structurally diverse and pharmacologically potent natural products, including antibiotics, immunosuppressants, and anticancer agents. Their programmable architecture has long inspired efforts in biosynthetic re-engineering. This review highlights recent advances that are transforming non-ribosomal peptide synthetase and polyketide synthase systems into versatile platforms for rational design. We discuss progress in genome mining, high-throughput screening, and dereplication, alongside emerging tools from synthetic biology and computational modeling. Particular focus is given to structure-based approaches-such as homology modeling, molecular docking, and molecular dynamics simulations-as well as deep learning strategies for enzyme prediction and design. Rather than replacing classical techniques, these computational methods now complement and extend them, enabling accelerating the discovery and assembly of tailor-made natural product analogs.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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