Natural Product Reports最新文献_第2页

Recent advances in the strategic use of multiple enzymatic transformations in the total synthesis of natural products. 多种酶转化在天然产物全合成中的战略性应用的最新进展。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-23 DOI: 10.1039/d6np00049e

Kridsadakorn Prakinee, Luca Schlautmann, Christopher Slotman, Alexander F Kiefer

引用次数: 0

Asymmetric synthesis of 3,3-disubstituted oxindoles: methodologies and applications in natural product synthesis. 3,3-二取代吲哚的不对称合成：方法及其在天然产物合成中的应用。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-23 DOI: 10.1039/d6np00015k

Rui Yang, Lihua Wei, Zhiqiang Ma

引用次数: 0

Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration. 视觉周期衍生的类双维甲酸作为内源性天然产物：无酶形成、光化学反应性和视网膜变性。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-23 DOI: 10.1039/d6np00038j

Hye Jin Kim, Janet R Sparrow, Young Pyo Jang

{"title":"Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration.","authors":"Hye Jin Kim, Janet R Sparrow, Young Pyo Jang","doi":"10.1039/d6np00038j","DOIUrl":"10.1039/d6np00038j","url":null,"abstract":"Covering: up to 2026Bisretinoids are a chemically distinct class of endogenous natural products formed by the non-enzymatic condensation of visual-cycle retinoids. Derived from dietary provitamin A carotenoids via retinaldehyde intermediates, these pigments form spontaneously within the photoreceptor disc membranes through Schiff base chemistry with phosphatidylethanolamine, generating structurally diverse pyridinium, dihydropyridine and retinal dimer species. In contrast to enzyme-directed biosynthesis, bisretinoid biogenesis is governed by the intrinsic electrophilicity of the conjugated retinaldehydes within a lipid-dense environment. Their extended polyene systems endow them with distinctive excited-state properties, enabling efficient intersystem crossing and photosensitized generation of singlet oxygen under visible light. Subsequent oxidative fragmentation produces reactive electrophilic carbonyl species, including methylglyoxal and glyoxal, which covalently modify biomolecules and contribute to retinal pigment epithelium dysfunction and drusen formation. Despite their well-documented pathological roles, bisretinoids have not been systematically examined within a natural product framework. Here, we integrate the current knowledge of their biogenesis, electronic structure, and photochemical reactivity and consider how factors such as retinaldehyde flux, membrane composition, and iron homeostasis modulate their accumulation and reactivity. By framing bisretinoids as autochthonous natural products governed by intrinsic chemical principles, this review highlights new opportunities for mechanistically informed therapeutic intervention in retinal degeneration.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"1908-1926"},"PeriodicalIF":12.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The elansolids: how nature shows chemists how to tamep-quinone methides. 固体：大自然如何向化学家展示如何合成醌类药物。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-23 DOI: 10.1039/d6np00030d

Liang-Liang Wang, Xiao-Qin Zhou, Andreas Kirschning

{"title":"The elansolids: how nature shows chemists how to tamep-quinone methides.","authors":"Liang-Liang Wang, Xiao-Qin Zhou, Andreas Kirschning","doi":"10.1039/d6np00030d","DOIUrl":"10.1039/d6np00030d","url":null,"abstract":"Covering: up to 2025Elansolids are metabolites isolated from the gliding bacterium Chitinophaga sancti (formerly Flexibacter spec.). The fascinating structures of this type of natural products, as well as their promising biological antibiotic activities, have triggered considerable efforts in the study of elansolids, especially their biosynthesis, which features the formation of highly reactive p-quinone methide intermediates in the enzymatic dehydration-IMDA process. This review focuses on the various aspects of p-quinone methides, including their formation, reactivities (chemical transformations), and applications in total synthesis, all of which are elucidated based on the example of elansolids. By highlighting this particular instance of p-quinone methides, it is shown how nature, namely, the enzymes in the PKS assembly line, could tame this type of highly reactive intermediate. Furthermore, by mimicking the p-quinone methide-mediated IMDA process as observed in biosynthesis, chemists can rationally access various synthetically challenging intermediates, for instance tetrahydroindanes, and utilize them in the total synthesis of the elansolid family.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"1804-1816"},"PeriodicalIF":12.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitors of nutrient pathways: nature's overlooked antibiotic arsenal. 营养途径的抑制剂：自然界被忽视的抗生素库。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-23 DOI: 10.1039/d6np00036c

R Gordzevich, K Y Jin, J M Ashe, E D Brown

{"title":"Inhibitors of nutrient pathways: nature's overlooked antibiotic arsenal.","authors":"R Gordzevich, K Y Jin, J M Ashe, E D Brown","doi":"10.1039/d6np00036c","DOIUrl":"10.1039/d6np00036c","url":null,"abstract":"Covering: 1920 to 2026The discovery of antibiotics has historically centered on a core set of physiological targets, including cell wall synthesis, protein translation, and DNA replication. As resistance accelerates and new drug classes remain scarce, there is a growing need to expand into alternative target spaces. One such unexplored area is bacterial nutrient biosynthesis and utilization. Although their therapeutic potential is increasingly recognized, these pathways have yet to be fully integrated into antibiotic discovery pipelines, due in part to longstanding methodological biases, including the widespread use of nutrient-rich screening media that obscure nutrient-targeting activity. In this review, we highlight an overlooked subset of natural product antibiotics that inhibit nutrient metabolism. We consolidate 73 compound classes primarily retrieved from the Dictionary of Natural Products and categorize them into four mechanistic classes: biosynthesis inhibitors, antimetabolites, pro-antimetabolites, and riboswitch inhibitors. Many display whole-cell activity, including against Gram-negative pathogens, and reveal underappreciated structural and functional diversity. Recent advances in defined media design, genome mining, and synthetic biology make these compounds more readily accessible for systematic re-evaluation and optimization. Nutrient pathway inhibitors offer a source of novel antibiotic scaffolds and a foundation for therapeutic strategies such as drug potentiation and resistance reversal. Reintegrating these compounds into discovery pipelines can help diversify antibacterial options and address pressing resistance challenges.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"1787-1803"},"PeriodicalIF":12.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing biosynthetic pathway discovery through short-read-directed long-read sequencing. 通过短读定向长读测序推进生物合成途径的发现。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-21 DOI: 10.1039/d6np00020g

Marco Gabrielli, Agathe Bredel, Lucas Paoli, Serina L Robinson

{"title":"Advancing biosynthetic pathway discovery through short-read-directed long-read sequencing.","authors":"Marco Gabrielli, Agathe Bredel, Lucas Paoli, Serina L Robinson","doi":"10.1039/d6np00020g","DOIUrl":"https://doi.org/10.1039/d6np00020g","url":null,"abstract":"Time span of literature: 2020-todayMetagenomic methods have rapidly advanced, enabling the identification of biosynthetic pathways directly from complex microbiome data. Short-read sequencing, while accurate and cost-effective, often generates fragmented assemblies that can lead to incomplete biosynthetic gene cluster (BGC) recovery. Although long-read sequencing offers a solution to the fragmentation problems, technical requirements and higher costs have limited its scalability. Here, we examine BGC fragmentation in short-read sequencing data across large databases of metagenome-assembled genomes (MAGs) and estimate the targeted genome contiguity required to recover 'complete' biosynthetic gene clusters. We argue that the increasing availability of MAGs recovered from short-read metagenomes with recent advancements in ultra-low input DNA amplification for high-fidelity PacBio sequencing-now requiring as little as nanograms of DNA-can be used sequentially to boost biosynthetic pathway discovery. We demonstrate how natural products researchers can benefit from using short-read MAG comparisons to guide targeted long-read re-sequencing efforts with low amounts of input DNA and/or limited financial resources. Our analysis provides strategic recommendations for the broader scientific community on how to best leverage the strengths of short- and long-read sequencing data to efficiently allocate resources and accelerate natural product discovery.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The roles of glycosyltransferases in shaping flavonoid diversity in plants. 糖基转移酶在植物类黄酮多样性形成中的作用。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-21 DOI: 10.1039/d6np00055j

Xiaoqiang Wang, Jaime Barros, Ryo Yokoyama

{"title":"The roles of glycosyltransferases in shaping flavonoid diversity in plants.","authors":"Xiaoqiang Wang, Jaime Barros, Ryo Yokoyama","doi":"10.1039/d6np00055j","DOIUrl":"https://doi.org/10.1039/d6np00055j","url":null,"abstract":"Covering: up to 2026Flavonoids belong to one of the largest families of specialized metabolites in plants and play pivotal roles in plant adaptation and human health. In their biosynthesis, the formation of core aromatic structures is followed by various chemical modifications that further decorate these scaffolds, shaping their chemical diversity, biological functions, and physicochemical properties. Among these modifications, glycosylation is the most prevalent, transferring monosaccharides from activated nucleotide sugars to acceptor molecules to form glycosidic bonds. This reaction is catalyzed by UDP-glycosyltransferases (UGTs), a class of enzymes that generate structurally diverse glycosides from a relatively limited set of flavonoid core structures. Through these catalytic processes, UGTs have driven the structural and functional diversification of flavonoids across plant lineages. This review highlights the structure, biochemistry, and phylogeny of UGTs participating in flavonoid biosynthesis. We discuss how substrate promiscuity, together with broad specificity toward both sugar donors and acceptor substrates, allows UGTs to expand flavonoid chemical diversity. Additional focus is placed on how UGT gene expression is integrated into tissue-specific and stress-responsive regulatory networks that shape flavonoid diversity, and how UGT-dependent glycosylation plays a critical role in the stabilization and subcellular sequestration of diverse flavonoids. Lastly, we highlight emerging strategies for engineering plant flavonoid UGTs and glycosylation pathways, including the opportunities and limitations of computational and artificial intelligence-assisted approaches.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances. 海洋真菌PKS-NRPS杂种的吡啶酮和大环吡咯烷酮：生物合成来源、生物活性和合成进展。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-21 DOI: 10.1039/d6np00050a

Ning Gao, Felix Boahen Owusu, Jiewen Yu, Fa-Liang An, Xu-Wen Li

{"title":"Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances.","authors":"Ning Gao, Felix Boahen Owusu, Jiewen Yu, Fa-Liang An, Xu-Wen Li","doi":"10.1039/d6np00050a","DOIUrl":"https://doi.org/10.1039/d6np00050a","url":null,"abstract":"Covering: 2002-2025Marine fungi have emerged as a prolific source of structurally unprecedented and biologically potent secondary metabolites, and hybrid polyketide synthase-non-ribosomal peptide synthase (PKS-NRPS) enzymes mainly from marine fungi like symbiotic Aspergillus and deep-sea Penicillium, represent an exceptionally fertile source of such complex natural products. Among the diverse products of these mega-enzymes, pyridones and macrocyclic pyrrolidone constitute a unique class of natural products with significant therapeutic potential. This review provides a comprehensive overview on this family of natural products, covering their global distribution and biosynthetic enzymology, chemical ecology, and biosynthesis. The bioactivities of these compounds, ranging from potent anticancer and antibacterial to immunosuppressive and anti-inflammatory effects, are discussed. Furthermore, this review summarises the synthetic strategies developed to access these complex chemical scaffolds. This review provides a roadmap for future genome-guided discovery and the rational design of novel therapeutics inspired by these privileged marine natural products.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radical SAM-dependent enzymes: Jacks-of-all-trades in RiPP pathways. 自由基sam依赖酶：RiPP途径中的千里手。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-15 DOI: 10.1039/d6np00051g

Panagiota-Hanna Koutsandrea, Lorenz Thost, Alicia Courvoisier-Clément, Anna Lisa Vagstad, Silja Mordhorst

{"title":"Radical SAM-dependent enzymes: Jacks-of-all-trades in RiPP pathways.","authors":"Panagiota-Hanna Koutsandrea, Lorenz Thost, Alicia Courvoisier-Clément, Anna Lisa Vagstad, Silja Mordhorst","doi":"10.1039/d6np00051g","DOIUrl":"https://doi.org/10.1039/d6np00051g","url":null,"abstract":"Covering: up to 2026The cofactor S-adenosyl-L-methionine (SAM) plays a key role in the biosynthesis of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products. SAM-dependent enzymes have been shown to catalyse important steps in RiPP biosynthesis, including methylation, desaturation, epimerisation, splicing reactions, and oxidative decarboxylation. Furthermore, a range of SAM-dependent cross-linking reactions result in the formation of complex macrocyclic peptide products, which often exhibit enhanced stability and intriguing biological activities. These post-translational modifications occur in all parts of the peptide molecule, including side chains, peptide backbones, and N- and C-termini. Newly identified RiPP pathways continue to reveal interesting SAM-dependent enzymes that install remarkable chemical moieties. In view of the recent advances in this field, the objective of this review is to provide an overview of the significant chemical diversity of RiPP natural products generated by SAM-dependent enzymes, with a particular focus on post-translational modifications introduced by radical SAM enzymes.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148965829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in phytomolecule isolation: green extraction and high-resolution separation. 植物分子分离研究进展：绿色提取和高分辨率分离。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-09-11 DOI: 10.1039/d6np00032k

Patil Shivprasad Suresh, Ruchika

{"title":"Advances in phytomolecule isolation: green extraction and high-resolution separation.","authors":"Patil Shivprasad Suresh, Ruchika","doi":"10.1039/d6np00032k","DOIUrl":"https://doi.org/10.1039/d6np00032k","url":null,"abstract":"Coveing: 2012-2026Over the last two decades, the process of isolating plant-derived natural products has undergone a significant transformation, moving from time-consuming, trial-and-error methods to more rational, data-driven, and eco-friendly approaches. This review highlights the technological advances in extraction and high-resolution separation that advances natural product research. It discusses the transition from traditional solvent extraction to sustainable techniques, including the rise of natural deep eutectic solvents and hybrid energy-transfer methods such as ultrasound- and microwave-assisted extraction, which offer higher yields and greater selectivity for thermolabile compounds. The review also covers progress in liquid-liquid partition chromatography, including high-speed countercurrent chromatography and centrifugal partition chromatography for industrial scaling and analytical precision. Additionally, the integration of advanced workflows, such as two-dimensional liquid chromatography (LC × LC) and supercritical fluid chromatography, demonstrates the efficiency of modern techniques in addressing prior limitations in yield, selectivity, and solvating capacity, thereby reinforcing the continued importance of natural products in drug discovery.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0