天然产物合成中[5 + 2]环加成反应的研究进展。

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2025-07-28 DOI:10.1039/d5np00023h

Nan Wang, Yu Bai, Qingyi Zeng, Tao Zhang, Jun Deng

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引用次数: 0

摘要

环加成反应可以有效地构建多环体系和立体中心，是天然产物全合成的有力工具。鉴于[5 + 2]环加成反应在过去十年中取得的重大进展和许多优秀的应用，本文系统地总结了2013年至2024年天然产物合成中三种主要的[5 + 2]环加成反应的进展。[5 + 2]环添加在构建复杂天然产物框架中的优势通过与相同目标的替代策略的比较来说明。此外，还讨论了[5 + 2]环加成的趋势和未来前景，为进一步研究和更广泛的应用提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis.

Covering: 2013 to 2024Cycloaddition reactions, which efficiently construct polycyclic ring systems and stereocenters, are powerful tools in the total synthesis of natural products. Given the significant progress and numerous elegant applications of [5 + 2] cycloaddition reactions over the past decade, this review systematically summarizes the advances in three major types of [5 + 2] cycloaddition reactions in natural product synthesis from 2013 to 2024. The advantages of [5 + 2] cycloadditions in constructing complex natural product frameworks are illustrated through comparisons with alternative strategies for the same targets. Additionally, trends and future prospects for [5 + 2] cycloadditions are discussed, offering valuable insights for further research and broader applications.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.