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Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids 撤回：原小檗碱和手性四氢小檗碱全合成的最新进展。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-16 DOI: 10.1039/D4NP90039A
Zhen-Xi Niu, Ya-Tao Wang and Jun-Feng Wang
{"title":"Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids","authors":"Zhen-Xi Niu, Ya-Tao Wang and Jun-Feng Wang","doi":"10.1039/D4NP90039A","DOIUrl":"10.1039/D4NP90039A","url":null,"abstract":"<p >Retraction of ‘Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids’ by Zhen-Xi Niu <em>et al.</em>, <em>Nat. Prod. Rep.</em>, 2024, https://doi.org/10.1039/d4np00016a.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np90039a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites. 比较真菌特殊代谢物的全化学合成和全生物合成途径。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-15 DOI: 10.1039/d4np00015c
Dong-Song Tian, Xiao Zhang, Russell J Cox
{"title":"Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites.","authors":"Dong-Song Tian, Xiao Zhang, Russell J Cox","doi":"10.1039/d4np00015c","DOIUrl":"https://doi.org/10.1039/d4np00015c","url":null,"abstract":"<p><p>Covering the period 1965-2024Total synthesis has been defined as the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. At the extremes, specialised metabolites can be created by total chemical synthesis or by total biosynthesis. In this review we explore the advantages and disadvantages of these two approaches using quantitative methodology that combines measures of molecular complexity, molecular weight and fraction of sp<sup>3</sup> centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi 从真菌中分离出的含蜕皮激素的四元酸衍生物的生物合成、生物活性和结构-活性关系。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00013g
{"title":"Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi","authors":"","doi":"10.1039/d4np00013g","DOIUrl":"10.1039/d4np00013g","url":null,"abstract":"<div><p>Covering: up to December 2023</p></div><div><p>Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure–activity relationship are then introduced.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2 通过 X 射线晶体学、冷冻电镜和 AlphaFold2 揭示全长 I 型模块化多酮合成酶的结构。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d3np00060e
{"title":"Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2","authors":"","doi":"10.1039/d3np00060e","DOIUrl":"10.1039/d3np00060e","url":null,"abstract":"<div><p>Covering: up to the end of 2023</p></div><div><p>Type I modular polyketide synthases construct polyketide natural products in an assembly line-like fashion, where the growing polyketide chain attached to an acyl carrier protein is passed from catalytic domain to catalytic domain. These enzymes have immense potential in drug development since they can be engineered to produce non-natural polyketides by strategically adding, exchanging, and deleting individual catalytic domains. In practice, however, this approach frequently results in complete failures or dramatically reduced product yields. A comprehensive understanding of modular polyketide synthase architecture is expected to resolve these issues. We summarize the three-dimensional structures and the proposed mechanisms of three full-length modular polyketide synthases, Lsd14, DEBS module 1, and PikAIII. We also describe the advantages and limitations of using X-ray crystallography, cryo-electron microscopy, and AlphaFold2 to study intact type I polyketide synthases.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hot off the press 热销中
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np90034k
Robert A. Hill , Andrew Sutherland
{"title":"Hot off the press","authors":"Robert A. Hill ,&nbsp;Andrew Sutherland","doi":"10.1039/d4np90034k","DOIUrl":"10.1039/d4np90034k","url":null,"abstract":"<div><p>A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as nitidane from <em>Heteromurus nitidus</em>.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medium-sized peptides from microbial sources with potential for antibacterial drug development† 具有抗菌药物开发潜力的微生物来源中型肽。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00002a
{"title":"Medium-sized peptides from microbial sources with potential for antibacterial drug development†","authors":"","doi":"10.1039/d4np00002a","DOIUrl":"10.1039/d4np00002a","url":null,"abstract":"<div><p>Covering: 1993 to the end of 2022</p></div><div><p>As the rapid development of antibiotic resistance shrinks the number of clinically available antibiotics, there is an urgent need for novel options to fill the existing antibiotic pipeline. In recent years, antimicrobial peptides have attracted increased interest due to their impressive broad-spectrum antimicrobial activity and low probability of antibiotic resistance. However, macromolecular antimicrobial peptides of plant and animal origin face obstacles in antibiotic development because of their extremely short elimination half-life and poor chemical stability. Herein, we focus on medium-sized antibacterial peptides (MAPs) of microbial origin with molecular weights below 2000 Da. The low molecular weight is not sufficient to form complex protein conformations and is also associated to a better chemical stability and easier modifications. Microbially-produced peptides are often composed of a variety of non-protein amino acids and terminal modifications, which contribute to improving the elimination half-life of compounds. Therefore, MAPs have great potential for drug discovery and are likely to become key players in the development of next-generation antibiotics. In this review, we provide a detailed exploration of the modes of action demonstrated by 45 MAPs and offer a concise summary of the structure–activity relationships observed in these MAPs.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140670631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties 含有 N-杂环连接分子的双吲哚和三吲哚生物碱的全合成进展。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00012a
{"title":"Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties","authors":"","doi":"10.1039/d4np00012a","DOIUrl":"10.1039/d4np00012a","url":null,"abstract":"<div><p>The past several years have seen an increase in the discovery and isolation of natural products of the indole alkaloid class. Bis- and tris-indole alkaloids are classes of natural products that have been shown to display diverse, potent biological activities. Of particular interest are bis- and tris-indole alkaloids containing N-heterocyclic linker moieties. It has been reported that more than 85% of biologically active compounds contain one or more heterocyclic moieties; of these, N-heterocycles have been identified as the most prevalent. The goal of this review is to provide a detailed overview of the recent advances in isolation and total synthesis of bis- and tris-indole alkaloids that contain N-heterocyclic linker moieties. The known biological activities of these natural products will also be discussed.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np00012a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140652380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scaling up for success: from bioactive natural products to new medicines. 扩大规模，取得成功：从生物活性天然产品到新药。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-12 DOI: 10.1039/d4np00022f
Maximilian J Helf, Kathrin Buntin, Andrej Klančar, Michael Rust, Frank Petersen, Dominik Pistorius, Eric Weber, Joanne Wong, Philipp Krastel
{"title":"Scaling up for success: from bioactive natural products to new medicines.","authors":"Maximilian J Helf, Kathrin Buntin, Andrej Klančar, Michael Rust, Frank Petersen, Dominik Pistorius, Eric Weber, Joanne Wong, Philipp Krastel","doi":"10.1039/d4np00022f","DOIUrl":"https://doi.org/10.1039/d4np00022f","url":null,"abstract":"<p><p>Covering 1986 to presentNatural product drug discovery at Novartis has a long and successful history of delivering life saving medicines to millions of patients. In this viewpoint, we are presenting the tools we use and challenges we face as we advance natural products from early research into development and beyond. We are leveraging our collection of 90 000 microbial strains and 20 000 isolated natural products to find new medications in an interdisciplinary approach that requires expertise in microbiology, computational biology, synthetic biology, chemistry, and process development. Technological advances, particularly in genome engineering and data science have transformed our field, accelerating discovery and facilitating sustainable compound supply. Emerging new modalities such as antibody drug conjugates, radioligand therapies and xRNA-based medications offer new opportunities for natural product-derived drugs. By taking advantage of these new modalities and the most recent research technologies, natural products will significantly contribute to the medicines of the future.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances 更正：真菌天然产物 "大黄素家族"--百年研究与最新基因组学进展的结合。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-09 DOI: 10.1039/D4NP90035A
Kate M. J. de Mattos-Shipley and Thomas J. Simpson
{"title":"Correction: The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances","authors":"Kate M. J. de Mattos-Shipley and Thomas J. Simpson","doi":"10.1039/D4NP90035A","DOIUrl":"10.1039/D4NP90035A","url":null,"abstract":"<p >Correction for ‘The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances’ by Kate M. J. de Mattos-Shipley <em>et al.</em>, <em>Nat. Prod. Rep.</em>, 2023, <strong>40</strong>, 174–201, https://doi.org/10.1039/D2NP00040G.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides 植物肽--重新定义核糖体合成和翻译后修饰肽的领域。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00042g
{"title":"Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides","authors":"","doi":"10.1039/d3np00042g","DOIUrl":"10.1039/d3np00042g","url":null,"abstract":"<div><p>Covering 1965 to February 2024</p></div><div><p>Plants are prolific peptide chemists and are known to make thousands of different peptidic molecules. These peptides vary dramatically in their size, chemistry, and bioactivity. Despite their differences, all plant peptides to date are biosynthesized as ribosomally synthesized and post-translationally modified peptides (RiPPs). Decades of research in plant RiPP biosynthesis have extended the definition and scope of RiPPs from microbial sources, establishing paradigms and discovering new families of biosynthetic enzymes. The discovery and elucidation of plant peptide pathways is challenging due to repurposing and evolution of housekeeping genes as both precursor peptides and biosynthetic enzymes and due to the low rates of gene clustering in plants. In this review, we highlight the chemistry, biosynthesis, and function of the known RiPP classes from plants and recommend a nomenclature for the recent addition of BURP-domain-derived RiPPs termed burpitides. Burpitides are an emerging family of cyclic plant RiPPs characterized by macrocyclic crosslinks between tyrosine or tryptophan side chains and other amino acid side chains or their peptide backbone that are formed by copper-dependent BURP-domain-containing proteins termed burpitide cyclases. Finally, we review the discovery of plant RiPPs through bioactivity-guided, structure-guided, and gene-guided approaches.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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