细菌有机砷天然产物生物合成研究的最新进展。

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2024-08-28 DOI:10.1039/d4np00036f

Shotaro Hoshino, Hiroyasu Onaka, Ikuro Abe

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引用次数: 0

摘要

覆盖范围：1977 年至今砷广泛分布于陆地和水生环境中，主要以剧毒的无机形式存在。为了适应环境中的无机砷，细菌结合亚砷酸盐甲基化和相关氧化还原反应，进化出了无处不在的砷代谢策略。最近的报告显示，一些细菌具有与结构和生物学上独特的有机砷天然产物相关的特定代谢途径。在这篇重点文章中，我们以氧化胂糖、胂霉素和双苯那桑为例，总结了细菌有机胂天然产物的鉴定和生物合成方面的最新进展。我们还讨论了细菌来源的新型含砷天然产物的潜在发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent advances in the biosynthetic studies of bacterial organoarsenic natural products.

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Recent advances in the biosynthetic studies of bacterial organoarsenic natural products.

Covering: 1977 to presentArsenic is widely distributed throughout terrestrial and aquatic environments, mainly in highly toxic inorganic forms. To adapt to environmental inorganic arsenic, bacteria have evolved ubiquitous arsenic metabolic strategies by combining arsenite methylation and related redox reactions, which have been extensively studied. Recent reports have shown that some bacteria have specific metabolic pathways associated with structurally and biologically unique organoarsenic natural products. In this highlight, by exemplifying the cases of oxo-arsenosugars, arsinothricin, and bisenarsan, we summarize recent advances in the identification and biosynthesis of bacterial organoarsenic natural products. We also discuss the potential discoveries of novel arsenic-containing natural products of bacterial origins.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.