Natural Product Reports最新文献_第4页

Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology 嘌呤核苷抗生素：利用化学和生物学的最新合成进展。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d3np00051f

Jonas Motter , Caecilie M. M. Benckendorff , Sarah Westarp , Peter Sunde-Brown , Peter Neubauer , Anke Kurreck , Gavin J. Miller

{"title":"Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology","authors":"Jonas Motter , Caecilie M. M. Benckendorff , Sarah Westarp , Peter Sunde-Brown , Peter Neubauer , Anke Kurreck , Gavin J. Miller","doi":"10.1039/d3np00051f","DOIUrl":"10.1039/d3np00051f","url":null,"abstract":"<div><p>Covering: 2019 to 2023</p></div><div><p>Nucleoside analogues represent one of the most important classes of small molecule pharmaceuticals and their therapeutic development is successfully established within oncology and for the treatment of viral infections. However, there are currently no nucleoside analogues in clinical use for the management of bacterial infections. Despite this, a significant number of clinically recognised nucleoside analogues are known to possess some antibiotic activity, thereby establishing a potential source for new therapeutic discovery in this area. Furthermore, given the rise in antibiotic resistance, the discovery of new clinical candidates remains an urgent global priority and natural product-derived nucleoside analogues may also present a rich source of discovery space for new modalities. This Highlight, covering work published from 2019 to 2023, presents a current perspective surrounding the synthesis of natural purine nucleoside antibiotics. By amalgamating recent efforts from synthetic chemistry with advances in biosynthetic understanding and the use of recombinant enzymes, prospects towards different structural classes of purines are detailed.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139400948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot off the Press 新闻热点

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d4np90026j

Robert A. Hill , Andrew Sutherland

引用次数: 0

Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing 释放潜能：放线菌中用于基因组编辑的 I 型 CRISPR-Cas 系统。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-06-18 DOI: 10.1039/D4NP00010B

Shuliu Wang, Xiaoqian Zeng, Yue Jiang, Weishan Wang, Linquan Bai, Yinhua Lu, Lixin Zhang and Gao-Yi Tan

{"title":"Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing","authors":"Shuliu Wang, Xiaoqian Zeng, Yue Jiang, Weishan Wang, Linquan Bai, Yinhua Lu, Lixin Zhang and Gao-Yi Tan","doi":"10.1039/D4NP00010B","DOIUrl":"10.1039/D4NP00010B","url":null,"abstract":"<p>Covering: up to the end of 2023</p><p>Type I CRISPR-Cas systems are widely distributed, found in over 40% of bacteria and 80% of archaea. Among genome-sequenced actinomycetes (particularly <em>Streptomyces</em> spp.), 45.54% possess type I CRISPR-Cas systems. In comparison to widely used CRISPR systems like Cas9 or Cas12a, these endogenous CRISPR-Cas systems have significant advantages, including better compatibility, wide distribution, and ease of operation (since no exogenous Cas gene delivery is needed). Furthermore, type I CRISPR-Cas systems can simultaneously edit and regulate genes by adjusting the crRNA spacer length. Meanwhile, most actinomycetes are recalcitrant to genetic manipulation, hindering the discovery and engineering of natural products (NPs). The endogenous type I CRISPR-Cas systems in actinomycetes may offer a promising alternative to overcome these barriers. This review summarizes the challenges and recent advances in CRISPR-based genome engineering technologies for actinomycetes. It also presents and discusses how to establish and develop genome editing tools based on type I CRISPR-Cas systems in actinomycetes, with the aim of their future application in gene editing and the discovery of NPs in actinomycetes.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical synthesis and functional evaluation of glycopeptides and glycoproteins containing rare glycosyl amino acid linkages 含有稀有糖基氨基酸连接的糖肽和糖蛋白的化学合成和功能评估。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-06-18 DOI: 10.1039/D4NP00017J

Weizhun Yang, Sherif Ramadan, Yan Zu, Mengxia Sun, Xuefei Huang and Biao Yu

{"title":"Chemical synthesis and functional evaluation of glycopeptides and glycoproteins containing rare glycosyl amino acid linkages","authors":"Weizhun Yang, Sherif Ramadan, Yan Zu, Mengxia Sun, Xuefei Huang and Biao Yu","doi":"10.1039/D4NP00017J","DOIUrl":"10.1039/D4NP00017J","url":null,"abstract":"<p>Covering: 1987 to 2023</p><p>Naturally existing glycoproteins through post-translational protein glycosylation are highly heterogeneous, which not only impedes the structure–function studies, but also hinders the development of their potential medical usage. Chemical synthesis represents one of the most powerful tools to provide the structurally well-defined glycoforms. Being the key step of glycoprotein synthesis, glycosylation usually takes place at serine, threonine, and asparagine residues, leading to the predominant formation of the <em>O</em>- and <em>N</em>-glycans, respectively. However, other amino acid residues containing oxygen, nitrogen, sulfur, and nucleophilic carbon atoms have also been found to be glycosylated. These diverse glycoprotein linkages, occurring from microorganisms to plants and animals, play also pivotal biological roles, such as in cell–cell recognition and communication. The availability of these homogenous rare glycopeptides and glycoproteins can help decipher the glyco-code for developing therapeutic agents. This review highlights the chemical approaches for assembly of the functional glycopeptides and glycoproteins bearing these “rare” carbohydrate–amino acid linkages between saccharide and canonical amino acid residues and their derivatives.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terpenoids of plants from Chloranthaceae family: chemistry, bioactivity, and synthesis† 绿茶科植物的萜类化合物：化学、生物活性和合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-05-29 DOI: 10.1039/D4NP00005F

Bin Zhou and Jian-Min Yue

引用次数: 0

Medicinal plant resin natural products: structural diversity and biological activities. 药用植物树脂天然产品：结构多样性和生物活性。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-05-24 DOI: 10.1039/d4np00007b

Madhu Babu Sura, Yong-Xian Cheng

引用次数: 0

Bacterial cyclophane-containing RiPPs from radical SAM enzymes 细菌含环烷的RiPPs来自自由基SAM酶。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-05-22 DOI: 10.1039/d3np00030c

Chin-Soon Phan , Brandon I. Morinaka

引用次数: 0

Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes 十字花科种子和植物的特殊代谢物修饰：多样性、功能和相关酶。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-05-22 DOI: 10.1039/d3np00043e

Léa Barreda , Céline Brosse , Stéphanie Boutet , François Perreau , Loïc Rajjou , Loïc Lepiniec , Massimiliano Corso

{"title":"Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes","authors":"Léa Barreda , Céline Brosse , Stéphanie Boutet , François Perreau , Loïc Rajjou , Loïc Lepiniec , Massimiliano Corso","doi":"10.1039/d3np00043e","DOIUrl":"10.1039/d3np00043e","url":null,"abstract":"<div><p>Covering: up to 2023</p></div><div><p>Specialized metabolite (SM) modifications and/or decorations, corresponding to the addition or removal of functional groups (<em>e.g.</em> hydroxyl, methyl, glycosyl or acyl group) to SM structures, contribute to the huge diversity of structures, activities and functions of seed and plant SMs. This review summarizes available knowledge (up to 2023) on SM modifications in Brassicaceae and their contribution to SM plasticity. We give a comprehensive overview on enzymes involved in the addition or removal of these functional groups. Brassicaceae, including model (<em>Arabidopsis thaliana</em>) and crop (<em>Brassica napus</em>, <em>Camelina sativa</em>) plant species, present a large diversity of plant and seed SMs, which makes them valuable models to study SM modifications. In this review, particular attention is given to the environmental plasticity of SM and relative modification and/or decoration enzymes. Furthermore, a spotlight is given to SMs and related modification enzymes in seeds of Brassicaceae species. Seeds constitute a large reservoir of beneficial SMs and are one of the most important dietary sources, providing more than half of the world's intake of dietary proteins, oil and starch. The seed tissue- and stage-specific expressions of <em>A. thaliana</em> genes involved in SM modification are presented and discussed in the context of available literature. Given the major role in plant phytochemistry, biology and ecology, SM modifications constitute a subject of study contributing to the research and development in agroecology, pharmaceutical, cosmetics and food industrial sectors.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours Vallesamidine 和 schizozygane 生物碱：重新排列的单萜吲哚生物碱和合成努力。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-05-22 DOI: 10.1039/d3np00048f

Xiangyu Zhang

{"title":"Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours","authors":"Xiangyu Zhang","doi":"10.1039/d3np00048f","DOIUrl":"10.1039/d3np00048f","url":null,"abstract":"<div><p>Covering 1963 to 2023</p></div><div><p>Monoterpene indole alkaloids are the main sub-family of indole alkaloids with fascinating structures, stereochemistry, and diverse bioactivities (<em>e.g.</em>, anticancer, anti-malarial and anti-arrhythmic <em>etc.</em>). Vallesamidine alkaloids and structurally more complex schizozygane alkaloids are small groups of rearranged monoterpene indole alkaloids with a unique 2,2,3-trialkylated indoline scaffold, while schizozygane alkaloids can generate a further rearranged skeleton, isoschizozygane, possessing a tetra-substituted, bridged tetrahydroquinoline core. In this review, the origin and structural features of vallesamidine and schizozygane alkaloids are introduced, and a discussion on the relationship of these alkaloids with aspidosperma alkaloids and a structural rearrangement hypothesis based on published studies is followed. Moreover, uncommon skeletons and potential bioactivities, such as anti-malarial and anti-tumour activities, make such alkaloids important synthetic targets, attracting research groups globally to accomplish total synthesis, resulting in impressive works on novel total synthesis, formal synthesis, and construction of key intermediates. These synthetic endeavours are systematically reviewed and highlighted with key strategies and efficiencies, providing different viewpoints on molecular structures and promoting the extension of chemical space and mining of new active scaffolds.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139562646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation 天然产物合成中的 Kornblum DeLaMare 重排：25 年的创新。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-05-22 DOI: 10.1039/d3np00058c

Marc C. Kimber , Darren S. Lee

引用次数: 0