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Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis† 头状二萜：结构多样性、生物活性、生物合成建议和化学合成。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00067b
{"title":"Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis†","authors":"","doi":"10.1039/d3np00067b","DOIUrl":"10.1039/d3np00067b","url":null,"abstract":"<div><p>Covering: up to the end of 2023</p></div><div><p>Cephalotane diterpenoids are a unique class of natural products exclusive to the genus <em>Cephalotaxus</em>, featuring a rigid 7,6,5,6-fused tetracyclic architecture. The study of cephalotanes dates back to the 1970s, when harringtonolide (<strong>1</strong>), a <em>Cephalotaxus</em> troponoid with a peculiar norditerpenoid carbon skeleton, was first discovered. In recent years, prototype C<sub>20</sub> diterpenoids proposed as cephalotane were disclosed, which triggered intense studies on this diterpenoid family. To date, a cumulative total of 105 cephalotane diterpenoids with great structural diversity and biological importance have been isolated. In addition, significant advances have been made in the field of total synthesis and biosynthesis of cephalotanes in recent years. This review provides a complete overview of the chemical structures, bioactivities, biosynthetic aspects, and completed total synthesis of all the isolated cephalotane diterpenoids, which will help guide future research on this class of compounds.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities and challenges of RiPP-based therapeutics 基于 RiPP 的疗法的机遇与挑战。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00057e
{"title":"Opportunities and challenges of RiPP-based therapeutics","authors":"","doi":"10.1039/d3np00057e","DOIUrl":"10.1039/d3np00057e","url":null,"abstract":"<div><p>Covering: up to 2024</p></div><div><p>Ribosomally synthesised and post-translationally modified peptides (RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy bioactivities ranging from antiinfective to anticancer and analgesic effects. Furthermore, RiPP biosynthetic pathways represent promising production routes for complex peptide drugs, and the RiPP technology is well-suited for peptide engineering to produce derivatives with specific functions. Thus, RiPP natural products possess features that render them potentially ideal candidates for drug discovery and development. Nonetheless, only a small number of RiPP-derived compounds have successfully reached the market thus far. This review initially outlines the therapeutic opportunities that RiPP-based compounds can offer, whilst subsequently discussing the limitations that require resolution in order to fully exploit the potential of RiPPs towards the development of innovative drugs.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d3np00057e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease 治疗阿尔茨海默病的天然药物加兰他敏全合成的最新进展。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d4np00001c
{"title":"Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease","authors":"","doi":"10.1039/d4np00001c","DOIUrl":"10.1039/d4np00001c","url":null,"abstract":"<div><p>Covering: 2006 to 2023</p></div><div><p>(−)-Galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (AChE). It is clinically approved for the treatment of Alzheimer's disease. The clinical significance and scarcity of this natural product have prompted extensive and ongoing efforts towards the chemical synthesis of this challenging tetracyclic structure. The objective of this review is to summarize and discuss recent progress in the total synthesis of galantamine from 2006 to 2023. The contents are organized according to the synthetic strategies for the construction of the quaternary center. Key features of each synthesis have been highlighted, followed by a summary and outlook at the end.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np00001c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies 揭秘细菌多炔：了解其生物活性特性、生物合成机制和可持续生产战略。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00059a
{"title":"Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies","authors":"","doi":"10.1039/d3np00059a","DOIUrl":"10.1039/d3np00059a","url":null,"abstract":"<div><p>Covering: up to 2023</p></div><div><p>Conjugated polyynes are natural compounds characterized by alternating single and triple carbon–carbon bonds, endowing them with distinct physicochemical traits and a range of biological activities. While traditionally sourced mainly from plants, recent investigations have revealed many compounds originating from bacterial strains. This review synthesizes current research on bacterial-derived conjugated polyynes, delving into their biosynthetic routes, underscoring the variety in their molecular structures, and examining their potential applications in biotechnology. Additionally, we outline future directions for metabolic and protein engineering to establish more robust and stable platforms for their production.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gold-catalyzed cyclization and cycloaddition in natural product synthesis 天然产物合成中的金催化环化和环化反应。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00056g
{"title":"Gold-catalyzed cyclization and cycloaddition in natural product synthesis","authors":"","doi":"10.1039/d3np00056g","DOIUrl":"10.1039/d3np00056g","url":null,"abstract":"<div><p>Covering: 2016 to mid 2023</p></div><div><p>Transition metal catalysis, known for its remarkable capacity to expedite the assembly of molecular complexity from readily available starting materials in a single operation, occupies a central position in contemporary chemical synthesis. Within this landscape, gold-catalyzed reactions present a novel and versatile paradigm, offering robust frameworks for accessing diverse structural motifs. In this review, we highlighted a curated selection of publications in the past 8 years, focusing on the deployment of homogeneous gold catalysis in the ring-forming step for the total synthesis of natural products. These investigations are categorized based on the specific ring formations they engender, accentuating the prevailing gold-catalyzed methodologies applied to surmount intricate challenges in natural products synthesis.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains 非核糖体肽合成酶腺苷酸化结构域的结构、生物化学和生物信息学分析。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00064h
{"title":"Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains","authors":"","doi":"10.1039/d3np00064h","DOIUrl":"10.1039/d3np00064h","url":null,"abstract":"<div><p>Covering: 1997 to July 2023</p></div><div><p>The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein synthesis in mammals. Several foundational studies on adenylation (A) domains have facilitated an improved understanding of their molecular structures and biochemical properties, in particular work on nonribosomal peptide synthetases (NRPSs). In NRPS pathways, A domains activate their respective acyl substrates for incorporation into a growing peptidyl chain, and many nonribosomal peptides are bioactive. From a natural product drug discovery perspective, improving existing bioinformatics platforms to predict unique NRPS products more accurately from genomic data is desirable. Here, we summarize characterization efforts of A domains primarily from NRPS pathways from July 1997 up to July 2023, covering protein structure elucidation, <em>in vitro</em> assay development, and <em>in silico</em> tools for improved predictions.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters 枯草芽孢杆菌作为天然产品发现和生物合成基因簇工程的宿主。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-17 DOI: 10.1039/d3np00065f
{"title":"Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters","authors":"","doi":"10.1039/d3np00065f","DOIUrl":"10.1039/d3np00065f","url":null,"abstract":"<div><p>Covering: up to October 2023</p></div><div><p>Many bioactive natural products are synthesized by microorganisms that are either difficult or impossible to cultivate under laboratory conditions, or that produce only small amounts of the desired compound. By transferring biosynthetic gene clusters (BGCs) into alternative host organisms that are more easily cultured and engineered, larger quantities can be obtained and new analogues with potentially improved biological activity or other desirable properties can be generated. Moreover, expression of cryptic BGCs in a suitable host can facilitate the identification and characterization of novel natural products. Heterologous expression therefore represents a valuable tool for natural product discovery and engineering as it allows the study and manipulation of their biosynthetic pathways in a controlled setting, enabling innovative applications. <em>Bacillus</em> is a genus of Gram-positive bacteria that is widely used in industrial biotechnology as a host for the production of proteins from diverse origins, including enzymes and vaccines. However, despite numerous successful examples, <em>Bacillus</em> species remain underexploited as heterologous hosts for the expression of natural product BGCs. Here, we review important advantages that <em>Bacillus</em> species offer as expression hosts, such as high secretion capacity, natural competence for DNA uptake, and the increasing availability of a wide range of genetic tools for gene expression and strain engineering. We evaluate different strain optimization strategies and other critical factors that have improved the success and efficiency of heterologous natural product biosynthesis in <em>B. subtilis</em>. Finally, future perspectives for using <em>B. subtilis</em> as a heterologous host are discussed, identifying research gaps and promising areas that require further exploration.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d3np00065f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi 更正：从真菌中分离出的含蜕皮激素的四元酸衍生物的生物合成、生物活性和结构-活性关系。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-10 DOI: 10.1039/D4NP90030H
Hyun Woo Kim, Jin Woo Lee and Sang Hee Shim
{"title":"Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi","authors":"Hyun Woo Kim, Jin Woo Lee and Sang Hee Shim","doi":"10.1039/D4NP90030H","DOIUrl":"10.1039/D4NP90030H","url":null,"abstract":"<p >Correction for ‘Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi’ by Hyun Woo Kim <em>et al.</em>, <em>Nat. Prod. Rep.</em>, 2024, https://doi.org/10.1039/d4np00013g.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np90030h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal plant resin natural products: structural diversity and biological activities† 药用植物树脂天然产品：结构多样性和生物活性。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-04 DOI: 10.1039/d4np00007b
{"title":"Medicinal plant resin natural products: structural diversity and biological activities†","authors":"","doi":"10.1039/d4np00007b","DOIUrl":"10.1039/d4np00007b","url":null,"abstract":"<div><div>Covering: up to the mid of 2023</div></div><div><div>Plants secrete defense resins rich in small-molecule natural products under abiotic and biotic stresses. This comprehensive review encompasses the literature published up to mid-2023 on medicinal plant resin natural products from six main contributor genera, featuring 275 citations that refer to 1115 structurally diverse compounds. The scope of this review extends to include essential information such as the racemic nature of metabolites found in different species of plant resins, source of resins, and revised structures. Additionally, we carefully analyze the reported biological activities of resins, organizing them based on the their structures. The findings offer important insights into the relationship between their structure and activity. Furthermore, this detailed examination can be valuable for researchers and scientists in the field of medicinal plant resin natural products and will promote continued exploration and progress in this area.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hot off the Press 新闻热点
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-04 DOI: 10.1039/d4np90043j
Robert A. Hill , Andrew Sutherland
{"title":"Hot off the Press","authors":"Robert A. Hill ,&nbsp;Andrew Sutherland","doi":"10.1039/d4np90043j","DOIUrl":"10.1039/d4np90043j","url":null,"abstract":"<div><div>A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as asperochone A from <em>Aspergillus</em> sp. MMC-2.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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