Natural Product Reports最新文献_第5页

From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis. 从植物起源到现代实验室：原小檗碱生物碱总合成的50年历程。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-31 DOI: 10.1039/d6np00046k

Weijian Li, Shuman Guan, Mingwei Li, Huijing Wang, Fener Chen

{"title":"From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis.","authors":"Weijian Li, Shuman Guan, Mingwei Li, Huijing Wang, Fener Chen","doi":"10.1039/d6np00046k","DOIUrl":"https://doi.org/10.1039/d6np00046k","url":null,"abstract":"Covering: up to 2025Protoberberine alkaloids (PBs) and tetrahydroprotoberberine alkaloids (THPBs) exhibit diverse pharmacological activities, driving significant interest in their efficient synthesis. This review systematically categorizes recent advances in the total synthesis of these alkaloids based on core-ring-closure strategies. For protoberberines, key methodologies include transition-metal-catalyzed coupling, C-H activation, Mannich/Friedel-Crafts reactions, and tandem cyclizations, enabling the rapid construction of the tetracyclic skeleton. In chiral THPB synthesis, asymmetric strategies, such as chiral auxiliaries, organocatalysis, and transition-metal-catalyzed asymmetric reactions, address the stereochemical challenges at the C14 position. Enzymatic and chemoenzymatic approaches further complement chemical synthesis by enhancing stereocontrol and sustainability. By critically analyzing the efficiency, scope, and limitations of existing strategies, this review highlights innovations in reaction design and underscores the importance of modular, catalytic, and bio-inspired methods for future alkaloid synthesis.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural products for benign prostatic hyperplasia (BPH): structure-activity relationships and pathway mechanisms. 良性前列腺增生（BPH）天然产物：构效关系及通路机制。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-29 DOI: 10.1039/d6np00001k

Tae-Young Gil, Ye-Seul Kim, Dong-Sung Lee, Hyo-Jin An

{"title":"Natural products for benign prostatic hyperplasia (BPH): structure-activity relationships and pathway mechanisms.","authors":"Tae-Young Gil, Ye-Seul Kim, Dong-Sung Lee, Hyo-Jin An","doi":"10.1039/d6np00001k","DOIUrl":"https://doi.org/10.1039/d6np00001k","url":null,"abstract":"Covering: 2012-2025Benign prostatic hyperplasia (BPH) is a prevalent age-related disorder characterized by non-malignant prostate enlargement and lower urinary tract symptoms, arising from the interplay of androgen dysregulation, chronic inflammation, oxidative stress, and stromal remodeling. Natural products and phyto-therapeutics have been extensively investigated as potential therapeutic agents for BPH. However, the literature remains dominated by compound-by-compound descriptions, limiting mechanistic generalization, and structure-guided prioritization. Here, we surveyed studies reported between 2012 and 2025 through a structure-guided, pathway-oriented framework to identify recurring links between chemical features and disease-relevant biological processes. Rather than cataloging individual agents, evidence is organized around major pathogenic axes (AR/5α-reductase-related growth control, inflammatory and redox networks such as NF-κB-Nrf2-NOX, and stroma-epithelium remodeling programs, including TGF-β/Smad and ECM dynamics) and interpreted using motif-level convergence across chemical classes. Across diverse scaffolds, polyphenolic hydroxyl arrays tend to align with inflammation and redox regulation, whereas nitrogen-containing and lipophilic polycyclic frameworks are more frequently associated with endocrine growth signaling and tissue-level remodeling. Importantly, many mechanistic claims rely on downstream biomarkers and are model-dependent, while direct target-engagement evidence remains limited, which constrains molecular-level structure-activity relationship interpretation. By explicitly mapping scaffold motifs to dominant pathogenic axes and highlighting translational gaps driven by pharmacokinetics, standardization, and experimental context, natural products are positioned as privileged starting scaffolds for pathway-directed optimization rather than empirically defined therapeutics.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opines: origins, roles, structures with a nomenclature proposal, and syntheses. 观点：起源、角色、具有命名建议的结构和综合。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-28 DOI: 10.1039/d6np00028b

Leon Otten, Patrick Pale

{"title":"Opines: origins, roles, structures with a nomenclature proposal, and syntheses.","authors":"Leon Otten, Patrick Pale","doi":"10.1039/d6np00028b","DOIUrl":"https://doi.org/10.1039/d6np00028b","url":null,"abstract":"Covering: 1927 to 2026.Although discovered almost a century ago, opines represent an ever-growing family of natural products, derived from a variety of organisms, including bacteria, fungi, plants, and marine invertebrates. Opines exhibit a wide variety of structures and play numerous biological roles, some of which have had significant implications in molecular biology, notably in the development of genetically modified organisms (GMOs) and in plant evolution with the recent discovery of natural GMOs. The opines structurally related to N-alkylated α-amino acids are useful chiral building blocks for the pharmaceutical and fine chemical industries, and some of the enzymes involved in their biosynthesis are now being exploited in these industries for drug development. This review first traces the history of opines from 1927 up to now in term of both chemical and biological views; then a new classification with clearer names is proposed mostly based on structural grounds. The various syntheses of opines are described and discussed according to this proposed classification, together with their known applications in biology, chemical biology and chemistry. Finally, several possible directions are highlighted as a roadmap for future research.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis. 邻烷基苯烯基天然产物：结构多样性、生物活性和生物合成。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-27 DOI: 10.1039/d6np00053c

Qianfei Huang, Xuxiang Chen, Shuhong Ma, Zilin Li, Peng Sun

{"title":"Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis.","authors":"Qianfei Huang, Xuxiang Chen, Shuhong Ma, Zilin Li, Peng Sun","doi":"10.1039/d6np00053c","DOIUrl":"https://doi.org/10.1039/d6np00053c","url":null,"abstract":"Covering: up to 2026.Ortho-alkyl phenylalkenoyl-containing natural products, including cinnamoyl-containing nonribosomal peptides (CCNPs) and ortho-alkyl phenylalkenoic acids (APAs), are structurally and biologically diverse bacterial metabolites that have become a major focus of natural product research. These metabolites exhibit broad bioactivities, including antimicrobial, antiangiogenic, cytotoxic, anti-inflammatory, and nematicidal effects. Biosynthetically, CCNPs and APAs share a conserved, highly reduced (HR) type II polyketide synthase (PKS)-derived framework, featuring characteristic isoenzymes (ISOs) and specialised cyclases that assemble the ortho-alkyl phenylalkenoyl core. They diverge fundamentally in pathway architecture: CCNPs contain NRPS-synthesised peptide backbones, whereas APAs lack NRPS components and possess expanded KS/CLF pairs. Biosynthetic studies have revealed novel mechanisms (e.g., isomerization, 6π-electrocyclisation) and multifunctional enzymes, providing valuable biocatalysts for synthetic biology. Although their biological activities depend strongly on structural context, emerging evidence highlights these metabolites as a promising source of lead compounds. Continued interdisciplinary efforts integrating natural product chemistry, biosynthesis, and medicinal chemistry are expected to unlock their therapeutic potential.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148589600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radical-mediated cross-linking enzymes in RiPP biosynthesis. 自由基介导的RiPP生物合成中的交联酶。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-23 DOI: 10.1039/d6np00029k

Jabal Rahmat Haedar, Ying Shi, Mit A Bhatt, Jonathan R Chekan, Huan Wang, Chin-Soon Phan

引用次数: 0

New secondary metabolites isolated from Streptomyces species. 链霉菌中新分离的次生代谢物。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-22 DOI: 10.1039/d5np00069f

William J Price Cunliffe, Peter J Rutledge

引用次数: 0

A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products. 本文综述了激光双plodia spp.天然产物的结构多样性、生物合成和化学合成。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-22 DOI: 10.1039/d5np00090d

Maria Michela Salvatore, Marco Masi, Marina DellaGreca, Anna Andolfi

引用次数: 0

Syntheses of furan natural products. 呋喃天然产物的合成。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-22 DOI: 10.1039/d6np00005c

Bichu Cheng

引用次数: 0

Unifying ten tryptophan dimer families: linkage diversity from bio-synthetic hypotheses to total synthesis and bioactivity. 统一十个色氨酸二聚体家族：从生物合成假说到全合成和生物活性的连锁多样性。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-22 DOI: 10.1039/d6np00021e

Leiyang Bai, Haiping Liu, Xuefeng Jiang

{"title":"Unifying ten tryptophan dimer families: linkage diversity from bio-synthetic hypotheses to total synthesis and bioactivity.","authors":"Leiyang Bai, Haiping Liu, Xuefeng Jiang","doi":"10.1039/d6np00021e","DOIUrl":"https://doi.org/10.1039/d6np00021e","url":null,"abstract":"Covering: up to July 2026Dimeric tryptophan alkaloids represent a structurally diverse family of natural products whose three-dimensional architectures and biological activities are fundamentally dictated by the linkage patterns between the two tryptophan-derived units. In this review, we connect ten seemingly unrelated natural product families through the unifying principle of tryptophan dimerization, with biological activities varying considerably across linkage types. They are systematically classified according to their covalent connectivity-C-N, C-C, or mixed C-C/C-N linkages-covering ten distinct linkage types: C3-N1', C3a-C3a' (symmetric and unsymmetric), C3-C5', C5-C5', C3-C6', C3-C7', C6-N1', C7-N1', and N1-N1'. For each class, we critically compare total syntheses reported from 1999 to 2026, with an emphasis on strategic solutions to the formidable synthetic challenges faced, e.g. the stereocontrolled formation of congested quaternary centers, chemo- and regioselective installation of heterodimeric linkages, and construction of intricate polycyclic frameworks. We further present a unified biosynthetic hypothesis for all ten linkage types, grounded in radical- and cation-mediated dimerization pathways and supported by recent enzyme characterization and synthetic studies, which not only rationalizes the known linkages but can also guide the discovery of new dimerization modes and their total syntheses, aiming to provide a comprehensive and critical overview of these dimeric tryptophan alkaloids.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing natural product R&D&I: guide for compliance with responsible research and innovation, ethics, Nagoya and Cartagena Protocols, and intellectual property protection. 推进天然产品研发与创新：遵守负责任研究与创新、道德规范、《名古屋议定书》和《卡塔赫纳议定书》以及知识产权保护指南。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-07-22 DOI: 10.1039/d5np00072f

Susana P Gaudêncio, Belma Kalamujić Stroil, Lucie Novoveska, Céline Rebours, Xenia T Schneider

引用次数: 0