Natural Product Reports最新文献_第6页

Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria† 解锁海洋宝藏：从海绵相关细菌中分离和开采天然产物的策略。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-04-17 DOI: 10.1039/d5np00013k

Jeong-A. Kim , Si-sun Choi , Jae Kyu Lim , Eung-Soo Kim

引用次数: 0

Configurational assignments of type-I polyketide synthase (PKS)-derived natural products based on spectroscopic and chemical analysis: methodologies and case studies 基于光谱和化学分析的i型聚酮合成酶（PKS）衍生天然产物的构型分配：方法和案例研究。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-04-17 DOI: 10.1039/d4np00061g

Jinsheng Cui , Prima F. Hillman , Geum Jin Kim , Thinh T. M. Bui , Kyuho Moon , Sang-Jip Nam , Hyukjae Choi , Dong-Chan Oh

引用次数: 0

40 Years of Natural Product Reports 40年的天然产品报告。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-09 DOI: 10.1039/D5NP90012C

引用次数: 0

Illuminating the dark space of bioactive peptides with mass spectrometry 用质谱法照亮生物活性肽的黑暗空间。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-11 DOI: 10.1039/D4NP00057A

Nicole C. Parsley and Leslie M. Hicks

{"title":"Illuminating the dark space of bioactive peptides with mass spectrometry","authors":"Nicole C. Parsley and Leslie M. Hicks","doi":"10.1039/D4NP00057A","DOIUrl":"10.1039/D4NP00057A","url":null,"abstract":"<p >Natural product peptides embody a suite of inherent bioactivities and serve as a template to inspire new chemistries and molecular scaffolds in drug discovery and agrotechnology. Mapping the vast and diverse bioactive peptidome, however, is largely obfuscated by unpredictable molecular transformations in both non-ribosomal sequences and highly post-translationally modified ribosomal protein products. Mass spectrometry is a powerful analytical technique with modern instrumentation achieving unprecedented resolving power, rapid and sensitive gas-phase separations, and versatile multistage fragmentation techniques. As such, mass spectrometry can be (1) leveraged to characterize traditionally difficult-to-sequence natural product peptide modifications <em>via</em> enhanced gas-phase technologies and (2) coupled with complementary ‘Omics’ approaches to predict peptide structure through transcripts, motifs, biosynthetic pathways, and the biomolecular machinery involved in peptide biogenesis. Herein, the challenges of and recent innovations in mass spectrometry towards the discovery and characterization of natural product bioactive peptides are profiled.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 6","pages":" 950-955"},"PeriodicalIF":10.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/np/d4np00057a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Privileged natural product compound classes for anti-inflammatory drug development 开发抗炎药物的天然产物化合物类。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d4np00066h

Malcolm Z. Y. Choo , Julian A. T. Chua , Sean X. Y. Lee , Yuet Ang , W. S. Fred Wong , Christina L. L. Chai

{"title":"Privileged natural product compound classes for anti-inflammatory drug development","authors":"Malcolm Z. Y. Choo , Julian A. T. Chua , Sean X. Y. Lee , Yuet Ang , W. S. Fred Wong , Christina L. L. Chai","doi":"10.1039/d4np00066h","DOIUrl":"10.1039/d4np00066h","url":null,"abstract":"<div><div>Covering: up to early 2025</div></div><div><div>Privileged compound classes of anti-inflammatory natural products are those where there are many reported members that possess anti-inflammatory properties. The identification of these classes is of particular relevance to drug discovery, as they could serve as valuable starting points in developing effective and safe anti-inflammatory agents. The privileged compound classes of natural products include the polyphenols, coumarins, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids, each offering a variety of molecular scaffolds and functional groups that enable diverse interactions with biological targets. From a medicinal chemistry point of view, natural products are both a boon and a bane. The multi-targeting nature of natural products is a boon in the treatment of multi-factorial diseases such as inflammation, but promiscuity, poor potency and pharmacokinetic properties are significant hurdles that must be addressed to ensure these compounds can be effectively used as therapeutics. In addition, there are continued controversies regarding the efficacies of some of these natural products that will continue to polarise their use. In this review, examples of natural products of six privileged compound classes will be discussed for their potential use and possible further development as anti-inflammatory drugs.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 5","pages":"Pages 856-875"},"PeriodicalIF":10.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights fast-tracked: AI in biosynthetic pathway research 分子洞察快速追踪：人工智能在生物合成途径研究中的应用。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d4np00003j

Lijuan Liao , Mengjun Xie , Xiaoshan Zheng , Zhao Zhou , Zixin Deng , Jiangtao Gao

{"title":"Molecular insights fast-tracked: AI in biosynthetic pathway research","authors":"Lijuan Liao , Mengjun Xie , Xiaoshan Zheng , Zhao Zhou , Zixin Deng , Jiangtao Gao","doi":"10.1039/d4np00003j","DOIUrl":"10.1039/d4np00003j","url":null,"abstract":"<div><div>Covering: 2000 to 2025</div></div><div><div>This review explores the potential of artificial intelligence (AI) in addressing challenges and accelerating molecular insights in biosynthetic pathway research, which is crucial for developing bioactive natural products with applications in pharmacology, agriculture, and biotechnology. It provides an overview of various AI techniques relevant to this research field, including machine learning (ML), deep learning (DL), natural language processing, network analysis, and data mining. AI-powered applications across three main areas, namely, pathway discovery and mining, pathway design, and pathway optimization, are discussed, and the benefits and challenges of integrating omics data and AI for enhanced pathway research are also elucidated. This review also addresses the current limitations, future directions, and the importance of synergy between AI and experimental approaches in unlocking rapid advancements in biosynthetic pathway research. The review concludes with an evaluation of AI's current capabilities and future outlook, emphasizing the transformative impact of AI on biosynthetic pathway research and the potential for new opportunities in the discovery and optimization of bioactive natural products.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 5","pages":"Pages 911-936"},"PeriodicalIF":10.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products 异恶唑啉路线合成醛醇在天然产物中的应用进展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d4np00069b

Pavel Yu. Ushakov , Alexey Yu. Sukhorukov

引用次数: 0

Enzymatic crosslinking of histidine side chains in peptide natural products 肽天然产物中组氨酸侧链的酶交联。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d5np00001g

Ying Shi , Yinzheng Xia , Weijiang Gao , Jingxue Wang , Bing Shi , Huan Wang

引用次数: 0

Antarctic bacterial natural products: from genomic insights to drug discovery† 南极细菌天然产物：从基因组洞察到药物发现。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d4np00045e

William Medeiros , Stanislava Kralova , Valéria Oliveira , Nadine Ziemert , Ludek Sehnal

{"title":"Antarctic bacterial natural products: from genomic insights to drug discovery†","authors":"William Medeiros , Stanislava Kralova , Valéria Oliveira , Nadine Ziemert , Ludek Sehnal","doi":"10.1039/d4np00045e","DOIUrl":"10.1039/d4np00045e","url":null,"abstract":"<div><div>Covering: up to the end of 2024</div></div><div><div>Microbial life dominates the extreme continent Antarctica, playing a pivotal role in ecosystem functioning and serving as a reservoir of specialized metabolites known as natural products (NPs). NPs not only contribute to microbial adaptation to harsh conditions but also modulate microbial community structure. Long-term isolation and environmental pressures have shaped the genomes of Antarctic bacteria, suggesting that they also encode unique NPs. Since NPs are also an important source of drugs, we argue that investigating Antarctic bacterial NPs is essential not only for understanding their ecological role and evolution, but also for discovering new chemical structures, biosynthetic mechanisms, and potential new drugs. Yet, despite advances in omics technologies and increased scientific activities in Antarctica, relatively few new bacterial NPs have been discovered. The lack of systematic research activities focused on the exploration of Antarctic bacteria and their NPs constitutes a big problem considering the climate change issue, to which ecosystems in polar regions are the most sensitive areas on the Earth. Here, we highlight the currently available data on Antarctic bacteria, their biosynthetic potential, and the successful NP discoveries, while addressing the challenges in NP research and advocating for systematic, collaborative efforts aligned with the Antarctic Treaty System and the Antarctic Conservation Biogeographic Regions.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 5","pages":"Pages 774-787"},"PeriodicalIF":10.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cytochalasans: potent fungal natural products with application from bench to bedside† 细胞分裂素：从工作台到床边都可应用的强效真菌天然产品。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d4np00076e

Mohamed A. Tammam , Florbela Pereira , Elizabeth Skellam , Stefan Bidula , A. Ganesan , Amr El-Demerdash

引用次数: 0