揭秘细菌多炔：了解其生物活性特性、生物合成机制和可持续生产战略。

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2024-07-17 DOI:10.1039/d3np00059a

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引用次数: 0

摘要

共轭多炔是一种天然化合物，其特点是交替存在单碳碳键和三碳碳键，因而具有独特的物理化学特性和一系列生物活性。虽然传统上主要来源于植物，但最近的研究发现许多化合物来源于细菌菌株。这篇综述综述了目前有关细菌衍生共轭多炔的研究，深入探讨了它们的生物合成路线，强调了它们分子结构的多样性，并考察了它们在生物技术中的潜在应用。此外，我们还概述了新陈代谢和蛋白质工程的未来发展方向，以建立更强大、更稳定的生产平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies

查看原文本刊更多论文

Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies

Covering: up to 2023

Conjugated polyynes are natural compounds characterized by alternating single and triple carbon–carbon bonds, endowing them with distinct physicochemical traits and a range of biological activities. While traditionally sourced mainly from plants, recent investigations have revealed many compounds originating from bacterial strains. This review synthesizes current research on bacterial-derived conjugated polyynes, delving into their biosynthetic routes, underscoring the variety in their molecular structures, and examining their potential applications in biotechnology. Additionally, we outline future directions for metabolic and protein engineering to establish more robust and stable platforms for their production.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.