治疗阿尔茨海默病的天然药物加兰他敏全合成的最新进展。

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2024-07-17 DOI:10.1039/d4np00001c

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引用次数: 0

摘要

覆盖时间：2006 年至 2023 年(-)-金刚烷胺是一种天然产品，具有独特的结构特征和对乙酰胆碱酯酶（AChE）的强效抑制活性。它已被临床批准用于治疗阿尔茨海默病。这种天然产物的临床意义和稀缺性促使人们不断努力对这种具有挑战性的四环结构进行化学合成。本综述旨在总结和讨论 2006 年至 2023 年期间加兰他敏全合成的最新进展。内容按照构建四元中心的合成策略编排。重点介绍了每种合成方法的主要特点，最后进行了总结和展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

查看原文本刊更多论文

Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

Covering: 2006 to 2023

(−)-Galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (AChE). It is clinically approved for the treatment of Alzheimer's disease. The clinical significance and scarcity of this natural product have prompted extensive and ongoing efforts towards the chemical synthesis of this challenging tetracyclic structure. The objective of this review is to summarize and discuss recent progress in the total synthesis of galantamine from 2006 to 2023. The contents are organized according to the synthetic strategies for the construction of the quaternary center. Key features of each synthesis have been highlighted, followed by a summary and outlook at the end.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.