Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2024-06-19 DOI:10.1039/d3np00051f

Jonas Motter , Caecilie M. M. Benckendorff , Sarah Westarp , Peter Sunde-Brown , Peter Neubauer , Anke Kurreck , Gavin J. Miller

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Abstract

Covering: 2019 to 2023

Nucleoside analogues represent one of the most important classes of small molecule pharmaceuticals and their therapeutic development is successfully established within oncology and for the treatment of viral infections. However, there are currently no nucleoside analogues in clinical use for the management of bacterial infections. Despite this, a significant number of clinically recognised nucleoside analogues are known to possess some antibiotic activity, thereby establishing a potential source for new therapeutic discovery in this area. Furthermore, given the rise in antibiotic resistance, the discovery of new clinical candidates remains an urgent global priority and natural product-derived nucleoside analogues may also present a rich source of discovery space for new modalities. This Highlight, covering work published from 2019 to 2023, presents a current perspective surrounding the synthesis of natural purine nucleoside antibiotics. By amalgamating recent efforts from synthetic chemistry with advances in biosynthetic understanding and the use of recombinant enzymes, prospects towards different structural classes of purines are detailed.

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嘌呤核苷抗生素：利用化学和生物学的最新合成进展。

覆盖时间：2019 年至 2023 年核苷类似物是最重要的小分子药物类别之一，其治疗开发已在肿瘤学和病毒感染治疗领域取得成功。然而，目前还没有核苷类似物用于临床治疗细菌感染。尽管如此，已知大量临床认可的核苷类似物具有一定的抗生素活性，从而为这一领域的新疗法发现提供了潜在的来源。此外，鉴于抗生素耐药性的增加，发现新的临床候选药物仍然是全球的当务之急，而天然产物衍生的核苷类似物也可能为新模式提供丰富的发现空间。本《亮点》涵盖 2019 年至 2023 年发表的研究成果，介绍了当前围绕天然嘌呤核苷类抗生素合成的观点。通过将合成化学的最新研究成果与生物合成认识的进步以及重组酶的使用相结合，详细介绍了不同结构类别嘌呤的前景。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.