{"title":"The ballet of nature: the interconvertible isomerisation of natural products.","authors":"Ze-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang Lou","doi":"10.1039/d5np00019j","DOIUrl":null,"url":null,"abstract":"<p><p>Covering: up to 2025The diverse interconversion of isomers among natural products (NPs) are shaped by both intrinsic structural characteristics and extrinsic environmental factors, representing a rich source of chemical complexity and biological diversity. Deciphering these intricate interconversion processes holds the potential to unlock a vast array of bioactive compounds, expanding our exploration of the chemical landscape. Identifying the specific conditions and molecular characteristics while accurately predicting 'the ballet of nature' will effectively achieve increased activity, lower toxicity, and superior pharmacokinetics. Such advancements will significantly broaden their applications in the development of valuable pharmaceuticals and products for medicine, agriculture, and industry. This review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers in nature, including positional, tautomeric, geometric, optical, and conformational isomerism. Particular focus is given to the formation mechanisms of these interconversion processes.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5np00019j","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Covering: up to 2025The diverse interconversion of isomers among natural products (NPs) are shaped by both intrinsic structural characteristics and extrinsic environmental factors, representing a rich source of chemical complexity and biological diversity. Deciphering these intricate interconversion processes holds the potential to unlock a vast array of bioactive compounds, expanding our exploration of the chemical landscape. Identifying the specific conditions and molecular characteristics while accurately predicting 'the ballet of nature' will effectively achieve increased activity, lower toxicity, and superior pharmacokinetics. Such advancements will significantly broaden their applications in the development of valuable pharmaceuticals and products for medicine, agriculture, and industry. This review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers in nature, including positional, tautomeric, geometric, optical, and conformational isomerism. Particular focus is given to the formation mechanisms of these interconversion processes.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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