Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids.

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2025-06-10 DOI:10.1039/d5np00025d

Chungwoo Lee, Sunkyu Han

引用次数: 0

Abstract

Covering: up to 2025Natural product-based research encompasses the discovery, structure elucidation, biosynthesis, synthesis, and application of naturally occurring secondary metabolites. Securingine alkaloids, isolated from Flueggea suffruticosa, have emerged as valuable molecular frameworks for exploring various aspects of natural product research due to their distinct chemical structures, characterized by unique oxidation and rearrangement patterns. Herein, we provide a comprehensive account of our journey in developing novel synthetic strategies and tactics for accessing all known and even unknown securingines and investigating the potential application of securingine B as a novel class of natural product-based molecular photoswitches.

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所有已知和未知的安全碱类生物碱的发现、结构修正、合成和应用。

涵盖：到2025年，基于天然产物的研究包括天然次生代谢物的发现、结构解析、生物合成、合成和应用。从Flueggea suffruticosa中分离出的安全碱生物碱，由于其独特的化学结构，具有独特的氧化和重排模式，已成为探索天然产物研究各个方面的有价值的分子框架。在此，我们提供了一个全面的说明，我们在开发新的合成策略和战术，以获取所有已知的甚至未知的securingine，并研究securingine B作为一类新的天然产物为基础的分子光开关的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.