Yujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan Zhang
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引用次数: 0
Abstract
Covering: 1950 to up to the end of 2024Natural products containing polycyclic aromatic hydrocarbons (PAHs) feature at least two fused aromatic ring systems, conforming to Hückel's rule and representing an important class of secondary metabolites with a wide range of biological activities. Among them, the subtype of natural products containing tricyclic and greater than tricyclic systems has been neglected for a long time. This review summarizes the isolation, structural features, bioactivities, biosynthetic pathways, and chemical synthesis of this special subtype reported over the past decades. This review provides a current understanding of the tricyclic and hyper-PAHs represented by anthracene, phenanthrene, acenaphthalene, pyrene, fluoranthene, and tetraphene from organic, biosynthetic, and pharmacological perspectives.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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