Nan Wang, Yu Bai, Qingyi Zeng, Tao Zhang, Jun Deng
{"title":"Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis.","authors":"Nan Wang, Yu Bai, Qingyi Zeng, Tao Zhang, Jun Deng","doi":"10.1039/d5np00023h","DOIUrl":null,"url":null,"abstract":"<p><p>Covering: 2013 to 2024Cycloaddition reactions, which efficiently construct polycyclic ring systems and stereocenters, are powerful tools in the total synthesis of natural products. Given the significant progress and numerous elegant applications of [5 + 2] cycloaddition reactions over the past decade, this review systematically summarizes the advances in three major types of [5 + 2] cycloaddition reactions in natural product synthesis from 2013 to 2024. The advantages of [5 + 2] cycloadditions in constructing complex natural product frameworks are illustrated through comparisons with alternative strategies for the same targets. Additionally, trends and future prospects for [5 + 2] cycloadditions are discussed, offering valuable insights for further research and broader applications.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5np00023h","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Covering: 2013 to 2024Cycloaddition reactions, which efficiently construct polycyclic ring systems and stereocenters, are powerful tools in the total synthesis of natural products. Given the significant progress and numerous elegant applications of [5 + 2] cycloaddition reactions over the past decade, this review systematically summarizes the advances in three major types of [5 + 2] cycloaddition reactions in natural product synthesis from 2013 to 2024. The advantages of [5 + 2] cycloadditions in constructing complex natural product frameworks are illustrated through comparisons with alternative strategies for the same targets. Additionally, trends and future prospects for [5 + 2] cycloadditions are discussed, offering valuable insights for further research and broader applications.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
