多组分立体选择性合成缩二聚体N-N肽类似物的方法。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-13 DOI:10.1039/d5cc05091j

Natalie J Roper,George M Hardy,Jack M Wootton,Paul G Waddell,James Wilson,Roly J Armstrong

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引用次数: 0

摘要

采用四组分Ugi反应有效地合成了具有中心手性和N-N轴向手性的肽类似物。该方法具有较宽的底物范围，使目标化合物具有优异的立体选择性（高达95:5 d.r）。热反缩异构化研究表明，取代基的性质显著影响反缩异构产物的构型稳定性和热力学偏好。

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A multicomponent approach for the stereoselective synthesis of atropisomeric N-N peptide analogues.

Peptide analogues featuring both central and N-N axial chirality were efficiently synthesised using a 4-component Ugi reaction. This method demonstrates a broad substrate scope, affording the target compounds with excellent stereoselectivity (up to >95 : 5 d.r.). Thermal atropisomerization studies revealed the identity of the substituents significantly influences the configurational stability and thermodynamic preferences of the atropisomeric products.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.