The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-10 DOI:10.1039/d5cc05507e

Marong Qin, Pawan Mishra, Jasmine Hind, Ian Fallis, Matthew Tredwell

引用次数: 0

Abstract

Enantioenrcihed [¹⁸F]SynVesT-1 and [¹⁸F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [¹⁸F]fluoride mediated by (Py)₄Cu(OTf)₂. The ¹⁸F-reaction is optimised on an automated synthesiser to produce multi-GBq quantites of both radiotracers to support (pre)clinical imaging.

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富对映体硼酯合成[18F]SynVesT-1和[18F]SynVesT-2

由相应的富集对映体芳基硼酯和（Py）4Cu(OTf)2介导的[18F]氟化物制备富集[18F]SynVesT-1和[18F]SynVesT-2。18f反应在自动合成器上进行优化，以产生多gbq数量的两种放射性示踪剂，以支持（预）临床成像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.