环境科学与技术最新文献_第10页

AtmosphericRemovalof Nitrous Oxide: Approaches andFeasibility 大气去除氧化亚氮：方法和可行性

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-16 DOI: 10.1021/acs.est.6c04107

William J. Sawyer

{"title":"Atmospheric\u0000Removal\u0000of Nitrous Oxide: Approaches and\u0000Feasibility","authors":"William J. Sawyer","doi":"10.1021/acs.est.6c04107","DOIUrl":"https://doi.org/10.1021/acs.est.6c04107","url":null,"abstract":"Abstract Nitrous oxide (N2O) is the third-largest contributor to anthropogenic greenhouse gas forcing and the dominant anthropogenic ozone-depleting emission. While mitigation can flatten emissions, there is no clear pathway to eliminate residual emissions from agriculture and other diffuse sources, a key challenge for climate stabilization. The potential role of atmospheric removal has not been holistically assessed, yet N2O’s high potency and long atmospheric lifetime indicate the potential for a durable climate benefit. This review synthesizes emerging approaches for atmospheric N2O removal, organized by reaction mechanism (thermal destruction and thermocatalysis, photolysis, gas-phase radical reactions, photocatalysis, and biological reduction) and deployment format (closed versus open system). Each is evaluated for technical efficacy, climate viability, environmental and social viability, and economic plausibility using lower-bound cost models. No approach yet satisfies all four: gas-phase radical reactors are precluded by their kinetics, thermocatalytic and photocatalytic reactors require ten- to hundred-fold performance gains, and open-system approaches have the lowest cost floors but face the greatest measurement and governance challenges. These results identify the performance thresholds and broader constraints that govern feasibility across pathways, providing a foundation for a research agenda and for assessing the role of N2O removal alongside emissions mitigation.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"236 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-SpecificAssociations of Gestational OPE Exposurewith Offspring Digit Ratio: A Birth Cohort Study 妊娠期暴露与后代手指比例的性别特异性关联：一项出生队列研究

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-16 DOI: 10.1021/acs.est.6c04831

Hongchao Lian,Xiuxia Song,Min Luan,Xinrang Liu,Haoyuan Chen,Longmei Jin,Huijia Su,Xiaohua Zhang,Ziliang Wang,Maohua Miao

{"title":"Sex-Specific\u0000Associations of Gestational OPE Exposure\u0000with Offspring Digit Ratio: A Birth Cohort Study","authors":"Hongchao Lian,Xiuxia Song,Min Luan,Xinrang Liu,Haoyuan Chen,Longmei Jin,Huijia Su,Xiaohua Zhang,Ziliang Wang,Maohua Miao","doi":"10.1021/acs.est.6c04831","DOIUrl":"https://doi.org/10.1021/acs.est.6c04831","url":null,"abstract":"Abstract The effect of prenatal organophosphate esters (OPEs) exposure on offspring reproductive development and the potential role of the placenta remain unclear. We investigated the associations of prenatal OPE exposure with the second-to-fourth digit ratio (2D:4D) and the mediating role of placental DNA methylation (DNAm) levels of PPAR pathway genes. Maternal urine OPE metabolites at 12–16 gestational weeks were measured. Placental DNAm levels at birth and children’s 2D:4D at ages 4 and 6 years were assessed. Multiple linear regression, BKMR, and causal mediation analyses were applied. We observed associations between prenatal exposure to BBOEP, BEHP, DBP, and DPP and increased 2D:4D in boys, whereas DBP and DCP were associated with decreased 2D:4D in girls. BKMR identified alkyl-OPEs, particularly BBOEP, as the primary contributors in boys. Moreover, hypermethylation of RXRA, ACAA1, and ACADM was associated with decreased 2D:4D in all populations. In girls, the associations among higher OPE exposure, increased ACAA1 methylation, and lower 2D:4D suggested a potential mediation pathway, while the mediation effects were not statistically significant. These findings suggest sex-specific associations between prenatal OPE exposure and 2D:4D. The potential role of placental PPAR-related DNAm in these associations warrants further investigation.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"22 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient WaterResistance via High-Spin-State ManganeseSpecies in Low-Temperature NH 3 -SCR 高自旋态锰在低温nh3 -SCR中的高效耐水性

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c12786

Ziyi Fan,Xinyuan Fang,Jieru Liu,Kaili Ma,Xiuwen Wang,Weixin Zou,Lin Dong

{"title":"Efficient Water\u0000Resistance via High-Spin-State Manganese\u0000Species in Low-Temperature NH\u0000 3\u0000 -SCR","authors":"Ziyi Fan,Xinyuan Fang,Jieru Liu,Kaili Ma,Xiuwen Wang,Weixin Zou,Lin Dong","doi":"10.1021/acs.est.6c12786","DOIUrl":"https://doi.org/10.1021/acs.est.6c12786","url":null,"abstract":"Abstract Development of highly efficient catalysts for low-temperature NH3–SCR remains a significant challenge, especially in the presence of high concentrations of water vapor. Herein, we have engineered a unique MnCeO2-TDA catalyst with high-spin manganese species by using electron-donating thiophene groups, achieving an excellent NO conversion of over 93% at 160 °C and under 60,000 mL·g–1·h–1 conditions in the higher water vapor of 10–20 vol %. Experimental and theoretical calculations demonstrate that, due to, asymmetrically occupied eg orbitals, high-spin Mn3+ triggers a strong Jahn–Teller distortion, which greatly decreases the O2 dissociation energy (from 2.837 to 1.979 eV) and coactivates O2 and H2O to form the *OOH oxidative species. This enhanced redox ability facilitates NO oxidation and the “fast SCR” reaction, leading to excellent deNOx efficiency under higher levels of water vapor at low temperatures. This work offers a new approach to modulating the spin state of active centers to enhance water resistance in flue gas purification.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"36 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Equilibrium:Tracing Redox-Driven PathwaysThat Shape Aqueous and Mineral Chemistry 超越平衡：追踪氧化还原驱动的途径，形成水和矿物化学

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c08480

Shishir Mundra,Mohit Pundir,Barbara Lothenbach,David S. Kammer,Ueli M. Angst

{"title":"Beyond Equilibrium:\u0000Tracing Redox-Driven Pathways\u0000That Shape Aqueous and Mineral Chemistry","authors":"Shishir Mundra,Mohit Pundir,Barbara Lothenbach,David S. Kammer,Ueli M. Angst","doi":"10.1021/acs.est.6c08480","DOIUrl":"https://doi.org/10.1021/acs.est.6c08480","url":null,"abstract":"Abstract Numerous aqueous and geochemical systems host elements in multiple redox states, with wide ranging implications such as their influence on the formation/dissolution of minerals, water toxicity, and nutrient cycling. To uncover governing mechanisms and complex chemical interactions in geochemical systems, reactive-transport models have increasingly gained importance. However, their predictive capabilities remain limited because existing approaches struggle to accurately account for the full complexities of redox reactions. Here, we develop a reactive-transport framework that leverages recent advances in thermodynamic modeling, speciation chemistry, and redox kinetics. Distinct from traditional models, we uniquely treat redox kinetics along with transport as transient phenomena, decoupled from Gibbs free energy minimization. By ensuring ionic concentrations are governed by nonequilibrium rate laws, this approach allows predicting the tempo-spatial distribution of speciation and precipitation of species across oxidation states. We illustrate the versatility of our framework through two case studies: manganese speciation in natural waters and the fate of dissolved iron in aqueous/porous media. Our framework significantly enhances the modeling of a diverse range of redox-sensitive environments.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"14 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Condensation SinkEfficiency of Atmospheric ParticlesRegulated by Their Chemical Compositions and Hygroscopicity 化学成分和吸湿性对大气粒子凝结沉降效率的影响

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c07189

Jiayi Zhou,Lei Yao,Kaiqi Lai,Chenxi Li,Runlong Cai,Chuang Li,Ning Wang,Qiaodi Lu,Cong An,Jiaping Wang,Jiandong Wang,Wei Du,Jingyu An,Rongjie Zhang,Yongchun Liu,Hongbin Xie,Mingyi Wang,Hugh Coe,Douglas R. Worsnop,Markku Kulmala,Lin Wang

{"title":"Condensation Sink\u0000Efficiency of Atmospheric Particles\u0000Regulated by Their Chemical Compositions and Hygroscopicity","authors":"Jiayi Zhou,Lei Yao,Kaiqi Lai,Chenxi Li,Runlong Cai,Chuang Li,Ning Wang,Qiaodi Lu,Cong An,Jiaping Wang,Jiandong Wang,Wei Du,Jingyu An,Rongjie Zhang,Yongchun Liu,Hongbin Xie,Mingyi Wang,Hugh Coe,Douglas R. Worsnop,Markku Kulmala,Lin Wang","doi":"10.1021/acs.est.6c07189","DOIUrl":"https://doi.org/10.1021/acs.est.6c07189","url":null,"abstract":"Abstract Condensation sink (CS) from atmospheric pre-existing particles is a crucial limiting factor for the occurrence of new particle formation (NPF). However, intense NPF events occur frequently in polluted urban areas despite high CS levels. Here, to address this discrepancy, we introduce an efficiency coefficient ε (ε = CSeff/CScal) to quantify the CS efficiency of pre-existing particles toward gaseous H2SO4, where CScal was calculated under the assumption of irreversible uptake. Results demonstrate that ε strongly depends on hygroscopicity and chemical compositions of particles. Under dry conditions, the ε of pure organic particles was less than that of pure inorganic particles, but high humidity increased ε for both. For mixed organic-inorganic particles, the ε was adjusted together by particle chemical compositions and humidity. Exploratory measurements further revealed a decline in CS efficiency for gaseous HIO3. Incorporating ε into field data and models improves cluster survival predictions and sub-3-nm particle formation simulations, potentially explaining the NPF mystery in megacities under high CS and leading to more accurate modeling of NPF impacts.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"482 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecological Rolesof Bacillus Lipopeptidesin Mediating Plant–Microbe Interactions and Rhizosphere CommunityDynamics 芽孢杆菌脂肽介导植物-微生物相互作用和根际群落动态的生态学作用

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c04887

Haozheng Li,Xiangfeng Zeng,Yimei Xi,Qinggang Li,Zhiheng Li,Zhangxun Huang,Zetao Peng,Shichao Liu,Shihao Cui,Cheng Li,Haiwei Wei,Shaofeng Wang,Yongfeng Jia

{"title":"Ecological Roles\u0000of\u0000 Bacillus\u0000 Lipopeptides\u0000in Mediating Plant–Microbe Interactions and Rhizosphere Community\u0000Dynamics","authors":"Haozheng Li,Xiangfeng Zeng,Yimei Xi,Qinggang Li,Zhiheng Li,Zhangxun Huang,Zetao Peng,Shichao Liu,Shihao Cui,Cheng Li,Haiwei Wei,Shaofeng Wang,Yongfeng Jia","doi":"10.1021/acs.est.6c04887","DOIUrl":"https://doi.org/10.1021/acs.est.6c04887","url":null,"abstract":"Abstract The plant-beneficial bacterium Bacillus velezensis and related Bacillus species are increasingly recognized as important contributors to plant growth and health, yet the ecological functions of their secondary metabolites in situ remain poorly understood. Here, we investigated how lipopeptides produced by Bacillus species influence plant performance and root-associated microbial communities. Using Arabidopsis thaliana as a model host, we show that bacterial lipopeptides produced during root colonization promote plant growth by enhancing the uptake of essential mineral elements, including magnesium, calcium, iron, and zinc. Transcriptomic analyses revealed that lipopeptides upregulated host genes involved in metal transport and homeostasis in roots, while downregulating negative regulators of metal uptake. The lipopeptide production reshaped the composition of root-associated bacterial communities by increasing the relative abundance of putatively beneficial taxa and altering overall rhizosphere community structure. Functional genes indicated that lipopeptide enrichment was associated with microbial pathways related to metal transport, nutrient acquisition, and stress adaptation, suggesting that lipopeptides modulate both plant and microbial traits relevant to nutrient cycling. These results provide new insight into the ecological roles of B. velezensis-derived metabolites in plant-associated microbiomes and highlight lipopeptides as promising targets for harnessing beneficial plant–microbe interactions in sustainable agriculture.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"86 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PFASin Follicular Fluid, Anti-Müllerian Hormone,and Oocyte Developmental Competence: A Prospective Study in GIVES PFASin卵泡液，抗<s:1>勒氏激素和卵母细胞发育能力：一项前瞻性研究

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c04119

Chu Chu,Yang Zhou,Jun-Heng Ma,Yun-Ting Zhang,Wan-Ting He,Xuan Liu,Yan-Xu Chen,Jing-Wen Huang,Lin-Tao Xue,Yin Liang,Zhong Lin,Guang-Hui Dong,Yan Yang

{"title":"PFAS\u0000in Follicular Fluid, Anti-Müllerian Hormone,\u0000and Oocyte Developmental Competence: A Prospective Study in GIVES","authors":"Chu Chu,Yang Zhou,Jun-Heng Ma,Yun-Ting Zhang,Wan-Ting He,Xuan Liu,Yan-Xu Chen,Jing-Wen Huang,Lin-Tao Xue,Yin Liang,Zhong Lin,Guang-Hui Dong,Yan Yang","doi":"10.1021/acs.est.6c04119","DOIUrl":"https://doi.org/10.1021/acs.est.6c04119","url":null,"abstract":"Abstract In this prospective study based on the Guangxi In Vitro Fertilization and the Environment Study (GIVES) cohort, we measured poly- and perfluoroalkyl substances (PFAS) in the ovarian follicular fluid of 729 participants to investigate their association with oocyte developmental competence. The PFAS mixture was negatively associated with Metaphase II (MII) oocyte rate, with chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) identified as the primary contributor in Bayesian kernel machine regression (BKMR) models. Cl-PFESAs were negatively associated with oocyte maturation [relative risk (RR) = 0.67, 95% CI: 0.56–0.79], fertilization (RR = 0.78, 95% CI: 0.67–0.90), blastocyst formation (RR = 0.81, 95% CI: 0.70–0.94), and high-quality blastocyst formation (RR = 0.49, 95% CI: 0.41–0.58). Serum anti-Müllerian hormone (AMH) may act as a key modifier, with a stronger association observed in women with low AMH for MII oocyte rate [relative excess risk due to interaction (RERI) = 0.33, 95% CI: 0.12–0.54] and fertilization rate (RERI = 0.24, 95% CI: 0.003–0.49). Our findings indicate that PFAS, particularly Cl-PFESAs, in follicular fluid are linked to impaired oocyte developmental competence, with AMH serving as a potential modifier. Further studies are warranted to validate our findings and assess the implications of PFAS for reproductive outcomes.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"23 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trimester-SpecificAssociations of Prenatal Heat Exposurewith Neonatal Amino Acid and Acylcarnitine Profiles 产前热暴露与新生儿氨基酸和酰基肉碱谱的孕期特异性关联

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c04144

Yun Huang,Ning Chen,Mengxuan Xie,Hong Jin,Yaohua Tian,Jun Zhang

{"title":"Trimester-Specific\u0000Associations of Prenatal Heat Exposure\u0000with Neonatal Amino Acid and Acylcarnitine Profiles","authors":"Yun Huang,Ning Chen,Mengxuan Xie,Hong Jin,Yaohua Tian,Jun Zhang","doi":"10.1021/acs.est.6c04144","DOIUrl":"https://doi.org/10.1021/acs.est.6c04144","url":null,"abstract":"Abstract It remains unclear whether prenatal heat exposure is associated with newborn metabolic profiles. Therefore, based on 4714 mother–infant pairs in Shanghai, we aimed to investigate the trimester-specific associations of prenatal heat exposure with neonatal amino acid (AA) and acylcarnitine (AC) profiles. Heat exposure was defined using the 90th percentile of trimester-specific temperature distributions from the ERA5-Land data set. For AAs, glutamate showed consistently positive associations across three trimesters, whereas phenylalanine, tyrosine, leucine, arginine, and citrulline showed consistently negative associations; other AAs exhibited trimester-specific patterns. For ACs, C2, C4, and C16 showed consistently negative associations, while a chain-length-dependent pattern was observed: short-chain ACs were predominantly negatively associated, whereas most medium- and long-chain ACs reversed to positive associations in the second and third trimesters. Network topology analysis revealed stronger metabolite correlation structures in the heat-exposed group across all trimesters, with AA-AC pairs accounting for the largest proportion of differential correlations. Distributed lag nonlinear models suggested susceptible windows at gestational weeks 10–17 and 25–27 for AAs, and weeks 8–14 and 26–34 for ACs. Overall, prenatal heat exposure was significantly associated with multiple neonatal AAs and ACs, with distinct trimester-specific patterns and a denser intermetabolite correlation network in the heat-exposed group.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"13 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing SynComsfor Resilience beyond Efficiency 设计超越效率的弹性syncoms

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c09502

Li Wang,Mohamed Hijri,Gary Y. Gan

引用次数: 0

Receptor BindingDrives Toxicokinetic Processes: Insightsfrom Two Amphipod Species Exposed to Insecticides Targeting the NicotinicAcetylcholine Receptor 受体结合驱动毒性动力学过程：两种片脚类动物暴露于针对烟碱乙酰胆碱受体的杀虫剂中的见解

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-15 DOI: 10.1021/acs.est.6c08872

Clarissa von Au,Natsumi Maeda,Johannes Raths,Juliane Hollender

{"title":"Receptor Binding\u0000Drives Toxicokinetic Processes: Insights\u0000from Two Amphipod Species Exposed to Insecticides Targeting the Nicotinic\u0000Acetylcholine Receptor","authors":"Clarissa von Au,Natsumi Maeda,Johannes Raths,Juliane Hollender","doi":"10.1021/acs.est.6c08872","DOIUrl":"https://doi.org/10.1021/acs.est.6c08872","url":null,"abstract":"Abstract Insecticides targeting nicotinic acetylcholine receptors (nAChRs) are used because of their high neuroactive efficacy. However, they can also exert substantial toxic pressure on nontarget aquatic invertebrates. A previous study suggested that irreversible receptor binding is the main driver of thiacloprid bioaccumulation. To determine whether the observed elimination resistance applies to other nAChR-binding insecticides and species, this study investigates five compounds from different substance classes that target nAChRs. Using the two amphipod species, Hyalella azteca and Gammarus pulex, toxicokinetic experiments were combined with assessing receptor binding in vivo and in vitro. The three N-cyanoamidines and N-nitroguanidine neonicotinoids (thiacloprid, acetamiprid, and imidacloprid) and the metabolite imidacloprid-olefin showed resistance toward elimination (i.e., over 15 days of depuration in both amphipod species). This observation could be well described by a two-compartment toxicokinetic (TK)-receptor model (&gt;0.89 R2) with integrated irreversible binding. In contrast, the butenolide flupyradifurone was fully eliminated, and the organic biocide spinosad was eliminated significantly but slowly, both fitted well with a one-compartment TK model (&gt;0.71 R2). These findings demonstrate that receptor-binding specificity and affinity are highly compound class dependent. Although no direct link between receptor binding and acute toxicity could be established, elimination resistance indicates a risk for delayed, sublethal effects that should be critically considered in regulatory risk assessment.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"99 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0