Colloids and Surfaces B: Biointerfaces最新文献_第2页

Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium surfaces: A review 医用镁表面mof膜多功能涂层的可控结构与腐蚀控制研究进展

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.colsurfb.2026.115477

Jiayu He, Yali Li, Xing Zhang, Aotian He, Chao Xiong, Luhong Sun, Xin Chen, Liang Liu, Yi Tu, Dong Zeng

{"title":"Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium surfaces: A review","authors":"Jiayu He, Yali Li, Xing Zhang, Aotian He, Chao Xiong, Luhong Sun, Xin Chen, Liang Liu, Yi Tu, Dong Zeng","doi":"10.1016/j.colsurfb.2026.115477","DOIUrl":"10.1016/j.colsurfb.2026.115477","url":null,"abstract":"<div><div>Biodegradable magnesium (Mg) and its alloys can degrade safely in vivo without toxicity to the human body. However, the major bottleneck inhibiting Mg-based implants’ clinical use is the high corrosion rate. The serious corrosion leads to loss of mechanical integrity prematurely and bad biocompatibility. To break the bottleneck, modification with anticorrosive and bioactive coating is an ideal strategy. Metal-organic frameworks (MOFs) show good anticorrosive performance and perform good biocompatibility with up-and-coming applications in biomedical area such as drug delivery system, biological imaging and antibacterial property. Although numerous reports have reviewed the preparation and application of magnesium-based implant coating, relatively few report the MOF membranes coating of magnesium-based implant. Herein, this review provides the strategies for controlling corrosion of magnesium-based implants. Meanwhile, fabrication of nanoscale MOF membranes (in-situ growth and secondary growth method) is also mentioned. The application of MOFs based materials in the fields of corrosion protection and biomedicine are introduced. This work aims to provide a theoretical basis for addressing the key challenges of corrosion protection and biofunctionalization of degradable metal implants by systematically analyzing the functional characteristics and engineering design principles of MOFs coatings on magnesium-based implants.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115477"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthetic fingerprints and strain-specific characterization of bacterial cellulose from vinegar-derived Komagataeibacter spp. 醋源Komagataeibacter spp细菌纤维素的生物合成指纹图谱及菌株特异性表征。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.colsurfb.2026.115453

Elif Naz Gürsoy, M. Burcu Kulahci, Kubra Sener, K. Barbaros Balabanli, Sule Coskun Cevher

{"title":"Biosynthetic fingerprints and strain-specific characterization of bacterial cellulose from vinegar-derived Komagataeibacter spp.","authors":"Elif Naz Gürsoy, M. Burcu Kulahci, Kubra Sener, K. Barbaros Balabanli, Sule Coskun Cevher","doi":"10.1016/j.colsurfb.2026.115453","DOIUrl":"10.1016/j.colsurfb.2026.115453","url":null,"abstract":"<div><div>Bacterial cellulose (BC) is a nanostructured biopolymer renowned for its high crystallinity, exceptional water-holding capacity, and biocompatibility. While interspecies differences in BC properties are documented, comprehensive insights into strain-level biosynthetic variability within and across Komagataeibacter species remain limited. In this study, ten BC-producing strains were isolated from vinegar samples of diverse botanical origins and identified via 16S rRNA sequencing as belonging to three species: K. europaeus, K. medellinensis, and K. xylinus. Despite the limited taxonomic diversity, the isolates exhibited ten distinct “biosynthetic fingerprints,” as evidenced by pronounced variations in production yield, micro- and nanostructural morphology (FE-SEM), chemical functionality (FTIR), crystallinity (XRD), thermal stability (TGA), and water-holding capacity (WHC). Quantitatively, BC yields ranged from 2.10 to 3.01 g L⁻¹ , crystallinity indices from 34.5 % to 65.6 %, DTG_max from 337.4 °C to 372.1 °C, and WHC from 87.3 % to 95.7 %. Interestingly, some low-crystallinity samples demonstrated higher thermal stability, indicating that microstructural organization and fibril network compactness contribute significantly to thermal resistance beyond crystallinity alone. These findings establish that vinegar-derived Komagataeibacter strains harbor substantial strain-specific structural and functional heterogeneity, underscoring the necessity of strain-level selection and characterization when tailoring BC for advanced biomedical and industrial applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115453"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-sealed mesoporous silica nanocarriers loaded with organic UV filters for effective full-spectrum UV protection 聚多巴胺密封介孔二氧化硅纳米载体负载有机紫外线过滤器，有效的全光谱紫外线防护

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115481

Zixin Kang , Kehan Du , Zhuo-Ran Yang , Shunlan Luo , Xiaoping Zeng , Dawei Wang , Hongyang Zhao , Xiaowen Ou , Qianqian Liu , Hao Jiang , Jiangyu Wu

{"title":"Polydopamine-sealed mesoporous silica nanocarriers loaded with organic UV filters for effective full-spectrum UV protection","authors":"Zixin Kang , Kehan Du , Zhuo-Ran Yang , Shunlan Luo , Xiaoping Zeng , Dawei Wang , Hongyang Zhao , Xiaowen Ou , Qianqian Liu , Hao Jiang , Jiangyu Wu","doi":"10.1016/j.colsurfb.2026.115481","DOIUrl":"10.1016/j.colsurfb.2026.115481","url":null,"abstract":"<div><div>Ultraviolet radiation induces skin carcinogenesis through DNA damage and oxidative stress, driving demand for high-efficacy sunscreens. Current organic filters (e.g., octyl methoxycinnamate, OMC) suffer from narrow spectral coverage and phototoxicity. To address these limitations, we engineered OMC-loaded hollow mesoporous silica nanoparticles with polydopamine coating (OMC@HMSN@PDA). This nanoplatform achieved: (i) synergistic broad-spectrum protection, the sun protection factor (SPF) and UVA protection factor (UVAPF) up to 54 ± 0.74, 26.8 ± 6 with the concentration of 6 wt% OMC respectively, exceeding OMC@HMSN by 10.4-fold in UVB and 11.2-fold in UVA attenuation; (ii) 93.1 ± 1.2 % of DPPH and 98.5 ± 2.5 % of ABTS radical scavenging at 10 µg mL<sup>−1</sup>, and 94.6 ± 0.03 % intracellular reactive oxygen species (ROS) suppression; and (iii) prevention of the payload leakage and photo-instability of OMC, resolution of OMC’s phototoxicity with above 80 % cell viability <em>in vitro</em>. <em>In vivo</em> studies demonstrated prevention of UV-induced epidermal hyperplasia and lower inflammation. This technology establishes a promising approach for photoprotection integrating UV filtering, antioxidant activity, and enhanced safety.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115481"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-based antibacterial strategies: Mechanisms, rational design, and future perspectives 基于纳米材料的抗菌策略：机制、合理设计和未来展望

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115478

Yong Su , Nini Wang , Jiaqi Li, Ying Han, Haiming Fan, Yuan He

{"title":"Nanomaterial-based antibacterial strategies: Mechanisms, rational design, and future perspectives","authors":"Yong Su , Nini Wang , Jiaqi Li, Ying Han, Haiming Fan, Yuan He","doi":"10.1016/j.colsurfb.2026.115478","DOIUrl":"10.1016/j.colsurfb.2026.115478","url":null,"abstract":"<div><div>The increasing challenge of antimicrobial resistance necessitates the development of innovative treatment strategies. This review comprehensively examines the recent advancements in nanomaterial-based antibacterial platforms, focusing on their diverse mechanisms of action, including chemodynamic therapy, nanozyme therapy, photodynamic therapy, sonodynamic therapy, photothermal therapy, magnetothermal therapy, ion interference therapy, and gas therapy. Furthermore, the integration of multimodal therapies as well as strategies to integrate diagnostic-therapeutic functionalities is highlighted as a promising avenue for enhanced antibacterial treatment. Next, the rational design approaches employed to enhance the performance of nanomaterials, such as elemental doping, morphology control, and surface functionalization, are discussed. Despite significant progress, critical challenges remain in the areas of targeting precision, therapeutic efficiency under complex physiological conditions, biosafety, and clinical translation. This work provides valuable insights and forward-looking perspectives to guide the development of next-generation nano-antibacterial agents with enhanced functionality.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115478"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic linking bone ECM-mimic hydrogel for anti-inflammatory therapy of cranial defect 动态连接骨ecm模拟水凝胶抗炎治疗颅骨缺损

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.colsurfb.2026.115462

Tao Ge, Hongcai Wang, Mengmeng Qiu, Kuan Feng, Taotao Shi, Jia Li, Shidi Yang, Maosong Chen

{"title":"Dynamic linking bone ECM-mimic hydrogel for anti-inflammatory therapy of cranial defect","authors":"Tao Ge, Hongcai Wang, Mengmeng Qiu, Kuan Feng, Taotao Shi, Jia Li, Shidi Yang, Maosong Chen","doi":"10.1016/j.colsurfb.2026.115462","DOIUrl":"10.1016/j.colsurfb.2026.115462","url":null,"abstract":"<div><div>Cranial defect repair is frequently hindered by limited intrinsic regenerative capacity, infection risks, and chronic inflammation, whereas conventional grafts and inert implants often suffer from poor host integration. Herein, we report an extracellular matrix–mimicking hydrogel that synchronizes angiogenesis, osteogenesis, and immunomodulation through dynamic thiol–disulfide chemistry and sacrificial prevascularization. Hyaluronic acid functionalized with <span>L</span>-cysteine ethyl ester (HACys) was crosslinked with allicin to yield a viscoadaptive, stress-relaxing network, within which type I collagen was extruded into VEGF-loaded threads to serve as sacrificial templates (HACys-VEGF@Coll-A). Upon enzymatic degradation, these threads generated VEGF-lined microchannels designed to guide rapid vascular ingress. The composite demonstrated excellent cytocompatibility with BMSCs and selectively enhanced HUVEC viability and spreading. Furthermore, VEGF-presenting constructs significantly promoted endothelial tube formation and migration while upregulating VEGF mRNA, confirming preserved bioactivity. In BMSCs, VEGF-containing hydrogels increased alkaline phosphatase activity and mineral deposition, concomitant with the upregulation of osteogenic genes (ALP, COL1, RUNX2, OCN). Notably, macrophages shifted from a CD86high/CD206low toward a CD86low/CD206high phenotype with decreased TNF-α and increased IL-10 secretion, indicating the establishment of a pro-resolution immune microenvironment. Collectively, HACys-VEGF@Coll-A forms a dynamic, remodelable scaffold that integrates preformed vascular conduits while supporting osteogenesis and tempering inflammation, thereby addressing major barriers to cranial defect repair and warranting further in vivo evaluation of release kinetics, channel architecture, and mechanics.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115462"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerium-cobalt composite nanoparticles (CC NPs) as a multifunctional reactive oxygen species (ROS) scavenger for psoriasis therapy 铈钴复合纳米颗粒（CC NPs）作为多功能活性氧（ROS）清除剂治疗银屑病

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.colsurfb.2026.115468

Jiao Zhang , Hao Sun , Hui Yuan , Wenyu Chen , Jialin Yan , Jie Ren , Ting Hu , Yuhang Li

{"title":"Cerium-cobalt composite nanoparticles (CC NPs) as a multifunctional reactive oxygen species (ROS) scavenger for psoriasis therapy","authors":"Jiao Zhang , Hao Sun , Hui Yuan , Wenyu Chen , Jialin Yan , Jie Ren , Ting Hu , Yuhang Li","doi":"10.1016/j.colsurfb.2026.115468","DOIUrl":"10.1016/j.colsurfb.2026.115468","url":null,"abstract":"<div><div>Psoriasis is a chronic inflammatory disorder with a worldwide prevalence of 1–3 %, which has no cure. By inducing inflammation, keratinocyte hyperproliferation, and oxidative stress, reactive oxygen species (ROS) play a pivotal role in the pathogenesis of psoriasis. Although the clinical application of ROS-scavenging nanozymes is expected, their translation has been limited by complicated synthesis and high cost. To bypass these problems, in the present study, cerium cobalt composite nanoparticles (CC NPs) were fabricated via facile coprecipitation. The optimization results revealed that 8CC NPs (CeCo = 8:2) were optimal with uniform spherical morphology and enhanced oxygen vacancies, which enhanced the ROS-scavenging activities, and enabled the efficient scavenging of H<sub>2</sub>O<sub>2</sub>, O<sub>2</sub>•<sup>-</sup>, and •OH radicals. Then, 8CC NPs suppressed the intracellular ROS accumulation, inhibited proliferation, and attenuated the NF-κB inflammatory signaling in the IL-17-stimulated HaCaT keratinocytes. Additionally, in a murine imiquimod-induced psoriasis model, the treatment with 8CC NPs markedly alleviated the clinical symptoms, and no toxicity was observed. Therefore, CC NPs could serve as a novel, cost-effective, and biocompatible nanozyme platform with powerful ROS scavenging, simple synthesis, and promising inflammatory suppression, which provided strong support for their application in the translation of psoriasis. Given the inherent differences between murine models and human psoriasis, further studies are essential to validate the therapeutic potential of this nanozyme platform in clinical settings.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115468"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis 口腔疾病与神经退行性疾病的相关性：生物蛋白在口脑轴和肠脑轴调节中的作用

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115480

Suraj Kumar , Saurabh Srivastava , Ching Siang Tan , Mohammed Abohashrh , Rishabha Malviya

{"title":"Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis","authors":"Suraj Kumar , Saurabh Srivastava , Ching Siang Tan , Mohammed Abohashrh , Rishabha Malviya","doi":"10.1016/j.colsurfb.2026.115480","DOIUrl":"10.1016/j.colsurfb.2026.115480","url":null,"abstract":"<div><div>Biological proteins play a crucial role at the intersection of oral health and neuroscience, offering promising opportunities for improved diagnosis, prevention, and treatment. This review highlights the molecular, inflammatory, and biochemical pathways linking oral diseases, particularly periodontal disease and microbial dysbiosis, with neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Key inflammatory, neuroprotective, and tissue-repair proteins play a crucial role in maintaining both oral integrity and neural function. Advances in proteomics and molecular imaging have clarified how protein misfolding, aggregation, and immune responses drive neuroinflammation and cognitive decline. Emerging therapies include protein-based biomaterials, such as hydrogels, nanocarriers, and protein–polymer hybrids, for delivering neuroprotective and regenerative agents through oral and nasal routes. Early diagnosis is being transformed by salivary proteomics and transcriptomics, enabling non-invasive detection of neurodegenerative biomarkers. Host-defense peptides and antimicrobial proteins also show promise in controlling oral infections that may exacerbate brain inflammation. Integrating oral biology, biomaterials science, and neuroscience is accelerating clinical translation through the development of innovative scaffolds and smart delivery systems. Despite challenges in biomarker validation and clinical application, advances in artificial intelligence, bioinformatics, and protein engineering are driving the future of personalized regenerative and preventive medicine. Overall, biological proteins provide a critical molecular link between oral and neural health, paving the way for novel non-invasive diagnostic and therapeutic strategies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115480"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CP-31398 restored the functional condensates of R175H p53 by stabilizing the zinc-binding domain and 251–258 segment CP-31398通过稳定锌结合结构域和251-258段恢复了R175H p53的功能缩合物

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-26 DOI: 10.1016/j.colsurfb.2026.115474

Yang Liu , Yuan Liu , Chang Xu , Fangming Jiang , Xiaorong Yang

引用次数: 0

Innovative applications and future challenges of shape memory scaffolds for functional reconstruction in diseases of the musculoskeletal system 形状记忆支架在肌肉骨骼系统疾病功能重建中的创新应用和未来挑战。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-01 Epub Date: 2026-01-09 DOI: 10.1016/j.colsurfb.2026.115426

Zhengguang Pu , Wang Gong , Haoming Wu , Hao Zhou , YiXuan Lan , Yingying Chen , Xiuxing Liu , Zhineng Lu , Xiaoyu Du , Xinlei Yang , Shuhao Yang , Wanyue Feng , Chao Peng , Hai Lan , Xulin Hu

{"title":"Innovative applications and future challenges of shape memory scaffolds for functional reconstruction in diseases of the musculoskeletal system","authors":"Zhengguang Pu , Wang Gong , Haoming Wu , Hao Zhou , YiXuan Lan , Yingying Chen , Xiuxing Liu , Zhineng Lu , Xiaoyu Du , Xinlei Yang , Shuhao Yang , Wanyue Feng , Chao Peng , Hai Lan , Xulin Hu","doi":"10.1016/j.colsurfb.2026.115426","DOIUrl":"10.1016/j.colsurfb.2026.115426","url":null,"abstract":"<div><div>Musculoskeletal disorders (MSDs), such as osteoporosis, cartilage degeneration, and tendon injuries, are common worldwide and have a significant impact on patients' quality of life. These conditions are frequently associated with aging, trauma, or chronic diseases. They are typically characterized by slow and limited self-repair, particularly in tissues like cartilage and tendons, which exhibit low regenerative potential. Traditional treatment methods, such as implantable scaffolds, often face challenges related to incomplete tissue integration and inadequate adaptation to dynamic biomechanical conditions. Shape memory scaffolds (SMSs) have emerged as promising candidates for repairing musculoskeletal tissues, due to their unique ability to respond to external stimuli, such as temperature, light, and pH. These materials can adapt to irregular tissue defects and dynamically adjust to biomechanical requirements during the healing process, thereby potentially supporting tissue regeneration. This review discusses the advantages of SMSs in musculoskeletal system reconstruction, emphasizing their mechanical responsiveness, adaptability, and bioactive potential. Furthermore, recent advancements in SMS-based scaffolds and the role of 4D printing in enhancing their functionality are systematically reviewed. Finally, we propose future research directions aimed at enabling more effective and personalized treatments for MSDs.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115426"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered dialdehyde dextran/quaternized chitosan hydrogel incorporating myricetin nanoparticles for diabetic oral wound management 含有杨梅素纳米颗粒的工程双醛葡聚糖/季铵化壳聚糖水凝胶用于糖尿病口腔伤口管理

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-01 Epub Date: 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115421

Xiaoqian Du , Huijie Zhang , Bo Li , Wei Dong , Shengye You

{"title":"Engineered dialdehyde dextran/quaternized chitosan hydrogel incorporating myricetin nanoparticles for diabetic oral wound management","authors":"Xiaoqian Du , Huijie Zhang , Bo Li , Wei Dong , Shengye You","doi":"10.1016/j.colsurfb.2026.115421","DOIUrl":"10.1016/j.colsurfb.2026.115421","url":null,"abstract":"<div><div>Conventional management of diabetic mouth ulcers often demonstrates limited efficacy. Primary obstacles to recovery encompass microbial colonization, damage from reactive oxygen species, and deficient blood vessel development. To meet this significant clinical challenge, an injectable hydrogel biomaterial termed DQM1 has been developed, specifically designed for promoting tissue regeneration in diabetic oral wounds. This composite construct comprises an interconnected polysaccharide network combining dialdehyde dextran and quaternized chitosan, strengthened through myricetin nanoparticles generated via magnesium ion-driven myricetin self-assembly. Post-injection, DQM1 rapidly establishes a protective hydrogel barrier. The dressing demonstrates potent antimicrobial activity coupled with effective scavenging of detrimental reactive species. Collective actions transform the injury environment from a chronically inflamed state to an active rebuilding phase. A significant benefit involves inherent post-treatment biodegradability, guaranteeing complete elimination after fulfilling its regenerative function. Outcomes from laboratory studies and animal models demonstrate that DQM1 markedly enhances oral mucosal wound healing. As an innovative therapeutic platform, such hydrogel-based technology presents considerable potential as a solution for diabetic oral lesions, thereby improving patient prognoses in this complex disorder.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115421"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0