Colloids and Surfaces B: Biointerfaces最新文献_第2页

Dynamic linking bone ECM-mimic hydrogel for anti-inflammatory therapy of cranial defect 动态连接骨ecm模拟水凝胶抗炎治疗颅骨缺损

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.colsurfb.2026.115462

Tao Ge, Hongcai Wang, Mengmeng Qiu, Kuan Feng, Taotao Shi, Jia Li, Shidi Yang, Maosong Chen

{"title":"Dynamic linking bone ECM-mimic hydrogel for anti-inflammatory therapy of cranial defect","authors":"Tao Ge, Hongcai Wang, Mengmeng Qiu, Kuan Feng, Taotao Shi, Jia Li, Shidi Yang, Maosong Chen","doi":"10.1016/j.colsurfb.2026.115462","DOIUrl":"10.1016/j.colsurfb.2026.115462","url":null,"abstract":"<div><div>Cranial defect repair is frequently hindered by limited intrinsic regenerative capacity, infection risks, and chronic inflammation, whereas conventional grafts and inert implants often suffer from poor host integration. Herein, we report an extracellular matrix–mimicking hydrogel that synchronizes angiogenesis, osteogenesis, and immunomodulation through dynamic thiol–disulfide chemistry and sacrificial prevascularization. Hyaluronic acid functionalized with <span>L</span>-cysteine ethyl ester (HACys) was crosslinked with allicin to yield a viscoadaptive, stress-relaxing network, within which type I collagen was extruded into VEGF-loaded threads to serve as sacrificial templates (HACys-VEGF@Coll-A). Upon enzymatic degradation, these threads generated VEGF-lined microchannels designed to guide rapid vascular ingress. The composite demonstrated excellent cytocompatibility with BMSCs and selectively enhanced HUVEC viability and spreading. Furthermore, VEGF-presenting constructs significantly promoted endothelial tube formation and migration while upregulating VEGF mRNA, confirming preserved bioactivity. In BMSCs, VEGF-containing hydrogels increased alkaline phosphatase activity and mineral deposition, concomitant with the upregulation of osteogenic genes (ALP, COL1, RUNX2, OCN). Notably, macrophages shifted from a CD86high/CD206low toward a CD86low/CD206high phenotype with decreased TNF-α and increased IL-10 secretion, indicating the establishment of a pro-resolution immune microenvironment. Collectively, HACys-VEGF@Coll-A forms a dynamic, remodelable scaffold that integrates preformed vascular conduits while supporting osteogenesis and tempering inflammation, thereby addressing major barriers to cranial defect repair and warranting further in vivo evaluation of release kinetics, channel architecture, and mechanics.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115462"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerium-cobalt composite nanoparticles (CC NPs) as a multifunctional reactive oxygen species (ROS) scavenger for psoriasis therapy 铈钴复合纳米颗粒（CC NPs）作为多功能活性氧（ROS）清除剂治疗银屑病

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.colsurfb.2026.115468

Jiao Zhang , Hao Sun , Hui Yuan , Wenyu Chen , Jialin Yan , Jie Ren , Ting Hu , Yuhang Li

{"title":"Cerium-cobalt composite nanoparticles (CC NPs) as a multifunctional reactive oxygen species (ROS) scavenger for psoriasis therapy","authors":"Jiao Zhang , Hao Sun , Hui Yuan , Wenyu Chen , Jialin Yan , Jie Ren , Ting Hu , Yuhang Li","doi":"10.1016/j.colsurfb.2026.115468","DOIUrl":"10.1016/j.colsurfb.2026.115468","url":null,"abstract":"<div><div>Psoriasis is a chronic inflammatory disorder with a worldwide prevalence of 1–3 %, which has no cure. By inducing inflammation, keratinocyte hyperproliferation, and oxidative stress, reactive oxygen species (ROS) play a pivotal role in the pathogenesis of psoriasis. Although the clinical application of ROS-scavenging nanozymes is expected, their translation has been limited by complicated synthesis and high cost. To bypass these problems, in the present study, cerium cobalt composite nanoparticles (CC NPs) were fabricated via facile coprecipitation. The optimization results revealed that 8CC NPs (CeCo = 8:2) were optimal with uniform spherical morphology and enhanced oxygen vacancies, which enhanced the ROS-scavenging activities, and enabled the efficient scavenging of H<sub>2</sub>O<sub>2</sub>, O<sub>2</sub>•<sup>-</sup>, and •OH radicals. Then, 8CC NPs suppressed the intracellular ROS accumulation, inhibited proliferation, and attenuated the NF-κB inflammatory signaling in the IL-17-stimulated HaCaT keratinocytes. Additionally, in a murine imiquimod-induced psoriasis model, the treatment with 8CC NPs markedly alleviated the clinical symptoms, and no toxicity was observed. Therefore, CC NPs could serve as a novel, cost-effective, and biocompatible nanozyme platform with powerful ROS scavenging, simple synthesis, and promising inflammatory suppression, which provided strong support for their application in the translation of psoriasis. Given the inherent differences between murine models and human psoriasis, further studies are essential to validate the therapeutic potential of this nanozyme platform in clinical settings.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115468"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis 口腔疾病与神经退行性疾病的相关性：生物蛋白在口脑轴和肠脑轴调节中的作用

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115480

Suraj Kumar , Saurabh Srivastava , Ching Siang Tan , Mohammed Abohashrh , Rishabha Malviya

{"title":"Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis","authors":"Suraj Kumar , Saurabh Srivastava , Ching Siang Tan , Mohammed Abohashrh , Rishabha Malviya","doi":"10.1016/j.colsurfb.2026.115480","DOIUrl":"10.1016/j.colsurfb.2026.115480","url":null,"abstract":"<div><div>Biological proteins play a crucial role at the intersection of oral health and neuroscience, offering promising opportunities for improved diagnosis, prevention, and treatment. This review highlights the molecular, inflammatory, and biochemical pathways linking oral diseases, particularly periodontal disease and microbial dysbiosis, with neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Key inflammatory, neuroprotective, and tissue-repair proteins play a crucial role in maintaining both oral integrity and neural function. Advances in proteomics and molecular imaging have clarified how protein misfolding, aggregation, and immune responses drive neuroinflammation and cognitive decline. Emerging therapies include protein-based biomaterials, such as hydrogels, nanocarriers, and protein–polymer hybrids, for delivering neuroprotective and regenerative agents through oral and nasal routes. Early diagnosis is being transformed by salivary proteomics and transcriptomics, enabling non-invasive detection of neurodegenerative biomarkers. Host-defense peptides and antimicrobial proteins also show promise in controlling oral infections that may exacerbate brain inflammation. Integrating oral biology, biomaterials science, and neuroscience is accelerating clinical translation through the development of innovative scaffolds and smart delivery systems. Despite challenges in biomarker validation and clinical application, advances in artificial intelligence, bioinformatics, and protein engineering are driving the future of personalized regenerative and preventive medicine. Overall, biological proteins provide a critical molecular link between oral and neural health, paving the way for novel non-invasive diagnostic and therapeutic strategies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115480"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CP-31398 restored the functional condensates of R175H p53 by stabilizing the zinc-binding domain and 251–258 segment CP-31398通过稳定锌结合结构域和251-258段恢复了R175H p53的功能缩合物

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-26 DOI: 10.1016/j.colsurfb.2026.115474

Yang Liu , Yuan Liu , Chang Xu , Fangming Jiang , Xiaorong Yang

引用次数: 0

Muscle-inspired, high-speed hydrogel based on magnetic carrageenan/mesona gum interpenetrating network for integrated actuation and strain sensing in motion monitoring. 基于磁性卡拉胶/中索纳胶互穿网络的肌肉启发型高速水凝胶，用于运动监测中的集成驱动和应变传感。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-04 DOI: 10.1016/j.colsurfb.2026.115781

Yu Fu, Chen Yang, Zhenshuai Wan, Peng Liu, Dengjie Zhu, Xingzhou Chen, Ronghan Wei

{"title":"Muscle-inspired, high-speed hydrogel based on magnetic carrageenan/mesona gum interpenetrating network for integrated actuation and strain sensing in motion monitoring.","authors":"Yu Fu, Chen Yang, Zhenshuai Wan, Peng Liu, Dengjie Zhu, Xingzhou Chen, Ronghan Wei","doi":"10.1016/j.colsurfb.2026.115781","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2026.115781","url":null,"abstract":"<p><p>The development of high-performance magnetic carrageenan/mesona gum (CMG) hydrogel-based soft actuators that integrate rapid response, autonomous motion, and real-time sensing capabilities remains a significant challenge. Inspired by the muscle fiber structure, a hamburger-like conductive composite is presented that achieved a synergistic combination of high biocompatibility, high-speed, integrated magnetic actuation and self-sensing functionality via an eco-friendly fabrication strategy. The magnetic actuation hydrogel exhibits excellent flexibility and magnetically actuated capability attributed to the gradient distribution of magnetic particles (MPs)@multi-walled carbon nanotube (MWCNTs) within the CMG interpenetrating network. Meanwhile, benefiting from the satisfied electrochemical performance, the MWCNTs/sodium alginate (SA) electrodes on both sides enhance the electrical responsiveness and reliability to external stimuli. The developed device demonstrates satisfied biocompatibility, high strain sensitivity (gauge factor of 3.06), fast response (107 ms), remarkable cycling durability (6000 cycles), and rapid magnetic actuation speed of 26.7°/s. The core achievement is that the co-localization of actuation and sensing within a monolithic structure, which allows simultaneous actuated deformation and real-time motion monitoring. This has been demonstrated in bio-inspired systems, including a gripper capable of detecting its own position and grip, and a fish-like actuator that can monitor its own movement. Therefore, this work offers a novel strategy and inspiration for designing intelligent flexible actuation with self-feedback loops, displaying great potentials in next-generation wearable electronics, soft bionic robots, and human-machine interaction.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"265 ","pages":"115781"},"PeriodicalIF":5.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of nucleic acid aptamer-functionalized metal-organic frameworks for cancer biomarker detection. 核酸适体功能化金属有机框架用于癌症生物标志物检测的研究进展。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-03 DOI: 10.1016/j.colsurfb.2026.115771

Qianqian Li, Gedong Meng, Lu Ga, Ailing Su, Lan Yu, Jun Ai

{"title":"A review of nucleic acid aptamer-functionalized metal-organic frameworks for cancer biomarker detection.","authors":"Qianqian Li, Gedong Meng, Lu Ga, Ailing Su, Lan Yu, Jun Ai","doi":"10.1016/j.colsurfb.2026.115771","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2026.115771","url":null,"abstract":"<p><p>Timely detection of cancer is an important step towards better cure rates, and patient prognosis, and the sensitive detection of biomarkers is a significant milestone in this direction. Biosensing uses of metal-organic frameworks (MOFs) due to the high specific surface area, tunable pore size, and excellent functionalization capability have unique benefits. Through the combination of high-affinity nucleic acid aptamers and MOFs, the resulting sensors could have a better sensitivity and sensing performance. This review is a summary of the research development in the last five years on aptamer-MOF composite systems in detecting cancer biomarkers. Particular emphasis is placed on immobilization strategies, signal transduction mechanisms, and the development of electrochemical、optical、photoelectrochemical、 electrochemiluminescent and other emerging sensing platforms, as well as their use in the detection of biomarkers, including ATP、CEA、CA15-3 and ctDNA. Lastly, the performance, constraints, and prospects of aptamer-MOF biosensors are addressed, including aptamer-MOF sensor sensitivity, aptamer-MOF sensor selectivity, aptamer-MOF sensor reproducibility, and aptamer-MOF sensor translatability.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"265 ","pages":"115771"},"PeriodicalIF":5.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism underlying the tolerance of lipase immobilized in porous organic frameworks in organic solvents. 脂肪酶在有机溶剂中固定化在多孔有机框架中的耐受性机制。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-03 DOI: 10.1016/j.colsurfb.2026.115773

Rui Pei

{"title":"Mechanism underlying the tolerance of lipase immobilized in porous organic frameworks in organic solvents.","authors":"Rui Pei","doi":"10.1016/j.colsurfb.2026.115773","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2026.115773","url":null,"abstract":"<p><p>Enzymes represent promising biocatalysts; however, their industrial application is often limited by instability under harsh conditions, particularly their low tolerance to organic solvents. Although immobilization within porous organic frameworks (POFs) offers a potential solution, systematic investigations remain limited. In this work, Aspergillus niger lipase (ANLP) was immobilized in three POFs (ZIF-8, COF-LZU1, and HOF-101), and the tolerance of these composites was evaluated in six common organic solvents, including n-hexane and dichloromethane. The underlying mechanisms governing solvent tolerance were further investigated. Free ANLP exhibited progressive aggregation with increasing solvent polarity, resulting in reduced activity, whereas immobilization within POFs prevented aggregation through spatial confinement. In addition, hydrophobic carriers promoted interfacial interactions with ANLP that induced opening of the catalytic \"lid,\" thereby enhancing substrate accessibility and enzymatic activity. In contrast, polar solvents promoted lid closure and reduced activity. Hydrophobic interfaces, therefore, contribute to stabilizing the active conformation of ANLP and counteracting the lid-closing effects of polar solvents. Overall, the organic solvent tolerance of immobilized ANLP is governed by both the porosity and hydrophobicity of the POF host. This study provides systematic insight into enzyme-POF-solvent interactions and offers perspectives for the rational design of efficient enzyme catalytic systems tailored to specific industrial environments.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"265 ","pages":"115773"},"PeriodicalIF":5.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative applications and future challenges of shape memory scaffolds for functional reconstruction in diseases of the musculoskeletal system 形状记忆支架在肌肉骨骼系统疾病功能重建中的创新应用和未来挑战。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-01 Epub Date: 2026-01-09 DOI: 10.1016/j.colsurfb.2026.115426

Zhengguang Pu , Wang Gong , Haoming Wu , Hao Zhou , YiXuan Lan , Yingying Chen , Xiuxing Liu , Zhineng Lu , Xiaoyu Du , Xinlei Yang , Shuhao Yang , Wanyue Feng , Chao Peng , Hai Lan , Xulin Hu

{"title":"Innovative applications and future challenges of shape memory scaffolds for functional reconstruction in diseases of the musculoskeletal system","authors":"Zhengguang Pu , Wang Gong , Haoming Wu , Hao Zhou , YiXuan Lan , Yingying Chen , Xiuxing Liu , Zhineng Lu , Xiaoyu Du , Xinlei Yang , Shuhao Yang , Wanyue Feng , Chao Peng , Hai Lan , Xulin Hu","doi":"10.1016/j.colsurfb.2026.115426","DOIUrl":"10.1016/j.colsurfb.2026.115426","url":null,"abstract":"<div><div>Musculoskeletal disorders (MSDs), such as osteoporosis, cartilage degeneration, and tendon injuries, are common worldwide and have a significant impact on patients' quality of life. These conditions are frequently associated with aging, trauma, or chronic diseases. They are typically characterized by slow and limited self-repair, particularly in tissues like cartilage and tendons, which exhibit low regenerative potential. Traditional treatment methods, such as implantable scaffolds, often face challenges related to incomplete tissue integration and inadequate adaptation to dynamic biomechanical conditions. Shape memory scaffolds (SMSs) have emerged as promising candidates for repairing musculoskeletal tissues, due to their unique ability to respond to external stimuli, such as temperature, light, and pH. These materials can adapt to irregular tissue defects and dynamically adjust to biomechanical requirements during the healing process, thereby potentially supporting tissue regeneration. This review discusses the advantages of SMSs in musculoskeletal system reconstruction, emphasizing their mechanical responsiveness, adaptability, and bioactive potential. Furthermore, recent advancements in SMS-based scaffolds and the role of 4D printing in enhancing their functionality are systematically reviewed. Finally, we propose future research directions aimed at enabling more effective and personalized treatments for MSDs.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115426"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered dialdehyde dextran/quaternized chitosan hydrogel incorporating myricetin nanoparticles for diabetic oral wound management 含有杨梅素纳米颗粒的工程双醛葡聚糖/季铵化壳聚糖水凝胶用于糖尿病口腔伤口管理

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-01 Epub Date: 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115421

Xiaoqian Du , Huijie Zhang , Bo Li , Wei Dong , Shengye You

{"title":"Engineered dialdehyde dextran/quaternized chitosan hydrogel incorporating myricetin nanoparticles for diabetic oral wound management","authors":"Xiaoqian Du , Huijie Zhang , Bo Li , Wei Dong , Shengye You","doi":"10.1016/j.colsurfb.2026.115421","DOIUrl":"10.1016/j.colsurfb.2026.115421","url":null,"abstract":"<div><div>Conventional management of diabetic mouth ulcers often demonstrates limited efficacy. Primary obstacles to recovery encompass microbial colonization, damage from reactive oxygen species, and deficient blood vessel development. To meet this significant clinical challenge, an injectable hydrogel biomaterial termed DQM1 has been developed, specifically designed for promoting tissue regeneration in diabetic oral wounds. This composite construct comprises an interconnected polysaccharide network combining dialdehyde dextran and quaternized chitosan, strengthened through myricetin nanoparticles generated via magnesium ion-driven myricetin self-assembly. Post-injection, DQM1 rapidly establishes a protective hydrogel barrier. The dressing demonstrates potent antimicrobial activity coupled with effective scavenging of detrimental reactive species. Collective actions transform the injury environment from a chronically inflamed state to an active rebuilding phase. A significant benefit involves inherent post-treatment biodegradability, guaranteeing complete elimination after fulfilling its regenerative function. Outcomes from laboratory studies and animal models demonstrate that DQM1 markedly enhances oral mucosal wound healing. As an innovative therapeutic platform, such hydrogel-based technology presents considerable potential as a solution for diabetic oral lesions, thereby improving patient prognoses in this complex disorder.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115421"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rationally designed BTO@MSN@PPy-PEG piezoelectric nanozyme for ultrasound/NIR-triggered synergistic piezodynamic-photothermal-chemo tumor therapy 合理设计BTO@MSN@ py - peg压电纳米酶用于超声/ nir触发的压电-光热-化疗协同肿瘤治疗

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-05-01 Epub Date: 2026-01-03 DOI: 10.1016/j.colsurfb.2025.115409

Yunxia Hu , Yangbei Zhu , Lijie Liu , Jiaxuan Guo , Wenjie Gao , Lei Tian , Shige Wang , Chengzheng Jia

{"title":"Rationally designed BTO@MSN@PPy-PEG piezoelectric nanozyme for ultrasound/NIR-triggered synergistic piezodynamic-photothermal-chemo tumor therapy","authors":"Yunxia Hu , Yangbei Zhu , Lijie Liu , Jiaxuan Guo , Wenjie Gao , Lei Tian , Shige Wang , Chengzheng Jia","doi":"10.1016/j.colsurfb.2025.115409","DOIUrl":"10.1016/j.colsurfb.2025.115409","url":null,"abstract":"<div><div>Conventional monotherapies for tumors face significant challenges due to their limited therapeutic efficacy and considerable side effects, which severely impede their broad clinical application. To overcome the advancement of multimodal synergistic treatment strategies, integrating diverse treatment modalities with complementary mechanisms has emerged as a crucial approach to enhance the therapeutic outcomes of tumors. In this context, we developed a multifunctional nanoplatform, designated as BaTiO<sub>3</sub>@MSN@PPy-PEG Nanoparticles (BMPP NPs), which can be activated by a combination of ultrasound and near-infrared (NIR) laser irradiation. This nanoplatform is centered around the piezoelectric material barium titanate (BTO), employs a mesoporous silica (MSN) coating for efficient encapsulation of the chemotherapeutic agent curcumin (Cur), and is further modified with polypyrrole (PPy) and polyethylene glycol (PEG) to confer both excellent photothermal conversion capability and enhanced biocompatibility. The synergistic interplay among the ultrasound-induced piezoelectric effect, NIR laser-triggered photothermal therapy, and MSN-mediated drug release results in a novel triple-modal therapy—piezoelectric dynamic, photothermal, and chemo. This integrated strategy effectively suppresses tumor growth and facilitates tumor ablation, holding great promise for future cancer therapeutics.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115409"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0