Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Ultrasound-responsive MoS2@pCu-MOF heterojunction scaffold: Enhancing bacterial membrane permeability, exhibiting efficient antibacterial activity and facilitating bone regeneration","authors":"Gao Pan ,&nbsp;Zheng Wang ,&nbsp;Qi Zhong ,&nbsp;Huixing Li ,&nbsp;Shuping Peng ,&nbsp;Cijun Shuai","doi":"10.1016/j.colsurfb.2025.114872","DOIUrl":"10.1016/j.colsurfb.2025.114872","url":null,"abstract":"<div><div>Phosphate-based Cu-MOF (<em>p</em>Cu-MOF), a bioactive material with copper ions as framework centers and phosphate as the skeleton, shows chemodynamic antibacterial properties and bone regeneration potential via <em>PO₄³ ⁻</em> release. However, its chemodynamic therapy (CDT) relies too much on cellular microenvironment's hydrogen peroxide (H₂O₂) level, and low-concentration reactive oxygen species (ROS) can't penetrate the bacterial membrane well, limiting antibacterial efficiency. To solve this, we created MoS₂@<em>p</em>Cu-MOF type-II heterojunction nanocomposites to boost bacterial membrane permeability, effectively eliminating bacteria and promoting bone regeneration. Sonodynamic therapy (SDT) increases membrane permeability, allowing ROS to penetrate and disrupt bacteria. The type-II heterojunction, with SDT ability, generates hydroxyl radicals (·OH) and singlet oxygen (¹O₂) independently of H₂O₂ level by promoting electron-hole pair separation, achieving high antibacterial activity. Also, heterojunction-induced microcurrents under SDT synergize with <em>PO₄³ ⁻</em> to stimulate osteogenesis. We incorporated MoS₂@pCu-MOF nanocomposites into a poly-l-lactic acid (PLLA) scaffold via selective laser sintering. Under ultrasonic stimulation, bacterial membrane permeability increases. Separated charge carriers bind to active sites of the MoS₂@<em>p</em>Cu-MOF heterojunction scaffold to generate ·OH and ¹O₂, enabling high antibacterial efficiency without relying on CDT. Electrochemical experiments showed improved electron-hole separation efficiency of the heterojunction scaffold. <em>PO₄³ ⁻</em> release and ultrasound-induced microcurrents promoted bone regeneration. Results indicated that the inhibition rates of <em>Staphylococcus aureus</em> (<em>S.aureus</em>) and <em>Escherichia coli</em> (<em>E.coli</em>) reached 99 % and 98.5 %, respectively. Notably, ultrasound-induced microcurrents enhanced the scaffold's osteogenic capacity by 36 % at the late osteogenesis stage on the basis of ion stimulation and facilitated the expression of osteogenic factors like Runx-2, Wnt-10b, and BMP-2. These findings suggest MoS₂@<em>p</em>Cu-MOF heterojunction scaffolds can achieve effective SDT/CDT dual-mode antibacterial activity and promote bone regeneration via ionic/sonoelectric dual-mode.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114872"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of crosslinked kudzu porous starch hemostatic","authors":"Yuanyuan Zhao ,&nbsp;Jinnan Guo ,&nbsp;Guanqun Peng ,&nbsp;Miaomiao Yao ,&nbsp;Jicui Wen ,&nbsp;Qi He ,&nbsp;Runtian Li ,&nbsp;Xiaohui Zhu ,&nbsp;Zhiyun Meng ,&nbsp;Shanshan Wang ,&nbsp;Hui Gan ,&nbsp;Ruolan Gu ,&nbsp;Zhuona Wu ,&nbsp;Guifang Dou ,&nbsp;Shuchen Liu ,&nbsp;Yunbo Sun","doi":"10.1016/j.colsurfb.2025.114871","DOIUrl":"10.1016/j.colsurfb.2025.114871","url":null,"abstract":"<div><div>Rapid and effective hemostasis is essential for the management of battlefield injuries and traumatic hemorrhages. Among various hemostatic agents, starch-based materials have attracted considerable attention due to their favorable biocompatibility, low immunogenicity, and cost-effectiveness. However, the potential of kudzu starch (KS) as a raw material for hemostatic applications remains underexplored. In this study, porous kudzu starch (PS) was crosslinked with sodium trimetaphosphate (STMP) to synthesize a novel hemostatic agent, STMP/PS (SPS), with enhanced functional performance. The structural and physicochemical properties of SPS were systematically characterized using Fourier-transform infrared (FT-IR) spectroscopy, Brunauer–Emmett–Teller (BET) surface area analysis, and other analytical techniques, confirming successful chemical modification and the formation of a highly porous architecture. SPS exhibited excellent water absorption and dye adsorption capacities. Hemostatic efficacy was evaluated through a series of in vitro and in vivo models, where SPS demonstrated significantly improved performance compared to a commercially available hemostatic product. Mechanistic investigations revealed that SPS facilitates red blood cell aggregation and platelet adhesion, thereby accelerating the coagulation cascade. In addition, biosafety assessments, including cytotoxicity, acute toxicity, and hemolysis assays, confirmed its excellent biocompatibility and low toxicity. These findings underscore the clinical potential of SPS as a rapid, effective, and safe starch-based hemostatic material.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114871"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-responsive chitosan-sodium alginate nanocarriers for curcumin delivery against brain cancer","authors":"Salar Mohammadi Shabestari ,&nbsp;Mehrab Pourmadadi ,&nbsp;Hamidreza Abdouss ,&nbsp;Taranom Ghanbari ,&nbsp;Majid Abdouss ,&nbsp;Abbas Rahdar ,&nbsp;Adriana Cambón ,&nbsp;Pablo Taboada","doi":"10.1016/j.colsurfb.2025.114875","DOIUrl":"10.1016/j.colsurfb.2025.114875","url":null,"abstract":"<div><div>Curcumin (CUR) exhibits potent anticancer properties and has been widely investigated for the treatment of various malignancies. However, its clinical application is limited by poor aqueous solubility, rapid systemic metabolism, and a short circulation half-life. In the present study, a pH-responsive hybrid nanocarrier system was developed based on sodium alginate (SA), chitosan (CS), and cerium oxide (CeO₂) nanoparticles (NPs), using a water-in-oil-in-water (W/O/W) double emulsion technique. This system was designed to enhance CUR stability, enable controlled and sustained release, and improve pharmacokinetic parameters such as half-life and biodistribution. The resulting nanocarriers exhibited spherical morphology with textured surfaces, a positive surface charge, and nanoscale dimensions. Structural characterization via XRD and FTIR confirmed a quasi-amorphous composite matrix and successful encapsulation of CUR, achieving an encapsulation efficiency of approximately 86 %. Drug release studies conducted at physiological and acidic pH demonstrated a sustained, pH-dependent release profile, well-fitted by the Baker–Lonsdale kinetic model. Cytotoxicity assays using U-87MG2 glioma and healthy astrocyte cell lines indicated that the CUR-loaded nanocarriers selectively induced tumor cell death while exhibiting minimal toxicity toward normal cells. Moreover, the inclusion of CeO₂ NPs was found to mitigate CUR degradation under physiological conditions, thereby contributing to its enhanced therapeutic performance. Flow cytometry analysis further revealed a significant induction of apoptosis in glioma cells treated with the CUR-loaded nanocomposites. Collectively, these findings underscore the potential of the developed CS/SA/CeO₂@CUR nanoplatform as an effective and biocompatible strategy for brain cancer therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114875"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artesunate carbon dots for attenuating periodontal inflammation and promoting bone regeneration via activation of AMPK","authors":"Shuo Yu ,&nbsp;Jinzhong Liu ,&nbsp;Xiaolin Ma ,&nbsp;Ziqing Wei ,&nbsp;Huiling Ye ,&nbsp;Liangheng Zou ,&nbsp;Dandan Liu ,&nbsp;Shanlin Qu ,&nbsp;Zhihui Liu ,&nbsp;Di Li ,&nbsp;Rui Wang","doi":"10.1016/j.colsurfb.2025.114873","DOIUrl":"10.1016/j.colsurfb.2025.114873","url":null,"abstract":"<div><div>Periodontitis, recognized as a chronic inflammatory condition, manifests through sustained gingival inflammation and gradual degradation of alveolar bone tissue. Without proper intervention, this pathological process may culminate in permanent tooth detachment. Consequently, therapeutic strategies for periodontitis primarily focus on mitigating inflammatory reactions and stimulating osseous tissue regeneration. Recent pharmacological investigations have highlighted artesunate (ART) as a compound exhibiting notable anti-inflammatory efficacy, though its clinical application is constrained by limited aqueous solubility and suboptimal pharmacokinetic properties. Carbon-based quantum dots, emerging as versatile nanoscale materials, demonstrate multiple biological functionalities. This research successfully synthesized artesunate-derived carbon dots (ACDs) through hydrothermal synthesis and comprehensively evaluated their dual therapeutic effects on inflammation suppression and bone formation enhancement in periodontal disease models. Experimental data revealed that ACDs exhibit improved hydrophilicity, favorable biocompatibility, and simultaneous anti-inflammatory/osteogenic capabilities. Mechanistically, ACDs activated the adenosine monophosphate-activated protein kinase (AMPK), subsequently inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling transduction, which effectively reduced pro-inflammatory cytokine secretion. AMPK pathway activation further upregulated expression patterns of osteogenic differentiation markers at both mRNA translation and protein synthesis levels, enhanced mineralization capacity in rat bone marrow mesenchymal stem cells (rBMSCs), and increased calcified nodule formation. Collectively, these findings demonstrate that ACDs effectively counteract lipopolysaccharide (LPS)-induced inflammatory responses while substantially improving bone regenerative processes through AMPK pathway modulation. This investigation suggests ACDs as a promising nanotechnology-based approach for periodontitis management.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114873"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-mode sensing platform based on novel Schiff base compounds for zinc ion detection and HeLa cell imaging via downconversion and NIR-excited upconversion luminescence","authors":"Zhihui Yang ,&nbsp;Longhao Lv ,&nbsp;Yuanrong Wang ,&nbsp;Xiaochen Wang ,&nbsp;Wenxiao Wu ,&nbsp;Qingtao Shen ,&nbsp;Chengyu Zhang ,&nbsp;Jianqi Qin ,&nbsp;Zhenhao Jiang ,&nbsp;Fanghao Sun ,&nbsp;Jinliang Liu ,&nbsp;Haifeng Lu","doi":"10.1016/j.colsurfb.2025.114866","DOIUrl":"10.1016/j.colsurfb.2025.114866","url":null,"abstract":"<div><div>We successfully synthesized two novel siloxane-containing Schiff base compounds, pBSIA and oBSIA, via a one-step process. These compounds exhibited remarkable upconversion luminescence properties, efficiently converting near-infrared (NIR) light into blue emission. Based on oBSIA, we developed a dual-mode sensing platform that integrates downconversion fluorescence and NIR-excited upconversion luminescence, enabling Zn²⁺ detection and NIR-excited imaging of HeLa cells. Experimental results demonstrated that the oBSIA-Zn²⁺ complex exhibited a nearly 30-fold enhancement in fluorescence intensity and over 500 % increase in absolute quantum yield compared to uncomplexed oBSIA. This ligand-enhanced fluorescence mechanism supports both qualitative and quantitative Zn²⁺ detection. Furthermore, the probe exhibited low cytotoxicity and excellent stability, facilitating efficient penetration into living HeLa cells and enabling noninvasive upconversion imaging under NIR excitation. This approach effectively addresses the limitations of conventional fluorescence imaging techniques. The developed Schiff base compounds serve as a powerful tool for fluorescence sensing in biological systems. They also offer new opportunities for designing NIR upconversion bioactive molecules with potential applications in biosensing and bioimaging.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114866"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"InterFace/Off: characterization of competitive adsorption of novel surfactants and proteins at the solid-liquid and oil-liquid interfaces","authors":"Vera Peters ,&nbsp;Leonie Schneider ,&nbsp;Sebastian Brosig,&nbsp;Stephanie Michelle Medrano,&nbsp;Stefano Cucuzza","doi":"10.1016/j.colsurfb.2025.114865","DOIUrl":"10.1016/j.colsurfb.2025.114865","url":null,"abstract":"<div><div>Interfacial stress encountered by biopharmaceuticals is often opposed by employing surfactants in their formulations. Surfactants protect proteins from this stress by either shielding the interface or displacing adsorbed proteins. Most previous studies were dedicated to the air-liquid interface, and to characterize monoclonal antibodies or non-pharmaceutically relevant proteins in combination with established surfactants (polysorbates and poloxamer 188). Herein, we employ quartz crystal microbalance with dissipation (QCM-D) and tensiometry to investigate the adsorption behavior of established surfactants as well as the novel surfactants VEDS and VEDG-3.3 at the solid-liquid and silicon oil-liquid interfaces in presence and absence of three model biotherapeutics of different modalities. Our study shows that the individual adsorption behavior is molecule-dependent, as expected. When mixed either simultaneously (co-adsorption) or sequentially (shielding and displacement), both proteins and surfactants were detected to co-adsorb at the interface. Compared to the established surfactants, VEDS and VEDG-3.3 showed a slower adsorption followed by molecular rearrangements that resulted in a denser packing, supporting the mechanistic explanation of their favorable protein stabilization effect previously reported. Collectively, our results support the generation of a unified thermodynamic description of the adsorption of protein-surfactants mixtures in pharmaceutically-relevant conditions.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114865"},"PeriodicalIF":5.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-aggregate morphological and biomechanical detection of atherogenic aggregated low-density lipoprotein (agLDL) by atomic force microscopy","authors":"Chenhan Sun ,&nbsp;Qinghua Sheng ,&nbsp;Ying Qin ,&nbsp;Yong Chen","doi":"10.1016/j.colsurfb.2025.114864","DOIUrl":"10.1016/j.colsurfb.2025.114864","url":null,"abstract":"<div><div>Aggregated low-density lipoprotein (agLDL) has long been regarded as an atherogenic factor and was recently supposed to play a driving force role in atherogenesis. However, the underlying mechanisms for its atherogenicity remain poorly understood. Here, agLDL was successfully induced by physical (vortexing) or biological (alpha-chymotrypsin or α-CT and sphingomyelinase or SMase, a protease and a phospholipase, respectively) methods, and verified by turbidimetry, size distribution, and relatively low-resolution morphology. Moreover, the produced agLDL had the aggregation degree-dependent atherogenic property according to macrophage lipid deposition data. Then, the single-aggregate morphological and biomechanical (stiffness and stickiness) properties of agLDL at early stages of aggregation (e.g., LDL dimer, trimer, and multimer) were detected by atomic force microscopy (AFM). Interestingly, intra-aggregate LDL of agLDL had a relatively larger average size than native LDL (i.e., LDL monomer). Most importantly, we revealed that agLDL has lower average Young's modulus and stronger average adhesion force than native LDL (i.e., agLDL is softer and stickier than native LDL). The softer and stickier properties of agLDL than native LDL probably are responsible for the atherogenicity of agLDL according to its aggregation degree-dependent atherogenic property. Targeting the biomechanical properties (e.g., stiffness and stickiness) of agLDL or other LDL derivatives may be a potential strategy for preventing atherosclerosis.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114864"},"PeriodicalIF":5.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing thrombolysis through targeted delivery of urokinase by H2O2-responsive nanoparticles delivery system","authors":"Qiwei Liang ,&nbsp;Xiancan Ban ,&nbsp;Siyuan Jiang ,&nbsp;Zhi Zeng ,&nbsp;Huigang Feng ,&nbsp;Yufeng Ye ,&nbsp;Yi Zhang ,&nbsp;Yan-Qing Guan ,&nbsp;Yi Huang","doi":"10.1016/j.colsurfb.2025.114849","DOIUrl":"10.1016/j.colsurfb.2025.114849","url":null,"abstract":"<div><div>Thrombotic diseases, such as stroke and myocardial infarction, represent significant threats to global health. Timely and safe thrombolysis is crucial in improving tissue ischemia and preventing thrombosis progression. Urokinase (UK) is a widely used thrombolytic agent, however, its clinical use is constrained by bleeding risks and other adverse effects. In this study, EGCG-Mn-Fuc nanoparticles with H₂O₂ responsiveness were successfully prepared. Urokinase was loaded into the nanomaterials via the direct assembly method, and the thrombolytic effect of these nanoparticles was investigated. The preparation process of the nanoparticles is straightforward, and the reaction conditions are relatively mild. The physical and chemical properties of the EGCG-Mn-Fuc nanoparticles were characterized by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), Ultraviolet and visible spectrum (UV-Vis) and X-ray photoelectron spectroscopy (XPS). In cell experiments, EGCG-Mn-Fuc nanoparticles showed low cytotoxicity and good biocompatibility. Furthermore, these nanoparticles effectively scavenged DPPH free radicals, attributing this capability primarily to their antioxidant properties. In vitro thrombolytic experiments showed that EGCG-Mn-Fuc nanoparticles intelligently responded to H₂O₂, releasing the loaded urokinase and exerting a thrombolytic effect. The microcapsules exhibited concentration-dependent thrombolytic effects, effectively dissolving thrombi in the presence of H₂O₂. Hemolysis and coagulation tests confirmed their good blood compatibility and anticoagulant properties. In addition, it is worth noting that the nanoparticle contains fucoidan that mimics P-selectin glycoprotein ligand-1(PSGL-1) and has a high affinity for activating P-selectin on the surface of platelets. Overall, the results of this study not only provide valuable experimental evidence and theoretical support for the application of EGCG-Mn-Fuc nanoparticles in the field of thrombolysis, but also establish a foundation for the biomedical application of drug carriers in this field.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114849"},"PeriodicalIF":5.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regeneration enhanced by green tea polyphenols/chitosan bifunctional hydrogel","authors":"Tongzhou Hu ,&nbsp;Biao Cheng","doi":"10.1016/j.colsurfb.2025.114824","DOIUrl":"10.1016/j.colsurfb.2025.114824","url":null,"abstract":"<div><div>Approximately 455 million fracture cases were reported globally in 2019, which is an increase of 33.4 % from 1990. Fractures affect the health status and quality of life of patients and bring a heavy burden to families and even society. Bone tissue engineering is an innovative technology in which composite scaffolds are used to treat defects and fractures. However, this technology lacks efficient dual-function materials for inducing bone regeneration. We here developed a bone tissue engineering scaffold with a structural and compositional bionic natural bone tissue having antibacterial properties, good biocompatibility, and appropriate mechanical strength. Methacrylated gelatin, carboxyethyl chitosan, green tea polyphenols, and oxidized hyaluronic acid were prepared through a photo-crosslinking reaction and Schiff base crosslinking to form a crosslinked dual-function hydrogel. The morphology of the hydrogels was observed through field-emission scanning electron microscopy. The mechanical properties were explored using a mechanical universal testing machine. The in vitro cell compatibility was also verified. Finally, the in vivo repair mechanism was unveiled using an animal model. The dual-function hydrogel exhibited a structure and mechanical properties similar to the bone tissue and good biocompatibility, and promoted good bone regeneration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114824"},"PeriodicalIF":5.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of heterologous extracellular vesicles and their analogs in anti-tumor activity research","authors":"Jianguo Gao,&nbsp;Yanqing Wu,&nbsp;Yuwei Zhao,&nbsp;Yingzhi Lu,&nbsp;Xiaoqing Cai","doi":"10.1016/j.colsurfb.2025.114850","DOIUrl":"10.1016/j.colsurfb.2025.114850","url":null,"abstract":"<div><div>Extracellular vesicles and their analogues can mediate intercellular communication for gene regulation, thereby activating corresponding cellular functions, which demonstrates promising applications in disease diagnosis and treatment. Extensive studies have indicated that extracellular vesicles and their analogues exhibit remarkable efficacy in various pharmacological activities, including anti-tumor effects, immune modulation, prevention and treatment of cardiovascular diseases, as well as tissue regeneration. Heterologous extracellular vesicles and their analogues possess diverse biological activities attributed to their compositions, distributions, and mechanisms of action. Their specific targeting ability, high biocompatibility, and low immunogenicity render them ideal delivery vehicles for precision therapeutic interventions. This article aims to comprehensively review the mechanisms of action of extracellular vesicles and their analogues in anti-tumor activity, as well as their unique advantages as drug delivery carriers, with the goal of providing a necessary reference foundation for further application and development in anti-tumor therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114850"},"PeriodicalIF":5.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}