Colloids and Surfaces B: Biointerfaces最新文献_第10页

Single-step method for the immobilization of hydroxyapatite on 3D-printed porous polyetherketoneketone implants for the enhanced cell adhesion and osteogenic differentiation 羟基磷灰石单步固定在3d打印多孔聚醚酮酮植入物上，增强细胞粘附和成骨分化

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-14 DOI: 10.1016/j.colsurfb.2025.114777

Semen Goreninskii , Igor Akimchenko , Alexander Vorobyev , Mikhail Konoplyannikov , Yuri Efremov , Evgeniy Sudarev , Peter Timashev , Andrei Zvyagin , Evgeny Bolbasov , Sergei Tverdokhlebov

{"title":"Single-step method for the immobilization of hydroxyapatite on 3D-printed porous polyetherketoneketone implants for the enhanced cell adhesion and osteogenic differentiation","authors":"Semen Goreninskii , Igor Akimchenko , Alexander Vorobyev , Mikhail Konoplyannikov , Yuri Efremov , Evgeniy Sudarev , Peter Timashev , Andrei Zvyagin , Evgeny Bolbasov , Sergei Tverdokhlebov","doi":"10.1016/j.colsurfb.2025.114777","DOIUrl":"10.1016/j.colsurfb.2025.114777","url":null,"abstract":"<div><div>Being biocompatible and extremely rigid polymer, polyetherketoneketone (PEKK) emerged as a promising material for the development of bone implants, but its inert surface limits bone-implant integration. Herein, we report a single-step approach for the immobilization of hydroxyapatite (HAp) particles on the surface of additively fabricated porous PEKK implants based on the swelling of the implant surface with subsequent entrapment of the HAp particles. By means of the scanning electron microscopy, it was established that this approach effectively preserved the morphology (pore diameter and printed line width) of the original implants. With that, up to 35.0 ± 14.0 % of the sample surface was covered with HAp particles, leading to improved hydrophilicity (<1° water contact angle). From the energy-dispersive spectroscopy results, calcium and phosphorus content on the surface of the modified samples reached 17.4 ± 4.1 wt% and 8.0 ± 1.7 wt%, respectively. Compression test revealed no changes in the samples strength. From the <em>in vitro</em> experiment with bone marrow multipotent stem cells (MSC) HAp immobilization improved cell adhesion (from 121 ± 40 cells/mm² to 234 ± 8 cells/mm²) and induced their osteogenic differentiation. Thus, the proposed method may be used for the development of PEKK-based implants for bone tissue restoration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114777"},"PeriodicalIF":5.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apatinib-loaded silicate nanoparticles coated with macrophage membranes and PD-1 antibody for enhanced chemo-immunotherapy in ovarian cancer via VEGFR2 and PD-1 dual inhibition 负载apatinib的硅酸盐纳米颗粒包被巨噬细胞膜和PD-1抗体，通过VEGFR2和PD-1双重抑制增强卵巢癌的化学免疫治疗

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-14 DOI: 10.1016/j.colsurfb.2025.114790

Hongru Li , Yuhan Wang , Shunqing Zhou , Jianli Liu , Yuemei Jin

{"title":"Apatinib-loaded silicate nanoparticles coated with macrophage membranes and PD-1 antibody for enhanced chemo-immunotherapy in ovarian cancer via VEGFR2 and PD-1 dual inhibition","authors":"Hongru Li , Yuhan Wang , Shunqing Zhou , Jianli Liu , Yuemei Jin","doi":"10.1016/j.colsurfb.2025.114790","DOIUrl":"10.1016/j.colsurfb.2025.114790","url":null,"abstract":"<div><div>Ovarian cancer remains one of the most challenging malignancies to treat due to its aggressive nature and resistance to conventional therapies. In this study, we developed a nanoparticle-based system (Apa@SiO<sub>2</sub>@MP) that combines chemotherapy with immune checkpoint inhibition for enhanced treatment of ovarian cancer. The system consists of mesoporous silica nanoparticles (SiO<sub>2</sub> NPs) coated with macrophage membranes (MP) and functionalized with programmed death 1 (PD-1) antibody, designed to improve the delivery and targeting of apatinib, a tyrosine kinase inhibitor. The system demonstrated effective drug encapsulation, controlled release, and stability in physiological environments. <em>In vitro</em> assays revealed that Apa@SiO<sub>2</sub>@MP had minimal cytotoxicity in normal cells but significantly reduced cell viability in ovarian cancer cells (SKOV-3), highlighting its cancer-targeting ability. Apatinib effectively inhibited VEGFR2 expression and induced reactive oxygen species (ROS) production, further promoting anti-cancer effects. <em>In vivo</em>, Apa@SiO<sub>2</sub>@MP treatment led to enhanced tumor inhibition, as well as significant immune response activation, including increased CD4<sup>+</sup> and CD8<sup>+</sup> T cells and elevated IFN-γ levels. This study provides a promising multi-modal strategy for overcoming challenges in cancer therapy by integrating chemotherapy, immunotherapy, and targeted drug delivery, offering potential for improved treatment outcomes in ovarian cancer.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114790"},"PeriodicalIF":5.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin loaded Mn3O4@SiO2 core–shell nanoparticles for glioblastoma multiforme targeted therapy 二甲双胍负载Mn3O4@SiO2核壳纳米颗粒用于胶质母细胞瘤多形性靶向治疗

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-14 DOI: 10.1016/j.colsurfb.2025.114789

Zahra Nozhat , Abdul Wahab , Asim Mushtaq , M. Zubair Iqbal , Xiangdong Kong

{"title":"Metformin loaded Mn3O4@SiO2 core–shell nanoparticles for glioblastoma multiforme targeted therapy","authors":"Zahra Nozhat , Abdul Wahab , Asim Mushtaq , M. Zubair Iqbal , Xiangdong Kong","doi":"10.1016/j.colsurfb.2025.114789","DOIUrl":"10.1016/j.colsurfb.2025.114789","url":null,"abstract":"<div><div>Glioblastoma multiforme (GBM) presents unique challenges that contribute to a poor early-stage prognosis, primarily due to the difficulty of chemotherapy drugs face in crossing the blood-brain barrier (BBB). Despite decades of research, overall survival rates for GBM patients remain low. However, modified nanoscale biomaterials show promise in enhancing drug delivery and efficacy by effectively penetrating the BBB. In this study, we developed metformin (MET)-loaded Mn₃O₄@SiO₂@cRGD nanoparticles (MSMC NPs) as a targeted pH-responsive drug delivery system for treating glioblastoma (GBM). The nanoparticles demonstrated a high drug-loading capacity of 69.4 ± 3.7 % and an encapsulation efficiency of 11.5 ± 2.1 %. In vitro studies showed that MSMC NPs significantly enhanced cellular uptake in U251 and U87 GBM cells, with a 2.5-fold increase in fluorescence intensity compared to non-targeted nanoparticles. The pH-responsive release of MET reached 70 % at pH 5.5, compared to only 30 % at pH 7.4 over 48 hours. MSMC NPs resulted in a 55.6 % reduction in U251 cell viability and a 43.4 % decrease in U87 cell viability at a 15 mM MET concentration, significantly outperforming free MET. Furthermore, the nanoparticles inhibited cell migration by 80 % in a 3D spheroid model and increased apoptosis rates by 40 % in U251 cells and 35 % in U87 cells. These findings highlight the potential of MSMC NPs as a targeted, pH-responsive, and theranostic platform for improving GBM treatment by enhancing drug delivery and minimizing off-target effects. This study establishes a foundation for developing Mn₃O₄-based nanomedicines for precise cancer therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114789"},"PeriodicalIF":5.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel colchicine ethosomes cataplasm for the treatment of acute gouty arthritis 新型秋水仙碱脂质体治疗急性痛风性关节炎

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-13 DOI: 10.1016/j.colsurfb.2025.114776

Yao-Yao Wei , Yang Zhang , Xue Lu , Jie Zhou , Huang-Wei Cheng , Yuan-Yuan Liu , Hua Zhang , Wen Chen

{"title":"Novel colchicine ethosomes cataplasm for the treatment of acute gouty arthritis","authors":"Yao-Yao Wei , Yang Zhang , Xue Lu , Jie Zhou , Huang-Wei Cheng , Yuan-Yuan Liu , Hua Zhang , Wen Chen","doi":"10.1016/j.colsurfb.2025.114776","DOIUrl":"10.1016/j.colsurfb.2025.114776","url":null,"abstract":"<div><div>Gout is a disease caused by the deposition of sodium urate (MSU) crystals in the joints and tissues. Colchicine (COL) has become the first-line drug for the treatment of acute gout due to its low price and efficacy. However, colchicine is highly cytotoxic and oral administration is prone to cause severe adverse effects on the gastrointestinal tract, liver and kidney. Therefore, this study aimed to develop a novel dermal delivery formulation for addressing the safety concerns of this drug. The researchers used ethosomes encapsulation technology to improve the skin permeability of COL. In addition, in order to improve the performance of the ethosomes, it was screened and determined that the addition of 1.0–1.5 mg of ceramide III (Cer3) per mL of ethosomes as a modifier could significantly enhance the stability of the ethosomes, Cer3/COL-ethosomes (CCE) were successfully constructed. The CCE was then mixed with a cataplasm matrix to produce a colchicine-carrying CCE cataplasm, which demonstrated the superimposed effect of the advantages of the two dosage forms, the ethosomes and the cataplasm. Compared with the traditional delivery method of COL, this topical formulation is an attractive alternative for the treatment of gout as it can achieve effective blood levels without causing fluctuations in blood levels, and has good efficacy and higher safety profile.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114776"},"PeriodicalIF":5.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amifostine-loaded Prussian blue nanoparticles for simultaneous efficient radioprotection and deep decorporation of radiocesium 氨磷汀负载的普鲁士蓝纳米粒子同时有效的辐射防护和放射性铯的深度降解

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-13 DOI: 10.1016/j.colsurfb.2025.114788

Boyan Wang, Yuchen Liu, Chengqi Li, Meiyun Xu, Daoben Hua

{"title":"Amifostine-loaded Prussian blue nanoparticles for simultaneous efficient radioprotection and deep decorporation of radiocesium","authors":"Boyan Wang, Yuchen Liu, Chengqi Li, Meiyun Xu, Daoben Hua","doi":"10.1016/j.colsurfb.2025.114788","DOIUrl":"10.1016/j.colsurfb.2025.114788","url":null,"abstract":"<div><div>Radiocesium is highly water-soluble and easily accumulates in agricultural products and seafood. Ingestion of radiocesium results in internal irradiation, significantly increasing the risk of tissue and organ damage as well as carcinogenesis. In this paper, we develop a strategy for simultaneous radioprotection and decorporation of radiocesium by amifostine-loaded Prussian blue (Am@PB) nanoparticles. The nanoparticles are prepared through chemical coordination between amine/phosphate groups of amifostine and Fe (II)/Fe (III) sites of Prussian blue (PB). Am@PB nanoparticles mitigate radiation-induced damage to peripheral blood cells and organs, improving the survival rate of irradiated mice. This is due to the synergistic effects of the nano-enzymatic activity of PB component and the high reducibility of sulfhydryl groups generated through amifostine hydrolysis by alkaline phosphatase. Furthermore, the deep excretion of cesium is achieved <em>via</em> feces along the metabolic pathway of Am@PB, leading to an enhanced decorporation efficiency of over 50 % compared to orally administered commercial PB. This work provides a design strategy for efficient radioprotective decorporation agents with potential applications in the treatment of internal radiocesium contamination.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114788"},"PeriodicalIF":5.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-driven optimization of spinal implant design using parametric modelling 使用参数化建模的人工智能驱动的脊柱植入物设计优化

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-13 DOI: 10.1016/j.colsurfb.2025.114753

Idowu O. Malachi , Adebukola O. Olawumi , B.I. Oladapo

{"title":"AI-driven optimization of spinal implant design using parametric modelling","authors":"Idowu O. Malachi , Adebukola O. Olawumi , B.I. Oladapo","doi":"10.1016/j.colsurfb.2025.114753","DOIUrl":"10.1016/j.colsurfb.2025.114753","url":null,"abstract":"<div><div>This study aimed to enhance vertebral implant design by using a parametric spine model and advanced simulation techniques to evaluate biomechanical behaviours under dynamic physiological conditions using Finite Element Analysis (FEA) in ANSYS Workbench. The primary objective was to refine implant designs to improve surgical outcomes and patient safety. We incorporated the anisotropic material properties of Magnesium-Rare Earth-Zirconium (Mg-RE-Zr) alloys, focusing on their Young's modulus (40–50 GPa), Poisson's ratio (0.35), and yield strengths (0.193 GPa tensile, 0.255 GPa compressive) to simulate real-world stress and deformation scenarios. Using Finite Element Analysis (FEA), we conducted a series of simulations to examine stress distribution and deformation patterns across various implant models under static and dynamic loads. These simulations provided detailed insights, revealing that maximum equivalent stresses could reach up to 0.160 GPa, with deformations ranging from 0.01875 mm at a lower modulus to 0.015 mm at a higher modulus, showcasing the influence of material stiffness on implant performance. The model demonstrated high accuracy, with an error margin of less than 5 % when validated against analysis test data. This research makes a significant contribution to the field by providing a validated method for predicting and enhancing the biomechanical performance of spinal implants, thereby ensuring their reliability and efficacy in clinical applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114753"},"PeriodicalIF":5.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-atom nanozymes: Synthesis, characterization, catalytic mechanism and biomedical applications 双原子纳米酶：合成、表征、催化机理及生物医学应用

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-12 DOI: 10.1016/j.colsurfb.2025.114774

Ran Bi , Jingyi Liu , Yuyao Cai , Shuangning Zhang , Maonan Lu , Chenxi Du , Mengyuan Liu , Xinyu Ding , Ke Xiao , Si Li , Tingting Jiang , Shidong Xiang

{"title":"Dual-atom nanozymes: Synthesis, characterization, catalytic mechanism and biomedical applications","authors":"Ran Bi , Jingyi Liu , Yuyao Cai , Shuangning Zhang , Maonan Lu , Chenxi Du , Mengyuan Liu , Xinyu Ding , Ke Xiao , Si Li , Tingting Jiang , Shidong Xiang","doi":"10.1016/j.colsurfb.2025.114774","DOIUrl":"10.1016/j.colsurfb.2025.114774","url":null,"abstract":"<div><div>Dual-atom nanozymes (DAzymes), a novel class of nanozymes featuring dual-metal atomic active centers, mimic the multi-metal synergistic mechanisms of natural enzymes to achieve superior catalytic activity compared to conventional single-atom nanozymes. Their unique dual-atom architecture not only effectively mitigates metal atom aggregation but also significantly enhances substrate adsorption capacity and catalytic efficiency through interatomic electronic coupling and spatial synergy. This structural innovation addresses critical limitations of single-atom nanozymes, including low metal loading and homogeneous active sites. This review systematically summarizes recent advancements in DAzymes: First, we elucidate their design principles and structural advantages, with a focus on precise synthesis strategies (e.g., spatial confinement, coordination stabilization) and atomic-level characterization techniques (e.g., synchrotron radiation-based X-ray absorption spectroscopy, spherical aberration-corrected electron microscopy). By unraveling structure-activity relationships, we clarify the multi-dimensional regulatory mechanisms of dual-atom systems—including coordination environments, electronic coupling, and spatial configurations—on redox enzyme-like activities such as peroxidase and superoxide dismutase mimics. Furthermore, we elaborate on their groundbreaking biomedical applications, including antibacterial and antitumor therapies via reactive oxygen species (ROS) regulation, antioxidant damage repair, and biosensing. This review aims to provide theoretical guidance for the rational design of high-performance DAzymes and to advance their translational applications in precision medicine and intelligent biomaterials.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114774"},"PeriodicalIF":5.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial activation via calcium peroxide/carrageenan/soybean lecithin-derived polypyrrole phototherapeutic microparticles 通过过氧化钙/卡拉胶/大豆卵磷脂衍生的聚吡咯光疗微粒激活线粒体

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-12 DOI: 10.1016/j.colsurfb.2025.114787

Sih-Chi Chuang , Shih-An Yu , Pei-Chia Hung , Andrew E.-Y. Chuang , Jia-Wei Liang , Chia-Lu Sun , Lekshmi Rethi , Hsu-Wei Fang , Hieu Trung Nguyen , Yao-Tung Tsai , Pei-Wei Weng

{"title":"Mitochondrial activation via calcium peroxide/carrageenan/soybean lecithin-derived polypyrrole phototherapeutic microparticles","authors":"Sih-Chi Chuang , Shih-An Yu , Pei-Chia Hung , Andrew E.-Y. Chuang , Jia-Wei Liang , Chia-Lu Sun , Lekshmi Rethi , Hsu-Wei Fang , Hieu Trung Nguyen , Yao-Tung Tsai , Pei-Wei Weng","doi":"10.1016/j.colsurfb.2025.114787","DOIUrl":"10.1016/j.colsurfb.2025.114787","url":null,"abstract":"<div><div>Mitochondria, often referred to as the \"powerhouses\" of eukaryotic cells, play a critical role in maintaining cellular homeostasis and supporting essential life functions, particularly in cell survival and apoptosis. This study introduces a composite formulation—combining carrageenan (Car), calcium peroxide (CaO<sub>2</sub>), and microparticles, derived from soybean oil lecithin, enhanced with photothermally active polypyrrole (PPy)—to create Car-Lec-PPy MP, aimed at promoting mitochondrial activation in cells. The investigation focuses on intercellular mitochondrial transfer and activation as a therapeutic strategy. The formulation seeks to stimulate mitochondrial biogenesis and enhance cellular resilience through targeted mitochondrial activation, leveraging the synergistic effects of near-infrared (NIR) therapy. In the in vivo experiment, phototherapeutic Car-Lec-PPy MP was administered to rodent muscle tissue. The results showed increased expression of heat-shock proteins and reduced oxidative stress in the treated muscle. Preliminary findings suggest that this approach not only boosts mitochondrial activity but also improves cell proliferation and survival, presenting significant potential for applications in regenerative medicine and cellular therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114787"},"PeriodicalIF":5.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mg-doped bioactive glass and tea polyphenols incorporated Janus wound dressing for antibacterial and promoting tissue repair 含镁生物活性玻璃和茶多酚的Janus伤口敷料具有抗菌和促进组织修复的作用

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-12 DOI: 10.1016/j.colsurfb.2025.114796

Xin Zhao , Jingjing Jiao , Man Ao , Lin Huang , Peng Xu , Yan Shi , Jiao-jing Shao , Yuanlong Guo , Haibo Xie , Long Li , Qiuyue Ding , Zhu Chen

{"title":"Mg-doped bioactive glass and tea polyphenols incorporated Janus wound dressing for antibacterial and promoting tissue repair","authors":"Xin Zhao , Jingjing Jiao , Man Ao , Lin Huang , Peng Xu , Yan Shi , Jiao-jing Shao , Yuanlong Guo , Haibo Xie , Long Li , Qiuyue Ding , Zhu Chen","doi":"10.1016/j.colsurfb.2025.114796","DOIUrl":"10.1016/j.colsurfb.2025.114796","url":null,"abstract":"<div><div>Bacterial infection, excessive inflammation, and insufficient tissue remodeling capacity are major factors to delayed or impaired wound healing. This study synthesized Mg-doped bioactive glass (MBG) using the sol-gel method. Subsequently, based on polycaprolactone (PCL), MBG and tea polyphenols (TP), a Janus wound dressing with an enhanced hydrophilic and antibacterial outer layer of PCL-TP (PT) and a hydrophobicity-preserved and tissue generation-promoting inner layer of PCL-MBG (PB) was further fabricated using a sequential electrospinning method. This design endowed the dressing with directional fluid transport property to effectively prevent tissue adhesion and exudate infiltration. In vitro drug release results demonstrated that ions such as Si, Mg, Ca, and P were sustainably released up to 5 days at least, while TP could be slowly released for over 7 days. The fibrous membrane loaded with TP showed significant inhibition against S. aureus and E. coli, with increasing antibacterial activity as the increase of TP content. The cytological evaluation confirmed that dressings incorporating with MBG and TP did not exhibit cytotoxicity but significantly promoted cell proliferation. The PB/PT Janus dressing demonstrated an apparent repair area exceeding 99 % in animal experiments, along with a significantly higher number of new hair follicles and collagen ratio compared to the blank and PCL groups. These results indicate the potential of this Janus wound dressing in effectively promoting wound healing.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114796"},"PeriodicalIF":5.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Merging fusogenic DOPE and a tumour targeted self-assembling biopolymer: Smart hybrid liposomes for drug vectorization in cancer therapy 融合融合融合的融合融合融合的自组装肿瘤靶向生物聚合物：智能杂化脂质体的药物载体在癌症治疗

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-12 DOI: 10.1016/j.colsurfb.2025.114786

Ludovica Scorzafave , Eugenia Nicol Manti , Marco Fiorillo, Manuela Curcio, Giuseppe Cirillo, Luca Frattaruolo, Fiore Pasquale Nicoletta, Anna Rita Cappello, Francesca Iemma

{"title":"Merging fusogenic DOPE and a tumour targeted self-assembling biopolymer: Smart hybrid liposomes for drug vectorization in cancer therapy","authors":"Ludovica Scorzafave , Eugenia Nicol Manti , Marco Fiorillo, Manuela Curcio, Giuseppe Cirillo, Luca Frattaruolo, Fiore Pasquale Nicoletta, Anna Rita Cappello, Francesca Iemma","doi":"10.1016/j.colsurfb.2025.114786","DOIUrl":"10.1016/j.colsurfb.2025.114786","url":null,"abstract":"<div><div>In this study, a smart hybrid liposome system was achieved combining a self-assembling biopolymer conjugate (human serum albumin-hyaluronic acid) with targeting and redox-responsive activity with dioleoyl phosphatidylethanolamine, a fusogenic phospholipid. The obtained hybrid liposomal structures were found to possess suitable physicochemical properties for cancer therapy application, with mean size of 65 nm, negative surface charge (-27 mV) and the ability to efficiently encapsulate Doxorubicin in the inner liposomal core with high efficiency. The drug loaded hybrid liposomes (DOX@HBLs) were able to trigger the drug release under simulated acidic and redox conditions of the tumor environment, whereas the biological characterization demonstrated the safety and the selectivity of the formulation, able to target the cancer cells (toxicity similar to that of the free drug) while sparing the healthy cells (viability > 90 % in all cases). Furthermore, compared to free drug, DOX@HBLs were able to reduce cell motility, impair metabolic pathways essential for cancer progression, and effectively inhibit spheroid formation (by almost 50 % after 20 days incubation) in both Estrogen Receptor-positive and Triple Negative Breast Cancer cells, demonstrating their high potential as unconventional drug delivery vectors in cancer therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114786"},"PeriodicalIF":5.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0