Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Rationally designed BTO@MSN@PPy-PEG piezoelectric nanozyme for ultrasound/NIR-triggered synergistic piezodynamic-photothermal-chemo tumor therapy","authors":"Yunxia Hu ,&nbsp;Yangbei Zhu ,&nbsp;Lijie Liu ,&nbsp;Jiaxuan Guo ,&nbsp;Wenjie Gao ,&nbsp;Lei Tian ,&nbsp;Shige Wang ,&nbsp;Chengzheng Jia","doi":"10.1016/j.colsurfb.2025.115409","DOIUrl":"10.1016/j.colsurfb.2025.115409","url":null,"abstract":"<div><div>Conventional monotherapies for tumors face significant challenges due to their limited therapeutic efficacy and considerable side effects, which severely impede their broad clinical application. To overcome the advancement of multimodal synergistic treatment strategies, integrating diverse treatment modalities with complementary mechanisms has emerged as a crucial approach to enhance the therapeutic outcomes of tumors. In this context, we developed a multifunctional nanoplatform, designated as BaTiO₃@MSN@PPy-PEG Nanoparticles (BMPP NPs), which can be activated by a combination of ultrasound and near-infrared (NIR) laser irradiation. This nanoplatform is centered around the piezoelectric material barium titanate (BTO), employs a mesoporous silica (MSN) coating for efficient encapsulation of the chemotherapeutic agent curcumin (Cur), and is further modified with polypyrrole (PPy) and polyethylene glycol (PEG) to confer both excellent photothermal conversion capability and enhanced biocompatibility. The synergistic interplay among the ultrasound-induced piezoelectric effect, NIR laser-triggered photothermal therapy, and MSN-mediated drug release results in a novel triple-modal therapy—piezoelectric dynamic, photothermal, and chemo. This integrated strategy effectively suppresses tumor growth and facilitates tumor ablation, holding great promise for future cancer therapeutics.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115409"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing properties of damaged hair through moisture control via construction of highly hydrophobic surface","authors":"Fubing Liu ,&nbsp;Chaohai Li ,&nbsp;Jinhua Li ,&nbsp;Jing Wang ,&nbsp;Kuan Chang","doi":"10.1016/j.colsurfb.2026.115427","DOIUrl":"10.1016/j.colsurfb.2026.115427","url":null,"abstract":"<div><div>Hair dyeing and perming processes damage could significantly reduce the stability and mechanical properties of keratin, making hair rough and fragile. Different hair repair ingredients have been developed by strengthening the chemical bonds inside hair. In this work, a new repair strategy of altering hair water content by construing highly hydrophobic surface was proposed. This was achieved by treating damaged hair with maleic-modified amino silicone oil (MASO), which was synthesized through the amidation reaction of maleic acid with poly[dimethylsiloxane-co-(3-aminopropyl)methylsiloxane] (ASO). Due to the thiol-Michael click reaction with free thiol groups on reduced hair surface, MASO presented high deposition efficiency at a low dosage of 0.1 wt%, which was confirmed by SEM and contact angle measurements. After MASO treatment, hair forms a highly hydrophobic surface with a contact angle of 137 °, significantly higher than that of virgin hair. The highly hydrophobic surface hinders the penetration of moisture into the hair, especially reducing the bound water content from 4.46 % to 2.81 %. This was jointly proven by the disappearance process of water droplets on hair strands, TGA testing, and DVS testing. The reduced water content in MASO-treated hair significantly lowered the combing work, with the wet combing work decreasing from 336.12 J to 43.52 J, giving a 87.05 % decrease, and enhanced the thermal stability of keratin, ultimately increasing Young's modulus and tensile strength by 13.99 % and 9.13 %, respectively. This finding demonstrates that the impact of water on tensile properties can even exceed the adverse effects caused by the breakage of disulfide bonds for reduce damaged hair.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115427"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional nanozyme-mediated synergistic activation of cuproptosis, ferroptosis, and pyroptosis for potent antitumor therapy","authors":"Yuxin Tian ,&nbsp;Junfeng Ke ,&nbsp;Min Yang ,&nbsp;Ping Gong ,&nbsp;Fuchen Xin ,&nbsp;Liping Wang","doi":"10.1016/j.colsurfb.2026.115415","DOIUrl":"10.1016/j.colsurfb.2026.115415","url":null,"abstract":"<div><div>Novel forms of programmed cell death are pivotal in regulating tumor progression and therapeutic response; however, single-mode cell death induction often fails to overcome apoptotic escape and drug resistance of tumor cells. This study designed and synthesized a multifunctional nanozyme, ZIF-8/Cu/Fe@GOx (ZCFG), to synergistically inhibit tumor cell growth via cuproptosis/ferroptosis/pyroptosis. Its compensatory mechanisms collectively overcome tumor cell characteristics such as apoptotic escape and drug resistance. Leveraging its multi-enzyme-like activity, ZCFG achieves self-sustained H₂O₂ production, massive glutathione (GSH) depletion, and hydroxyl radical (·OH) bursts to induce tumor cell death. Furthermore, copper and iron ions overload induce metabolic disruption and mitochondrial dysfunction, triggering abnormal aggregation of dihydrolipoamide S-acetyltransferase (DLAT), loss of Fe-S cluster proteins, and accumulation of lipid peroxides to induce cuproptosis and ferroptosis in tumor cells. Notably, the intracellular reactive oxygen species (ROS) bursts and zinc ion overload synergistically activate the caspase-1/GSDMD-dependent pyroptosis pathway, which further amplifies the antitumor effects of cuproptosis and ferroptosis, achieving mutually reinforcing therapeutic effects. This work provides a novel therapeutic strategy for tumor treatment by constructing a cascade-catalyzed nanozyme platform that mediates multimodal synergistic antitumor therapy via cuproptosis, ferroptosis, and pyroptosis.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115415"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic pore-throat engineered ultrahigh molecular weight polyethylene with sustained tea polyphenol release for infection-resistant joint implant material","authors":"Kang Li ,&nbsp;Yi-Zi Wang ,&nbsp;Shao-Peng Zhao ,&nbsp;Peiqi Yu ,&nbsp;Zhi Qiao ,&nbsp;Mengfan Jing ,&nbsp;Yaming Wang ,&nbsp;Yue Ren ,&nbsp;Yu Han ,&nbsp;Chuntai Liu","doi":"10.1016/j.colsurfb.2026.115458","DOIUrl":"10.1016/j.colsurfb.2026.115458","url":null,"abstract":"<div><div>To address the limitations of systemic antibiotics in treating prosthetic joint infections (PJI), ultrahigh molecular weight polyethylene (UHMWPE)-based polyphenol delivery systems have been developed as an antibiotic-free strategy. However, challenges exist in achieving sustained antimicrobial efficacy and enhancing overall performance. To achieve threshold-insensitive sustained release, a biomimetic pore-throat structure inspired by geologic capillary transport mechanisms was engineered within UHMWPE. This structure was constructed through strategic co-incorporation of polyethylene oxide (PEO) and a sub-permeation-threshold tea polyphenol (epigallocatechin gallate, EGCG as representative). PEO-encapsulated EGCG clusters formed expanded pore-throat networks with enhanced distribution uniformity, facilitated by hydrogen bonding between PEO’s ether groups and EGCG’s phenolic hydroxyls. This microstructure enabled swelling-regulated drug release obeying Korsmeyer-Peppas kinetics. The PEO concentration directly modulated sustained EGCG release through capillary action and swelling-erosion. The resulting composites achieved &gt; 80 % antibacterial efficacy against major pathogens while PEO simultaneously formed boundary-hydrated lubrication layers that reduced the friction coefficient to 0.065. Combined with favorable biocompatibility and effective suppression of bacterial-induced inflammation, this biomimetic strategy establishes a material-level, proof-of-concept approach with potential for future development toward infection-resistant orthopedic devices.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115458"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic acid-based strategies for prostate cancer therapy","authors":"Xueling Lan ,&nbsp;Qunhua Zhou ,&nbsp;Haitong Wang ,&nbsp;Zhongyi Mu ,&nbsp;Liyang Pan ,&nbsp;Liqun Yang ,&nbsp;Qiang Du","doi":"10.1016/j.colsurfb.2026.115448","DOIUrl":"10.1016/j.colsurfb.2026.115448","url":null,"abstract":"<div><div>Hyaluronic acid (HA) has emerged as a pivotal biomaterial in prostate cancer management, bridging the gap between physical tissue spacing and targeted molecular therapy. While HA-based hydrogels are clinically established, and nanomedicines are rapidly evolving, a comprehensive integration of these distinct domains remains lacking. This review critically synthesizes the dual roles of HA in prostate cancer radiotherapy and drug delivery. We first delineate the biological basis of HA, emphasizing its interactions with CD44/RHAMM receptors and the implications for material design. Clinically, we systematically evaluate the efficacy of HA hydrogel spacers across diverse radiotherapy modalities, including SBRT, brachytherapy, and hypofractionated regimens, highlighting their quantitative impact on prostate-rectum separation and the substantial reduction of gastrointestinal toxicity. Beyond physical spacing, we analyze the translational status of HA-based nanocarriers, discussing their potential to overcome drug resistance through receptor-mediated active targeting. Crucially, we address significant limitations in current strategies, such as the structural heterogeneity arising from imprecise chemical modifications and the lack of standardized in vivo stability evaluation systems. Finally, we propose a roadmap for future research, advocating for subtype-specific material design, the development of intelligent stimuli-responsive derivatives, and synergy with emerging immunotherapies to realize precision medicine in prostate cancer.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115448"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature-responsive hydrogel delivery of antimicrobial peptide engineered watermelon-derived extracellular vesicles enables sequential infection control and wound healing","authors":"Ziyang Bai ,&nbsp;Yifan Zhao ,&nbsp;Yajuan Gong ,&nbsp;Meijun Du ,&nbsp;Wenjun Zhang ,&nbsp;Ke Zhang ,&nbsp;Yongchao Zhi ,&nbsp;Yanan Nie ,&nbsp;Xia Li ,&nbsp;Xiuping Wu ,&nbsp;Bing Li","doi":"10.1016/j.colsurfb.2026.115438","DOIUrl":"10.1016/j.colsurfb.2026.115438","url":null,"abstract":"<div><div>Infected wounds present major clinical challenges due to excessive bacterial colonization, sustained inflammation, and impaired tissue repair. To address these barriers, we developed a temperature-responsive hydrogel delivery system incorporating watermelon-derived extracellular vesicles (wEV), antimicrobial peptide-engineered for the topical treatment of infected wounds. wEVs contained terpenoids, flavonoids, alkaloids, and proteins with intrinsic anti-inflammatory and pro-regenerative activity. To enhance stability and antibacterial potency, antimicrobial peptides (AMP) were conjugated to wEVs via mussel derivatives, producing wEV-AMP. These were embedded in a temperature-responsive Pluronic F127/chitosan hydrogel that gels at 37 °C for wound coverage and controlled release. <em>In vitro</em>, PF127/CS+wEV-AMP inhibited &gt; 95 % of <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>, suppressed biofilms, reduced inflammatory cytokines, and enhanced fibroblast migration. In infected rat wounds, healing rate reached ∼60 % by day 5 and nearly complete closure by day 14, with greater collagen deposition and M2 macrophage polarization. This multifunctional hydrogel integrates antimicrobial, immunomodulatory, and regenerative effects, offering strong potential for infectious wound treatment.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115438"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lysosome-targeted ROS-responsive graphene oxide-based drug delivery system to overcome tumor DOX resistance","authors":"Fengzhu Yang ,&nbsp;Jintao Deng ,&nbsp;Xinyu Yu ,&nbsp;Wenhao Fu ,&nbsp;Wenlong Sun ,&nbsp;Zhengbao Xu ,&nbsp;Xinhua Song ,&nbsp;Chao Wang ,&nbsp;Qingqing Du ,&nbsp;Meng Wang","doi":"10.1016/j.colsurfb.2026.115434","DOIUrl":"10.1016/j.colsurfb.2026.115434","url":null,"abstract":"<div><div>The lysosomes of drug-resistant tumor cells transport doxorubicin (DOX) and its nanocarriers into lysosomes through a sequestration mechanism, making it difficult for DOX to reach the therapeutic concentration. In this study, a nanodrug delivery system (Dp/DGPP) capable of overcoming tumor lysosomal resistance was developed. The system consists of three parts: graphene oxide (GO)-Se-Se-DOX, polyethyleneimine-pluronic F127 (PEI-PF127) for improved biocompatibility, and Dp44mT for amplifying reactive oxygen species (ROS) and disrupting lysosomes. After entering MCF-7/ADR tumor cells, loading Dp44mT can reduce the permeability of lysosomal membranes by increasing the level of ROS. DOX subsequently escapes from lysosomes and breaks the diselenide bond to complete its release. The experiment proved that Dp/DGPP exhibited a significant ROS-dependent response to the release of DOX. Compared with the other groups, it had greater cytotoxicity, and the IC50 value of DOX against MCF-7/ADR cells was as low as 6.71 μM. Compared with the DOX group, the Dp/DGPP group exhibited greater DOX accumulation in MCF-7/ADR cells, with 1.5-fold greater fluorescence at 4 h. Meanwhile, Dp/DGPP can cause lysosomal dysfunction by reducing lysosomal membrane permeability. Western blot results revealed that the expression of Pgp protein decreased in the Dp/DGPP group, whereas the expression of autophagy related LC3-II and P62 protein increased, which confirmed that autophagic flux was blocked. This reduces potential drug resistance and promotes cell death. In addition, the Dp/DGPP group achieved a 70 % inhibition rate in MCF-7/ADR tumors in vivo. This nanodrug delivery system provides a potential strategy to overcome tumor DOX resistance via lysosomes.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115434"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, characterization, and in vitro evaluation of Eudragit-coated aminated mesoporous silica nanoparticles loaded with pterostilbene for colon delivery","authors":"Nikhil Raut ,&nbsp;Manasa N. ,&nbsp;Swornahuti Panda,&nbsp;Victor Hmingthangsanga,&nbsp;Subramanian Natesan","doi":"10.1016/j.colsurfb.2026.115452","DOIUrl":"10.1016/j.colsurfb.2026.115452","url":null,"abstract":"<div><div>Ulcerative colitis (UC), a chronic inflammatory colon disease, often requires long-term care. Pterostilbene (PTB), a naturally occurring substance with strong anti-inflammatory and antioxidant properties, has shown therapeutic potential; however, its poor aqueous solubility and instability at stomach pH limit its clinical application. A colon-targeted drug delivery system loaded with PTB and coated with Eudragit S100 (EU) was developed using mesoporous silica nanoparticles (MSN). The MSN were surface-aminated using 3-aminopropyl triethoxysilane (APTES) to obtain aminated mesoporous silica nanoparticles (AMSN), which provided pH-responsive release and enhanced drug binding. FT-IR spectroscopy confirmed the encapsulation of the drug and amine functionalization through characteristic spectral shifts. X-ray diffraction (XRD) showed decreased crystallinity of PTB, suggesting effective molecular dispersion within the MSN matrix. Differential scanning calorimetry (DSC) was used to confirm the amorphous form of the encapsulated medication. Morphological study using SEM and TEM revealed consistently spherical, porous nanoparticles. Thermogravimetric analysis (TGA) demonstrated the formulation's thermal stability, and Brunauer-Emmett-Teller (BET) analysis showed high surface area and pore volume, both of which are advantageous for efficient drug loading. In vitro release investigations confirmed a pH-dependent, extended release of the drug under intestinal conditions. Additionally, pro-inflammatory cytokines (TNF-α and IL-6) were significantly reduced in the ELISA assays of LPS-stimulated HT-29 cells, demonstrating the formulation's anti-inflammatory efficacy. The development of colon-specific delivery of pterostilbene, the Eudragit-coated PTB-loaded AMSN (Eu-PTB-AMSN), effectively addresses the primary shortcomings of conventional PTB formulations, including low solubility, stomach instability, and systemic adverse effects, while offering a practical therapeutic approach for the treatment of UC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115452"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating Mn²⁺ ions in bioactive sol-gel coatings: Impact on cell adhesion, inflammation and bone regeneration","authors":"C. Arias-Mainer ,&nbsp;F. Romero-Gavilán ,&nbsp;L. Abenia-Artigas ,&nbsp;I. García-Arnáez ,&nbsp;O. Amorrotu ,&nbsp;M. Azkargorta ,&nbsp;F. Elortza ,&nbsp;M. Gurruchaga ,&nbsp;I. Goñi ,&nbsp;J. Suay","doi":"10.1016/j.colsurfb.2026.115436","DOIUrl":"10.1016/j.colsurfb.2026.115436","url":null,"abstract":"<div><div>Manganese (Mn), an essential trace element involved in bone metabolism, plays a crucial role in key biological functions, including the regulation of cell adhesion, modulation of immune responses, and promotion of osteogenesis. In this study, sol-gel coatings with increasing concentrations of MnCl₂ (0.5, 1 and 1.5 % wt) were synthesised and applied onto titanium (Ti) surfaces. The materials were characterised physicochemically, and <em>in vitro</em> responses were assessed using human osteoblasts (HOb) and THP-1-derived macrophages. Protein adsorption from human serum was analysed by nLC-MS/MS. The incorporation of MnCl₂ did not disrupt the sol-gel silica network and enabled a sustained release of Mn²⁺ ions, and all coatings showed good biocompatibility with no cytotoxicity. Immune response analysis revealed that 0.5Mn promoted anti-inflammatory markers (IL-10, TGF-β), while 1Mn and 1.5Mn induced strong proinflammatory profiles, reflected in increased TNF-α and IL-1β. Proteomics identified preferential adsorption of immune-related proteins such as complement components, ficolins, acute-phase proteins and apolipoproteins to 1Mn and 1.5Mn. Conversely, 0.5Mn enhanced the adsorption of proteins linked to anti-inflammatory effects and oxidative stress regulation. Mn-doped surfaces also enhanced gene expression related to cell adhesion (CTNNB1, ITG1B, PTK2) and osteogenic markers (RUNX2, BMP2, BGLAP), particularly on 1.5Mn, correlating with increased calcium deposition and adsorption of mineralisation-related proteins (FETUA, ECM1, IGF2). All Mn sol-gel coatings promoted the coagulation cascade through increased adsorption of FA9, FA12 and ZPI. These results demonstrate the capacity of Mn-doped sol-gel coatings to modulate immune and osteogenic responses, underscoring the relevance of optimising Mn concentration to improve bone–implant integration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115436"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-enhanced Raman scattering (SERS) in antibiotic resistance detection: Advances, challenges, and future perspectives","authors":"Biqing Chen ,&nbsp;Jiayin Gao ,&nbsp;Haizhu Sun ,&nbsp;Yan Liu ,&nbsp;Yinghan Zhao ,&nbsp;Xiaohong Qiu ,&nbsp;Yang Li","doi":"10.1016/j.colsurfb.2026.115423","DOIUrl":"10.1016/j.colsurfb.2026.115423","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) has emerged as one of the most critical global public health crises, causing an estimated 700,000 deaths annually according to the World Health Organization. Achieving early, rapid, and accurate detection and identification of drug-resistant bacteria is essential to addressing this challenge. Surface-enhanced Raman scattering (SERS), a highly sensitive, label-free, and non-invasive optical detection technology, has demonstrated great potential in bacterial identification and antimicrobial resistance analysis. In recent years, the integration of SERS with artificial intelligence (AI) technologies particularly machine learning (ML) and deep learning (DL) methods has enabled unprecedented accuracy and efficiency in resistance detection. This review systematically summarizes recent advances in SERS–AI combined strategies for AMR detection, analyzes the strengths and limitations of various approaches, and explores their potential applications in clinical and surveillance settings. Finally, the importance of continuous technological innovation and interdisciplinary collaboration in this field is emphasized to promote the translational application of SERS–AI strategies in the global fight against AMR.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115423"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}