Colloids and Surfaces B: Biointerfaces最新文献_第3页

Precise size control of superparamagnetic Fe3O4 nanoparticles for liver cancer diagnosis and magnetic hyperthermia therapy 超顺磁性Fe3O4纳米颗粒的精确尺寸控制用于肝癌诊断和磁热疗

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-08 DOI: 10.1016/j.colsurfb.2025.114763

Linxue Zhang , Qifan Li , Junxiao Liu , Zunyi Deng , Xiaofeng Zhang , Kaifang Wang , Qianxiong He , Ruiji Liu , Qi Sun , Zhong Yu , Zhongwen Lan , Tianlong Wen , Ke Sun

{"title":"Precise size control of superparamagnetic Fe3O4 nanoparticles for liver cancer diagnosis and magnetic hyperthermia therapy","authors":"Linxue Zhang , Qifan Li , Junxiao Liu , Zunyi Deng , Xiaofeng Zhang , Kaifang Wang , Qianxiong He , Ruiji Liu , Qi Sun , Zhong Yu , Zhongwen Lan , Tianlong Wen , Ke Sun","doi":"10.1016/j.colsurfb.2025.114763","DOIUrl":"10.1016/j.colsurfb.2025.114763","url":null,"abstract":"<div><div>Multifunctional superparamagnetic iron oxide nanoparticles are pivotal in bioapplications, with optimal size ranges varying by application. Exploring each size is essential to maximize functionality, as even 1–2 nm variations can significantly affect their properties. Therefore, discussing the effects of different sizes within the single-domain range of superparamagnetic ferrites is essential for understanding their performance in bioapplications. In this study, we synthesize monodisperse Fe<sub>3</sub>O<sub>4</sub> nanoparticles with diameter ranging from 4.0 to 13.5 nm, the surface modified with PEGylated (Fe<sub>3</sub>O<sub>4</sub>-mPEG<sub>2000</sub>; FP), and systematically evaluate size-dependent biobehavior and potential application of FP nanoparticles in SNU423 cells. The results reveal that specific loss power (<em>SLP</em>) is directly proportional to particle size, and the larger FP nanoparticles enable higher hyperthermal ablation efficacy <em>in vitro</em>, leading to more effective tumor growth inhibition <em>in vivo</em>. Meanwhile, particles with smaller sizes (< 8.5 nm) generate negligible heat, rendering them unsuitable for hyperthermal therapy, but optimal for magnetic resonance imaging (MRI). This work demonstrates that FPs nanoparticles with diameter of 13.5 nm exhibit a significant synergistic anticancer effect of magnetic hyperthermal therapy and effective T<sub>2</sub>-weighted MRI with minimal side effects. This research presents important insights for nanoparticle design by precisely identifying the suitable size ranges for the biofunctions of Fe<sub>3</sub>O<sub>4</sub> nanoparticles.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114763"},"PeriodicalIF":5.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of platelet adhesion forces by atomic force microscope under magneto-thermal conditions 磁热条件下血小板粘附力的原子力显微镜表征

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-08 DOI: 10.1016/j.colsurfb.2025.114764

Xiaotong Yan , Xilong Zhang , Kai Yue , Anqi Wang , Weishen Zhong , Genpei Zhang

{"title":"Characterization of platelet adhesion forces by atomic force microscope under magneto-thermal conditions","authors":"Xiaotong Yan , Xilong Zhang , Kai Yue , Anqi Wang , Weishen Zhong , Genpei Zhang","doi":"10.1016/j.colsurfb.2025.114764","DOIUrl":"10.1016/j.colsurfb.2025.114764","url":null,"abstract":"<div><div>Magnetic hyperthermia inhibits platelet (PLT) aggregation and thrombus formation, emerging as a new therapeutic strategy for thrombolysis. It is crucial to have a good understanding of PLT adhesion forces under magneto-thermal conditions to prevent thrombosis formation and improve the efficiency of thrombolytic treatment. The effects of temperature, non-thermal magnetic field (MF) exposure, and combined magneto-thermal conditions on the interaction forces between PLT and various materials (PLT-PLT, PLT-HUVEC, PLT-collagen, and PLT-RBC) were measured using a modified atomic force microscope. The viscoelastic modulus and morphology of PLTs were assessed by atomic force microscope and scanning electron microscopy, and the concentrations of GPIIb/IIIa glycoproteins on the PLT surface and reactive oxygen species within PLTs were quantified to elucidate the mechanisms driving PLT adhesion changes induced by external fields. The results indicate that the interaction forces for all pairs peak at 37 °C and decrease with rising temperatures. High temperatures (>37 °C) inhibit PLT interactions by reducing GPIIb/IIIa receptor activity, thereby lowering thrombosis risk. At 47 °C, PLTs rupture into small spherical vesicles, with significant activity reduction and functional damage. Moreover, MF strength positively correlates with the interaction forces of all pairs at a given temperature, with the most pronounced effect observed in PLT-PLT interactions. Elevated MF strength enhances PLT interaction forces by activating reactive oxygen species and GPIIb/IIIa, as well as increasing the viscoelasticity of the PLT membrane. Additionally, the presence of an MF delays PLT morphological transformation at temperatures exceeding 37 °C.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114764"},"PeriodicalIF":5.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-membrane-engineered NIR II biomimetic nanomaterials for enhanced synergistic chemo-photothermal immunotherapy in cancer treatment 巨噬膜工程NIR II仿生纳米材料在癌症治疗中的增效化学-光热免疫治疗

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-08 DOI: 10.1016/j.colsurfb.2025.114759

Bo Yao, Jingpei Zhang, Zhenghui Chen, Huayu Qiu, Dongdong Xu, Yang Li, Shouchun Yin

{"title":"Macrophage-membrane-engineered NIR II biomimetic nanomaterials for enhanced synergistic chemo-photothermal immunotherapy in cancer treatment","authors":"Bo Yao, Jingpei Zhang, Zhenghui Chen, Huayu Qiu, Dongdong Xu, Yang Li, Shouchun Yin","doi":"10.1016/j.colsurfb.2025.114759","DOIUrl":"10.1016/j.colsurfb.2025.114759","url":null,"abstract":"<div><div>Nanoparticle encapsulated with PEG-based polymers face limitations in their circulation stability and tumor tissue accumulation during blood transport due to the production of anti-PEG antibodies and their inherent nature as foreign substances, which leads to immune surveillance and clearance by the body. The design of biomimetic nanomaterials based on cell membranes offers a solution to these issues. In this context, we have successfully developed a biomimetic nanomaterials designed for the near-infrared region II (NIR II), which leverage the combined power of chemotherapy and photothermal therapy to activate an immune response against tumors. We synthesized nanoparticle loaded with IR1061 and doxorubicin (DOX) using microemulsion and nano-precipitation techniques, and then coated them with the pluronic (F127) polymer to enhance their stability and biocompatibility within biological systems. To further extend their circulation time and minimize the risk of immune detection, we encapsulated the nanoparticle within macrophage membranes. These customized nanoparticle, termed <strong>CIN</strong> and <strong>CDN</strong>, are capable of precisely targeting tumors through the bloodstream and effectively eliminating cancer cells under the dual onslaught of photothermal and chemotherapeutic actions. Throughout the treatment, the destruction of tumor cells triggers the release of antigens, which in turn activate CD4<sup>+</sup> and CD8<sup>+</sup> T cells, stimulating an immune response. Our findings indicate that the integration of chemotherapy with immunotherapy can significantly amplify the immune response by facilitating the demise of tumor cells, representing a highly promising synergistic strategy in the fight against cancer.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114759"},"PeriodicalIF":5.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial and biofilm-eradicating properties of simple double-chain arginine-based surfactants 简单双链精氨酸表面活性剂的抗菌和生物膜去除性能

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-07 DOI: 10.1016/j.colsurfb.2025.114762

Zakaria Hafidi , Maria Teresa García , Sergio Vazquez , Marta Martinavarro-Mateos , Anderson Ramos , Lourdes Pérez

{"title":"Antimicrobial and biofilm-eradicating properties of simple double-chain arginine-based surfactants","authors":"Zakaria Hafidi , Maria Teresa García , Sergio Vazquez , Marta Martinavarro-Mateos , Anderson Ramos , Lourdes Pérez","doi":"10.1016/j.colsurfb.2025.114762","DOIUrl":"10.1016/j.colsurfb.2025.114762","url":null,"abstract":"<div><div>The increasing emergence of multidrug-resistant bacteria and fungi represents a significant challenge for contemporary medicine. In an effort to design and develop new antimicrobial drugs, we have prepared double chain arginine-based surfactants using a simple and cost-effective procedure. These compounds consist of the cationic arginine linked by amide bonds to two hydrophobic chains, one containing 12 carbon atoms, while the length of the other has been systematically varied. We investigated their self-assembly in an aqueous medium, their antimicrobial efficiency against a panel of clinically relevant bacteria and fungi, their antibiofilm activity, and their cytotoxicity. The results demonstrated that these arginine-based surfactants were effective against a broad spectrum of bacteria and fungi, including methicillin-resistant strains. Their antimicrobial activity depends on their hydrophobic content, with the LANHC<sub>5</sub> and LANHC<sub>6</sub> homologs being the most effective. Notably, these compounds can eradicate mature biofilms of MRSA <em>C. albicans</em> and <em>C. tropicalis</em> at low concentrations. Furthermore, they induced cell lysis only at concentrations exceeding their MIC values against both bacteria and fungi. The findings presented here provide valuable insights into the structure–activity relationships underlying the toxicity of cationic surfactants, which must be better understood to facilitate their transition from bench research to pharmaceutical applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114762"},"PeriodicalIF":5.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing near-infrared-activated gold nanostructures for targeted combination cancer therapy 优化近红外活化金纳米结构用于靶向联合癌症治疗

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-07 DOI: 10.1016/j.colsurfb.2025.114687

Nutan Shukla , Ratnesh Das , Carol Yazbleydy Cárdenas Rodriguez , Elizaveta Mukhanova , Alexander Soldatov , Aadil Bathla , Indu kumari , Nitin Hauserao , Sabrina Belbekhouche

{"title":"Optimizing near-infrared-activated gold nanostructures for targeted combination cancer therapy","authors":"Nutan Shukla , Ratnesh Das , Carol Yazbleydy Cárdenas Rodriguez , Elizaveta Mukhanova , Alexander Soldatov , Aadil Bathla , Indu kumari , Nitin Hauserao , Sabrina Belbekhouche","doi":"10.1016/j.colsurfb.2025.114687","DOIUrl":"10.1016/j.colsurfb.2025.114687","url":null,"abstract":"<div><div>The application of near-infrared (NIR)-activated gold nanostructures, particularly gold nanostars (AuNSs) and gold nanorods (AuNRs), has emerged as a promising strategy in targeted combination cancer therapy (Figure 1). These nanostructures leverage their unique localized surface plasmon resonance (LSPR) properties, which enable effective absorption and conversion of NIR light into heat, facilitating photothermal therapy (PTT) to selectively destroy cancer cells. Recent advancements in the synthesis and functionalization of AuNSs and AuNRs have enhanced their biocompatibility, stability, and therapeutic efficacy. This review highlights the mechanisms by which these gold nanostructures can be optimized for synergistic effects when combined with other therapeutic modalities such as chemotherapy and photodynamic therapy (PDT). We discuss the importance of surface modifications that improve tumor targeting and retention, as well as the potential to overcome limitations associated with conventional therapies. The integration of AuNSs and AuNRs into multi-faceted treatment regimens represents a significant step forward in the development of effective cancer therapies, aiming to maximize therapeutic outcomes while minimizing side effects.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114687"},"PeriodicalIF":5.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-modulation of nutrient-transporter axis and functionalized carriers: A paradigm shift for precision oral vitamin D delivery 营养转运体轴和功能化载体的双重调节：精确口服维生素D递送的范式转变

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-07 DOI: 10.1016/j.colsurfb.2025.114769

Zixiao Wang, Yixiang Liu

{"title":"Dual-modulation of nutrient-transporter axis and functionalized carriers: A paradigm shift for precision oral vitamin D delivery","authors":"Zixiao Wang, Yixiang Liu","doi":"10.1016/j.colsurfb.2025.114769","DOIUrl":"10.1016/j.colsurfb.2025.114769","url":null,"abstract":"<div><div>The transintestinal epithelial absorption of vitamin D is intricately regulated by specific transport protein networks. Emerging evidence from molecular nutrition research reveals that certain dietary nutrients can enhance intestinal vitamin D absorption through targeted modulation of lipid transport pathways. Despite significant advancements in vitamin D delivery systems demonstrating excellent intestinal mucoadhesion and in vitro bioaccessibility, their clinical translation remains limited by suboptimal in vivo bioavailability. To address this critical challenge, we propose an innovative synergistic nutrient absorption strategy that establishes precise coordination among three key elements: dietary nutrient composition, transport protein regulation, and intestinal absorption optimization. This comprehensive review systematically examines: (1) The molecular mechanisms governing transintestinal vitamin D transport and physiological modulation of protein-mediated absorption pathways; (2) The regulatory effects of dietary components on vitamin D absorption efficiency through protein pathway modulation, proposing a novel \"nutrient-transporter-vitamin D axis\" strategy integrating cutting-edge carrier technologies; (3) Future perspectives for developing functionalized vitamin D delivery systems. The proposed paradigm shift, combining nutrient-mediated transport enhancement with advanced carrier engineering, represents a transformative approach to overcome current limitations in oral vitamin D delivery. This dual-modulation strategy synergistically improves intestinal absorption and systemic bioavailability through simultaneous optimization of biological transport mechanisms and pharmaceutical delivery parameters, offering new possibilities for precision nutrition interventions.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114769"},"PeriodicalIF":5.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crack patterns induced by auto-stratification in drying sessile droplets of dairy proteins 乳蛋白固结液滴干燥过程中自分层诱导的裂纹模式

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-07 DOI: 10.1016/j.colsurfb.2025.114761

C. Le Floch-Fouéré , M. Yu , F. Boissel , R. Jeantet , L. Pauchard , L. Lanotte

{"title":"Crack patterns induced by auto-stratification in drying sessile droplets of dairy proteins","authors":"C. Le Floch-Fouéré , M. Yu , F. Boissel , R. Jeantet , L. Pauchard , L. Lanotte","doi":"10.1016/j.colsurfb.2025.114761","DOIUrl":"10.1016/j.colsurfb.2025.114761","url":null,"abstract":"<div><div>Exploring the interfacial mechanisms involved in the evaporation of colloidal solutions is currently an open question with potential biomedical and industrial applications. In biological systems, unraveling evidence of self-arrangement is even more challenging due to the different size, structure and charge of their multi-components. In this work, we study the evaporation dynamics in mixes of dairy proteins, <em>i.e.</em>, whey proteins and casein micelles. Combining the observation of crack formation in drying droplets and the evaluation of the elastic response in films during the evaporation, we highlight interfacial stratification resulting in the external accumulation of whey proteins. We also relate such preferential segregation to the mechanical properties of the dry matrices, showing that whey protein overrepresentation confers a brittle behavior to the mixes. These experimental results enable the development of a first predictive model of the elastic modulus for biocolloid binary mixes, taking into account their deformability and different ratio in the samples. Unraveling the link between colloid self-arrangement and the evolution of skin properties during the evaporation is a first step towards controlling structure and use properties of the dry particles composing dairy powders.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114761"},"PeriodicalIF":5.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast-dissolving nanofibrous facial masks for delivering skincare ingredients 快速溶解的纳米纤维面膜，用于输送护肤成分

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-06 DOI: 10.1016/j.colsurfb.2025.114770

Gengxin Liu , Juan Li , Lu Wang , Ling Zhang , Tingting Yang , Yingfan Guo , Guorui Zhang , Siyu Ni , Lu Qiao , Huali Nie

{"title":"Fast-dissolving nanofibrous facial masks for delivering skincare ingredients","authors":"Gengxin Liu , Juan Li , Lu Wang , Ling Zhang , Tingting Yang , Yingfan Guo , Guorui Zhang , Siyu Ni , Lu Qiao , Huali Nie","doi":"10.1016/j.colsurfb.2025.114770","DOIUrl":"10.1016/j.colsurfb.2025.114770","url":null,"abstract":"<div><div>Facial masks are widely used in skincare, but traditional wet masks often require preservatives to prevent microbial growth, which can cause skin irritation and environmental issues due to plastic waste from excessive packaging. To address these issues, we have developed an innovative, fast-dissolving nanofibrous facial mask that delivers curcumin (Cur), a potent antioxidant, without the need for preservatives or additives. Utilizing electrospinning technology, the polyvinylpyrrolidone nanofibrous mask not only serves as a reservoir that enhances the stability and solubility of Cur but also dissolves rapidly upon contact with minimal moisture, efficiently releasing the active compound onto the skin. The mask demonstrates strong antioxidant properties, with a DPPH radical scavenging rate of approximately 90 %, and excellent biocompatibility, as shown by its mild pH, high cell viability in fibroblast cultures, and non-irritating nature in HET-CAM assays. This novel design addresses key challenges in the facial mask industry, such as the reliance on preservatives, plastic waste, and the instability of active ingredients, while providing enhanced skincare benefits through the targeted delivery of Cur. Our approach offers a safe, eco-friendly, and effective alternative for anti-aging and protective skincare, with significant advantages over conventional wet masks.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114770"},"PeriodicalIF":5.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-regulation biomimetic composite nerve scaffold with oriented structure and conductive function for skin peripheral nerve injury repair 具有定向结构和导电功能的双调节仿生复合神经支架用于皮肤周围神经损伤修复

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-06 DOI: 10.1016/j.colsurfb.2025.114768

Jinzhi Liu , Zhiyuan Lin , Huanyou Wu , Jianming Zhang , Fujun Wang , Lu Wang , Shuliang Lu , Jing Gao

{"title":"Dual-regulation biomimetic composite nerve scaffold with oriented structure and conductive function for skin peripheral nerve injury repair","authors":"Jinzhi Liu , Zhiyuan Lin , Huanyou Wu , Jianming Zhang , Fujun Wang , Lu Wang , Shuliang Lu , Jing Gao","doi":"10.1016/j.colsurfb.2025.114768","DOIUrl":"10.1016/j.colsurfb.2025.114768","url":null,"abstract":"<div><div>Skin peripheral nerve injury repair still faces significant clinical challenges. Although nerve tissue engineering scaffolds show potential, issues such as limited functionality and low repair efficiency persist. This study developed a dual-regulation biomimetic composite nerve scaffold with oriented structure and conductive function to promote nerve injury repair. The structural layer was a chitosan (CS)/polycaprolactone (PCL) oriented nanofiber membrane, which could promote cell adhesion and induce directional growth of cells. The functional layer was a CS/sodium alginate (SA) ionic conductive hydrogel, which could enhance endogenous electric fields to promote cell proliferation and differentiation. The two layers were combined through physical crosslinking, avoiding the use of chemical adhesives and preserving the surface morphology of the nanofibrous membrane and the porous structure of the hydrogel. The biomimetic composite nerve scaffold exhibited layered degradability, excellent orientation, conductivity, and biocompatibility. Cell experiments indicated that the scaffold effectively induced directional migration, growth, and differentiation of cells and enhanced cell activity, thereby providing a favorable microenvironment for nerve regeneration. This study not only overcomes the limitation of functional singularity in traditional nerve scaffolds but also aligns with the forefront trend in tissue engineering toward multifunctional and biomimetic materials. It demonstrates great potential for treating complex conditions such as traumatic nerve defects and post-surgical nerve regeneration and has broad application prospects in the field of neural tissue engineering.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114768"},"PeriodicalIF":5.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in biomimetic hydrogel for articular cartilage defect repair: Enabling immunomodulation and chondrogenesis

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-06 DOI: 10.1016/j.colsurfb.2025.114760

Chenxiao Zheng , Yurui Wu , Feifan Luan , Chunwei Wei , Chunye Zhang , Wenjun Liu , Wenjun Wang , Jiayi Chen

{"title":"Advances in biomimetic hydrogel for articular cartilage defect repair: Enabling immunomodulation and chondrogenesis","authors":"Chenxiao Zheng , Yurui Wu , Feifan Luan , Chunwei Wei , Chunye Zhang , Wenjun Liu , Wenjun Wang , Jiayi Chen","doi":"10.1016/j.colsurfb.2025.114760","DOIUrl":"10.1016/j.colsurfb.2025.114760","url":null,"abstract":"<div><div>Articular cartilage defects, as a core pathologic feature in the progression of osteoarthritis, and their irreversible degenerative changes lead to functional impairment and socioeconomic burden for tens of millions of patients worldwide. Hydrogels have become key biomaterials in cartilage regeneration with the three-dimensional network structure, programmable mechanical properties, and cell-adaptive microenvironment of biomimetic extracellular matrix. In recent years, several hydrogel systems with in <em>vitro</em>/in <em>vivo</em> repair potential have been developed by modulating the material topology, dynamic mechanical response, and delivery of bioactive factors, and some of them have entered the clinical translation stage. This review systematically explains the biomimetic design principles of hydrogels. It analyzes the immunomodulation and chondrogenic mechanisms mediated by hydrogels, providing a theoretical framework for the development of next-generation smart cartilage repair materials.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114760"},"PeriodicalIF":5.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0