Colloids and Surfaces B: Biointerfaces最新文献_第4页

Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal barrier and gut microbiota. 负载小檗碱双盐的结肠靶向自组装纳米粒子可通过改善肠粘膜屏障和肠道微生物群来缓解溃疡性结肠炎。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-11-02 DOI: 10.1016/j.colsurfb.2024.114353

Yalong Wang, Yan Chen, Hongjuan Zhang, Shihui Yu, Gang Yuan, Haiyan Hu

{"title":"Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal barrier and gut microbiota.","authors":"Yalong Wang, Yan Chen, Hongjuan Zhang, Shihui Yu, Gang Yuan, Haiyan Hu","doi":"10.1016/j.colsurfb.2024.114353","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114353","url":null,"abstract":"Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease marked by disturbances in intestinal mucosal barriers, persistent inflammation, oxidative stress, and dysbiosis of the intestinal microbiota. Traditional treatments often fail to adequately address these issues, primarily targeting inflammation. To address these limitations, this study developed an innovative approach using self-assembled nanoparticles for oral administration that target colonic inflammation. Berberine hydrochloride and ursodeoxycholic acid were combined to form a double salt (BeU), enhancing solubility and encapsulation. An amphiphilic polymer (FU-PA) was created by esterifying fucoidan with palmitic acid. FU-PA/BeU nanoparticles were prepared using the nanoprecipitation method and further encapsulated in acid-resistant sodium alginate microspheres (FU-PA/BeU NPs@MS) for targeted delivery to colonic lesions. The aggregation rate of nanoparticles with mucus was significantly reduced to 59 % of free berberine, while the apparent permeability coefficient increased by 2.4 times. In vitro, FU-PA/BeU NPs effectively targeted inflammatory macrophages, reducing IL-6 and NO levels while increasing IL-10 level (to 42.5 %, 26.8 %, and 539 % of the LPS-treated group, respectively). Additionally, the ABTS and DPPH radical scavenging capabilities of FU-PA/BeU NPs were 177.8 % and 151.7 % of BeU, respectively. In dextran sulphate sodium-induced UC mice, oral FU-PA/BeU NPs@MS significantly improved epithelial and mucosal barriers, restored gut microbiota diversity, reduced inflammation and oxidative stress. Remarkably, the mean colon length in the FU-PA/BeU NPs@MS group was 1.2 times longer than that in the sulfasalazine group. These dual-targeted FU-PA/BeU NPs@MS show great potential for UC treatment.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114353"},"PeriodicalIF":5.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-induced self-assembly of peptides turns superhydrophobic surface of electrospun fibrous into superhydrophilic one. 表面诱导的多肽自组装将电纺纤维的超疏水表面变成超亲水表面。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-11-01 DOI: 10.1016/j.colsurfb.2024.114350

Xuan Sun, Han Ren, Yue-Chan Cui, Qian Liu, Jie Li, Jie Gao

引用次数: 0

Time-dependent corrosion behavior of EH36 steel caused by Pseudomonas aeruginosa based on big data monitoring technology. 基于大数据监测技术的铜绿假单胞菌对 EH36 钢腐蚀行为的时间依赖性。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-11-01 DOI: 10.1016/j.colsurfb.2024.114349

Shihang Lu, Nianting Xue, Mingxu Gao, Shiqiang Chen, Renzheng Zhu, Xinyu Wang, Guangzhou Liu, Wenwen Dou

{"title":"Time-dependent corrosion behavior of EH36 steel caused by Pseudomonas aeruginosa based on big data monitoring technology.","authors":"Shihang Lu, Nianting Xue, Mingxu Gao, Shiqiang Chen, Renzheng Zhu, Xinyu Wang, Guangzhou Liu, Wenwen Dou","doi":"10.1016/j.colsurfb.2024.114349","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114349","url":null,"abstract":"Marine microbial corrosion poses a significant threat to the safe service of marine engineering equipment. Previous studies have often failed to thoroughly analyze the continuous and prolonged microbial corrosion process, resulting in an incomplete understanding of microbial corrosion mechanisms involved at various stages and the development of ineffective control strategies. This study employed a corrosion big data online real-time monitoring technique to investigate the time-dependent corrosion behavior of EH36 steel caused by Pseudomonas aeruginosa in aerobic environments over a 30-d incubation period. It was found that P. aeruginosa accelerated the corrosion of EH36 steel in the early stages by enhancing the cathodic oxygen reduction process. As oxygen levels declined, P. aeruginosa transitioned from aerobic to anaerobic respiration, promoting corrosion through biocatalytic nitrate reduction. In the later stages, the reduction in sessile cell counts, extreme low oxygen concentration, and dense surface film increased the charge transfer and film resistances, ultimately leading to corrosion inhibition. The weight loss and electrochemical data confirmed the effectiveness of the big data monitoring technique in investigating microbial corrosion, which provides new approaches for diagnosing and preventing microbial corrosion.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114349"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun nanofibrous scaffolds reinforced with therapeutic lithium/manganese-doped calcium phosphates: Advancing skin cancer therapy through apoptosis induction. 用治疗性锂/锰掺杂磷酸钙增强的电纺纳米纤维支架：通过诱导细胞凋亡推进皮肤癌治疗。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-31 DOI: 10.1016/j.colsurfb.2024.114348

Sara Gorgani, Farzad Kermani, Khatereh Sadeghzadeh, Arghavan Vojdani, Sara Hooshmand, Kobra Foroughi, Zoleikha Azari, Seyede Atefe Hosseini, Sahar Mollazadeh, Alireza Ebrahimzadeh Bideskan, Simin Nazarnezhad

{"title":"Electrospun nanofibrous scaffolds reinforced with therapeutic lithium/manganese-doped calcium phosphates: Advancing skin cancer therapy through apoptosis induction.","authors":"Sara Gorgani, Farzad Kermani, Khatereh Sadeghzadeh, Arghavan Vojdani, Sara Hooshmand, Kobra Foroughi, Zoleikha Azari, Seyede Atefe Hosseini, Sahar Mollazadeh, Alireza Ebrahimzadeh Bideskan, Simin Nazarnezhad","doi":"10.1016/j.colsurfb.2024.114348","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114348","url":null,"abstract":"In the current study we fabricated potent materials by incorporating therapeutic elements into calcium phosphates (CPs) to combat cancer. This involved synthesizing manganese (Mn)- and lithium (Li)-doped CPs and loading them into electrospun nanofibers (NFs) composed of chitosan (CS) and polyethylene oxide (PEO). The characterized CPs exhibited excellent properties, including a particle size of 47-75 nm, surface charge of -(30-56) mV, and specific surface area of 75-266 m2/g. The electrochemical analysis revealed that Mn and Mn/Li-doped CPs are promising for generating oxygen free radicals and H2O2, crucial for cancer therapy. Biological evaluation showcased the outstanding performance of the developed materials. MTT assay revealed a cytotoxic effect of nano-constructs on melanoma A375 cell line without adverse effects on normal L929 cells over 72 h. Annexin V/PI apoptosis assay indicated substantial apoptosis rates in A375 cells treated with PC-20 % (62.55 ± 4.59 %). The obtained data of qPCR analysis of pro-apoptotic and anti-apoptotic genes (P53, Bax, Bcl-2) in A375 cells treated with different CP nanoparticles (NPs) showed a significant increase in P53 and Bax gene expression, indicating high levels of A375 cell apoptosis. Additionally, the samples containing Mn ion exhibited high reactive oxygen species (ROS) generation. In conclusion, the fabricated NFs scaffolds hold promising potential for cancer therapy.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114348"},"PeriodicalIF":5.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nickel-doped cuprous oxide nanocauliflowers with specific peroxidase-like activity for sensitive detection of hydrogen peroxide and uric acid. 具有特异性过氧化物酶样活性的掺镍氧化亚铜纳米金花，用于灵敏检测过氧化氢和尿酸。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-29 DOI: 10.1016/j.colsurfb.2024.114347

Rou Cheng, Zhengyue Xiao, Xiaomin Tang, Peng Xu, Ping Qiu

{"title":"Nickel-doped cuprous oxide nanocauliflowers with specific peroxidase-like activity for sensitive detection of hydrogen peroxide and uric acid.","authors":"Rou Cheng, Zhengyue Xiao, Xiaomin Tang, Peng Xu, Ping Qiu","doi":"10.1016/j.colsurfb.2024.114347","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114347","url":null,"abstract":"Copper-based nanomaterials have the properties of mimetic enzymes and can be used as excellent candidates for colorimetric sensing due to their environmental friendliness, low cost, and high abundance. In this paper, Ni-doped Cu2O nano cauliflower (Ni-Cu2O) was synthesized for the first time and applied to the detection of H2O2 and uric acid (UA) in human serum and urine. It was found that the proportion of Ni incorporation controls the morphology and the catalytic effect of Ni-Cu2O. The catalytic mechanism was studied by X-ray photoelectron spectroscopy, free radical capture experiments, photoluminescence spectroscopy, and steady-state kinetic analysis, which verified the redox reactions involving electron transfer and active substances. The results showed that Ni-Cu2O could catalyze the formation of reactive oxygen species (•OH, O2•-, 1O2, h+) from H2O2, which could oxidize 3,3', 5,5'-tetramethylbenzidine (TMB) to oxTMB, and the color changed from colorless to blue. The Michaelis-Menten constant (Km) and the maximum initial velocity (Vmax) of Ni-Cu2O were 1.8 mM and 15.2×10-8 M/s, respectively. Based on the excellent peroxidase-like (POD) activity of Ni-Cu2O, a colorimetric sensing platform combined with TMB was proposed to sensitively detect H2O2 and UA in a wide range, and the detection limits were as low as 0.17 μM and 0.22 μM, respectively. This study creates a platform for using the Cu-based cauliflowers as a biosensor to detect UA in the medical and biomedicine fields.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114347"},"PeriodicalIF":5.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional injectable oxidized sodium alginate/carboxymethyl chitosan hydrogel for rapid hemostasis. 用于快速止血的多功能注射用氧化海藻酸钠/羧甲基壳聚糖水凝胶。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-29 DOI: 10.1016/j.colsurfb.2024.114346

Xuanyu Liu, Junjie Hu, Yinchun Hu, Yeying Liu, Yan Wei, Di Huang

{"title":"Multifunctional injectable oxidized sodium alginate/carboxymethyl chitosan hydrogel for rapid hemostasis.","authors":"Xuanyu Liu, Junjie Hu, Yinchun Hu, Yeying Liu, Yan Wei, Di Huang","doi":"10.1016/j.colsurfb.2024.114346","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114346","url":null,"abstract":"Uncontrolled bleeding from incompressible or irregularly shaped wounds is a major factor in the death of people in the battlefield or surgery process. Ideal rapid hemostatic materials should have the performance of rapid hemostasis and at the same time can be applied to a variety of complex wound trauma types, in addition, excellent antimicrobial properties, adhesion, biocompatibility, degradation, and the non-toxicity of degradation products are also necessary, but there are fewer hemostatic materials that meet these requirements. Herein, we prepared an injectable hemostatic hydrogel based on the natural products sodium alginate (SA) and carboxymethyl chitosan (CMC). Oxidized sodium alginate (OSA) was prepared by the oxidation reaction of NaIO4 with SA, and OSA with aldehyde group was mixed with CMC with amino group to rapidly form an in situ injectable hemostatic hydrogel (OSA/CMC) by the Schiff base reaction. OSA/CMC hydrogel exhibited excellent antimicrobial and adhesion properties by the Schiff base reaction. In addition, OSA/CMC hydrogel directly activate the endogenous coagulation pathway through the synergistic effect of OSA, CMC to enhance the hemostatic effect. The results of in vivo hemostasis study showed that OSA/CMC hydrogel significantly accelerated hemostasis and reduced blood loss in liver hemorrhage model and tail amputation model. Therefore, OSA/CMC hydrogel is expected to be a potential material in the direction of rapid clinical hemostasis due to its good adhesion properties, antimicrobial properties, biocompatibility, blood compatibility, and efficient rapid hemostasis.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114346"},"PeriodicalIF":5.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imparting insoluble-soluble property to Cyt c by immobilizing Cyt c in UCST-pH dual responsive polymer for highly sensitive detection of phenol. 通过将 Cyt c 固定在 UCST-pH 双响应聚合物中，为 Cyt c 赋予不溶性-溶性特性，从而实现对苯酚的高灵敏度检测。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-29 DOI: 10.1016/j.colsurfb.2024.114344

Yuanyuan Wang, Weimin Guan, Yulin Yang, Huiling Lan, Yu Wang, Yun Wang, Juan Han, Lei Wang

{"title":"Imparting insoluble-soluble property to Cyt c by immobilizing Cyt c in UCST-pH dual responsive polymer for highly sensitive detection of phenol.","authors":"Yuanyuan Wang, Weimin Guan, Yulin Yang, Huiling Lan, Yu Wang, Yun Wang, Juan Han, Lei Wang","doi":"10.1016/j.colsurfb.2024.114344","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114344","url":null,"abstract":"Immobilization of enzymes in porous organic framework (POF) materials is popular strategy to stabilize enzymes. For such solid enzyme catalysis system, improving the catalytic efficiency is challenging due to the diffusion resistance from solid-liquid interface and inner pores. Here, UCST-pH dual responsive polymeric carrier (PEG-b-PAAm-b-P(GMA-co-AAc)) was synthesized to immobilize cytochrome c (Cyt c), which impart the reversibly insoluble-soluble property to the immobilized Cyt c. The PEG-b-PAAm-b-P(GMA-co-AAc) could serve as an insoluble-soluble matrix to fast and efficiently immobilize Cyt c via covalent attachment, achieving a remarkable 92 % loading efficiency within just 120 min. The obtained insoluble PEG-b-PAAm-b-P(GMA-co-AAc)-Cyt c micelles exhibited an improvement in thermal, pH stability and reusability. The completely soluble PEG-b-PAAm-b-P(GMA-co-AAc)-Cyt c conjugates accelerated substrate diffusion and then enhanced the catalytic efficiency. These excellent advantages led to low detection limit (1.99 μM), lower than the presently reported biosensors based on enzyme mimics in the colorimetric detection of phenol. This UCST-pH dual responsive window presents a new platform to efficiently control the immobilization and release of enzymes, which will achieve excellent stability and catalytic efficiency.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114344"},"PeriodicalIF":5.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translocation mechanism of anticancer drugs through membrane with the assistance of graphene quantum dot. 石墨烯量子点辅助下抗癌药物的膜转移机制。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-28 DOI: 10.1016/j.colsurfb.2024.114340

Luxi Weng, Hao Ren, Ruru Xu, Jiahao Xu, Jun Lin, Jia-Wei Shen, Yongke Zheng

{"title":"Translocation mechanism of anticancer drugs through membrane with the assistance of graphene quantum dot.","authors":"Luxi Weng, Hao Ren, Ruru Xu, Jiahao Xu, Jun Lin, Jia-Wei Shen, Yongke Zheng","doi":"10.1016/j.colsurfb.2024.114340","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114340","url":null,"abstract":"In recent years, as a new type of quasi-zero-dimensional nanomaterials, graphene quantum dots (GQDs) have shown excellent performance in advanced drug targeted delivery and controlled release. In this work, the delivery process of model drugs translocating into POPC lipid membrane with the assistance of GQDs was investigated via molecular dynamics (MD) simulation. Our simulation results demonstrated that a single doxorubicin (DOX) or deoxyadenine (DA) molecule is difficult to penetrate into the cell membrane. GQD7 could form sandwich-like structure with DOX and assist DOX to enter into the POPC membrane. However, due to the weak interaction with DA, both GQD7 and GQD19 can not assist DA translocating the POPC membrane in the limited MD simulation time. The drug delivery process for DOX could be divided into two steps: 1. GQDs and DOX aggregated into a cluster; 2. the aggregates enter into the POPC membrane. In all our simulation systems, if GQDs loaded with model drugs and entered the cell membrane, it had little effect on the cell membrane structure, and the cell membrane could maintain high integrity and stability. These results may promote the molecular design and application of GQD-based drug delivery systems.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114340"},"PeriodicalIF":5.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive dextran-based scaffolds from emulsion templates co-stabilized by poly(lactic-co-glycolic acid) nanocarriers. 由聚（乳酸-共聚乙醇酸）纳米载体共同稳定的乳液模板制成的生物活性葡聚糖基支架。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-28 DOI: 10.1016/j.colsurfb.2024.114342

Maude Ducrocq, Arianna Rinaldi, Boris Halgand, Joëlle Veziers, Pierre Guihard, Frank Boury, Antoine Debuigne

{"title":"Bioactive dextran-based scaffolds from emulsion templates co-stabilized by poly(lactic-co-glycolic acid) nanocarriers.","authors":"Maude Ducrocq, Arianna Rinaldi, Boris Halgand, Joëlle Veziers, Pierre Guihard, Frank Boury, Antoine Debuigne","doi":"10.1016/j.colsurfb.2024.114342","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114342","url":null,"abstract":"Porous polymer scaffolds are widely investigated as temporary implants in regenerative medicine to repair damaged tissues. While biocompatibility, degradability, mechanical properties comparable to the native tissues and controlled porosity are prerequisite for these scaffolds, their loading with pharmaceutical or biological active ingredients such as growth factors, in particular proteins, opens up new perspective for tissue engineering applications. This implies the development of scaffold loading strategies that minimize the risk of protein denaturation and allow to control their release profile. This work reports on a straightforward method for preparing bioactive dextran-based scaffolds from high internal phase emulsion (HIPE) templates containing poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) serving both as co-stabilizers for the emulsion and nanocarriers for drug or therapeutic protein models. Scaffold synthesis are achieved by photocuring of methacrylated dextran located in the external phase of a HIPE stabilized by the NPs in combination or not with a non-ionic surfactant. Fluorescent labelling of the NPs highlights their integration in the scaffold. The introduction of NPs, and even more so when combined with a surfactant, increases the stability and mechanical properties of the scaffolds. Cell viability tests demonstrate the non-toxic nature of these NPs-loaded scaffolds. The study of the release of a model protein from the scaffold, namely lysozyme, shows that its encapsulation in nanoparticles decreases the release rate and provides additional control over the release profile.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114342"},"PeriodicalIF":5.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo. 负载柚皮苷的褐藻糖胶/聚乙烯吡咯烷酮纳米颗粒在体内外保护叶酸诱导的急性肾损伤。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-28 DOI: 10.1016/j.colsurfb.2024.114343

Tao Jiang, Feikai Zhu, Xintao Gao, Xiaochen Wu, Wenyong Zhu, Chuanlong Guo

{"title":"Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.","authors":"Tao Jiang, Feikai Zhu, Xintao Gao, Xiaochen Wu, Wenyong Zhu, Chuanlong Guo","doi":"10.1016/j.colsurfb.2024.114343","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2024.114343","url":null,"abstract":"Acute kidney injury (AKI) is a common clinical problem with no effective treatment. Excessive folic acid (FA) induced kidney tubular injury is characterized by oxidative stress and inflammation, and is a common model of AKI. The excellent pharmacological activity of naringenin (NAR) makes it a potential agent for treating AKI, but its poor solubility limits its application. This study prepared NAR loaded nanoparticles (FU/PVP-NAR) using fucoidan (FU) and polyvinylpyrrolidone (PVP) as carriers, with a particle size of 23.96 ± 2.77 nm. In vitro studies showed that FU/PVP-NAR inhibited excessive FA induced proliferation inhibition, accumulation of reactive oxygen species (ROS), and disruption of mitochondrial membrane potential (MMP) of HK-2 cells. Further confirmed that FU/PVP-NAR inhibited FA induced DNA damage and Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation. In vivo studies showed that excessive FA induced AKI features in mice, such as elevated serum creatinine (SCr) and blood urea nitrogen (BUN) levels, accompanied by pathological damage to kidney tissues. The above AKI characteristics induced by FA were alleviated by FU/PVP-NAR. FU/PVP-NAR also inhibited the decrease in antioxidant enzyme levels in kidney tissues induced by FA. Furthermore, in vivo mechanism studies indicated that FU/PVP-NAR inhibited the release of inflammatory factors by inhibiting DNA damage-cGAS-STING pathway. In summary, this study provided the possibility for FU/PVP-NAR as a potential candidate drug for treating FA induced AKI.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114343"},"PeriodicalIF":5.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0