Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Conformal polypyrrole biointerfaces on porous PHA monoliths via oxidative chemical vapor deposition","authors":"Adriana Kovalcik ,&nbsp;Nicole Cernekova ,&nbsp;Fika Fauzi ,&nbsp;Ranjita K. Bose ,&nbsp;Zdenko Spitalsky ,&nbsp;Zuzana Kadlecova ,&nbsp;Lucy Vojtova ,&nbsp;Zdenka Víchová ,&nbsp;Petr Humpolíček ,&nbsp;Patrycja Bober","doi":"10.1016/j.colsurfb.2026.115417","DOIUrl":"10.1016/j.colsurfb.2026.115417","url":null,"abstract":"<div><div>Chronic wounds require dressings that manage exudate, conform to soft tissue, provide mechanical support, and deliver intrinsic bioactivity. Here, we report conductive, hydrogel-like porous polyhydroxyalkanoate (PHA) monoliths dressings coated with polypyrrole (PPy) using oxidative chemical vapor deposition (oCVD). Porous PHA substrates were prepared from polyhydroxybutyrate (PHB) and a P4HB-containing copolymer by thermally induced phase separation and were uniformly functionalized throughout their three-dimensional architecture by this solvent-free process. The resulting PHA/PPy porous monoliths combine high water uptake with electrical conductivity and biological activity. They exhibit a swelling ratio of ∼250 %, maintaining a moist environment while preserving viscoelastic integrity. Sheet resistance ranges from 26 to 86 kΩ/sq, enabling platforms for electrical sensing in tissue repair. The composites do not induce cytotoxicity and exhibit intrinsic radical-scavenging capacity and antibacterial activity against both <em>Gram-positive</em> and <em>Gram-negative</em> bacteria. These properties are achieved without chemical derivatization of the PHA matrix. The hydrophobic PHA core provides mechanical robustness, while the conformal PPy layer imparts conductivity and bioactivity. Overall, this oCVD route provides a scalable, solvent-free strategy to engineer multifunctional, hydrogel-like porous monolith dressings that integrate moisture management, mechanical resilience, electrical conduction, and inherent antioxidant and antimicrobial activity. These features position the developed materials as promising bioactive and bioelectronic wound dressings and soft tissue interfaces.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115417"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizations and controlled drug release behavior of acyclovir-loaded starch-based microneedles patches for transdermal herpes simplex virus therapy","authors":"Kyeongjung Kim ,&nbsp;Se-woon Choe ,&nbsp;Jae-Young Je ,&nbsp;Min-Jin Hwang ,&nbsp;Yoonhang Lee ,&nbsp;Do-Hyung Kim ,&nbsp;Kwangcheol Casey Jeong ,&nbsp;Soon-Do Yoon","doi":"10.1016/j.colsurfb.2026.115430","DOIUrl":"10.1016/j.colsurfb.2026.115430","url":null,"abstract":"<div><div>Transdermal drug delivery systems (TDDS) using microneedles (MNs) patches have shown promise for improved therapeutic outcomes. In this study, acyclovir (ACV)-loaded MNs patches for herpes simplex virus (HSV) therapy were prepared using mungbean starch (MBS), polyvinyl alcohol (PVA), and plasticizers (arginine and mannitol), and their physicochemical properties, ACV release behavior, antimicrobial activity, and biodegradation, cell viability, and antiviral efficacy were investigated. The MNs exhibited compression forces of 1.30 – 4.80 N/needle and a pyramidal square shape with a length of 620–640 μm, ensuring efficient skin penetration. The ACV release (%) from the ACV-loaded MNs patches during an artificial skin test was found to be 2.50 – 4.32 times higher than that from ACV-loaded biomaterial as the film-type formulation. Additionally, over 98.0 % of ACV was released from the prepared MNs patches within 80 min. The ACV release mechanism was analyzed using zero-order, first-order, Higuchi, Fickian diffusion, and Korsmeyer-Peppas models, which revealed a Fickian diffusion mechanism. Visualization of intradermal drug release were conducted using ACV- and riboflavin-loaded MNs patches on agar blocks and pig ears/agar block models. Biodegradability, cell viability, and antiviral studies further demonstrated the potential of MNs patches as a TDDS. These results suggest that the prepared MNs patches are promising candidates for transdermal HSV therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115430"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in metal-organic framework-based nanozymes for cancer theranostics driven by synthetic innovation and machine learning design","authors":"Sangeeta Yadav ,&nbsp;Aditi Sarkar ,&nbsp;Saurabh Shivalkar ,&nbsp;Fiza Fatima ,&nbsp;Siddharth Kumar Thakur ,&nbsp;Ankita Chaudhary ,&nbsp;Sintu Kumar Samanta ,&nbsp;Amaresh Kumar Sahoo","doi":"10.1016/j.colsurfb.2026.115463","DOIUrl":"10.1016/j.colsurfb.2026.115463","url":null,"abstract":"<div><div>Nanozymes are engineered nanomaterials designed at the atomic scale to fine-tune their structure, composition, and electronic properties, thereby creating active sites that mimic those of natural enzymes. Among these materials, Metal-organic frameworks (MOFs) are notable for their well-defined, porous frameworks, which are created by connecting metal ions or clusters with organic linkers. Their large surface area, adjustable porosity, and superior biocompatibility enable excellent catalytic activity. By containing specific catalytic functionalities, MOF-based nanozymes can mimic peroxidase, oxidase, catalase, and superoxide dismutase activities. These properties make them genuinely promising for biomedical applications, particularly in cancer diagnosis and therapy. Recent progress in synthetic design, post-synthetic modification, and machine learning–assisted optimization has enhanced their structural precision and catalytic efficiency. Furthermore, MOFs serve as multifunctional therapeutic platforms capable of supporting combined treatment strategies and producing synergistic therapeutic effects, thereby establishing their potential as next-generation systems for targeted cancer treatment and diagnostic integration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115463"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallic- and ω-3-linolenic-acids-mediated MgO nanoplates enable band-edge tuning and ROS-driven anticancer activity","authors":"Ankita Thakur ,&nbsp;Ahmed Ahmed Ibrahim ,&nbsp;Khalid Mujasam Batoo ,&nbsp;Jyoti Gaur ,&nbsp;Kasim Sakran Abass ,&nbsp;Sanjeev Kumar","doi":"10.1016/j.colsurfb.2026.115455","DOIUrl":"10.1016/j.colsurfb.2026.115455","url":null,"abstract":"<div><div>Green nanotechnology seeks earth-abundant, low-toxicity oxides that can deliver biomedical benefits with minimal environmental impact. We report the first magnesium oxide (MgO) nanoparticles (NPs) synthesised exclusively from Pinus patula needle waste via a one-pot, aqueous route that requires no organic solvents or post-calcination. Targeted GC–MS profiling pinpoints gallic acid, ω-3 linolenic-acid bis-TMS ether and three mono-linoleoylglycerol derivatives as the dominant reductive/capping agents (Σ &gt; 35 % TIC), while FT-IR confirms they are in-situ chelation to Mg²⁺. The renewable extract simultaneously reduces Mg²⁺, caps nascent nuclei and templates mesoporosity, affording a 78 % yield of well-crystalized platelets (XRD domain 55 ± 3 nm; BET surface area 54 m² g⁻¹; pore diameter 3.8 nm). Oxygen-vacancy enrichment contracts the bulk 7.8 eV gap to an indirect 3.24 eV; the resulting band edges (–0.29 V and +1.81 V vs NHE, pH 7) favour superoxide but suppress hydroxyl-radical formation, enabling stimulus-dependent redox switching. In vitro, the particles trigger intrinsic apoptosis in MCF-7 cells with an IC₅₀ of 71 ng mL⁻¹ and a 32-fold Bax/Bcl-2 shift, yet exhibit negligible haemolysis toward erythrocytes. Antioxidant assays reveal a DPPH•-scavenging IC₅₀ of 25 µg mL⁻¹ lower than any green-synthesised MgO reported to date. Comprehensive GC-MS, FT-IR and time-resolved XRD tracking link the vacancy stabilization and ripening inhibition to the coordinated gallic-acid/flavolipid corona.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115455"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringenin nanosuspensions embedded glycyrrhizin-based hydrogel ameliorates cholestatic liver injury in mice by inhibiting oxidative stress and HMGB1-mediated inflammation","authors":"Qiqi Li ,&nbsp;Yaochen Deng ,&nbsp;Xiaolu Han ,&nbsp;Yuhan Dong ,&nbsp;Xianggen Wu ,&nbsp;Wei Zhu ,&nbsp;Meixing Yan","doi":"10.1016/j.colsurfb.2026.115466","DOIUrl":"10.1016/j.colsurfb.2026.115466","url":null,"abstract":"<div><div>Naringenin (NAR) possesses remarkable hepatoprotective potential. However, its extremely low aqueous solubility and oral bioavailability greatly constrain its therapeutic efficacy. To overcome these limitations, we developed a novel oral nanodelivery system, NanoNAR@Glycygel, by embedding NAR nanosuspensions (NanoNAR) into a self-assembled glycyrrhizin-based hydrogel (Glycygel). The design of this delivery system improves solubility, enhances absorption, and provides synergistic hepatoprotective effects. NanoNAR, when stabilized by the natural biosurfactant glycyrrhizin, exhibited a uniform particle size of approximately 230 nm and showed markedly improved solubility in physiologically relevant media. The hydrogel network formed by Glycygel effectively encapsulated NanoNAR, further enhancing its solubility and controlled release behavior. Pharmacokinetic analyses revealed that NanoNAR@Glycygel significantly enhanced the oral bioavailability of NAR and increased its hepatic accumulation, demonstrating how the synergistic interplay between nanonization and the glycyrrhizin hydrogel matrix facilitates rapid absorption and sustained release. In a cholestatic liver injury mouse model, NanoNAR@Glycygel treatment markedly alleviated cholestasis and hepatic histopathological damage, restoring liver morphology and serum biochemical parameters to near-normal levels. Mechanistic investigations revealed for the first time that HMGB1 signaling is involved in this cholestatic liver injury, and NanoNAR@Glycygel exerted its potent therapeutic effect by inhibiting this signaling. The NanoNAR@Glycygel cloud also reduced malondialdehyde (MDA) levels and enhanced superoxide (SOD) activity, thereby mitigating oxidative injury. Collectively, these findings demonstrate that NanoNAR@Glycygel is a safe, simple, and highly effective oral delivery platform that not only unleashes the therapeutic potential of NAR but also highlights the distinctive advantages of glycyrrhizin-based matrices for the targeted oral delivery of hydrophobic natural bioactives.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115466"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane-mimicking surfaces modulate the heme pocket structure and oxygen affinity in myoglobin: A surface-enhanced resonance Raman study","authors":"Ulises A. Zitare ,&nbsp;Andresa Messias ,&nbsp;Santiago Di Lella ,&nbsp;Magalí F. Scocozza ,&nbsp;Darío A. Estrin ,&nbsp;Luciana Capece ,&nbsp;Daniel H. Murgida","doi":"10.1016/j.colsurfb.2026.115457","DOIUrl":"10.1016/j.colsurfb.2026.115457","url":null,"abstract":"<div><div>In this study, we investigated how membrane-mimicking surfaces modulate the structure and oxygen affinity of myoglobin (Mb) using surface-enhanced resonance Raman spectroscopy under electrochemical control. Nanostructured silver electrodes functionalized with self-assembled monolayers of varying charge and composition were employed to model basic features of the outer mitochondrial membrane in a controlled fashion. Molecular dynamics simulations show that the interactions of Mb with these surfaces are mediated by lysine-rich domains in helix F and the CD region. These interactions induce subtle structural changes in Mb’s heme pocket, of both the ferric and ferrous protein, that imply the loss of the proximal ligand, water and molecular oxygen, respectively. The fraction of ferrous OxyMb that retains the oxygen ligand in the biomimetic complexes exhibits spectral features consistent with a weakened Fe–O₂ bond and decreased O₂ affinity. Overall, our findings show that Mb’s transient interaction with a mitochondrial membrane model facilitates O₂ release through fine structural modulation, providing a possible molecular basis for how such interactions might influence oxygen delivery in cells.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115457"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esterase-activatable dimeric HDAC inhibitor nanotherapeutics for enhanced lymphoma epigenetic therapy","authors":"Tongyu Li ,&nbsp;Wanchuan Zhuang ,&nbsp;Shufang Fan ,&nbsp;Ping Yi ,&nbsp;Guifang Ouyang ,&nbsp;Wenbin Qian","doi":"10.1016/j.colsurfb.2026.115416","DOIUrl":"10.1016/j.colsurfb.2026.115416","url":null,"abstract":"<div><h3>Background</h3><div>Despite advances in lymphoma therapy, significant challenges persist including R-CHOP resistance and CAR-T toxicity. Hydroxamate-based histone deacetylase inhibitors (HDACi) like vorinostat (SAHA) offer epigenetic therapeutic potential but are limited by poor bioavailability and rapid clearance.</div></div><div><h3>Methods</h3><div>To overcome these barriers, we rationally designed an esterase- activatable dimeric prodrug by conjugating two SAHA molecules <em>via</em> a glutaric acid linker (SAHA-cc-SAHA). This prodrug co-assembled with DSPE-PEG₂₀₀₀ into nanoparticles (cc-diSAHA NPs). The system was characterized (DLS/TEM), and its drug release profile was assessed with/without porcine liver esterase (PLE). Antitumor activity was evaluated in EL4/A20 lymphoma cells (apoptosis/cycle assays, etc) and EL4 allograft. Transcriptomic mechanisms were deciphered by RNA-seq.</div></div><div><h3>Results</h3><div>The cc-diSAHA NPs were uniform spheres (∼74 nm, PDI = 0.187) with excellent colloidal stability and minimal drug leakage (&lt;4 % in 7 days), while enabling rapid drug release upon esterase stimulation (92.4 % within 7 h with PLE). <em>In vitro</em>, they demonstrated broad-spectrum anti-lymphoma activity, inducing G₀/G₁ arrest and apoptosis, albeit with delayed kinetics versus free formulations, consistent with a sustained-release profile. Transcriptomics revealed multifaceted mechanisms, including potent activation of interferon-mediated immunogenic stress and hematopoietic differentiation, alongside enriched adhesion and redox metabolism pathways. <em>In vivo</em>, intravenous cc-diSAHA NPs suppressed EL4 tumor growth significantly more than oral SAHA (819.36 vs 1594.40 mm³; <em>p</em> &lt; 0.01), without inducing systemic toxicity or organ damage.</div></div><div><h3>Conclusion</h3><div>This nanoplatform overcomes HDACi delivery barriers by reconciling the stability-activation paradox, providing a therapeutically viable option for lymphoma patients ineligible for standard intensive therapies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115416"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualizing intracellular and extracellular cell-mineral interactions in a three-dimensional breast tumor model","authors":"Amit Cohen ,&nbsp;Einat Nativ-Roth ,&nbsp;Netta Vidavsky","doi":"10.1016/j.colsurfb.2026.115450","DOIUrl":"10.1016/j.colsurfb.2026.115450","url":null,"abstract":"<div><div>Microcalcifications (MCs) in breast tissue, with particularly high prevalence in precancerous lesions, such as ductal carcinoma <em>in situ</em> (DCIS), represent important diagnostic markers for cancer screening. Two primary crystal types, hydroxyapatite (HA) and calcium oxalate dihydrate (COD), occur within breast tumor microenvironments. Evidence from clinical samples has demonstrated that COD is usually found as individual crystals, whereas HA tends to aggregate. Notably, MC crystal types and properties are linked to malignancy, with COD crystals being associated with benign lesions. <em>In-vitro</em> studies have shown that COD crystals can suppress cancerous behavior, whereas HA often promotes it. However, crystal–cell interactions in tumor microenvironments that may explain differential responses to COD and HA remain poorly investigated. Thus, to examine mineral–cell interactions based on cell malignancy potential and crystal type, a three-dimensional multicellular model consisting of precancerous and cancerous human cell lines was employed. Through cryo-scanning electron microscopy (cryo-SEM), we visualized mineral–biological interfaces and showed that cellular types and processes govern crystal aggregation patterns and distribution. Both precancerous and invasive models exhibited enhanced COD crystal packing, while HA crystals formed predominantly loose structures with notable malignancy-dependent variations. In all cases, crystals were found both extra- and intracellularly, the latter being located inside vesicles in some cases, especially for COD crystals. The predominance of intracellular vesicles containing COD crystals rather than HA crystals across both cell types may reflect enhanced cellular processes that promote reduced malignant behavior. These findings may explain why seemingly similar calcium-containing minerals associate differently with malignancy and induce distinct cellular responses.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115450"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenylboronic acid modification and small-molecule assembly to enhance the safety of resiquimod and its synergistic anti-tumor efficacy with paclitaxel","authors":"Ziqi Liu ,&nbsp;Manzhen Li ,&nbsp;Pengxin Li ,&nbsp;Miao Chen ,&nbsp;Tianchi Cui ,&nbsp;Yaoyao Guo ,&nbsp;Xiangtao Wang","doi":"10.1016/j.colsurfb.2026.115449","DOIUrl":"10.1016/j.colsurfb.2026.115449","url":null,"abstract":"<div><div>To overcome the systemic toxicity and poor tumor targeting of the TLR7/8 agonist R848, this study developed a derivative by attaching a phenylboronic acid (PBA) group to R848. The resultant R848-PBA retain the immune activation of R848, easily assembly with indocyanine green (ICG) into nanoparticles (R-P@ICG NPs), which demonstrated greatly improved safety and excellent tumor targetability. Inspired by this, paclitaxel (PTX) was also conjugated with PBA and self-assembly with chlorogenic acid (CA) into nanoparticles (P-P@CA NPs). In 4T1 tumor mice mode, P-P@CA NPs induced significant immunogenic cell death (ICD) to release damage-associated molecular patterns (DAMPs) while R-P@ICG NPs synergistically promoted dendritic cells (DCs) maturation and trigger both innate and adaptive immune responses. This combined therapy achieved a tumor inhibition rate of 93.2 % and a tumor eradication rate of 33.3 %, accompanied by a long-lasting anti-tumor immune memory and no evident toxic effect. Phenylboronic acid modification and self-assembly with small molecules presents a promising strategy to realize the clinical translation of the synergistic antitumor efficacy of R848-based chemoimmunotherapy and chemotherapeutics by alleviated systemic toxicity and endowed tumor targetability.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115449"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic nano-quantum dots of salvianolic acid B modified with photosensitive cypate for diagnosis and treatment of myocardial","authors":"Na Wang ,&nbsp;Ye Zhang ,&nbsp;Wen Huang ,&nbsp;Wei Du ,&nbsp;Chunhua Ma ,&nbsp;YuQiang Fang ,&nbsp;Chunyu Zeng","doi":"10.1016/j.colsurfb.2026.115414","DOIUrl":"10.1016/j.colsurfb.2026.115414","url":null,"abstract":"<div><div>Salvianolic acid B (SaB) demonstrates significant cardioprotective effects against myocardial ischemia–reperfusion injury (I/R). However, its clinical application is limited by rapid metabolism and poor bioavailability. To address this, we synthesized SaB-loaded organic quantum dots (SaB@qd) via a hydrothermal method and functionalized them with the near-infrared (NIR) dye cypate (SaB@qd@Cy). Proteomic analysis of cardiac tissues from I/R model rats identified SIRT2 as a key downregulated protein. Molecular docking and cell membrane chromatography confirmed SaB as a natural SIRT2 agonist, binding specifically to the SER-263 residue. SaB@qd@Cy enhanced myocardial SaB accumulation by 3.2-fold compared to free SaB (P &lt; 0.01). In vivo, SaB@qd@Cy reduced the infarct area by 41 % (compared to 28 % reduction by mitochondrial-targeted CoQ10 nanoparticles) and attenuated inflammatory cytokine expression (IL-1β, TNF-α) via the SIRT2/NLRP3 pathway. Additionally, cypate enabled real-time NIR imaging of ischemic borders, with a temperature increase of 15.3 ± 1.2°C under 808 nm laser irradiation. This study presents a novel theranostic nanoplatform that integrates natural compounds with photoresponsive quantum dots for targeted therapy and intraoperative imaging in I/R management.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115414"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}