Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Fabrication of piezoelectric/conductive composite nerve conduits for peripheral nerve regeneration","authors":"Taotao Bian ,&nbsp;Yuhui Jiang ,&nbsp;Jie Cao,&nbsp;Wenpin Wu,&nbsp;Luzhong Zhang,&nbsp;Yumin Yang","doi":"10.1016/j.colsurfb.2025.114544","DOIUrl":"10.1016/j.colsurfb.2025.114544","url":null,"abstract":"<div><div>Due to the complex regenerative microenvironment after peripheral nerve injury (PNI), developing a piezoelectric/conductive composite nerve guidance conduit (NGC) for repairing nerve defects remains a great challenge. The conductivity and piezoelectricity have been separately demonstrated to enhance the repair of PNI, yet there is a paucity of studies investigating the synergistic effects of both functions. Herein, a piezoelectric/conductive nerve conduit composed of chitosan (CS), reduced graphene oxide (rGO), and poly-L-lactic acid (PLLA) was fabricated, which provided the conductivity, mechanical support and piezoelectricity. Tensile strength, conductivity, antibacterial activity, and cell viability of piezoelectric/conductive composite NGCs were evaluated. Piezoelectric/conductive composite NGCs exhibited electrical signal output capability and conductive performance. Moreover, rGO significantly promoted cell proliferation and adhesion. Overall, the piezoelectric/conductive CS/rGO/PLLA nerve conduit shows great promise as a potential treatment of PNI.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114544"},"PeriodicalIF":5.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Droplet capture mechanism and sustainable drug release of a titanium mandibular drug reservoir modified by laser grid texturing and silicone oil heat treatment","authors":"Zhiwen Xiang ,&nbsp;Maoyong Liu ,&nbsp;Shufan Liu ,&nbsp;Chengfeng Sun ,&nbsp;Ping Nie ,&nbsp;Chengdong Wang","doi":"10.1016/j.colsurfb.2025.114552","DOIUrl":"10.1016/j.colsurfb.2025.114552","url":null,"abstract":"<div><div>Customized titanium implants are commonly used for repairing mandibular defects caused by accidents. However, the semi-open nature of the oral environment increases the likelihood of inflammation around the implant, which has a significant impact on the therapeutic outcomes. Most existing research tackles this issue by achieving drug loading through surface modifications to create local drug delivery systems. Nevertheless, several technical challenges remain in constructing effective local drug delivery systems based on the implant structure. In this study, a titanium drug reservoir was designed and fabricated, incorporating laser grid texturing and silicone oil heat treatment. The droplet capture mechanism was analyzed, and the effect of the sustainable release area on droplet motion resistance was evaluated. In vitro antibacterial tests revealed that the modified drug reservoir, characterized by high adhesion and superhydrophobicity, exhibited the most effective sustained release. It had a texturing interval of 500 µm, and the duration of the zone of inhibition was 60 h. This approach presents a new method for fabricating titanium implants integrated with local drug delivery systems, offering significant potential for improved clinical outcomes.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114552"},"PeriodicalIF":5.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143278595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fibrillogenesis influence the binding specificity of collagen to discoidin domain receptor 2 and cell behavior","authors":"Huizhi Kou ,&nbsp;Qingqiu Han ,&nbsp;Chengzhi Xu ,&nbsp;Lixia Liao ,&nbsp;Yuanjing Hou ,&nbsp;Haibo Wang ,&nbsp;Juntao Zhang","doi":"10.1016/j.colsurfb.2025.114554","DOIUrl":"10.1016/j.colsurfb.2025.114554","url":null,"abstract":"<div><div>Collagen is one of the most important natural biopolymers, it plays its role as a load-bearing structure in tissues only after polymerizing into fibrils. DDR2 is a collagen-binding receptor tyrosine kinases, playing a role in the regulation of collagen-cell interactions. Here, we studied the recognition of collagen fibrils by DDR2 and the effect of fibrillogenesis on cell biological activity. Our results showed that for monomeric collagen, the binding affinity of DDR2 to mammalian porcine skin collagen is higher than that to fish collagen. When the assembly of collagen monomers into the collagen fibril, the binding affinity of DDR2 is enhanced. In contrast, the binding ability of the hybrid fibril is stronger than the corresponding black carp skin collagen fibrils, and slightly weaker than corresponding porcine skin collagen fibril. This indicates that the introduction of porcine skin collagen in the co-assembly system can regulate the binding of DDR2 to fish-sourced collagen. We also find that compared to monomers, the fibrillogenesis of collagen promotes cell interaction with the collagen substrate, and has an increased ability to induce cells spreading. Our results confirmed that the physical state of collagen impacts its binding with DDR2 and cell behavior. These findings provide new insights into cell-collagen interactions.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114554"},"PeriodicalIF":5.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of neonicotinoid compounds on the structure and function of Apis mellifera OBP14: Insights from SPR, ITC, multispectroscopy, and molecular modeling","authors":"Xiangshuai Li ,&nbsp;Shiyu Li ,&nbsp;Fangkui Zhao ,&nbsp;Ruohan Fu ,&nbsp;Li Cui ,&nbsp;Shuning Chen ,&nbsp;Daibin Yang ,&nbsp;Huizhu Yuan ,&nbsp;Xiaojing Yan","doi":"10.1016/j.colsurfb.2025.114551","DOIUrl":"10.1016/j.colsurfb.2025.114551","url":null,"abstract":"<div><div>Honeybees are vital for biodiversity and agricultural productivity, yet their populations are declining globally, partly due to exposure to neonicotinoid pesticides. Odorant-binding protein 14 (OBP14) plays an important role in honeybee chemosensation, but its involvement in neonicotinoid toxicity remains underexplored due to limitations in traditional fluorescence spectroscopy techniques. This gap hampers our understanding of neonicotinoid risks to honeybee health. Here, we explored the molecular interactions between OBP14 from <em>Apis mellifera</em> and three widely used neonicotinoids (imidacloprid, thiamethoxam, and clothianidin) using molecular modeling, surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and multispectroscopy. SPR and ITC characterized the binding affinity, specificity, and thermodynamic parameters of AmelOBP14 interacting with three neonicotinoid compounds, revealing that the binding process is spontaneous and primarily driven by hydrophobic and electrostatic interactions. Molecular modeling highlighted that phenylalanine residue Phe54, near the binding site, plays a critical role in these interactions. UV–vis absorption spectroscopy and synchronous fluorescence spectroscopy (SFS) support slight changes in the microenvironment around the aromatic amino acids of OBP14. Fourier Transform Infrared Spectroscopy (FTIR) and circular dichroism spectroscopy (CD) indicate a decrease in the α-helix content of OBP14, suggesting a change in its secondary structure, while three-dimensional (3D) fluorescence spectroscopy confirms the non-fluorescent nature of the OBP14 polypeptide backbone. The study results revealed its potential as a biomarker for pesticide risk assessment, providing important insights into the molecular mechanisms by which neonicotinoids may impair bee chemosensory function, and offering guidance for the design of safer pesticides to minimize harm to these important pollinators.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114551"},"PeriodicalIF":5.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly sensitive quantification of carbon black in lung burden through simplified proteinase K-mediated digestion","authors":"Geunyoung Beak ,&nbsp;Wan-Seob Cho ,&nbsp;Ee Taek Hwang","doi":"10.1016/j.colsurfb.2025.114547","DOIUrl":"10.1016/j.colsurfb.2025.114547","url":null,"abstract":"<div><div>Accurate evaluation and quantification of nanomaterials are crucial in hazard and risk assessment. In this study, we tested simplified proteinase K (PK)-mediated digestion methods via a UV<img>Vis spectrophotometer for sensitive and accurate quantification of carbon black (CB) on the lung burden. We evaluated enzyme activity and digestion efficiency under different buffer conditions for lung burden digestion, focusing on the effects of varying surfactant and calcium chloride concentrations. The most effective conditions for PK characteristics with the model peptide substrate involved the use of Triton X-100, SDS, and CaCl₂. However, better results were observed for lung burden digestion when only SDS-containing media were used. Based on the influence of the interactions between lung burden tissue and PK, we improved the digestion efficiency and catalytic activity of PK. This led to 98 % recovery rates when 10 μg of PK was added to a buffer containing only the SDS surfactant within a 24-hour reaction time. These results demonstrate that the reaction media significantly affects the enzymatic reactions with different substrates. Proper conditions can be challenging to predict or engineer by solely studying the PK enzyme itself. Furthermore, this study provides potential fundamental features for future biomolecule extraction designs and clearance kinetics, utilizing protein digestive enzymatic strategies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114547"},"PeriodicalIF":5.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arginine tagged liposomal carrier for the delivery of celastrol for ferroptosis-induced hepatocellular carcinoma therapy","authors":"Manman Qi ,&nbsp;Kai Zhang ,&nbsp;Xue Zhang ,&nbsp;Yuzhao Zhu ,&nbsp;Banglan Cai ,&nbsp;Chao Wang ,&nbsp;Gang Zhao ,&nbsp;Denghai Zhang ,&nbsp;Jian Zhang","doi":"10.1016/j.colsurfb.2025.114546","DOIUrl":"10.1016/j.colsurfb.2025.114546","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is a predominant malignant liver tumor that cannot be efficiently treated because of poor response, toxicity, and drug resistance. Ferroptosis is an iron-dependent way of cell death associated with abnormal intracellular lipid metabolism. Celastrol (Cel) has the ability to inhibit the progression of HCC by regulating multiple signaling pathways and induce ferroptosis. However, Cel exists the limitations of low water solubility, low oral bioavailability, and high organ toxicity. Cel was encapsulated in polyethylene glycol–based liposomes modified with L-arginine (Cel@Lip-Arg). Cel@Lip-Arg has a uniform size distribution (∼100 nm), high drug loading (80 %), and excellent ability to target liver cancer cells. <em>In vitro</em> experiments demonstrated that Cel@Lip-Arg considerably suppressed the activity of HuH7 (hepatoma) cells but had a negligible effect on L02 (normal) cells. Cel@Lip-Arg induced ferroptosis in hepatoma cells by promoting transferrin receptor expression, inhibiting system xc⁻ and glutathione peroxidase 4, and favoring intracellular peroxide accumulation. <em>In vivo</em> experiments revealed that Cel@Lip-Arg plays a therapeutic role by inducing ferroptosis. Compared to Cel, Cel@Lip-Arg had a higher anti-hepatoma activity and effectively reduced the toxicity of Cel in mice. Cel@Lip-Arg-induced ferroptosis was concluded to be an attractive strategy for the precise treatment of HCC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114546"},"PeriodicalIF":5.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143279173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannose-modified multifunctional iron-based nanozyme for hepatocellular carcinoma treatment by remodeling the tumor microenvironment","authors":"Qi Liu ,&nbsp;Ziwei Liang ,&nbsp;Jiapu Wang ,&nbsp;Yuhui Wang ,&nbsp;Jie Wang ,&nbsp;Shaojie Wang ,&nbsp;Zhi Du ,&nbsp;Liqin Zhao ,&nbsp;Yan Wei ,&nbsp;Di Huang","doi":"10.1016/j.colsurfb.2025.114548","DOIUrl":"10.1016/j.colsurfb.2025.114548","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with conventional treatments often accompanied by severe side effects. Recently, nanozymes have been extensively employed in cancer therapy due to their enhanced enzymatic activities, stability compared to native enzymes. However, a standalone nanozyme exhibits insufficient targeting capability and fails to specifically localize to the pathological site. In this study, we successfully synthesized a multifunctional iron-based-nanozyme delivery system - Fe₃O₄-OA-DHCA-PEI-MAN@DSF modified with PEI and MAN by the thermal decomposition method. This mannose-modified nanozyme can specifically target HCC cells via an external magnetic field and mannose-mannose receptor (MRC2) binding. In addition, it exhibits good biocompatibility and pH-dependent drug release characteristics. Within the acidic tumor microenvironment, the iron-based nanozyme initiates intracellular fenton reactions, boosting reactive oxygen species (ROS) production, which ultimately induces apoptosis in HCC cells. Concurrently, the disulfiram small molecule released from the Fe₃O₄-OA-DHCA-PEI-MAN@DSF nanozyme binds to the FROUNT factor within monocyte-macrophages, thereby inhibiting their response to chemotactic signals emitted by liver cancer cells. This process ultimately suppresses the recruitment of macrophages by HCC cells, reshaping the tumor microenvironment and supporting effective liver cancer treatment. Moreover, this nanozyme system holds potential for MRI-guided targeted chemotherapy combined with chemodynamic therapy, aiming to refine the early diagnosis and precision treatment of hepatic carcinoma, and paving the way for the creation of sophisticated integrated nanoplatforms melding diagnostic and therapeutic functionalities.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114548"},"PeriodicalIF":5.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCL-fibrin-alginate hydrogel based cell co-culture system for improving angiogenesis and immune modulation in limb ischemia","authors":"Gyubok Lee ,&nbsp;Yeong Hwan Kim ,&nbsp;Dongwoo Kim ,&nbsp;Dong-Hyun Lee ,&nbsp;Suk Ho Bhang ,&nbsp;Kangwon Lee","doi":"10.1016/j.colsurfb.2025.114553","DOIUrl":"10.1016/j.colsurfb.2025.114553","url":null,"abstract":"<div><div>Stem cell therapy has demonstrated promise in regenerative medicine due to their ability to differentiate into various cell types and secrete growth factors. However, challenges such as poor survival rate of transplanted cells under ischemic and immune conditions limit its effectiveness. To address these issues, we developed a polycaprolactone (PCL)-fibrin-alginate matrix hydrogel, which combines adipose-derived stem cells and human umbilical vein endothelial cells with a PCL fiber, encapsulated within fibrin and alginate hydrogel to enhance cell survival, proliferation, and immune modulation. This structure offers protection to the encapsulated cells, supports angiogenesis, and modulates the immune response, significantly improving therapeutic outcomes in a mouse model of hindlimb ischemia. Our <em>in vitro</em> and <em>in vivo</em> results demonstrate the scaffold's ability to support cell viability, promote angiogenesis, and modulate inflammatory responses, indicating its potential as a promising platform for ischemic tissue repair and regenerative medicine. This innovative approach to cell-based therapy highlights the importance of scaffold design in enhancing the therapeutic efficacy of stem cell treatments for ischemic diseases.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114553"},"PeriodicalIF":5.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143279174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis","authors":"Haoqiang Lei ,&nbsp;Yipeng Liu ,&nbsp;Jing Li ,&nbsp;Junyuan Chen ,&nbsp;Liji Chen ,&nbsp;Ying Liu ,&nbsp;Hongsheng Liu ,&nbsp;Wenqiang Li ,&nbsp;Zhuofei Jiang ,&nbsp;Zhidong Li ,&nbsp;Xiaohua Su","doi":"10.1016/j.colsurfb.2025.114545","DOIUrl":"10.1016/j.colsurfb.2025.114545","url":null,"abstract":"<div><div>The inflammatory response is the core mechanism of the pathogenesis and symptoms of ulcerative colitis (UC), and inhibiting inflammation is a promising therapeutic approach to improving UC. Curcumin is considered a potential treatment for UC due to its significant anti-inflammatory and antioxidant effects. However, its bioavailability in the post-oral administration is limited. Therefore, the stability, sustained release, and colon targeting of curcumin in the treatment of UC have become a challenge. Herein, curcumin was efficiently filled in the porous structure of University of Oslo 66 (UiO-66). Amino-functionalized UiO-66 (MOF) was bound to hyaluronic acid (HA) via chemical crosslinking and electrostatic interactions. Polydopamine (PDA) layer was then applied to form Cur@MOF@HA-PDA NPs for colon targeting for UC treatment. Cur@MOF@HA-PDA NPs not only enhanced the stability of curcumin but also possessed acid resistance and reactive oxygen species (ROS) responsive properties, enabling it to be effectively delivered to the UC lesion site for curcumin release after oral administration, thereby enhancing the therapeutic effect. <em>In vitro</em> studies revealed that Cur@MOF@HA-PDA NPs possessed the ability to eliminate intracellular ROS, inhibit inflammatory (M1) polarization, and promote anti-inflammatory (M2) polarization. Additionally, <em>in vivo</em> experiments demonstrated that Cur@MOF@HA-PDA NPs could effectively alleviate the intestinal inflammatory symptoms of UC mice, promoting intestinal tissue repair. Furthermore, it was also confirmed that Cur@MOF@HA-PDA NPs achieved the treatment of UC by inhibiting inflammatory responses, modulating intestinal immune functions, and promoting the polarization of M2 macrophages. In short, Cur@MOF@HA-PDA NPs, as colon-targeted drug delivery nanosystems, offer a promising therapeutic strategy for the treatment of UC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114545"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet membrane-cloaked biomimetic nanoparticles for targeted acute lung injury therapy","authors":"Peihong Lin ,&nbsp;Rui Gao ,&nbsp;Wenjing Yang ,&nbsp;Zhengyu Fang ,&nbsp;Zhouru Wang ,&nbsp;Mengdie Yu ,&nbsp;Lihua Xu ,&nbsp;Zhen Ma ,&nbsp;Jie Fang ,&nbsp;Wenying Yu","doi":"10.1016/j.colsurfb.2025.114542","DOIUrl":"10.1016/j.colsurfb.2025.114542","url":null,"abstract":"<div><div>Acute lung injury (ALI) is a medical condition characterized by significant morbidity and elevated mortality rates; however, to date, there are no clinically approved pharmacological interventions that are both safe and effective for its treatment. In the pathophysiology of ALI, a robust inflammatory response is a critical factor. Dexamethasone (Dex), a potent glucocorticoid, is commonly employed in clinical settings to manage inflammatory conditions. However, the frequent or high-dose administration of corticosteroids can result in significant adverse effects and long-term complications. In this study, we have developed a biomimetic anti-inflammatory nanosystem, designated PM-LPs@Dex, aimed at treating ALI. This system leverages the inherent affinity of platelets for sites of inflammation, alongside the advantageous drug encapsulation properties of liposomes (LPs). By harnessing the suitable physicochemical characteristics of LPs and the distinctive biological functions of platelet membranes (PM), PM-LPs@Dex is capable of stable and sustained drug release in vitro. Experimental results regarding cellular uptake and biodistribution reveal that PM-LPs@Dex is preferentially internalized by inflammatory cells and exhibits enhanced accumulation in inflamed lung tissue compared to LPs@Dex. Pharmacokinetic studies displayed that PM-LPs@Dex showed prolonged circulation time in blood. Additionally, pharmacodynamic assessments demonstrate that PM-LPs@Dex significantly mitigates the severity of ALI, as evidenced by reductions in pulmonary edema, tissue pathology, bronchoalveolar lavage cell counts, protein concentration, and levels of inflammatory cytokines. Notably, PM-LPs@Dex also exhibits favorable biocompatibility. This research is anticipated to contribute novel strategies for the safe and effective targeted management of inflammatory diseases.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"250 ","pages":"Article 114542"},"PeriodicalIF":5.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}