Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Dual-mode sensors based on double enzyme-mimicking MnCu nanoflowers as fluorescence probe for the detection of organophosphorus pesticides and 2,4-dichlorophenol","authors":"Ziyu Yan ,&nbsp;Ziwen Liao ,&nbsp;Zhengyue Xiao ,&nbsp;Yining Zhang ,&nbsp;Huajie Peng ,&nbsp;Jiali Zhong ,&nbsp;Zhuo Li ,&nbsp;Peng Xu ,&nbsp;Ping Qiu","doi":"10.1016/j.colsurfb.2025.114608","DOIUrl":"10.1016/j.colsurfb.2025.114608","url":null,"abstract":"<div><div>Organophosphorus pesticides (OPs) and 2,4-dichlorophenol (2,4-DP) are widely used, but their residues have brought serious threatens to environment and human health as environmental pollutants. We synthesized double enzyme-mimicking and multifunctional MnCu flower-like nanoenzymes (NH₂-MnCu NFs) with fluorescence properties, oxidase (OXD)-like activity and laccase-like activity. NH₂-MnCu NFs exhibit excitation-independent emission fluorescence properties, as well as excellent OXD-like activity (<em>K</em>_<em>m</em> = 0.230 mM, <em>V</em>_<em>max</em> = 2.46 × 10⁻⁶ M/s) and laccase-like activity (<em>K</em>_<em>m</em> = 0.186 mM, <em>V</em>_<em>max</em> = 3.46 × 10⁻² mM/min). The mechanism of 2,3-diaminophenazine (DAP)-induced quenching of the fluorescence of NH₂-MnCu NFs was thoroughly investigated, revealing that it results from the combined effects of the internal filtering effect (IFE), dynamic quenching effect (DQE), and static quenching effect (SQE). It was found that -SH could disrupt the OXD-like activity of NH₂-MnCu NFs according to morphological and structural perspectives using SEM and in situ Raman spectroscopy. Based on OXD-like activity, ratiometric fluorescence and colorimetric dual-mode sensor was constructed for the detection of OPs. Additionally a colorimetric fluorescence dual-mode sensor was proposed for the specific detection of 2,4-DP with the use of laccase-like activity of the material. Two sensors were constructed using a single type of nanoenzyme, leveraging their dual-enzyme activities for the detection of OPs and 2,4-DP, respectively. This approach expands the potential applications of nanoenzymes and provides versatile scenarios for their multifunctional use.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114608"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional semi-interpenetrating polymer network hydrogel dressing for wound healing","authors":"Ning Sun ,&nbsp;Jiaxin Zhu ,&nbsp;Yuzhu Li ,&nbsp;Fangfang Hu ,&nbsp;Jianguo Dong ,&nbsp;Shengjie Shen ,&nbsp;Xiaohua Xu ,&nbsp;Xiaoma Cao ,&nbsp;Zheng Zhou ,&nbsp;Hai Ming Wong ,&nbsp;Leping Wu ,&nbsp;Quan-Li Li","doi":"10.1016/j.colsurfb.2025.114616","DOIUrl":"10.1016/j.colsurfb.2025.114616","url":null,"abstract":"<div><div>Hydrogels have exhibited significant application potential in the field of new wound dressings due to their unique physicochemical properties and biological functions. However, traditional hydrogels possess limitations regarding mechanical properties, adhesion, and the promotion of wound healing. Herein, a multifunctional polyvinyl alcohol-tannic acid/polyacrylamide-polydopamine (PVA-TA/PAM-PDA) hydrogels are developed. By combining an amide-rich crosslinked polyacrylamide (PAM) network with a hydroxyl-rich linear polyvinyl alcohol (PVA) structure, a semi-interpenetrating polymer network (semi-IPN) is formed, which serves as a scaffold to enhance mechanical properties. The incorporation of tannic acid (TA) and polydopamine (PDA) into the semi-IPN framework can enhance cell affinity and tissue adhesiveness. This multifunctional composite hydrogel demonstrates outstanding physical and mechanical properties, including excellent elasticity and toughness, stable rheological properties, and favorable swelling properties. It also exhibits strong adhesive properties to various materials and skin, and can promote tissue regeneration and wound healing. This study offers novel ideas for the development and application of multifunctional composite hydrogel wound dressings, and the PVA-TA/PAM-PDA hydrogel shows great promise for clinical applications as an innovative wound dressing.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114616"},"PeriodicalIF":5.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of hydrophilic residues in the transmembrane region on lipid scrambling activity of dimeric helices","authors":"Hiroyuki Nakao ,&nbsp;Toshiki Tsujii ,&nbsp;Hiroaki Saito ,&nbsp;Keisuke Ikeda ,&nbsp;Minoru Nakano","doi":"10.1016/j.colsurfb.2025.114612","DOIUrl":"10.1016/j.colsurfb.2025.114612","url":null,"abstract":"<div><div>Phospholipid scramblases promote lipid transbilayer movement (flip-flop) in the plasma membrane, which is involved in a wide range of cellular functions, such as phagocytosis and blood coagulation. One structural characteristic of scramblases and model lipid scrambling peptides is the presence of hydrophilic residues in their transmembrane domains. These hydrophilic regions are considered the active sites through which lipid polar headgroups pass during the translocation process. However, how the structural arrangement of hydrophilic residues results in strong lipid scrambling activities in scramblases needs to be investigated, because the effects of a single hydrophilic residue on lipid scrambling are much lower than the activity of natural scramblases. Here, we developed double-spanning transmembrane peptides containing varying numbers of Gln residues. A combination of lipid vesicle experiments and molecular dynamics simulations indicates that lipid scrambling activities are synergistically enhanced by the proximity between planes created by Gln residues aligned parallel to the helix and that interactions between Gln and Trp residues stabilize the strongly active structures. The contribution of Gln residues to lipid scrambling activity suggests that the alignment and proximity of hydrophilic residues in the transmembrane region is one of the mechanisms of lipid scrambling by natural scramblases. This study provides clues for the energetic and structural mechanisms of lipid scrambling and for the design of artificial phospholipid scramblases.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114612"},"PeriodicalIF":5.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed gelatin/dialdehyde starch hydrogels for hydrocortisone topical administration and in vivo treatment of atopic dermatitis","authors":"Andressa B. Nörnberg ,&nbsp;Matheus S. Gularte ,&nbsp;Caren A.R. da Fonseca ,&nbsp;Daniel E.J.M. San José ,&nbsp;Ethel A. Wilhelm ,&nbsp;André R. Fajardo","doi":"10.1016/j.colsurfb.2025.114613","DOIUrl":"10.1016/j.colsurfb.2025.114613","url":null,"abstract":"<div><div>Atopic dermatitis (AD) is a chronic disorder affecting millions worldwide. Recent advancements suggest that combining therapies can significantly improve AD treatment outcomes and mitigate the challenges of long-term drug use, particularly with corticosteroids. In this study, we developed a 3D-printed hydrogel composed of gelatin (Gel) and dialdehyde starch (DAS), capable of encapsulating and delivering hydrocortisone (HC). DAS was synthesized via an oxidation reaction, introducing aldehyde groups that facilitated hydrogel formation with Gel through imine bond formation (Schiff base reaction). By adjusting the Gel/DAS ratio, we formulated inks with suitable rheological properties for extrusion-based 3D printing, an approach not yet fully exploited in this context. The resulting Gel/DAS network successfully encapsulated HC, as demonstrated by characterization analyses. The printed hydrogel exhibited a well-defined microstructure, significant water absorption and retention capabilities, and excellent stability. HC release followed a controlled mechanism consistent with Korsmeyer-Peppas kinetics. In an in vivo model, the 3D-printed hydrogel containing HC showed therapeutic efficacy comparable to conventional HC treatments in alleviating AD symptoms in mice. Additionally, the hydrogel significantly reduced myeloperoxidase (MPO) activity and increased non-protein thiol (NPSH) levels in the dorsal skin of DNCB-exposed mice, underscoring its therapeutic potential.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114613"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating strategies for creating cross-linked amyloid fibril networks through branching of amyloid growth","authors":"William P. Olsen ,&nbsp;Anne-Kathrine K. Larsen ,&nbsp;Jakob L. Christensen ,&nbsp;Mette G. Malle ,&nbsp;Daniel E. Otzen","doi":"10.1016/j.colsurfb.2025.114617","DOIUrl":"10.1016/j.colsurfb.2025.114617","url":null,"abstract":"<div><div>Hydrogel biomaterials have been extensively explored for applications in medicine, materials science, and the development of functionalized materials. Traditionally, hydrogels were produced using simple polymers, but advancements over recent decades have enabled the use of biological materials such as proteins, peptides, polysaccharides, and even amyloid fibrils. Among these, amyloid-based hydrogels have demonstrated unique advantages, including enhanced cell adhesion and differentiation. Furthermore, they can be engineered as living materials using bacteria capable of producing and repairing the hydrogel <em>in situ</em>. Here we investigate novel strategies for controlling amyloid fibrillation using the functional amyloid CsgA. We designed fusion proteins combining two CsgA moieties to explore methods for creating branched fibril networks. Our approach utilized two distinct strategies: passive and active branching. The passive strategy involved direct fusion of two CsgA moieties separated by a designed alpha-helical linker and engineered to integrate into fibrils without external intervention. The active branching approach incorporated a redox-sensitive CsgA variant containing an internal disulfide bridge that blocks fibrillation until reduced. This design allows for precise control of amyloid fibrillation in the active variants. We analyzed these constructs qualitatively approach using a combination of transmission electron microscopy (TEM), real-time atomic force microscopy (AFM), and total internal reflection fluorescence (TIRF) microscopy, supported by quantitative image analysis. While we did not observe direct evidence of fibril branching, our modifications led to significant changes in fibrillation behavior. Notably, TIRF imaging revealed a marked increase in high-density fibril regions following the activation of our engineered constructs, indicating the potential for controlled assembly of higher-order structures. These findings provide new insights into controlling amyloid fibrillation and suggest alternative strategies for manipulating fibril organization. The observed ability to alter local fibril density through chemical triggers offers promising directions for developing responsive biomaterials. We propose refinements for future design and suggest new directions to optimize amyloid-based hydrogels for next-generation biomaterial applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114617"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth","authors":"Phanindra Babu Kasi ,&nbsp;Henry Opoku ,&nbsp;Liudmila N. Novikova ,&nbsp;Mikael Wiberg ,&nbsp;Paul J. Kingham ,&nbsp;Jia Wang ,&nbsp;Lev N. Novikov","doi":"10.1016/j.colsurfb.2025.114609","DOIUrl":"10.1016/j.colsurfb.2025.114609","url":null,"abstract":"<div><div>Quercetin, a flavonoid known for its antioxidant properties, has recently garnered attention as a potential neuroprotective agent for treatment of the injured nervous system. The repair of peripheral nerve injuries hinges on the proliferation and migration of Schwann cells, which play a crucial role in supporting axonal growth and myelination. In this study we synthesized Quercetin-derived carbon dots (QCDs) and investigated their effects on cultured Schwann cells and the NG108-15 cell line. QCDs was obtained by solvothermal synthesis and characterized via UV–vis absorption spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis. The particles demonstrated significant dose-dependent free radical scavenging activity in DPPH and ABTS radical scavenging assays, supported in vitro proliferation and migration of Schwann cells, expression of neurotrophic and angiogenic growth factors, and stimulated neurite outgrowth from NG108-15 cells. Thus, QCDs could serve as a potential novel treatment strategy to promote regeneration in the injured peripheral nervous system.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114609"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A glycopeptide-based pH-responsive hydrogel promotes diabetic wound healing via antimicrobial and remodeling microenvironment","authors":"Hailong Xie ,&nbsp;Shibo Tian ,&nbsp;Chao Cui ,&nbsp;Chenglu Sun ,&nbsp;Yi Hu ,&nbsp;Chuang Tang ,&nbsp;Dengfeng Gao ,&nbsp;Lu Lu ,&nbsp;Long Jin ,&nbsp;Funeng Xu ,&nbsp;Juchun Lin ,&nbsp;Hualin Fu ,&nbsp;Xiaoxia Liang ,&nbsp;Ling Zhao ,&nbsp;Fanli Kong ,&nbsp;Xiaoyuan Wei ,&nbsp;Wei Sun ,&nbsp;Mingzhou Li ,&nbsp;Haohuan Li","doi":"10.1016/j.colsurfb.2025.114614","DOIUrl":"10.1016/j.colsurfb.2025.114614","url":null,"abstract":"<div><div>Treating bacterium-infected diabetic wounds remains a major medical challenge. Antimicrobial activity, remodeling of oxidative stress-heavy and angiogenesis-impaired microenvironments are critical factors for effective wound healing. Hydrogels can function as drug delivery systems that encompass all these capabilities to enhance wound healing. In this study, we developed a glycopeptide-based hydrogel (DA/bF@OD-PL) composed of oxidized dextran (OD), polylysine (PL), dopamine (DA), and basic fibroblast growth factor (bF). This hydrogel exhibits excellent structural integrity, injectability, adhesion properties, swelling capacity, and degradability. Notably, the hydrogel is responsive to acidic conditions due to the presence of Schiff base bonds, enabling it to respond to the acidic environment characteristic of bacterium-infected wounds and release its encapsulated drugs accordingly. Among these components, PL has a strong antibacterial effect and can easily kill <em>S. aureus</em> and <em>E. coli</em>. DA effectively scavenges multiple reactive oxygen species (ROS) and induces macrophage polarization to M2 macrophages to alleviate oxidative stress. bF upregulates the expression of CD31 and vascular endothelial growth factor (VEGF) to promote angiogenesis. Finally, we validated the ability of this hydrogel to promote rapid wound healing in an <em>S. aureus</em>-infected diabetic mouse wound model.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114614"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled-release of cinnamaldehyde from MXene/ZIF8/gelatin composite coatings: An integrated strategy to combat implant-associated infection","authors":"Jiaxin Guan ,&nbsp;Xiaofeng Wang ,&nbsp;Zitong Tian ,&nbsp;Fengzhen Jia ,&nbsp;Jiali Wang ,&nbsp;Lei Xie ,&nbsp;Jinping Lan ,&nbsp;Pengde Han ,&nbsp;He Lin ,&nbsp;Xiao Huang ,&nbsp;Meiyu Li ,&nbsp;Yong Huang","doi":"10.1016/j.colsurfb.2025.114615","DOIUrl":"10.1016/j.colsurfb.2025.114615","url":null,"abstract":"<div><div>Infections and chronic inflammation surrounding titanium implants frequently impair angiogenesis and osseointegration, substantially heightening the risk of implant failure. In this study, titanium dioxide nanotube arrays (TN) were fabricated on titanium metal substrates to serve as reservoirs for cinnamaldehyde (CA). Subsequently, MXene and ZIF-8 were deposited onto the TN surface to seal the nanotube pores. Finally, the gelatin methacrylate (GelMA) hydrogel system was utilized as a nanoparticle-controlled release platform to construct the Gel@MX-ZIF8/CA functional integrated coating. The results demonstrated that the Gel@MX-ZIF8/CA coating exhibited optimized roughness, improved hydrophilicity, and superior bioactivity. Furthermore, the Gel@MX-ZIF8/CA coating exhibited robust antibacterial efficacy against <em>Escherichia coli</em> (<em>E. coli</em>) and <em>Staphylococcus aureus</em> (<em>S. aureus</em>). At the cellular and molecular levels, Gel@MX-ZIF8/CA modulated mouse macrophage cells (RAW264.7) polarization toward the M2 phenotype, enhanced human umbilical vein endothelial cell (HUVEC) angiogenesis, and facilitated the osteogenic differentiation of mouse embryo osteoblast precursor cell (MC3T3-E1). In vivo studies using a rat bone defect model highlighted the coating's strong anti-inflammatory, antibacterial, angiogenic, and osteogenic capabilities of Gel@MX-ZIF8/CA. Additionally, Gel@MX-ZIF8/CA exhibited excellent blood compatibility and biosafety. In conclusion, the Gel@MX-ZIF8/CA coating integrated multiple advantages, offering significant potential in addressing orthopedic implant-associated infections and bone defects.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114615"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoelectric activity of titania nanotube by dimensionality control for neural-stimulated osteoblast activation","authors":"Kai Li ,&nbsp;Xinwei Zhang ,&nbsp;Jieping Li ,&nbsp;Xuebin Zheng","doi":"10.1016/j.colsurfb.2025.114619","DOIUrl":"10.1016/j.colsurfb.2025.114619","url":null,"abstract":"<div><div>Simultaneous bone and nerve regeneration is important in facilitating osseointegration. However, regeneration of neural elements is often overlooked when designing orthopedic implants. Since nerves are electroactive tissues that regulate bone formation via neuropeptide release, developing photoelectric coating material on implants is optimal for neural-stimulated osteoblast activation. In this study, three kinds of vertically oriented TiO₂ nanotube (TNT) coatings with tube diameter of 60, 110 and 180 nm were fabricated on Ti implants denoting as TNT-60, TNT-110 and TNT-180, respectively. TNT-60 coating with higher oxygen-vacancy concentration and lower crystallinity displayed higher visible-light absorption capacity and transient photocurrent density. Enhanced photoelectric activity of TNT-60 was ascribed to narrowed bandgap of TiO₂ and enhanced separation efficiency of photogenerated carriers. TNTs coatings under visible-light irradiation significantly improved proliferation of PC12 cells and cell differentiation in terms of neurite outgrowth and calcitonin gene-related peptide release. Among them, TNT-60 coating exerted the greatest enhancement via Ca^2 + influx mechanism. Osteoblast differentiation and mineralization of MC3T3-E1 cells were significantly enhanced when cells were cultured with conditioned medium from PC12 cells cultured on the TNTs coatings with visible-light illumination. This indicated neural-stimulated osteoblast activation. Above all, photoelectric TNT coating provides a promising approach for targeting nerve activation to stimulate osteogenesis.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114619"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterial-based drug delivery strategies for oral mucosa","authors":"Junhui Liu ,&nbsp;Jiao Sun ,&nbsp;Jun Hu ,&nbsp;Huaqian Xue ,&nbsp;Lanjie Lei ,&nbsp;Xiaoyi Pan","doi":"10.1016/j.colsurfb.2025.114604","DOIUrl":"10.1016/j.colsurfb.2025.114604","url":null,"abstract":"<div><div>Drug therapy is a key field in modern medicine, and the optimization of its delivery method is crucial. Traditional methods are inherently limited by first-pass effects, high-risk adverse reactions, and patient compliance challenges, which significantly restrict the effectiveness and application potential of drugs. Oral mucosal drug delivery has become a minimally invasive and effective drug delivery strategy. The unique anatomical structure of the oral mucosa facilitates the rapid absorption of drugs into the systemic circulation, thus producing rapid therapeutic effects. However, a complex oral microenvironment and mucosal barrier impede drug absorption. Biomaterials have become an important driving force for the innovative development of oral medicine, owing to their unique and excellent properties. They are widely used for preventing, diagnosing, treating, and rehabilitating oral diseases. This review explores recent advancements in biomaterial-enabled oral mucosal drug delivery systems, analyzing key physiological factors and absorption barriers that impact therapeutic outcomes. Focusing on innovative material engineering strategies highlights significant progress in extending drug residence time and improving delivery precision within the oral cavity. Furthermore, the study identifies critical challenges in translating these advancements from research to clinical practice, emphasizing the need for solutions to bridge this gap.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"251 ","pages":"Article 114604"},"PeriodicalIF":5.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}