Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Mechanically robust zwitterionic hydrogel coating reinforced by microgels for antibacterial and anticoagulant applications","authors":"Haiyang Chai ,&nbsp;Kai Cheng ,&nbsp;Jiru Miao ,&nbsp;Longxing Niu ,&nbsp;Xiao Cen ,&nbsp;Ying Xiao ,&nbsp;Feiyu Chen ,&nbsp;Rong Wang","doi":"10.1016/j.colsurfb.2026.115422","DOIUrl":"10.1016/j.colsurfb.2026.115422","url":null,"abstract":"<div><div>Nosocomial infections and thrombosis associated with implantable medical devices have emerged as increasingly critical clinical challenges. Antifouling hydrogels, owing to their biocompatibility and highly hydrophilic surfaces, have garnered significant attention as a promising strategy to mitigate these complications. However, conventional hydrogels often suffer from poor mechanical strength due to their high-water content and the absence of efficient energy dissipation mechanisms, leading to weak adhesion to underlying substrates and potential detachment under physiological conditions. In this study, vinyl-functionalized poly(<em>N</em>-isopropylacrylamide-<em>co</em>-acrylic acid) microgels were incorporated into polysulfobetaine hydrogel networks to overcome these limitations. The microgels enhanced the crosslinking density to improve the mechanical strength of the hydrogels, acted as sacrificial bonds for energy dissipation, and functioned as carriers for antibacterial agents. The polysulfobetaine hydrogel coating effectively reduced the friction coefficient and significantly improved antibacterial and anti-platelet adhesion performance. Moreover, antimicrobial-loaded microgels imparted the hydrogel coating with enhanced antibacterial functionality. The <em>in vivo</em> anticoagulant performance of the hydrogel-coated catheter was validated through implantation into the external jugular vein of rabbits, confirming its therapeutic potential. This multifunctional hydrogel coating strategy presents a promising avenue for the development of mechanically robust, antibacterial, and anticoagulant surface modifications for implantable biomedical devices.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115422"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-modal GSH depletion and NIR-triggered nanoplatform for cascade-amplified phototherapy","authors":"Shuang Liu ,&nbsp;Xingyu Chen ,&nbsp;Xiaojin Liu ,&nbsp;Hao Zhang ,&nbsp;Keyue Zhou ,&nbsp;Yuting Shan ,&nbsp;Minghui Chen ,&nbsp;Dan Wang ,&nbsp;Guohui Cheng","doi":"10.1016/j.colsurfb.2026.115461","DOIUrl":"10.1016/j.colsurfb.2026.115461","url":null,"abstract":"<div><div>In tumor phototherapy, the intracellular antioxidant defenses, such as high concentrations of glutathione (GSH) and inefficient generation of reactive oxygen species (ROS) significantly restrict the therapeutic efficacy. In this research, we construct a dual-modal GSH depletion and near-infrared (NIR)-triggered nanoplatform (Ce6@CDP) for cascade-amplified photothermal therapy (PTT) and photodynamic therapy (PDT). This nanoplatform featured a hollow mesoporous copper sulfide (CuS) core loaded with Ce6 and encapsulated by a disulfide bond-containing polymer (DS-ANPA-PEG). Upon tumor accumulation, the polymer DS-ANPA-PEG reacts with intracellular GSH to form highly reactive quinone methides (QMs), enabling rapid GSH depletion through alkylation. This dual GSH depletion ‌intensifies oxidative stress, potentiating Ce6-based PDT efficacy. Additionally, the CuS carrier exhibits high photothermal conversion performance (η = 39.68 %), enabling‌ PTT under 808 nm laser irradiation ‌for‌ synergistic tumor eradication. Both <em>in vitro</em> and <em>in vivo</em> studies ‌demonstrate that the PDT/PTT combination therapy ‌significantly‌ inhibits tumor growth while maintaining‌ negligible systemic toxicity. Our findings provide a rational design strategy for developing‌ tumor-microenvironment-responsive multimodal nanoplatforms.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115461"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc oxide quantum dots enhanced growth performance and zinc metabolism in weaned piglets","authors":"Xin Li ,&nbsp;Jintao Wang ,&nbsp;Chen Liang ,&nbsp;Wei Fan ,&nbsp;Wenshuang Chen ,&nbsp;Bing Wu ,&nbsp;Liu Chen ,&nbsp;Daiwen Chen ,&nbsp;Aimin Wu ,&nbsp;Xianxiang Wang","doi":"10.1016/j.colsurfb.2026.115456","DOIUrl":"10.1016/j.colsurfb.2026.115456","url":null,"abstract":"<div><div>The widespread use of conventional high-dose zinc oxide (ZnO) for diarrhea prevention and growth promotion in weaned piglets carries risks of toxicity, bacterial resistance, and environmental harm. This study assessed zinc oxide quantum dots (ZnO-QDs) as a safer, effective alternative. In vitro antibacterial tests demonstrated that, at the same dosage, ZnO-QDs exhibited superior antimicrobial activity compared to conventional ZnO. Subsequent animal trials were conducted using 192 weaned piglets (Duroc × Landrace × Yorkshire; age=21d old; BW=7.70 ± 0.20 kg), which were randomly assigned to four dietary treatment groups (CON, 2-ZnO, 1-ZnO-QDS and 0.5- ZnO-QDS) in a completely randomized design. Results showed that, comparable under the present conditions, lower doses of ZnO-QDs (500 mg/kg, 0.5- ZnO-QDS) provide growth and anti-diarrheal benefits equal to higher doses of conventional ZnO (2000 mg/kg, 2-ZnO) (<em>P</em> &gt; 0.05). ZnO-QDs upregulated jejunal <em>ZIP-1, ZIP-5, ZIP-9</em> and <em>ZIP-13</em> gene expression (<em>P</em> &lt; 0.05) for zinc transport and increase total antioxidant capacity in serum (<em>P</em> &lt; 0.01). Importantly, it also improved intestinal health, as evidenced by increased villus height in the duodenum (<em>P</em> &lt; 0.05) and modulation of gut microbiota composition. Substituting conventional ZnO with 500 mg/kg ZnO-QDs could effectively promote piglet growth and reduce diarrhea, while decreasing zinc emissions and environmental impact.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115456"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental mesenchymal stem cell-derived exosomes for oral diseases: Classification, functionalization and clinical prospects","authors":"Yuxuan Teng ,&nbsp;Qijing Yang ,&nbsp;Yang Zhao ,&nbsp;Lingao Zhu ,&nbsp;Bingwen Zhong ,&nbsp;Bowei Wang ,&nbsp;Zhihui Liu","doi":"10.1016/j.colsurfb.2026.115431","DOIUrl":"10.1016/j.colsurfb.2026.115431","url":null,"abstract":"<div><div>The conventional therapeutic approaches for oral diseases primarily encompass dental restoration, pulp therapy, and maxillofacial surgical interventions. However, these methods are difficult to promote tissue regeneration and immune regulation. Mesenchymal stem cell-derived exosomes (MSC-Exos), mainly derived from tissues such as bone marrow, umbilical cord blood, umbilical cord, placenta, and fat, have been used to study the treatment of oral diseases. Conventional MSCs-Exos have relatively low immunogenicity and ethical issues, but exosomes derived from dental mesenchymal stem cells (DSCs) not only have abundant sources but also lower immunogenicity, which can circumvent ethical restrictions. This review aims to comprehensively investigate the isolation and characterization methods of exosomes derived from dental-derived mesenchymal stem cells (DSC-Exos) as well as their sources and biological properties. It further reviews recent advances in their application within the field of stomatology and summarizes various material-based delivery systems for exosomes. Particular emphasis is placed on their therapeutic potential in inflammatory conditions such as pulpitis, periodontitis, temporomandibular joint disorders, and immune-related diseases, as well as the application prospects of inducing cell directional differentiation in pulp-dentin complex regeneration, jawbone repair, and soft tissue regeneration. In addition, we have reviewed here some possible applications of DSC-Exos to prevent orthodontic relapse and treat oral cancer. The DSC-Exos play multiple roles, including anti-inflammatory activity, immunomodulatory effect, and tissue regeneration, and have a great potential in the clinical treatment of oral inflammation, tissue defects, and immune dysregulation. Their therapeutic efficacy could also be improved by combining them with other biomaterials.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115431"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegetable-inspired biomimetic surfaces for preventing Escherichia coli binding in the food industry","authors":"Fábio M. Carvalho ,&nbsp;Marta Lima ,&nbsp;Iffat Shahzad ,&nbsp;Kathryn A. Whitehead ,&nbsp;Luciana C. Gomes ,&nbsp;Filipe J. Mergulhão","doi":"10.1016/j.colsurfb.2026.115435","DOIUrl":"10.1016/j.colsurfb.2026.115435","url":null,"abstract":"<div><div>Pathogen contamination of food contact surfaces poses serious public health and economic risks. Bacterial binding to these surfaces enhances microbial resistance to cleaning and disinfection, thus requiring novel antifouling strategies. This study explored a biomimetic approach to surface engineering by replicating the microtopographies of four plant leaves – Tenderheart (TH), Cauliflower (CF), White Cabbage (WC) and Leek (L) – onto wax and silicone substrates, aiming to reduce <em>Escherichia coli</em> binding. The biomimetic surfaces were fabricated using a moulding technique and characterized for topography (Optical Profilometry and Scanning Electron Microscopy), wettability (Water Contact Angle), and surface chemistry (Raman Spectroscopy), before and after conditioning with a casein film. Antifouling performance was evaluated through spray-and-wash (Attachment) and 1-hour static immersion (Retention) assays. All biomimetic surfaces exhibited significantly higher roughness and lower wettability than the flat controls. Silicone biomimetic surfaces, being less wettable, generally outperformed the wax surfaces, reducing bacterial attachment by up to 88 % (CF) and retention by up to 82 % (WC). The L topography consistently demonstrated strong anti-binding activity against <em>E. coli</em> attachment, whereas the WC surface proved particularly effective in reducing bacterial numbers in retention assays. Although conditioning the surfaces with casein partially masked the surface features and increased their wettability, silicone biomimetic surfaces (WC and L) maintained a significant antifouling efficacy (up to 90 % reduction). Overall, higher roughness and low wettability synergistically hindered bacterial colonization. These findings support the potential of nature-inspired surfaces as a promising strategy to minimize bacterial contamination in food processing equipment.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115435"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug delivery system based on the novel acidic self-assembling peptide hydrogels: Insights into N-terminal modulation, assembly mechanism, and applications","authors":"Yang Guo ,&nbsp;Yang Deng ,&nbsp;Wei Huang ,&nbsp;Liang Song ,&nbsp;Pengxin Jia ,&nbsp;Cungang Gao ,&nbsp;Fei Xu ,&nbsp;Wenshuai Liu ,&nbsp;Rui Nian","doi":"10.1016/j.colsurfb.2026.115451","DOIUrl":"10.1016/j.colsurfb.2026.115451","url":null,"abstract":"<div><div>Self-assembling peptide hydrogels show considerable promise as drug delivery platforms. However, their application in the gastrointestinal tract is hindered by pepsin-induced degradation and inadequate pH-responsiveness. Herein, this study systematically investigates the regulatory role of N-terminal appended residues in modulating the solubility, self-assembly, and physicochemical properties of (RADA)₄ peptides. The X(RADA)₄ variants (X = G/S/A/M/Q/D) formed nanofibrous hydrogels at pH 1.2, characterized by a typical β-sheet secondary structure. Notably, their fiber diameters and thermal stability varied significantly depending on the specific N-terminal residue, with fiber diameters ranging from 5.0 to 10.6 nm and melting temperature (<em>T</em>_<em>m</em>) ranging from 42.1 to 71.5 °C respectively. In contrast, the X(RADA)₄ variants with X = C or H lacked β-sheet structures and failed to assemble into hydrogels. Among all variants, G(RADA)₄ was identified as the optimal candidate, exhibiting high-yield production (25.9 mg/L, 70.6 % recovery rate) and exceptional acid and pepsin-resistance at pH 1.2 over 14 days, rendering them suitable as oral carriers for sulfasalazine and insulin in simulated gastrointestinal environments. At gastric pH 2.0, less than 5 % of sulfasalazine was released within the initial 2 h, whereas intestinal pH 7.2 triggered 70 % release over 24 h. Insulin exhibited analogous pH-dependent release with less than 10 % release at pH 2.0 and 75 % release at pH 7.2. Transmission electron microscopy and cryo-scanning electron microscopy analysis revealed that pH-mediated disassembly of nanofibers and loss of porous architecture, transitioning from entangled fibers at pH 2.0 to aggregated short fibers at pH 7.2, accounted for the pH-responsive release behavior of the encapsulated drugs. In conclusion, the acid-stable G(RADA)₄ hydrogel system minimized gastric drug loss and enabled targeted intestinal delivery, highlighting its significant potential in gastrointestinal drug delivery.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115451"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mn-incorporated porphyrinic metal-organic framework with near-infrared light responsive photothermal effect and intrinsic ROS scavenging ability for promoted healing of bacteria-infected wounds","authors":"Haihan Song,&nbsp;Mengli Zhang,&nbsp;Zhefeng Qian,&nbsp;Zhengwei Mao,&nbsp;Weijun Tong","doi":"10.1016/j.colsurfb.2026.115460","DOIUrl":"10.1016/j.colsurfb.2026.115460","url":null,"abstract":"<div><div>Photothermal nanomaterials constitute a promising platform for a broad spectrum of antimicrobial applications. However, the efficacy of photothermal therapy alone is often compromised by associated thermal stress, which elevates mitochondrial reactive oxygen species (ROS) production. The bacterial lysis can also release endotoxins to exacerbate oxidative stress and impede wound healing. Herein, we develop a Mn-incorporated porphyrinic metal–organic framework (Mn@PCN-224). Beyond the previously reported ROS scavenging abilities, it demonstrates outstanding near-infrared responsive photothermal conversion with a photothermal conversion efficiency of 34.1 %. Experimental results and theoretical calculations indicate the incorporation of Mn enhances light absorption, suppresses electron-hole recombination, forms sub-gap transitions and narrows the band gap. Moreover, Mn@PCN-224 exhibits intrinsic superoxide dismutase-like and catalase-like activities unaffected by light exposure, enabling effective scavenging of excess ROS to alleviate inflammation. In the <em>Staphylococcus aureus</em>-infected mouse wound model, Mn@PCN-224 not only eradicates bacteria but also accelerates healing by reducing inflammation, promoting collagen deposition, and stimulating angiogenesis. This synergistic antibacterial and anti-inflammatory therapeutic strategy offers a promising therapeutic paradigm for bacteria-infected wounds.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115460"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-assisted ratiometric surface-enhanced Raman scattering for reliable creatinine quantification in serum","authors":"Dechan Lu ,&nbsp;Xiaoqi Zhou ,&nbsp;Dandan Su ,&nbsp;Jundong Li ,&nbsp;Huizhen Lin ,&nbsp;Rongmao Qiu","doi":"10.1016/j.colsurfb.2026.115454","DOIUrl":"10.1016/j.colsurfb.2026.115454","url":null,"abstract":"<div><div>Abnormal serum creatinine levels are a key clinical biomarker for kidney dysfunction, making its accurate monitoring essential for early diagnosis and prevention. Current commercial kits based on the creatine kinase method are often affected by matrix interference, limiting their reliability in clinical settings. To address this issue, we developed a pH- assisted ratiometric surface-enhanced Raman scattering (SERS) approach for precise creatinine detection in biological samples. We synthesized core-shell nanoparticles (Au@MPA@Ag NPs) with 3-mercaptopropionic acid (MPA) as the internal standard. Under optimized alkaline conditions (pH = 9), the adsorption of creatinine onto the substrate was significantly enhanced, leading to a strong and reproducible SERS response. Moreover, the internal standard-calibrated Raman intensity exhibited a strong linear correlation with creatinine concentration, achieving the limit of detection as 3.3 μM. As a proof of concept, this method was successfully applied to quantify creatinine in human serum. The recovery rates ranged from 98 % to 107 %, demonstrating high consistency with results obtained using a commercial creatinine assay kit. This method provides a clinically accurate and reliable for creatinine monitoring, offering strong potential for point-of-care testing.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115454"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printable, heat-resistant polycaprolactone-based polymer scaffold for sustained NO release in tissue engineering applications","authors":"Seung Hyeon Kim ,&nbsp;Sangmin Lee ,&nbsp;Han-Jun Kim ,&nbsp;Jae Seo Lee ,&nbsp;Sang Jin Lee ,&nbsp;Haram Nah ,&nbsp;Sung Jun Min ,&nbsp;Jae Beum Bang ,&nbsp;Dae Hyeok Yang ,&nbsp;Won Jong Kim ,&nbsp;Il Keun Kwon ,&nbsp;Dong Nyoung Heo","doi":"10.1016/j.colsurfb.2026.115447","DOIUrl":"10.1016/j.colsurfb.2026.115447","url":null,"abstract":"<div><div>This study entailed the development of a nitric oxide (NO)-releasing, 3D-printable, heat-resistant polymer scaffold to support angiogenesis and osteogenesis for tissue engineering applications. A scaffold synthesized with poly(nitrocarbonate)-poly(ε-caprolactone) random copolymer (PNC-<em>ran</em>-PCL) enabled controlled NO release, addressing the rapid diffusion limitations found in conventional NO delivery systems. The thermoplastic properties of PNC-<em>ran</em>-PCL facilitate the creation of biomimetic structures tailored to patient-specific requirements. <em>In vitro</em> assessments showed that the scaffold was non-toxic and that it promoted the proliferation and activity of human umbilical vein endothelial cells, supporting angiogenic functions. <em>In vivo</em> studies using a rat calvarial defect model further demonstrated enhanced vascularization and initial bone formation around the scaffold, highlighting its potential to promote early bone regeneration. The proposed NO-releasing scaffold, which is capable of low-temperature extrusion, has promising applications in in-situ tissue engineering and provides a versatile solution for large-area tissue repair. Further studies on optimized NO-release kinetics are required to enhance the efficacy of the proposed scaffold in osteogenic applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"261 ","pages":"Article 115447"},"PeriodicalIF":5.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon quantum dot modified MoS2 mediating photodynamic and photothermal therapy in rapid inactivation of pathogenic microorganisms","authors":"Yuting Zhai ,&nbsp;Jiaxiu Liu ,&nbsp;Yangru Dai ,&nbsp;Tianyang Li ,&nbsp;Pingping Meng ,&nbsp;Dongjiang Yang ,&nbsp;Daohao Li ,&nbsp;Shuchao Zhang","doi":"10.1016/j.colsurfb.2025.115386","DOIUrl":"10.1016/j.colsurfb.2025.115386","url":null,"abstract":"<div><div>Traditional antibacterial strategies encounter challenges such as drug resistance and environmental pollution. In contrast, nanomaterial-based phototoxic therapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), show promise in enhancing antibacterial efficacy and mitigating drug resistance. In this work, the potential and effectiveness of carbon quantum dot-modified molybdenum disulfide (CQDs@MoS₂) composite has investigated for the rapid inactivation of pathogenic microorganisms in photodynamic and photothermal therapies. Under xenon lamp illumination, MoS₂ generates reactive oxygen species (ROS) that damage bacterial membranes and DNA. The incorporation of CQDs generates localized heat under infrared light, enhances the charge separation of the composite, and increases ROS production, thus producing a PTT effect for amplifying photocatalytic and antibacterial activities. This approach significantly inactivates Gram positive Staphylococcus aureus (<em>S.aureus</em>) and Gram negative Escherichia coli (<em>E. coli</em>) within 5 min and demonstrates high stability. The synergistic effects of these therapies promote effective bacterial inactivation, presenting a promising solution for water disinfection and biomedical applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115386"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}