Microarc oxidation-PBAT composite coating on EK30 biodegradable magnesium alloys to enhance corrosion resistance and cytocompatibility

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-18 DOI:10.1016/j.colsurfb.2025.114720

Weisheng Cao , Siyu Zhu , Weiqiang Wang , Yahui Wang , Shuaikang Yang , Haiyang Sun

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引用次数: 0

Abstract

The rapid degradation rate of biodegradable magnesium alloys restricts their use in medical implants. Therefore, designing a protective coating with a slow degradation rate and good biocompatibility is crucial. For biodegradable magnesium alloy stents, it is equally important to enhance the material's corrosion resistance and ensure the coating's deformation adaptability to the stent. This study, utilized a combination of micro-arc oxidation (MAO) and dip-coating techniques to develop a novel composite coating comprising an MAO base layer and a poly(butylene adipate-co-terephthalate) (PBAT) outer layer on EK30 magnesium alloy. This composite coating was designed to enhance the corrosion resistance and biocompatibility of EK30 magnesium alloy for stent applications. The surface characteristics, corrosion resistance, in vitro cytocompatibility, and deformation adaptability of the composite coating to the stent were evaluated. The MAO-PBAT composite coating demonstrated a low corrosion current density (I_corr = 2.381 ×10⁻⁸ A/cm²), three orders of magnitude lower than that of unmodified EK30 magnesium alloy. Live/dead cell staining results confirmed that the composite coating exhibited good cytocompatibility with human aortic endothelial cells (HAECs) and human aortic smooth muscle cells (HASMCs). Observations of the stent treated with the composite coating during crimping and expansion showed that the composite coating possessed excellent deformation adaptability. These results indicate that the MAO-PBAT composite coating has significant potential for vascular stent application.

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EK30可生物降解镁合金微弧氧化- pbat复合涂层提高其耐腐蚀性和细胞相容性

可生物降解镁合金的快速降解速度限制了其在医疗植入物中的应用。因此，设计一种降解速度慢、生物相容性好的保护涂层是至关重要的。对于可生物降解镁合金支架来说，提高材料的耐腐蚀性和保证涂层对支架的变形适应性同样重要。本研究利用微弧氧化（MAO）和浸涂技术在EK30镁合金上制备了一种由MAO基层和聚己二酸丁二酯（PBAT）外层组成的新型复合涂层。该复合涂层旨在增强EK30镁合金支架应用的耐腐蚀性和生物相容性。评估复合涂层对支架的表面特性、耐腐蚀性、体外细胞相容性和变形适应性。MAO-PBAT复合镀层具有较低的腐蚀电流密度（Icorr = 2.381 ×10−8 a /cm2），比未改性的EK30镁合金低3个数量级。活/死细胞染色结果证实复合涂层与人主动脉内皮细胞（HAECs）和人主动脉平滑肌细胞（HASMCs）具有良好的细胞相容性。对经复合涂层处理的支架在卷曲和膨胀过程中的观察表明，复合涂层具有良好的变形适应性。这些结果表明MAO-PBAT复合涂层在血管支架应用中具有重要的潜力。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.