Colloids and Surfaces B: Biointerfaces最新文献_第7页

Carboxymethyl cellulose-based injectable hydrogel as co-delivery platform for doxorubicin and decitabine: Inducing pyroptosis and enhancing immunotherapy in breast cancer 基于羧甲基纤维素的可注射水凝胶作为阿霉素和地西他滨的共同递送平台：诱导乳腺癌焦亡和增强免疫治疗

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.colsurfb.2025.115391

Xueyan Hou , Yuxin Wang , Chunyan Li , Yanan Lu , Jie Hao , Jingya Zhao , Yanwei Hou , Xue Yang , Sisi He , Yongli Shi

{"title":"Carboxymethyl cellulose-based injectable hydrogel as co-delivery platform for doxorubicin and decitabine: Inducing pyroptosis and enhancing immunotherapy in breast cancer","authors":"Xueyan Hou , Yuxin Wang , Chunyan Li , Yanan Lu , Jie Hao , Jingya Zhao , Yanwei Hou , Xue Yang , Sisi He , Yongli Shi","doi":"10.1016/j.colsurfb.2025.115391","DOIUrl":"10.1016/j.colsurfb.2025.115391","url":null,"abstract":"<div><div>Despite remarkable advances in breast cancer treatment, conventional chemotherapy still faces major challenges, including insufficient drug accumulation at the tumor site, severe systemic toxicity, and limited immune induction. To overcome these challenges, we developed an injectable carboxymethyl cellulose (CMC)-based hydrogel for the localized co-delivery of doxorubicin (DOX) and decitabine (DAC). Beyond conventional drug delivery hydrogels, this CMC-based hydrogel exhibited an optimal gelation time, favorable physicochemical properties, porous three-dimensional microstructures, excellent biocompatibility, and ideal sustained drug-release capability. Notably, the DAC+DOX/Gel system could synergistically induce pyroptosis through the caspase-3/GSDME pathway, with a ∼26-fold increase in the pyroptosis index compared to free drugs. The HMGB1 secretion and CRT exposure suggested the induction of immunogenic cell death and the potential for anti-tumor immune activation. Furthermore, in vivo evaluation in 4T1 tumor-bearing mice demonstrated superior anti-tumor effects and inhibition of distant metastasis. Importantly, this platform significantly enhanced tumor-specific T cell immunity and promoted localized immune activation within the tumor microenvironment without triggering systemic inflammatory responses. Therefore, this bioengineered hydrogel represents a breakthrough in localized combination therapy that simultaneously overcomes drug delivery challenges and transforms immunologically “cold” tumors through pyroptosis-mediated immune activation, offering a promising therapeutic strategy for chemo-immunotherapy of breast cancer.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115391"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145838042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable carbon nanotube-reinforced calcium phosphate bone cements with high-strength and improved osteogenesis for bone regeneration 可注射碳纳米管增强磷酸钙骨水泥，具有高强度和促进骨再生的成骨作用。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-26 DOI: 10.1016/j.colsurfb.2025.115401

Meng Wu , Yucheng Zhou , Zhanxiang He , Bixin Jiang , Laijun Xu

{"title":"Injectable carbon nanotube-reinforced calcium phosphate bone cements with high-strength and improved osteogenesis for bone regeneration","authors":"Meng Wu , Yucheng Zhou , Zhanxiang He , Bixin Jiang , Laijun Xu","doi":"10.1016/j.colsurfb.2025.115401","DOIUrl":"10.1016/j.colsurfb.2025.115401","url":null,"abstract":"<div><div>Although brushite bone cements have achieved good results for bone defect repair, their disadvantages such as too fast setting, poor handling ability, and low compressive strength, were a big challenge in clinical application. In order to solve these problems, a novel injectable carbon nanotubes (CNTs)-reinforced brushite bone cement (denoting as BrMo/CNTs-CHP) with enhanced compressive strength and biological characteristics was successfully developed. The results showed that the liquid phase containing citric acid (CA), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol 400 (PEG400) significantly prolonged the setting time, and improved the injectability and resistance to washout of BrMo/CNTs-CHP bone cements while the addition of CNTs effectively enhanced its compressive strength owing to the nano-filling and bridging effect. However, too many CNTs increased the injection force and decreased slightly the compressive strength and flowability of the cement. Additionally, BrMo/CNTs-CHP bone cements induced apatite deposition and showed good biocompatibility, which can effectively promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). <em>In vivo</em> experimental results demonstrated that BrMo/CNTs-CHP had good bone regeneration ability. Therefore, BrMo/CNTs-CHP is a promising injectable bone cement for bone repair and regeneration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115401"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145861626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The encapsulation mechanism of palmatine in anionic liposomes during flash nanoprecipitation 闪蒸纳米沉淀法中棕榈素在阴离子脂质体中的包封机制。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-19 DOI: 10.1016/j.colsurfb.2025.115384

Zehao Qu , Weifan Niu , Ziling Teng , Ting Chen , Yanlin Song , Dongcui Li , Yan Huang

{"title":"The encapsulation mechanism of palmatine in anionic liposomes during flash nanoprecipitation","authors":"Zehao Qu , Weifan Niu , Ziling Teng , Ting Chen , Yanlin Song , Dongcui Li , Yan Huang","doi":"10.1016/j.colsurfb.2025.115384","DOIUrl":"10.1016/j.colsurfb.2025.115384","url":null,"abstract":"<div><div>Liposomes, with their unique bilayer structure and biocompatibility, have attracted widespread attention in the food, pharmaceutical, and cosmetic industry. However, low production rate, spontaneous fusion, and the leakage of the encapsulated drugs (especially small hydrophilic molecules) have limited the application of such delivery vesicle. In this study, flash nano-precipitation (FNP) technology is used to achieve high throughput liposome preparation. By introducing an anionic phospholipid, dihexadecyl phosphate (DHP), the zeta-potential of liposome was largely increased to enhance the colloidal stability. Representative hydrophilic molecules (anionic tartrazine, cationic palmatine, and zwitterionic rhodamine B) were successfully encapsulated by FNP produced anionic liposomes at high encapsulation efficiency (40 % - 80 %), where, counterintuitively, the cationic palmatine showed the least encapsulation. The encapsulation mechanism of palmatine during FNP was then further investigated by quasi-crystal microbalance (QCM-D), Raman spectroscopy, and fluorescence probing. The results demonstrated that palmatine molecules, instead of adsorbing on the anionic lipid membrane surface, inserted into the lipid bilayer and interacted simultaneously with the C-N bond in the phospholipid head group and the C-C bond in the hydrophobic tail. The insertion of palmatine molecules caused the exposure of the hydrophobic region in lipid bilayer, increased the microenvironmental polarity, and enhanced the fluidity of the membrane. This study provided molecular level insight into the encapsulation mechanism of small molecules in liposome vesicles during FNP, which could provide guidelines for future liposome research and production.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115384"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145825422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tunable additive strategy for enantioseparation of hydrophobic racemic ibuprofen through agarose-based hydrogels 琼脂糖基水凝胶用于疏水外消旋布洛芬对映体分离的可调添加剂策略。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-30 DOI: 10.1016/j.colsurfb.2025.115393

Yunna Xue, Xiangyang Zhang, Xinggui Zhou

{"title":"A tunable additive strategy for enantioseparation of hydrophobic racemic ibuprofen through agarose-based hydrogels","authors":"Yunna Xue, Xiangyang Zhang, Xinggui Zhou","doi":"10.1016/j.colsurfb.2025.115393","DOIUrl":"10.1016/j.colsurfb.2025.115393","url":null,"abstract":"<div><div>Chiral drugs often exhibit stereoselective pharmacological activity, yet their separation remains challenging due to virtually identical physicochemical properties. Here, we propose a tunable additive strategy using agarose hydrogels (AG) as chiral enantioseparation scaffolds, where non-covalent interactions between drug and additives enable chiral recognition. Using racemic ibuprofen (Ibu) as a model compound, Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction analyses revealed the enhanced loading, modified morphology, and altered crystallinity of hydrophobic Ibu induced by additives. Non-covalent interactions between the additives and Ibu, revealed by molecular docking, quantum chemical calculation, and IRI analysis, promote the dispersion of Ibu within the matrix and preferentially release the pharmacologically active enantiomer. Notably, while additive free AG afforded an enantiomeric excess of 1.7 %, the cyclodextrin-modified hydrogel achieved up to 15.6 %, a more than 9 times improvement, highlighting the potential of this strategy for the adjustable enantioseparation at the biointerface.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115393"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional collagen hydrogel accelerates infected wound repair through photothermal disinfection and pro-angiogenic activity 多功能胶原水凝胶通过光热消毒和促血管生成活性加速感染伤口修复。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.colsurfb.2025.115382

Hao Shen , Tong Li , Xueying Chen , Zhurun Fang , Yan Xu , Kai Zheng , Ming Zhang

{"title":"Multifunctional collagen hydrogel accelerates infected wound repair through photothermal disinfection and pro-angiogenic activity","authors":"Hao Shen , Tong Li , Xueying Chen , Zhurun Fang , Yan Xu , Kai Zheng , Ming Zhang","doi":"10.1016/j.colsurfb.2025.115382","DOIUrl":"10.1016/j.colsurfb.2025.115382","url":null,"abstract":"<div><div>As the primary physical and immunological barrier against external insults, skin integrity is frequently compromised by trauma, disease, or iatrogenic injury, leading to pathogenic microorganism invasion and infected wounds. The escalating challenges posed by bacterial antibiotic resistance and biofilm formation highlight the urgent need for therapeutic systems that synergistically combine potent antibacterial efficacy with effective tissue regeneration modulation. Therefore, this study developed a multifunctional hydrogel platform integrating rapid photothermal sterilization and pro-regenerative bioactivity. We engineered an aggregation-induced emission (AIE) nanoparticle-loaded type I recombinant humanized collagen hydrogel (AIE@RHCI), achieving rapid UV-triggered crosslinking from liquid to gel state. The hydrogel demonstrates appropriate swelling capacity, controllable degradation kinetics, and favorable mechanical properties, enabling stable adhesion to dynamically deforming skin during movement. The incorporated AIE component exhibits 39.7 % photothermal conversion efficiency under 808 nm near-infrared (NIR) irradiation. <em>In vitro</em> studies confirmed that the AIE@RHCI hydrogel under NIR irradiation reduced methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) viability to 22.2 %, while concurrently achieving 79.8 % biofilm inhibition. Simultaneously, the recombinant collagen matrix promotes vascular endothelial cell migration and accelerates vascularization, with significant upregulation of key pro-angiogenic genes <em>VEGF</em> and <em>CD31</em>. This integrated platform synergistically combines photothermal bactericidal nanoparticles with bioactive recombinant collagen scaffolding, offering a novel and promising therapeutic strategy for the management of antibiotic-resistant wound infections, with potential for clinical translation in chronic and infected wound care.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115382"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How water models influence the interfacial organization of oxysterol epimers: A comparative simulation study using TIP3P and OPC 水模型如何影响氧甾醇外聚物的界面组织：使用TIP3P和OPC的比较模拟研究

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-31 DOI: 10.1016/j.colsurfb.2025.115407

Jan Kobierski , Sławomir Stachura , Anita Wnętrzak , Anna Chachaj-Brekiesz , Michał Świątek , Wojciech Jawień , Patrycja Dynarowicz-Latka

{"title":"How water models influence the interfacial organization of oxysterol epimers: A comparative simulation study using TIP3P and OPC","authors":"Jan Kobierski , Sławomir Stachura , Anita Wnętrzak , Anna Chachaj-Brekiesz , Michał Świątek , Wojciech Jawień , Patrycja Dynarowicz-Latka","doi":"10.1016/j.colsurfb.2025.115407","DOIUrl":"10.1016/j.colsurfb.2025.115407","url":null,"abstract":"<div><div>Water is a critical determinant of interfacial behavior, therefore the choice of water model in molecular dynamics (MD) simulations can profoundly influence the accuracy of predicted monolayer properties. In this work, we compare the impact of two water models—three-point TIP3P and four-point OPC—on the interfacial organization, hydration, and hydrogen bonding of epimeric 22-hydroxycholesterols [22(<em>R</em>)-OH and 22(<em>S</em>)-OH] in model membranes. All-atom MD simulations, complemented by Langmuir monolayer experiments, demonstrate that the water model selection strongly affects monolayer behavior: the OPC model produces sharper density gradients and reduced water penetration at the interface, whereas TIP3P permits deeper water ingress and yields a more diffuse interfacial region. As a result, stereochemical differences are more pronounced with the OPC model, particularly for the hydration-prone 22(<em>R</em>)-OH. Specifically, 22(<em>S</em>)-OH forms more condensed monolayers with the side-chain hydroxyl group buried within the interface, whereas 22(<em>R</em>)-OH generates more expanded monolayers characterized by enhanced hydration in close agreement with experimental observations. These stereochemistry-dependent effects arise from distinct hydrogen-bonding patterns: 22(<em>S</em>)-OH preferentially engages in sterol–sterol hydrogen bonds, while 22(<em>R</em>)-OH remains more hydrated through hydrogen bonding with water molecules. Collectively, these findings underscore the importance of accurate water model selection for reliable representation of biointerface properties and highlight that even subtle stereochemical modifications can exert disproportionate effects on interfacial organization and hydration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115407"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of metal enhanced fluorescence for the detection and quantification of extracellular vesicles 金属增强荧光在细胞外囊泡检测和定量中的应用

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-18 DOI: 10.1016/j.colsurfb.2025.115385

Isabella Walker, Huiyan Li

{"title":"Applications of metal enhanced fluorescence for the detection and quantification of extracellular vesicles","authors":"Isabella Walker, Huiyan Li","doi":"10.1016/j.colsurfb.2025.115385","DOIUrl":"10.1016/j.colsurfb.2025.115385","url":null,"abstract":"<div><div>Early detection of diseases significantly improves patient outcomes, yet many biomarkers remain at ultra-low concentrations in body fluids during the initial stages, posing challenges for conventional diagnostic techniques. Extracellular vesicles (EVs) have emerged as promising non-invasive biomarkers due to their presence in body fluids such as blood, saliva and urine, and because their molecular cargo reflects their cells of origin. However, sensitive and accurate detection of disease related EVs is challenging because of their low concentrations and nanoscale size. Metal enhanced fluorescence (MEF) has recently been applied to overcome these limitations by amplifying the fluorescent signal of labeled EVs through localized surface plasmon resonances of metallic nanostructures. This amplification enables the detection and quantification of EV-associated biomarkers with improved sensitivity, offering potential for earlier disease diagnosis. However, to date, few reviews have focused specifically on MEF-based applications for the detection and quantification of EVs and their molecular cargo. This review examines recent advances in MEF-based platforms for EV analysis, including nanohole arrays, metal nano islands and nanoarrays, gold nanoparticles in three-dimensional matrices, metal-organic frameworks and other plasmonic approaches. While current reviews have discussed the use of MEF biosensing application, this article specifically focuses on MEF- based EV detection highlighting the design principles, optical properties, advantages, and limitations of these platforms. Collectively, MEF offers a powerful strategy to enhance EV detection, bridging the gap between experimental analysis and clinical application.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115385"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECM-responsive nanomedicine to enhance immunotherapy in pancreatic cancer 纳米药物增强胰腺癌免疫治疗的ecm反应

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-08 DOI: 10.1016/j.colsurfb.2025.115356

Li Li , Junxiong Wen , Hao Xu , Hongyuan Yu , Xue Bai , Yue Zhang

{"title":"ECM-responsive nanomedicine to enhance immunotherapy in pancreatic cancer","authors":"Li Li , Junxiong Wen , Hao Xu , Hongyuan Yu , Xue Bai , Yue Zhang","doi":"10.1016/j.colsurfb.2025.115356","DOIUrl":"10.1016/j.colsurfb.2025.115356","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) remains one of the most treatment-resistant malignancies, primarily attributed to its dense and fibrotic extracellular matrix (ECM), which impedes both immune cell infiltration and drug delivery. Despite the remarkable success of immunotherapy in other cancer types, its efficacy in PDAC has been significantly compromised by the immune-exclusion barrier. Recent advancements in nanomedicine offer a compelling strategy to overcome this hurdle through the development of ECM-responsive delivery systems. These platforms are engineered to respond to ECM-specific triggers such as hyaluronidase or matrix metalloproteinases, enabling localized degradation of the tumor stroma while simultaneously releasing immunostimulatory agents. This review summarizes the unique ECM biology of PDAC, current limitations of immunotherapy, and recent breakthroughs in stimuli-responsive nanotechnology. This study also comprehensively discusses design principles, preclinical validation outcomes, translational challenges, and emerging strategies integrating ECM modulation with next-generation immune activation. ECM-responsive nanomedicine represents a transformative paradigm in stroma-immune co-engineering and offers a promising avenue for unlocking immunotherapy in PDAC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115356"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive human placental ECM hydrogels crosslinked with tannic acid enhance stability and antioxidant properties for diabetic wound healing 与单宁酸交联的生物活性人胎盘ECM水凝胶增强了糖尿病伤口愈合的稳定性和抗氧化性能

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-29 DOI: 10.1016/j.colsurfb.2025.115406

Sunil Gujjar , Pratibha Jaipal , Prakash Jayabal , Bhisma Narayan Panda , Priyanka Sharma , Jagadish Chandra Sharma , Anil Kumar Pandey , Santosh Mathapati

{"title":"Bioactive human placental ECM hydrogels crosslinked with tannic acid enhance stability and antioxidant properties for diabetic wound healing","authors":"Sunil Gujjar , Pratibha Jaipal , Prakash Jayabal , Bhisma Narayan Panda , Priyanka Sharma , Jagadish Chandra Sharma , Anil Kumar Pandey , Santosh Mathapati","doi":"10.1016/j.colsurfb.2025.115406","DOIUrl":"10.1016/j.colsurfb.2025.115406","url":null,"abstract":"<div><div>Hydrogels are promising materials for minimally invasive surgical interventions and tissue regeneration. However, hydrogels derived from the extracellular matrix (ECM) frequently suffer from rapid degradation, poor injectability, limited bioactivity, and weak stability. The purpose of this work is to combine decellularized placental extracellular matrix (PECM) hydrogels with tannic acid (TA) to enhance the stability and biological characteristics. PECM hydrogels were subjected to proteomic analysis to detect and describe bioactive proteins. PECM hydrogels crosslinked with TA demonstrated antibacterial efficiency, antioxidant activity, hemocompatibility, and biocompatibility. Notable improvements in stability were observed following enzymatic degradation and rheological characterization. Mice treated with PECM hydrogels crosslinked with TA in a diabetic wound healing model show sustained vascularization, reduced inflammation over time, faster wound closure, and cell infiltration. These findings highlight the synergistic effect of TA crosslinking in modulating both the structural integrity and the biological function of PECM hydrogels. Furthermore, the integration of TA contributes to the controlled degradation profile, enabling prolonged residence time at the wound site for effective tissue regeneration. The enhanced stability, presence of bioactive molecules, and microenvironment for host remodelling, as well as the demonstrated therapeutic efficacy of these hydrogels, suggest significant promise for their clinical application in tissue repair.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115406"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multifunctional nanozyme integrating panoptosis induction and T-cell metabolic reprogramming to augment the efficacy of PD-1 inhibitors 整合泛光诱导和t细胞代谢重编程以增强PD-1抑制剂功效的多功能纳米酶

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI: 10.1016/j.colsurfb.2025.115389

Feng Lin , Hong Huang , Jie Long , Renchuan Liang , Yunxi Huang , Xiaoling Luo

{"title":"A multifunctional nanozyme integrating panoptosis induction and T-cell metabolic reprogramming to augment the efficacy of PD-1 inhibitors","authors":"Feng Lin , Hong Huang , Jie Long , Renchuan Liang , Yunxi Huang , Xiaoling Luo","doi":"10.1016/j.colsurfb.2025.115389","DOIUrl":"10.1016/j.colsurfb.2025.115389","url":null,"abstract":"<div><div>Cancer remains a major global health burden due to its high rates of recurrence and resistance to conventional therapies. Although PD-L1/PD-1 immune checkpoint inhibitors (ICIs) have emerged as promising treatments by restoring T cell function and enhancing anti-tumor immunity, their efficacy is often limited by immunosuppressive tumor microenvironment (ITM) and metabolic adaptations that impair T cell activity. To address these challenges, we developed a novel intelligent drug delivery platform that integrates PANoptosis induction, metabolic modulation and targeted nanotherapy. Specifically, hollow mesoporous manganese dioxide (H-MnO<sub>2</sub>) nanoshells were synthesized and co-loaded with SOAT1 inhibitor avasimibe (Ava). Trop2-specific targeting ligands were further conjugated to enable precise tumor localization, resulting in the multifunctional nanoplatform Ava@HM/Trop2. Upon tumor accumulation via Trop2-mediated targeting, acidic pH conditions and tumor microenvironment (TME) stimuli trigger rapid degradation of the H-MnO<sub>2</sub> nanoshells, releasing Ava and inducing PANoptosis. This process activates the cGAS-STING pathway, remodels immunosuppressive TME, mitigates lipid-induced T cell senescence, and synergizes with PD-1 blockade to potentiate anti-tumor immunity. Both <em>in vitro</em> and <em>in vivo</em> experiments demonstrate that Ava@HM/Trop2 achieves efficient tumor targeting, robust tumor cell apoptosis, and improved therapeutic outcomes. This innovative multi-modal strategy highlights a promising avenue for overcoming immunotherapy resistance and advancing the clinical management of solid tumors.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115389"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0