渗出物管理非织造布装载日本卷叶草DC提取物增强止血和伤口愈合

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-04 DOI:10.1016/j.colsurfb.2025.114673

Liying Zou , Jingjun Dong , Ruyi Xie , Aihua Cui , Zunyuan Wang , Guoxin Wang , Jiwei Li , Weichao Chen

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引用次数: 0

摘要

采用针刺法制备了壳聚糖-粘胶-聚酯复合非织造布（CS-VIS-PET），该材料具有单向输液性能。然后，在CS-VIS-PET （CJDC@CS-VIS-PET）的cs层上喷涂鸢鸢花DC （CJDC）提取物，提高其抗菌、抗氧化和止血性能。载药量为10 %时，10 %CJDC@CS-VIS-PET具有较高的抗氧化率（87.3% %），对大肠杆菌和金黄色葡萄球菌的抑菌率分别为99.5 %和99.7 %。由于cs层的捕血作用、vis层的血浓度作用、pet层的排血作用以及CJDC的化学活化的协同机制，10 %CJDC@CS-VIS-PET取得了优异的止血能力。此外，夹层结构的10 %CJDC@CS-VIS-PET具有良好的透气性、透湿性和创面渗出物管理性能，有利于创面愈合。第14天创面愈合率高达92 %。此外，得益于壳聚糖、粘胶和CJDC的良好生物相容性，10 %CJDC@CS-VIS-PET具有良好的血液和细胞相容性。因此，夹心结构非织造布负载CJDC可为开发具有增强止血和伤口环境管理性能的多功能伤口敷料提供参考。

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Exudate management nonwovens loaded with Cirsium japonicum DC extract for enhanced hemostatic and wound healing

The chitosan-viscose-polyester composite nonwoven (CS-VIS-PET) was successfully prepared by needle-punching, which exhibited a unidirectional liquid transport property. Then, the extract of Cirsium japonicum DC (CJDC) was sprayed on the CS-layer of the CS-VIS-PET (CJDC@CS-VIS-PET) to improve the antibacterial, anti-oxidation, and hemostatic properties. With 10 % drug-loaded, the 10 %CJDC@CS-VIS-PET represented a high antioxidant rate (87.3 %), and the antibacterial rate against E. coli and S. aureus was 99.5 % and 99.7 %, respectively. Due to the synergistic mechanism of the blood capture effect of the CS-layer, the blood concentration effect of the VIS-layer, the blood expulsion effect of the PET-layer, and the chemical activation of CJDC, 10 %CJDC@CS-VIS-PET achieved excellent bleeding control ability. Moreover, the sandwich-structured 10 %CJDC@CS-VIS-PET showed excellent air permeability, water vapor permeability, and wound exudate management performance, which is beneficial for wound healing. The wound healing ratio on day 14 was as high as 92 %. In addition, profited from the excellent biocompatibility of chitosan, viscose and CJDC, 10 %CJDC@CS-VIS-PET exhibited outstanding blood and cell compatibility. Therefore, the sandwich-structured nonwovens loaded with the CJDC may provide a reference for developing multifunctional wound dressings with enhanced hemostatic and wound environment management properties.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.