Enhanced cancer therapy using modified magnetic α-Fe2O3/Fe3O4 nanorods: Dual role in curcumin delivery and ferroptosis induction

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-08 DOI:10.1016/j.colsurfb.2025.114689

Mingyi Ma , Zhongjun Pan , Ziye Zhu , Chen Ling , Jiahao Yuan , Xiangdong Huo , Shasha Li , Ruijiang Liu

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引用次数: 0

Abstract

Curcumin (CUR) has gained considerable attention in oncology due to its potent anti-tumor, anti-inflammatory, and antioxidant properties. However, its clinical utility was significantly hindered by low bioavailability and rapid metabolic degradation. This work designed a magnetic α-Fe₂O₃/Fe₃O₄ heterogeneous nanorod prepared via a urea hydrolysis-calcination process for curcumin delivery. The nanorods were modified with hyaluronic acid (HA), providing a stable matrix for curcumin encapsulation. The zeta potential of α-Fe₂O₃/Fe₃O₄/HA/CUR was −3.94 mV, the saturation magnetization was 7.82 emu·g⁻¹, the encapsulation rate and drug loading rate were 10.53 % and 29.64 % respectively. At pH 5.4, 6.5, and 7.4, the release rates were 44.8 %, 40.2 %, and 39.3 %, respectively. Kinetic modeling indicated that release profiles followed the Weibull kinetic model, with an R² value greater than 0.98. The α-Fe₂O₃/Fe₃O₄/HA/CUR exhibited excellent magnetic responsiveness, demonstrating a significant inhibitory effect on human liver cancer (HepG2) cells (inhibition rate greater than 60 %) under a magnetic field. Moreover, they substantially reduced the cytotoxicity of curcumin on normal human (LO2) cells. The α-Fe₂O₃/Fe₃O₄/HA/CUR inhibited migration and proliferation of HepG2 cells, induced apoptosis via the Caspase pathway, and synergistically suppressed tumor cell development through ferroptosis. The drug release from the α-Fe₂O₃/Fe₃O₄/HA/CUR was stable, significantly enhancing the bioavailability of curcumin. This provided a promising strategy for improving the bioavailability of poorly soluble drugs and enhancing liver cancer treatment outcomes.

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改良磁性α-Fe2O3/Fe3O4纳米棒增强癌症治疗：姜黄素传递和铁下垂诱导的双重作用

姜黄素（CUR）具有强大的抗肿瘤、抗炎和抗氧化特性，因此在肿瘤学领域受到广泛关注。然而，由于生物利用率低和代谢降解快，它的临床应用受到严重阻碍。本研究设计了一种通过尿素水解-煅烧工艺制备的磁性α-Fe2O3/Fe3O4异质纳米棒，用于姜黄素的递送。纳米棒用透明质酸（HA）修饰，为姜黄素的封装提供了稳定的基质。α-Fe2O3/Fe3O4/HA/CUR的ZETA电位为-3.94 mV，饱和磁化率为7.82 emu-g-1，包封率和载药率分别为10.53%和29.64%。在 pH 值为 5.4、6.5 和 7.4 时，释放率分别为 44.8%、40.2% 和 39.3%。动力学模型表明，释放曲线遵循 Weibull 动力学模型，R2 值大于 0.98。α-Fe2O3/Fe3O4/HA/CUR表现出优异的磁响应性，在磁场下对人肝癌（HepG2）细胞有显著的抑制作用（抑制率大于 60%）。此外，它们还大大降低了姜黄素对正常人（LO2）细胞的细胞毒性。α-Fe2O3/Fe3O4/HA/CUR能抑制HepG2细胞的迁移和增殖，通过Caspase途径诱导细胞凋亡，并通过铁凋亡协同抑制肿瘤细胞的发展。α-Fe2O3/Fe3O4/HA/CUR的药物释放稳定，显著提高了姜黄素的生物利用度。这为改善难溶性药物的生物利用度和提高肝癌治疗效果提供了一种前景广阔的策略。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.