聚乙二醇化PAMAM树状大分子纳米平台用于化疗药物和无机纳米颗粒的共递送，增强化学-光热联合治疗

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-08 DOI:10.1016/j.colsurfb.2025.114688

Binzhong Lu , Yingying Yang , Xiang Li , Qiuli Cheng , Leitao Zhang , Wenlan Wu , Junbo Li

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引用次数: 0

摘要

化学-光热联合治疗已成为提高肿瘤治疗效果的重要途径。然而，开发一种能够包封无机光热剂（pta）和有机抗肿瘤药物的柔性纳米平台仍然具有挑战性。聚乙二醇功能化聚氨基酰胺（PAMAM）树状大分子（PAMAM- peg）作为模板用于合成硫化铜（cu）纳米颗粒并随后将阿霉素（DOX）包封在其内腔中。该多功能纳米平台在980 nm激光照射下具有较高的胶体稳定性和光热转换效率。这种协同作用极大地改善了DOX的细胞摄取和肿瘤穿透，导致比单独化疗更优越的抗肿瘤疗效。这些结果表明PAMAM-PEG代表了一个有前途的化学光热联合治疗纳米平台，提供了一种新的策略来解决当前肿瘤治疗的局限性，同时提高治疗效果。

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PEGylated PAMAM dendrimer nanoplatform for co-delivery of chemotherapeutic agents and inorganic nanoparticles enhancing chemo-photothermal combination therapy

Chemo-photothermal combination therapy has emerged as an important approach for enhancing therapeutic efficacy against tumors. However, developing a flexible nanoplatform capable of co-encapsulating inorganic photothermal agents (PTAs) and organic antitumor drugs remains challenging. A polyethylene glycol-functionalized polyamidoamine (PAMAM) dendrimer (PAMAM-PEG) served as a template for the synthesis of copper sulfide (CuS) nanoparticles and subsequent encapsulation of doxorubicin (DOX) within its inner cavities. The multifunctional nanoplatform demonstrated high colloidal stability along with photothermal conversion efficiency upon 980 nm laser irradiation. This synergistic effect substantially improved DOX cellular uptake and tumor penetration, resulting in superior antitumor efficacy relative to chemotherapy alone. These results demonstrate that PAMAM-PEG represents a promising nanoplatform for combined chemo-photothermal therapy, providing a novel strategy to address current limitations in tumor treatment while enhancing therapeutic outcomes.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.