Colloids and Surfaces B: Biointerfaces最新文献_第8页

Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery 用ph触发的纳米涂层对抗牙周炎：辛伐他汀递送的缓释策略。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-15 DOI: 10.1016/j.colsurfb.2025.115375

Siyu Du , Yi Zheng , Yabing Chen , Yijing Guo , Xinyue Kang , Lei Wang

{"title":"Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery","authors":"Siyu Du , Yi Zheng , Yabing Chen , Yijing Guo , Xinyue Kang , Lei Wang","doi":"10.1016/j.colsurfb.2025.115375","DOIUrl":"10.1016/j.colsurfb.2025.115375","url":null,"abstract":"<div><div>The growing incidence of periodontitis demands innovative therapies, as current drug treatments are limited by short retention times, rapid clearance, and the risk of antimicrobial resistance. This study introduces a novel pH-responsive nano-miclle system for simvastatin (SIM) delivery. Its core innovation lies in being the first system ((SIM NP)n) of its kind to be stabilized by a cross-linked \"outer shell,\" which significantly enhances its stability and controlled release capabilities. This \"smart\" system remains stable in a neutral environment (pH 7.4), preventing premature drug release. However, upon encountering the acidic inflammatory microenvironment of periodontitis, the shell degrades, triggering the sustained release of SIM directly at the site of inflammation. In vitro studies demonstrated that the SIM-loaded micelles possess potent immunomodulatory effects: they effectively suppressed pro-inflammatory M1 macrophage polarization (decreasing IL-1β, iNOS) while promoting anti-inflammatory M2 macrophage polarization (increasing Arg-1, IL-10). Mechanistic investigation confirmed this therapeutic effect is mediated by the PI3K/AKT/mTOR signaling pathway. More importantly, in a mouse model of periodontitis, the nano-micelles significantly reduced alveolar bone resorption, demonstrating potent anti-inflammatory and bone-protective efficacy in vivo. In conclusion, this \"smart\" pH-triggered delivery system for SIM offers a highly promising and effective strategy to overcome the limitations of traditional therapies, providing a new targeted path for the treatment of periodontitis.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115375"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZIF-8-based Schottky heterojunction for boosting the sonodynamic antimicrobial effect of chlorin e6 on MRSA 基于zif -8的肖特基异质结增强氯e6对MRSA的声动力抗菌作用

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115419

Xiaoyang Xu , Danni Wang , Bingjie Leng , Tingting Gao , Zhenning Cui , Xiao Wang , Bin Liu

{"title":"ZIF-8-based Schottky heterojunction for boosting the sonodynamic antimicrobial effect of chlorin e6 on MRSA","authors":"Xiaoyang Xu , Danni Wang , Bingjie Leng , Tingting Gao , Zhenning Cui , Xiao Wang , Bin Liu","doi":"10.1016/j.colsurfb.2026.115419","DOIUrl":"10.1016/j.colsurfb.2026.115419","url":null,"abstract":"<div><div>Sonodynamic antimicrobial chemotherapy (SACT) has been regarded as an emerging approach for antimicrobial treatment due to its advantages of deep tissue penetration, non-invasive nature, and absence of resistance. However, several challenges hinder its clinical application, for example insufficient oxygen levels at infection sites, poor solubility and stability of sonosensitizers. Herein, we developed chlorin e6@ZIF-8@Ag (CZ@Ag) nanocomposite as a Schottky heterojunction sonosensitizer with high electron-hole separation and narrow bandgap. The results reveal that the Schottky barrier between ZIF-8 and Ag nanoparticles can availably restrain electron backflow, further promoting the yield of reactive oxygen species (ROS) under ultrasound treatment. Experimentally, the minimum inhibitory concentration of CZ@Ag against methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) reduced from 320 μg/mL to 80 μg/mL, and its antibacterial rate was up to 96.3 % after 3 min of ultrasound irradiation. Furthermore, mechanistic studies found that CZ@Ag-mediated SACT is mainly achieved by inhibiting biofilm formation, damaging cell membrane integrity, enhancing more ROS generation, and increasing cell membrane permeability, leading to the leakage of intracellular contents. All these findings proved that CZ@Ag had great possibility for antibacterial therapy, and this investigation offered a feasible direction for developing efficient sonosensitizers.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115419"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fluorescein-tagged pH-low insertion peptide (pHLIP) for glioblastoma imaging: Lipid membrane interaction and cancer cell targeting 荧光素标记的低ph插入肽（pHLIP）用于胶质母细胞瘤成像：脂膜相互作用和癌细胞靶向。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.colsurfb.2025.115398

Cristina Chirizzi , Martina Maffezzini , Nadia Mosca , Arianna Balestri , Costanza Montis , Francesco Acerbi , Martina Beccalli , Alessandro Gori , Marina Grisoli , Serena Pellegatta , Francesca Baldelli Bombelli

{"title":"A fluorescein-tagged pH-low insertion peptide (pHLIP) for glioblastoma imaging: Lipid membrane interaction and cancer cell targeting","authors":"Cristina Chirizzi , Martina Maffezzini , Nadia Mosca , Arianna Balestri , Costanza Montis , Francesco Acerbi , Martina Beccalli , Alessandro Gori , Marina Grisoli , Serena Pellegatta , Francesca Baldelli Bombelli","doi":"10.1016/j.colsurfb.2025.115398","DOIUrl":"10.1016/j.colsurfb.2025.115398","url":null,"abstract":"<div><div>Glioblastoma (GB) is the most aggressive and common malignant brain tumor, and despite current therapeutic approaches, prognosis remains poor. Given that surgical resection is frequently the sole potentially curative option, precise intraoperative tumor delineation is crucial for reducing recurrence rates and enhancing patient outcomes. In this study, we developed a novel pH-responsive imaging tool by coupling the pH-low insertion peptide (pHLIP) with fluorescein (FL) to enable targeted fluorescence-guided visualization of tumor margins. We investigated pHLIP–lipid membrane interactions using model systems, including liposomes and supported lipid bilayers (SLB), assessing peptide’s pH-dependent insertion mechanism. Complementary <em>in vitro</em> experiments on patient-derived GB cell lines were performed to show the tracer’s pH sensitivity, selective membrane targeting, and potential off-target effects. The FL-pHLIP construct showed robust, pH-dependent membrane insertion and selectivity in GB cellular models with minimal interaction under physiological conditions. These findings support FL-pHLIP as a promising candidate for fluorescence-guided surgery in GB and highlight its potential for clinical translation and for the broader development of pH-responsive diagnostic tools.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115398"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside-based nanoliposomes co-delivering ergothioneine and coenzyme Q10 to combat skin aging via mitochondrial modulation 基于人参皂苷的纳米脂质体通过线粒体调节共同递送麦角硫因和辅酶Q10来对抗皮肤衰老。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-28 DOI: 10.1016/j.colsurfb.2025.115405

Shining Li , Ying Luo , Dan Wang , Bingqing Wang , Jun Gao , Xin Chen , Zhigang Li , Haixiao Wan , Ying Wu , Zhuang Ma , Yongjie Lu , Lin Geng , Yan Huang , Na Li , Li Ye , Dongcui Li , Naisheng Jiang

{"title":"Ginsenoside-based nanoliposomes co-delivering ergothioneine and coenzyme Q10 to combat skin aging via mitochondrial modulation","authors":"Shining Li , Ying Luo , Dan Wang , Bingqing Wang , Jun Gao , Xin Chen , Zhigang Li , Haixiao Wan , Ying Wu , Zhuang Ma , Yongjie Lu , Lin Geng , Yan Huang , Na Li , Li Ye , Dongcui Li , Naisheng Jiang","doi":"10.1016/j.colsurfb.2025.115405","DOIUrl":"10.1016/j.colsurfb.2025.115405","url":null,"abstract":"<div><div>Skin aging is closely linked to mitochondrial dysfunction, yet effective delivery of mitochondrial therapeutics to the skin remains a challenge. Here, we report ECG-Lipo, a mitochondria-modulating nanoliposome system that co-delivers hydrophilic ergothioneine (EGT) and lipophilic coenzyme Q10 (CoQ10) for rejuvenation therapy. ECG-Lipo was fabricated by flash nanoprecipitation using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and protopanaxatriol-type ginsenoside metabolites (PPTGM) as liposome-forming agents, yielding uniform nanosized unilamellar vesicles with high stability and encapsulation efficiency. Compared with free drug solutions, ECG-Lipo significantly enhanced skin penetration and cellular repair, as demonstrated by in vitro Franz diffusion assays, in vivo fluorescence imaging in mouse skin, and fibroblast migration assays. Molecular docking indicated that PPTGM exhibits stronger predicted interactions with the EGT transporter OCTN-1 than cholesterol through combined hydrophobic and hydrogen-bonding interactions, suggesting a potential structural basis for the observed biological effects. In oxidative stress-challenged human dermal fibroblasts, ECG-Lipo preserved mitochondrial integrity by maintaining mitochondrial signal and morphology, restoring membrane potential, and suppressing mitochondrial superoxide accumulation. These results highlight ECG-Lipo as a promising mitochondria-modulating nanoliposome system for transdermal delivery with potential for therapeutic intervention against intrinsic skin aging.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115405"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of immune-enhancing vesicles from reassembled yeast vacuolar membranes 重组酵母液泡膜制备免疫增强囊泡

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.colsurfb.2025.115380

Su-Min Lee , Yunyoung Cho , Jiwoo Lim , Seungwoo Chung , Ngoc-Tu Nguyen , Yang-Hoon Kim , Sang-Ho Park , Jiho Min

{"title":"Fabrication of immune-enhancing vesicles from reassembled yeast vacuolar membranes","authors":"Su-Min Lee , Yunyoung Cho , Jiwoo Lim , Seungwoo Chung , Ngoc-Tu Nguyen , Yang-Hoon Kim , Sang-Ho Park , Jiho Min","doi":"10.1016/j.colsurfb.2025.115380","DOIUrl":"10.1016/j.colsurfb.2025.115380","url":null,"abstract":"<div><div>Yeast vacuoles have recently emerged as promising bio-nanomaterials for drug delivery, offering improved stability and efficacy compared with traditional synthetic systems. Their membranes share structural and compositional similarities with those of mammalian cells, offering excellent biocompatibility and potential for efficient cellular interaction. These unique properties make reassembled vacuoles (ReV) attractive candidates for developing safe and effective therapeutic delivery platforms. This study optimized the vacuole reassembly process to enhance the performance of drug delivery. We compared two methods: Method 1, using conventional long-duration sonication and filtration, and Method 2, featuring an optimized 5-minute sonication without filtration. Reassembled vacuoles produced by method 1 (ReV<sub>Mtd1</sub>), induced moderate TLR2 expression, suggesting mild immune priming without significant activation of inflammatory cytokines. In contrast, Reassembled vacuoles produced by method 2 (ReV<sub>Mtd2</sub>) demonstrated superior immune activation, showing a dose-dependent upregulation of iNOS and TLR2. Additionally, ReV<sub>Mtd2</sub> achieved an encapsulation efficiency of 12.9 % for daunorubicin (DNR), comparable to native vacuoles, and maintained structural stability over a 12-month period. These findings highlight the potential of ReV<sub>Mtd2</sub> as a robust, biocompatible, and efficient drug delivery system, offering enhanced therapeutic performance and long-term stability.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115380"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Polycaprolactone/polyvinylpyrrolidone coaxial electrospun fibers containing veratric acid-loaded chitosan nanoparticles for bone regeneration” [Colloids Surf. B Biointerfaces 193 (2020) 111110] “含有载戊三酸壳聚糖纳米颗粒的骨再生用聚己内酯/聚乙烯吡咯烷酮同轴静电纺丝纤维”的勘误表[Colloids Surf]。[j].中国生物医学工程学报，2016,32(1):1 - 4。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2026-01-24 DOI: 10.1016/j.colsurfb.2026.115467

Sruthi Ranganathan, Kalimuthu Balagangadharan, Nagarajan Selvamurugan

引用次数: 0

Enhancing radiosensitization in triple-negative breast cancer by aptamer-modified nanoclusters NC-T5-5TR1 适配体修饰纳米簇NC-T5-5TR1增强三阴性乳腺癌的放射致敏性

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.colsurfb.2025.115397

Xuechun Kan , Jifei Wang , Yan Li , Dongdong Li , Fan Li , Cheng Huang , Peidang Liu

{"title":"Enhancing radiosensitization in triple-negative breast cancer by aptamer-modified nanoclusters NC-T5-5TR1","authors":"Xuechun Kan , Jifei Wang , Yan Li , Dongdong Li , Fan Li , Cheng Huang , Peidang Liu","doi":"10.1016/j.colsurfb.2025.115397","DOIUrl":"10.1016/j.colsurfb.2025.115397","url":null,"abstract":"<div><div>Radiotherapy is an important part of standard treatment for triple-negative breast cancer (TNBC); however, radioresistance significantly limits therapeutic outcomes. In this study, we developed a novel radiosensitizer based on aptamer-modified silver nanoclusters, NC-T5–5TR1, to potentiate radiotherapy efficacy against TNBC. NC-T5–5TR1 enabled real-time tumor imaging and accurate localization via their intrinsic fluorescence and targeting capability. When combined with ionizing radiation (IR), NC-T5–5TR1 significantly enhanced radiosensitization <em>in vitro</em>, as evidenced by decreased proliferation, increased apoptosis and higher reactive oxygen species (ROS) levels, and also markedly inhibited tumor growth <em>in vivo</em>. Transcriptomic analysis indicated that the IL-6/JAK2/STAT3 signaling pathway was downregulated under NC-T5–5TR1 + IR treatment, which was subsequently validated <em>in vitro</em> and <em>in vivo</em>. Rescue experiments confirmed that IL-6 overexpression reversed NC-T5–5TR1 combined with IR-induced JAK2/STAT3 inhibition and its downstream effects on proliferation, apoptosis, and ROS accumulation. Collectively, our findings demonstrated that NC-T5–5TR1 enhanced the radiosensitivity of TNBC cells, and this effect was associated with the modulation of the IL-6/JAK2/STAT3 axis, offering a promising strategy for improving the therapeutic efficacy of radiotherapy in TNBC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115397"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145838043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-functionalized PCN-224-supported Pt-Pd bimetallic nanozyme with intrinsic oxidase activity for hydrogen peroxide-free ultrasensitive colorimetric sensing of ascorbic acid 具有内在氧化酶活性的聚多巴胺功能化pcn -224负载的Pt-Pd双金属纳米酶用于抗坏血酸的无过氧化氢超灵敏比色检测。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2026-01-02 DOI: 10.1016/j.colsurfb.2026.115413

Huan Luo , Shoubei Gao , Chenran Zhen , Haiyan Xiao , Yanshuai Cui , Longgang Wang

{"title":"Polydopamine-functionalized PCN-224-supported Pt-Pd bimetallic nanozyme with intrinsic oxidase activity for hydrogen peroxide-free ultrasensitive colorimetric sensing of ascorbic acid","authors":"Huan Luo , Shoubei Gao , Chenran Zhen , Haiyan Xiao , Yanshuai Cui , Longgang Wang","doi":"10.1016/j.colsurfb.2026.115413","DOIUrl":"10.1016/j.colsurfb.2026.115413","url":null,"abstract":"<div><div>Ascorbic acid (AA), an essential water-soluble antioxidant in humans, plays a critical role in disease prevention and health maintenance, necessitating accurate detection methods. However, conventional H<sub>2</sub>O<sub>2</sub>-dependent colorimetric methods face inherent limitations, creating a demand for alternative detection strategies that operate independently of H<sub>2</sub>O<sub>2</sub>. To address this problem, a composite nanozyme (PCN-224-PDA-PdPt<sub>3</sub>) was constructed by employing a zirconium-based porphyrin metal-organic framework (PCN-224) as a substrate, followed by sequential polydopamine (PDA) surface functionalization and PdPt<sub>3</sub> bimetallic nanoparticle deposition. The synthetic nanozyme exhibited exceptional oxidase-mimicking activity at pH 4.0 and 40 °C. Mechanism studies confirmed that its activity originates from the catalytic generation of reactive oxygen species (O<sub>2</sub>•⁻ and <sup>1</sup>O<sub>2</sub>) from dissolved oxygen. Leveraging this, an H<sub>2</sub>O<sub>2</sub>-independent colorimetric AA detection method was developed, which demonstrated a wide linear range (1–900 μM), a low detection limit (0.56 μM), and high selectivity against interfering species like amino acids and metal ions. The clinical applicability was further verified through satisfactory recoveries (96.84–104.46 %) and low RSD (< 5 %) in spiked human serum samples. Moreover, the nanozyme showed excellent biocompatibility with a hemolysis rate below 5 %. This work not only provides a robust and safe platform for biomedical detection but also paves the way for the rational design of multifunctional nanozymes for developing H₂O₂-independent sensing systems.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115413"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transformative progress of SPIONs in cancer theranostics: A comprehensive review on recent advances in SPIONs technology SPIONs在癌症治疗中的革命性进展：SPIONs技术最新进展的综合综述。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-13 DOI: 10.1016/j.colsurfb.2025.115372

Gourang Hari Gupta , Khyati Parmar , Sumanta Ghosh , Simran Gupta , Vijay Aherwar , Shreya Kadam , Saichand Thakkellapati , Mounika Choppadandi , K. Srinivasa Rao , Sarath Babu Srivalliputtur , Govinda Kapusetti

{"title":"Transformative progress of SPIONs in cancer theranostics: A comprehensive review on recent advances in SPIONs technology","authors":"Gourang Hari Gupta , Khyati Parmar , Sumanta Ghosh , Simran Gupta , Vijay Aherwar , Shreya Kadam , Saichand Thakkellapati , Mounika Choppadandi , K. Srinivasa Rao , Sarath Babu Srivalliputtur , Govinda Kapusetti","doi":"10.1016/j.colsurfb.2025.115372","DOIUrl":"10.1016/j.colsurfb.2025.115372","url":null,"abstract":"<div><div>To explore the fundamental properties and biomedical potential of Superparamagnetic Iron Oxide Nanoparticles (SPIONs), a multidisciplinary approach involving chemists, physicists, and material scientists is essential. This review highlights the unique magnetic properties of SPIONs compared to bulk magnetic materials, alongside their synthesis, characterization methods, and the factors influencing their magnetic behavior. We delve into the diverse biomedical applications of SPIONs, including their roles as contrast agents in imaging, drug carriers, and therapeutic agents for cancer treatment. Special attention is given to the concept of theranostics, where SPIONs are utilized for both therapy and diagnosis within a single system. We comprehensively summarize recent advances in the use of SPIONs for cancer theranostics over the past decade while briefly addressing their toxicity and biodegradability. Finally, the review discusses the current challenges and future prospects of SPIONs in theranostic applications including its explorations in ongoing clinical trials. The current study addresses the challenges and future perspectives in applying SPIONs in oncology, providing a roadmap for future research and development. Furthermore, considering the potential of SPION-based therapeutic platforms to achieve targeted anticancer efficacy, this article is expected to make a significant contribution to the existing body of knowledge and inspire further advancements in this rapidly evolving field.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115372"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vibrio cholerae adhesin-derived peptides mediate strong pull-off forces in aqueous media with high ionic strength 霍乱弧菌黏附素衍生肽在高离子强度的水介质中介导强牵引力

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.colsurfb.2025.115390

Syeda Tajin Ahmed , Sixin Zhai , Xin Huang , Sarvagya Sulaja , Adekunle Adewole , Alisa Ioffe , Andrea D. Merg , Jing Yan , Roberto C. Andresen Eguiluz

{"title":"Vibrio cholerae adhesin-derived peptides mediate strong pull-off forces in aqueous media with high ionic strength","authors":"Syeda Tajin Ahmed , Sixin Zhai , Xin Huang , Sarvagya Sulaja , Adekunle Adewole , Alisa Ioffe , Andrea D. Merg , Jing Yan , Roberto C. Andresen Eguiluz","doi":"10.1016/j.colsurfb.2025.115390","DOIUrl":"10.1016/j.colsurfb.2025.115390","url":null,"abstract":"<div><div>In this study, the pull-off forces of adsorbed films of four Bap1-inspired peptides in various solvents were investigated on negatively charged mica substrates using the surface forces apparatus (SFA), complemented with dynamic light scattering (DLS) for characterizing the aggregation behavior of peptides in solution. Bap1-inspired peptides consisted of the 57 amino acid wild-type sequence (WT); a scrambled version of the WT used to investigate the impact of the primary amino acid sequence in pull-off forces (Scr); a ten amino acid sequence rich in hydrophobic content (CP) of the WT sequence, and an eight amino acid sequence (Sh1) that corresponds to the pseudo-repeating sequence in the 57 AA. SFA results showed remarkable pull-off forces for CP, particularly in the presence of salts: measured pull-off forces were 26.0 ± 7.0 mN/m for no dwell-time and up to 42.0 ± 8.8 mN/m when surfaces were left in contact for 30 min. Sh1 did not bridge mica surfaces, while large aggregates clouded SFA measurements of Scr. DLS observations indicated that salts favored large peptide aggregation for all constructs (<em>D</em><sub>H</sub> > 1 µm), as compared to milliQ (<em>D</em><sub>H</sub> ≈ 100–500 nm) water and DMSO (<em>D</em><sub>H</sub> ≈ 5 nm), resulting in heterogeneous peptide film thicknesses.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115390"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0