Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Corrigendum to \"Immobilization of Candida antarctica lipase B on MWNTs modified by ionic liquids with different functional groups\" [Colloids Surf. B Biointerfaces 160 (2017) 416-422].","authors":"Xiaomei Wan, Xinran Xiang, Susu Tang, Dinghua Yu, He Huang, Yi Hu","doi":"10.1016/j.colsurfb.2025.114921","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2025.114921","url":null,"abstract":"","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":" ","pages":"114921"},"PeriodicalIF":5.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NO-generating self-delivery liposomes for synergistic photodynamic-gas therapy against hypoxic tumors","authors":"Yimei Zhang,&nbsp;Kai Ran,&nbsp;Hui Liu,&nbsp;Dianyong Tang,&nbsp;Zhongzhu Chen,&nbsp;Zheng Huang","doi":"10.1016/j.colsurfb.2025.114910","DOIUrl":"10.1016/j.colsurfb.2025.114910","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is an effective non-invasive tumor treatment strategy that has been widely used for anti-tumor therapy. However, the hypoxic tumor microenvironment significantly limits the therapeutic efficacy of photodynamic therapy (PDT). Herein, a laser-activated drug delivery system is successfully developed for photodynamic-gas synergistic therapy. Specifically, reactive oxygen species (ROS)-responsive liposomes loaded with pyropheophorbide a (<strong>PPa@FALA NPs</strong>) are constructed using Fmoc-L-arginine-linolyl alcohol (FALA) as both the carrier and a nitric oxide (NO)-generating agent. The obtained liposomes exhibit 4-fold higher cellular internalization efficiency than free PPa. Upon laser irradiation, the encapsulated photosensitizer PPa generated ROS, which oxidize the linolyl alcohol chains. This oxidation could result in structural disruption of the liposomes and subsequent drug release. Crucially, the released FALA efficiently produced NO through both endogenous and exogenous ROS pathways. This NO generation downregulated HIF-1α protein expression to 65 % compared with control, alleviated tumor hypoxia and consequently enhanced PDT efficacy ∼2-fold. Notably, these self-delivery liposomes were fabricated without complex synthesis procedures, ensuring potential for mass production and biosafety. This study presented a simple and effective drug delivery system, which provided a promising strategy for synergistic photodynamic-gas therapy in tumor treatment.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114910"},"PeriodicalIF":5.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial optical nociceptors utilizing photoelectric synaptic transistors","authors":"Gexun Qin ,&nbsp;Yanmei Sun ,&nbsp;Xinru Meng","doi":"10.1016/j.colsurfb.2025.114926","DOIUrl":"10.1016/j.colsurfb.2025.114926","url":null,"abstract":"<div><div>As a critical neural component for detecting noxious stimuli, pain receptors are capable of sensing external harmful stimuli and promptly transmitting signals to the brain, thereby enabling the human body to react in a timely manner to avoid potential risks. Consequently, integrating pain receptors into bionic devices can significantly enhance storage density and processing efficiency, as well as improve information transmission, thus markedly boosting the performance of these devices. In this study, the solution method is employed to fabricate optoelectronic synaptic transistor that exhibit bipolar behavior, excellent gate control, and negative photoconductivity. These transistors can emulate the plasticity of biological synapses under various light and electrical stimuli. Based on this device, artificial optical nociceptors that possess biomimetic properties similar to human skin have been developed, mimicking the response of human skin to UV stimulation. Moreover, these artificial photoreceptors can activate a defense mechanism to repair themselves when UV intensity reaches a certain threshold. This innovation offers new insights into the development of photosensitive devices and holds promise for applications in neuromorphic computing, facilitating brain-like computing and intelligent information processing, and advancing artificial intelligence technology.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114926"},"PeriodicalIF":5.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of multifunctional NaYbF4:Er3+ upconversion nanoparticle-based dual drug delivery system for enhanced chemo-photodynamic therapy in prostate cancer","authors":"Subhadeep Ghosh ,&nbsp;Madhura Deshpande ,&nbsp;Ping Xu ,&nbsp;Rohini Shinde ,&nbsp;Weon-Sik Chae ,&nbsp;Seung-Hae Kwon ,&nbsp;Joo-Yeong Jeon ,&nbsp;Kwan Soo Hong ,&nbsp;Chan Yeong Park ,&nbsp;Yeong Hyeock Kim ,&nbsp;Tae Jung Park","doi":"10.1016/j.colsurfb.2025.114919","DOIUrl":"10.1016/j.colsurfb.2025.114919","url":null,"abstract":"<div><div>Upconversion efficiency in heterostructure hosts is critical for multicolor emission in biomedical applications, where cellular uptake is dependent on particle size. In chemo-photodynamic therapy (chemo-PDT), reducing cellular glutathione (GSH) levels through reactive nitrogen species (RNS) generation, combined with reactive oxygen species (ROS), offers a dual strategy to halt cancer cell proliferation. Herein, We optimized NaYbF₄:Er³⁺ upconversion nanoparticles (UCNPs) with size control (final nanocapsule size: 60.5 nm) and applied heterogeneous NaGdF₄:Yb³⁺,Er³⁺ and inert NaGdF₄ shelling, achieving a 30-fold enhancement in fluorescence intensity at 520 nm and 545 nm, alongside improved magnetic resonance imaging (MRI) efficacy. These core@shell@shell UCNPs were nano-precipitated with O²-(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate a class of diazeniumdiolate prodrug and AIEgen molecule to form nanocapsules that generate reactive oxygen and nitrogen species (RONS). Under 980 nm NIR laser (0.25 W/cm²) and white light (0.5 W/cm²) irradiation, these nanocapsules deplete GSH to produce nitric oxide (NO), while AIEgen generates superoxide (∙O₂^-) and hydroxyl (•OH) radicals <em>via</em> type-I PDT, with NO and ∙O₂^- forming peroxynitrite (OONO^-). In LNCaP prostate cancer cells, 99.7 % nanocapsule internalization occurred within 1 h, and a low dose of 0.625 µg/mL achieved near-complete cell death under dual irradiation, demonstrating synergistic chemo-PDT efficacy. This dual drug delivery system, combining enhanced fluorescence, MRI, and RONS generation, holds promise for precise bioimaging and effective prostate cancer therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114919"},"PeriodicalIF":5.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular nanosponges featuring hydrazone bonds: A smart solution for pH-triggered drug delivery","authors":"Serap Sezen ,&nbsp;Atefeh Zarepour ,&nbsp;Ali Zarrabi ,&nbsp;Feray Bakan Misirlioglu","doi":"10.1016/j.colsurfb.2025.114920","DOIUrl":"10.1016/j.colsurfb.2025.114920","url":null,"abstract":"<div><div>Cyclodextrin nanosponges (CD NSs) are smart materials, serving as drug delivery vehicles, increasing the effectiveness of anti-cancer drugs while reducing their side effects as they respond to the external forces. Here, a novel class of pH-responsive CD NSs was developed by oxidation of CD, followed by the crosslinking with adipic acid dihydrazide, forming pH-sensitive hydrazone bonds inside the NS then loaded with Doxorubicin (Dox) as a model drug. Characterizations indicated that CD NSs were successfully synthesized, having a spherical shape, thermally stable, amorphous structure, acceptable size distribution, and almost neutral surface charge. The NSs encapsulated approximately 58 % of Dox, while the release profile was found to be pH-dependent; almost 1.5 times higher Dox was released when pH was switched from neutral (pH 7.4) to acidic (pH 5.5). It was shown that NS was not toxic to both MCF-7 and L929 cells. IC₅₀ values for each specimen were found to be 2.12 μM for free Dox and 0.82 μM for encapsulated Dox, respectively. Thus, NS-Dox was able to protect L929 cells from Dox-mediated toxicity. Moreover, NS-Dox showed a similar internalization pattern with free Dox, while both reached the nucleus after 6 h of incubation. In addition, cellular uptake of Dox was significantly enhanced by encapsulation altered from 38 % for Dox to 69 % for NS-Dox after 2 h of incubation. In the light of these findings, we propose that this new type of pH-responsive CD NS is a cost-effective and promising alternative as a pH-responsive smart material to be a drug delivery vehicle, which could be useful for cancer therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114920"},"PeriodicalIF":5.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study\" [Colloid. Surf. B Biointerfaces 203 (2021) 111759 /COLSUB-D-20-01957].","authors":"Shaoxuan Yu, Shanyu Wang, Zhike Xie, Shuyan Yu, Ling Li, Haifang Xiao, Yuanda Song","doi":"10.1016/j.colsurfb.2025.114894","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2025.114894","url":null,"abstract":"","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":" ","pages":"114894"},"PeriodicalIF":5.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATB0,+-targeted nanoparticles trigger STAT3-ferroptosis regulatory axis for enhanced gastric cancer therapy","authors":"Hailun Zheng ,&nbsp;Xiaoyan Mao ,&nbsp;Zhiwei Chen ,&nbsp;Linying Wang ,&nbsp;Fuxiang Shangguan ,&nbsp;Zihao Tao ,&nbsp;Jinyao Ye ,&nbsp;Weilan Cao ,&nbsp;Qing Yao ,&nbsp;Lili Yan ,&nbsp;Ruijie Chen ,&nbsp;Shihui Bao ,&nbsp;Longfa Kou","doi":"10.1016/j.colsurfb.2025.114918","DOIUrl":"10.1016/j.colsurfb.2025.114918","url":null,"abstract":"<div><div>Chemotherapy remains one of the main treatments for gastric cancer, but the efficacy of 5-fluorouracil (5-FU) is limited by drug resistance. Ferroptosis is a unique mode of regulated cell death characterized by iron accumulation and lipid peroxidation, and its induction by aberrant STAT3 signaling may contribute to chemotherapy resistance. Cryptotanshinone (Cpt) is a bioactive compound extracted from Salvia miltiorrhiza that acts as a STAT3 inhibitor and has shown efficacy against several malignancies, endowing its potential as an agent to overcome the chemotherapy of gastric cancer. Importantly, cancer cells—especially drug-resistant cells—often upregulate amino acid transporters to import indispensable nutrients that support rapid proliferation, and therefore these transporters could guide the target delivery of chemotherapeutics for enhanced delivery efficiency. Here, we developed an amino acid transporter-targeted nanoplatform (F/C@Trp-NPs) co-loaded with 5-FU and Cpt to target the SLC6A14 (ATB^0,+) transporter, which is abnormally upregulated in gastric cancer cells, and evaluated its anticancer effects. The F/C@Trp-NPs significantly inhibited gastric cancer cell proliferation in vitro, consistent with the in vivo results. This study provides a promising new therapeutic strategy for gastric cancer.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114918"},"PeriodicalIF":5.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partially substituting whey protein by rice protein hydrolysate to fabricate emulsions: Physicochemical properties, stability and digestion behavior","authors":"Wen Wang ,&nbsp;Yaxuan Liu ,&nbsp;Meijun Liu,&nbsp;Feng Gao,&nbsp;Boxue Xia,&nbsp;Ru Zhao,&nbsp;Xinxin Yin,&nbsp;Cuina Wang","doi":"10.1016/j.colsurfb.2025.114917","DOIUrl":"10.1016/j.colsurfb.2025.114917","url":null,"abstract":"<div><div>The partial substitution of whey protein with plant-derived proteins in the formulation of new products has garnered significant attention. This study investigated emulsions stabilized by varying blends of whey protein concentrate (WPC) and rice protein hydrolysate (RPH) in mass ratios ranging from 100:0–0:100, focusing on their physicochemical properties, stability, and digestive characteristics. RPH was obtained via trypsin hydrolysis, achieving a solubility of up to 92.4 % across pH values of 3–9. Increasing the ratio of RPH in blend led to a reduction in particle size, an increase in surface charge, a decrease in surface hydrophobicity, and a more flexible secondary structure. The emulsions exhibited particle sizes below 325 nm with a narrow size distribution and high surface charge. The gradual replacement of WPC with RPH resulted in decreased physical stability of the emulsions under varying pH and ionic strength conditions. Emulsions composed of 75 % WPC and 25 % RPH demonstrated the highest stability against lipid oxidation. The incorporation of RPH into WPC formulations enhanced the fatty acid release rate of the emulsions compared to those stabilized by individual emulsifiers. These findings may offer a robust theoretical foundation for the selection and utilization of blended animal and plant proteins in emulsion technology.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114917"},"PeriodicalIF":5.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A smart ultra-small near infrared persistent luminescence nanoprobe for non-invasive detection of early rheumatoid arthritis","authors":"Yanping Xie ,&nbsp;Qiong Zou ,&nbsp;Yunfei Zhu ,&nbsp;Ya Wen ,&nbsp;Siqi Hu ,&nbsp;Jing Wang ,&nbsp;Chenyang Lu ,&nbsp;Rui Zou ,&nbsp;Ju Jiao","doi":"10.1016/j.colsurfb.2025.114915","DOIUrl":"10.1016/j.colsurfb.2025.114915","url":null,"abstract":"<div><div>Early detection of rheumatoid arthritis (E-RA) is crucial for long-term patient health, but current methods lack precision. Overproduced reactive oxygen species (ROS) in hypoxic and inflammatory synovium are early markers of RA, appearing years before significant radiological findings, making them attractive biomarkers for early detection. Here, an ultrasensitive ROS-responsive nanoprobe are developed based on glutathione (GSH) modified Cr^3 + doped ZnGa₂O₄ ultra-small near-infrared (NIR) persistent luminescence nanoparticles (denoted as ZnGa₂O₄:Cr³⁺-GSH). The well-designed ZnGa₂O₄:Cr³⁺-GSH responds to ROS and cross-link by forming disulfide bonds, enabling autofluorescence-free NIR persistent luminescence (NIR-PL) imaging in vivo with a 1.9-fold signal to noise ratio (SNR) increase in collagen-induced arthritis mice paws compared to healthy control. Leveraging its ROS-responsive crosslinking and superior SNR performance, ZnGa₂O₄:Cr³⁺-GSH achieves ultrasensitive E-RA lesion detection through NIR-PL imaging. In addition, pharmacokinetic analysis shows that ultra-small ZnGa₂O₄:Cr³⁺-GSH has an elimination half-life of 19.85 min, with 3.45 % ID and 20.43 % ID excreted via urine and feces at 2 days post-injection, confirming its excellent biosafety. The study demonstrates the clinical promise of ZnGa₂O₄:Cr³⁺-GSH for precise diagnosis of E-RA, which might also offer an alternative basis for existing diagnostic procedures of RA.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114915"},"PeriodicalIF":5.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic ferroptosis-photo-chemo to disrupt redox homeostasis for augmenting cancer chemoimmunotherapy","authors":"Cheng-Lei Li ,&nbsp;Wen-Zhong Zhang ,&nbsp;Rui-Rui Zhao ,&nbsp;Jing-Qing Le ,&nbsp;Bing-Chen Zhang ,&nbsp;Huan-Zhang Xie ,&nbsp;Yu-Sheng Lu ,&nbsp;Jing-Wei Shao","doi":"10.1016/j.colsurfb.2025.114908","DOIUrl":"10.1016/j.colsurfb.2025.114908","url":null,"abstract":"<div><div>Immune checkpoint blockade (ICB) holds broad application prospects in tumor treatment. However, the poor immunogenicity and the adaptive resistance cells severely limit the clinical efficacy. Immunogenic cell death (ICD) can sensitize the cells which were initially lower responsive to ICB. Based on this, we reported a metal coordination co-assembly nanocomposite (SIF NPs), which can enhance cancer immunotherapy by strengthening ICD induction through inducing ferroptosis-photo-chemo. The SIF NPs possess excellent biocompatibility and stability, and exhibit good PTT and PDT effects both <em>in vitro</em> and <em>in vivo</em>. The SIF NPs disrupt redox homeostasis and induce ferroptosis by consuming glutathione (GSH), downregulating the expression of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), and enhancing the generation of lipid hydroperoxides (LPO). Importantly, SIF NPs trigger an ICD cascade via inducing the cell death, thus enhancing the immunogenicity of tumors. In a tumor-bearing mice model, the synergistic‌ therapy of SIF NPs and anti-PD-L1 antibody demonstrated a powerful inhibition effectiveness on bilateral tumors and instigated a long-time immune memory effect. This study indicates that the combined treatment of ferroptosis-photo-chemo and immunotherapy possess promising application prospects.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114908"},"PeriodicalIF":5.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}