Colloids and Surfaces B: Biointerfaces最新文献_第8页

Biocompatible semiconducting molybdenum diselenide nanosheets with glycyrrhizic acid for enhanced photothermal cancer therapy 生物相容性半导体二硒化钼纳米片与甘草酸增强光热癌症治疗

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-30 DOI: 10.1016/j.colsurfb.2025.115411

Su Jeong Lee , Won Hur , Chang Hyeon Ha , Da Yeong Choi , Jayachandran Venkatesan , Gi Hun Seong

{"title":"Biocompatible semiconducting molybdenum diselenide nanosheets with glycyrrhizic acid for enhanced photothermal cancer therapy","authors":"Su Jeong Lee , Won Hur , Chang Hyeon Ha , Da Yeong Choi , Jayachandran Venkatesan , Gi Hun Seong","doi":"10.1016/j.colsurfb.2025.115411","DOIUrl":"10.1016/j.colsurfb.2025.115411","url":null,"abstract":"<div><div>Nanosheets of molybdenum diselenide (MoSe<sub>2</sub>), a representative two-dimensional (2D) transition metal dichalcogenide, have attracted considerable attention for biological and medical applications due to their excellent biocompatibility and near-infrared (NIR) absorption capabilities. In this work, we present a simple method for preparing 2D therapeutic nanosheets that incorporate glycyrrhizic acid (GA), a naturally derived amphiphilic surfactant with anticancer properties, for the liquid exfoliation of bulk MoSe<sub>2</sub> to produce 2D GA-MoSe<sub>2</sub> nanosheets. GA is an excellent exfoliation agent because it can achieve a high yield of around 22 %, and it allows for liquid exfoliation of nanosheets in aqueous solutions. To improve their biocompatibility and cellular uptake, we coated them with polyethylene glycol (PEG), resulting in PEG-GA-MoSe<sub>2</sub> (PGM). PGM exhibited robust photothermal performance under 808 nm NIR laser irradiation (0.8 W/cm<sup>2</sup>, 5 min) and achieved a temperature rise of approximately 55 ℃, even at concentrations as low as 30 μg/mL. As a result, the PEG coating did not affect the photothermal performance of PGM and showed cellular uptake results of PGM that increased by around 3.5 times compared to those of the GA-MoSe<sub>2</sub> nanosheets. Furthermore, the nanosheets displayed remarkable colloidal stability without indications of structural degradation after multiple laser irradiation cycles. Both <em>in vitro</em> and <em>in vivo</em> experiments demonstrated minimal cytotoxicity, excellent cellular uptake, and prominent photothermal therapeutic effects, resulting in significant tumor reduction or complete elimination in laser-treated tumor regions. These findings establish PGM as a promising biocompatible platform for photothermal cancer therapy that offers efficient NIR-induced hyperthermia for targeted tumor treatment.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115411"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of SilMA hydrogels with stiffness gradients for soft-to-hard interface tissue engineering 软硬界面组织工程中具有刚度梯度的SilMA水凝胶的制备。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115425

Siyuan Liu , Xialing Tu , Jiaxuan Huang , Nianjie Wu , Bin Xia , Guobao Chen

{"title":"Fabrication of SilMA hydrogels with stiffness gradients for soft-to-hard interface tissue engineering","authors":"Siyuan Liu , Xialing Tu , Jiaxuan Huang , Nianjie Wu , Bin Xia , Guobao Chen","doi":"10.1016/j.colsurfb.2026.115425","DOIUrl":"10.1016/j.colsurfb.2026.115425","url":null,"abstract":"<div><div>Native tissue interfaces exhibit continuous gradients in mechanical stiffness and extracellular matrix (ECM) composition, which are essential for effective load transmission and functional integration between adjacent tissues. However, accurately replicating these intricate biomechanical gradients in engineered biomaterials remains a significant challenge in interface tissue engineering. In this study, we present a stiffness-gradient methacrylated silk fibroin (SilMA) hydrogel designed to promote tissue interface regeneration, with a focus on mechanical cues as a critical design parameter. Silk fibroin was chemically modified into SilMA, and its concentration systematically varied to produce multilayer hydrogels exhibiting a continuous stiffness gradient ranging from 7.07 ± 4.02 kPa to 71.30 ± 0.97 kPa, effectively mimicking the native mechanical heterogeneity found at tissue interfaces. Functional assays revealed that the low-stiffness layer significantly enhanced angiogenesis, the intermediate-stiffness layer provided an optimal mechanical environment for stem cell osteogenic differentiation, and the high-stiffness layer recapitulated the biomechanical properties of native cartilage tissue. This biomimetic stiffness-gradient SilMA hydrogel scaffold offers a promising strategy for regenerating complex tissue interfaces by harnessing the instructive role of mechanical microenvironments. Our findings underscore the importance of spatially graded mechanical properties in guiding cellular responses and tissue repair, and advance the design of next-generation materials for interface tissue engineering.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115425"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zwitterionic hydrogel coatings enhance anti-fouling and anti-thrombogenicity of decellularized swim bladder for bioprosthetic heart valves 两性离子水凝胶涂层增强生物人工心脏瓣膜去细胞鱼鳔的防污性和抗血栓性。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-23 DOI: 10.1016/j.colsurfb.2025.115349

Haiyue Ren , Zhicheng Pan , Jinfeng Yuan , Jing Liu

{"title":"Zwitterionic hydrogel coatings enhance anti-fouling and anti-thrombogenicity of decellularized swim bladder for bioprosthetic heart valves","authors":"Haiyue Ren , Zhicheng Pan , Jinfeng Yuan , Jing Liu","doi":"10.1016/j.colsurfb.2025.115349","DOIUrl":"10.1016/j.colsurfb.2025.115349","url":null,"abstract":"<div><div>Glutaraldehyde cross-linked bovine/porcine pericardium has been used as prosthetic heart valves (BHVs), while residual aldehyde groups induce cytotoxicity, thrombus formation, and progressive calcification deposition, which ultimately limits instrument life span to 10–15 years. We innovatively designed a multifunctional zwitterionic hydrogel coating copolymer poly (SBMA-co-DMEMAm) on swim bladder-derived material, which is composed of hydrophilic monomer SBMA and aldehyde-containing monomer DMEMAm; besides the aldehyde group can crosslink fish bladder tissue and improve the mechanical properties. This multifunctional hydrophilic polymer coatings provide effective anti-fouling properties, better anti-platelet adsorption and anti-thrombotic properties in <em>in vitro</em> blood compatibility evaluation. In addition, it showed better anti-inflammatory and anti-calcification properties in rat subcutaneous implantation. Thus, this study presents a versatile zwitterionic hydrogel coating strategy that simultaneously endows decellularized swim bladder with superior anti-fouling, hemocompatibility, cytocompatibility, and anti-thrombogenicity, offering a comprehensive solution for durable bioprosthetic heart valves.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115349"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH-responsive phytochemical hydrogel loaded with antioxidant nanozymes for synergistic ROS scavenging and targeted inflammatory bowel disease therapy 负载抗氧化纳米酶的ph响应植物化学水凝胶，用于协同ROS清除和靶向炎症性肠病治疗。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.colsurfb.2025.115381

Yunong Shi , Miaosheng Tian , Shuo Shi , Jihua Gao

{"title":"pH-responsive phytochemical hydrogel loaded with antioxidant nanozymes for synergistic ROS scavenging and targeted inflammatory bowel disease therapy","authors":"Yunong Shi , Miaosheng Tian , Shuo Shi , Jihua Gao","doi":"10.1016/j.colsurfb.2025.115381","DOIUrl":"10.1016/j.colsurfb.2025.115381","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) remains a therapeutic challenge due to its complex pathophysiology involving oxidative stress and chronic inflammation. Here, we developed a multifunctional hydrogel system (CeO<sub>2</sub>@Rh-gel) integrating rhein, a natural anti-inflammatory agent, and CeO<sub>2</sub> NPs with ROS scavenging nanozyme activity for controlled release IBD therapy. The CeO<sub>2</sub>@Rh-gel was fabricated through self-assembly, forming a pH-responsive network that protected payloads in the stomach while enabling controlled release in the inflamed colon. In vitro, CeO<sub>2</sub>@Rh-gel exhibited synergistic antioxidant effects, mimicking SOD and CAT to eliminate ROS, while suppressing pro-inflammatory cytokines in LPS-stimulated macrophages. In a DSS-induced murine colitis model, oral CeO<sub>2</sub>@Rh-gel significantly alleviated disease severity, as evidenced by reduced weight loss, normalized colon length, and improved histopathology. Mechanistically, the hydrogel restored redox homeostasis and attenuated systemic inflammation. By combining ROS scavenging, anti-inflammatory action, and controllable delivery, CeO<sub>2</sub>@Rh-gel offers a promising dual-functional strategy for precision IBD therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115381"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fluorescein-tagged pH-low insertion peptide (pHLIP) for glioblastoma imaging: Lipid membrane interaction and cancer cell targeting 荧光素标记的低ph插入肽（pHLIP）用于胶质母细胞瘤成像：脂膜相互作用和癌细胞靶向。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.colsurfb.2025.115398

Cristina Chirizzi , Martina Maffezzini , Nadia Mosca , Arianna Balestri , Costanza Montis , Francesco Acerbi , Martina Beccalli , Alessandro Gori , Marina Grisoli , Serena Pellegatta , Francesca Baldelli Bombelli

{"title":"A fluorescein-tagged pH-low insertion peptide (pHLIP) for glioblastoma imaging: Lipid membrane interaction and cancer cell targeting","authors":"Cristina Chirizzi , Martina Maffezzini , Nadia Mosca , Arianna Balestri , Costanza Montis , Francesco Acerbi , Martina Beccalli , Alessandro Gori , Marina Grisoli , Serena Pellegatta , Francesca Baldelli Bombelli","doi":"10.1016/j.colsurfb.2025.115398","DOIUrl":"10.1016/j.colsurfb.2025.115398","url":null,"abstract":"<div><div>Glioblastoma (GB) is the most aggressive and common malignant brain tumor, and despite current therapeutic approaches, prognosis remains poor. Given that surgical resection is frequently the sole potentially curative option, precise intraoperative tumor delineation is crucial for reducing recurrence rates and enhancing patient outcomes. In this study, we developed a novel pH-responsive imaging tool by coupling the pH-low insertion peptide (pHLIP) with fluorescein (FL) to enable targeted fluorescence-guided visualization of tumor margins. We investigated pHLIP–lipid membrane interactions using model systems, including liposomes and supported lipid bilayers (SLB), assessing peptide’s pH-dependent insertion mechanism. Complementary <em>in vitro</em> experiments on patient-derived GB cell lines were performed to show the tracer’s pH sensitivity, selective membrane targeting, and potential off-target effects. The FL-pHLIP construct showed robust, pH-dependent membrane insertion and selectivity in GB cellular models with minimal interaction under physiological conditions. These findings support FL-pHLIP as a promising candidate for fluorescence-guided surgery in GB and highlight its potential for clinical translation and for the broader development of pH-responsive diagnostic tools.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115398"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside-based nanoliposomes co-delivering ergothioneine and coenzyme Q10 to combat skin aging via mitochondrial modulation 基于人参皂苷的纳米脂质体通过线粒体调节共同递送麦角硫因和辅酶Q10来对抗皮肤衰老。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-28 DOI: 10.1016/j.colsurfb.2025.115405

Shining Li , Ying Luo , Dan Wang , Bingqing Wang , Jun Gao , Xin Chen , Zhigang Li , Haixiao Wan , Ying Wu , Zhuang Ma , Yongjie Lu , Lin Geng , Yan Huang , Na Li , Li Ye , Dongcui Li , Naisheng Jiang

{"title":"Ginsenoside-based nanoliposomes co-delivering ergothioneine and coenzyme Q10 to combat skin aging via mitochondrial modulation","authors":"Shining Li , Ying Luo , Dan Wang , Bingqing Wang , Jun Gao , Xin Chen , Zhigang Li , Haixiao Wan , Ying Wu , Zhuang Ma , Yongjie Lu , Lin Geng , Yan Huang , Na Li , Li Ye , Dongcui Li , Naisheng Jiang","doi":"10.1016/j.colsurfb.2025.115405","DOIUrl":"10.1016/j.colsurfb.2025.115405","url":null,"abstract":"<div><div>Skin aging is closely linked to mitochondrial dysfunction, yet effective delivery of mitochondrial therapeutics to the skin remains a challenge. Here, we report ECG-Lipo, a mitochondria-modulating nanoliposome system that co-delivers hydrophilic ergothioneine (EGT) and lipophilic coenzyme Q10 (CoQ10) for rejuvenation therapy. ECG-Lipo was fabricated by flash nanoprecipitation using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and protopanaxatriol-type ginsenoside metabolites (PPTGM) as liposome-forming agents, yielding uniform nanosized unilamellar vesicles with high stability and encapsulation efficiency. Compared with free drug solutions, ECG-Lipo significantly enhanced skin penetration and cellular repair, as demonstrated by in vitro Franz diffusion assays, in vivo fluorescence imaging in mouse skin, and fibroblast migration assays. Molecular docking indicated that PPTGM exhibits stronger predicted interactions with the EGT transporter OCTN-1 than cholesterol through combined hydrophobic and hydrogen-bonding interactions, suggesting a potential structural basis for the observed biological effects. In oxidative stress-challenged human dermal fibroblasts, ECG-Lipo preserved mitochondrial integrity by maintaining mitochondrial signal and morphology, restoring membrane potential, and suppressing mitochondrial superoxide accumulation. These results highlight ECG-Lipo as a promising mitochondria-modulating nanoliposome system for transdermal delivery with potential for therapeutic intervention against intrinsic skin aging.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115405"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZIF-8-based Schottky heterojunction for boosting the sonodynamic antimicrobial effect of chlorin e6 on MRSA 基于zif -8的肖特基异质结增强氯e6对MRSA的声动力抗菌作用

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115419

Xiaoyang Xu , Danni Wang , Bingjie Leng , Tingting Gao , Zhenning Cui , Xiao Wang , Bin Liu

{"title":"ZIF-8-based Schottky heterojunction for boosting the sonodynamic antimicrobial effect of chlorin e6 on MRSA","authors":"Xiaoyang Xu , Danni Wang , Bingjie Leng , Tingting Gao , Zhenning Cui , Xiao Wang , Bin Liu","doi":"10.1016/j.colsurfb.2026.115419","DOIUrl":"10.1016/j.colsurfb.2026.115419","url":null,"abstract":"<div><div>Sonodynamic antimicrobial chemotherapy (SACT) has been regarded as an emerging approach for antimicrobial treatment due to its advantages of deep tissue penetration, non-invasive nature, and absence of resistance. However, several challenges hinder its clinical application, for example insufficient oxygen levels at infection sites, poor solubility and stability of sonosensitizers. Herein, we developed chlorin e6@ZIF-8@Ag (CZ@Ag) nanocomposite as a Schottky heterojunction sonosensitizer with high electron-hole separation and narrow bandgap. The results reveal that the Schottky barrier between ZIF-8 and Ag nanoparticles can availably restrain electron backflow, further promoting the yield of reactive oxygen species (ROS) under ultrasound treatment. Experimentally, the minimum inhibitory concentration of CZ@Ag against methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) reduced from 320 μg/mL to 80 μg/mL, and its antibacterial rate was up to 96.3 % after 3 min of ultrasound irradiation. Furthermore, mechanistic studies found that CZ@Ag-mediated SACT is mainly achieved by inhibiting biofilm formation, damaging cell membrane integrity, enhancing more ROS generation, and increasing cell membrane permeability, leading to the leakage of intracellular contents. All these findings proved that CZ@Ag had great possibility for antibacterial therapy, and this investigation offered a feasible direction for developing efficient sonosensitizers.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115419"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery 用ph触发的纳米涂层对抗牙周炎：辛伐他汀递送的缓释策略。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-15 DOI: 10.1016/j.colsurfb.2025.115375

Siyu Du , Yi Zheng , Yabing Chen , Yijing Guo , Xinyue Kang , Lei Wang

{"title":"Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery","authors":"Siyu Du , Yi Zheng , Yabing Chen , Yijing Guo , Xinyue Kang , Lei Wang","doi":"10.1016/j.colsurfb.2025.115375","DOIUrl":"10.1016/j.colsurfb.2025.115375","url":null,"abstract":"<div><div>The growing incidence of periodontitis demands innovative therapies, as current drug treatments are limited by short retention times, rapid clearance, and the risk of antimicrobial resistance. This study introduces a novel pH-responsive nano-miclle system for simvastatin (SIM) delivery. Its core innovation lies in being the first system ((SIM NP)n) of its kind to be stabilized by a cross-linked \"outer shell,\" which significantly enhances its stability and controlled release capabilities. This \"smart\" system remains stable in a neutral environment (pH 7.4), preventing premature drug release. However, upon encountering the acidic inflammatory microenvironment of periodontitis, the shell degrades, triggering the sustained release of SIM directly at the site of inflammation. In vitro studies demonstrated that the SIM-loaded micelles possess potent immunomodulatory effects: they effectively suppressed pro-inflammatory M1 macrophage polarization (decreasing IL-1β, iNOS) while promoting anti-inflammatory M2 macrophage polarization (increasing Arg-1, IL-10). Mechanistic investigation confirmed this therapeutic effect is mediated by the PI3K/AKT/mTOR signaling pathway. More importantly, in a mouse model of periodontitis, the nano-micelles significantly reduced alveolar bone resorption, demonstrating potent anti-inflammatory and bone-protective efficacy in vivo. In conclusion, this \"smart\" pH-triggered delivery system for SIM offers a highly promising and effective strategy to overcome the limitations of traditional therapies, providing a new targeted path for the treatment of periodontitis.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115375"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of immune-enhancing vesicles from reassembled yeast vacuolar membranes 重组酵母液泡膜制备免疫增强囊泡

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.colsurfb.2025.115380

Su-Min Lee , Yunyoung Cho , Jiwoo Lim , Seungwoo Chung , Ngoc-Tu Nguyen , Yang-Hoon Kim , Sang-Ho Park , Jiho Min

{"title":"Fabrication of immune-enhancing vesicles from reassembled yeast vacuolar membranes","authors":"Su-Min Lee , Yunyoung Cho , Jiwoo Lim , Seungwoo Chung , Ngoc-Tu Nguyen , Yang-Hoon Kim , Sang-Ho Park , Jiho Min","doi":"10.1016/j.colsurfb.2025.115380","DOIUrl":"10.1016/j.colsurfb.2025.115380","url":null,"abstract":"<div><div>Yeast vacuoles have recently emerged as promising bio-nanomaterials for drug delivery, offering improved stability and efficacy compared with traditional synthetic systems. Their membranes share structural and compositional similarities with those of mammalian cells, offering excellent biocompatibility and potential for efficient cellular interaction. These unique properties make reassembled vacuoles (ReV) attractive candidates for developing safe and effective therapeutic delivery platforms. This study optimized the vacuole reassembly process to enhance the performance of drug delivery. We compared two methods: Method 1, using conventional long-duration sonication and filtration, and Method 2, featuring an optimized 5-minute sonication without filtration. Reassembled vacuoles produced by method 1 (ReV<sub>Mtd1</sub>), induced moderate TLR2 expression, suggesting mild immune priming without significant activation of inflammatory cytokines. In contrast, Reassembled vacuoles produced by method 2 (ReV<sub>Mtd2</sub>) demonstrated superior immune activation, showing a dose-dependent upregulation of iNOS and TLR2. Additionally, ReV<sub>Mtd2</sub> achieved an encapsulation efficiency of 12.9 % for daunorubicin (DNR), comparable to native vacuoles, and maintained structural stability over a 12-month period. These findings highlight the potential of ReV<sub>Mtd2</sub> as a robust, biocompatible, and efficient drug delivery system, offering enhanced therapeutic performance and long-term stability.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115380"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transformative progress of SPIONs in cancer theranostics: A comprehensive review on recent advances in SPIONs technology SPIONs在癌症治疗中的革命性进展：SPIONs技术最新进展的综合综述。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-04-01 Epub Date: 2025-12-13 DOI: 10.1016/j.colsurfb.2025.115372

Gourang Hari Gupta , Khyati Parmar , Sumanta Ghosh , Simran Gupta , Vijay Aherwar , Shreya Kadam , Saichand Thakkellapati , Mounika Choppadandi , K. Srinivasa Rao , Sarath Babu Srivalliputtur , Govinda Kapusetti

{"title":"Transformative progress of SPIONs in cancer theranostics: A comprehensive review on recent advances in SPIONs technology","authors":"Gourang Hari Gupta , Khyati Parmar , Sumanta Ghosh , Simran Gupta , Vijay Aherwar , Shreya Kadam , Saichand Thakkellapati , Mounika Choppadandi , K. Srinivasa Rao , Sarath Babu Srivalliputtur , Govinda Kapusetti","doi":"10.1016/j.colsurfb.2025.115372","DOIUrl":"10.1016/j.colsurfb.2025.115372","url":null,"abstract":"<div><div>To explore the fundamental properties and biomedical potential of Superparamagnetic Iron Oxide Nanoparticles (SPIONs), a multidisciplinary approach involving chemists, physicists, and material scientists is essential. This review highlights the unique magnetic properties of SPIONs compared to bulk magnetic materials, alongside their synthesis, characterization methods, and the factors influencing their magnetic behavior. We delve into the diverse biomedical applications of SPIONs, including their roles as contrast agents in imaging, drug carriers, and therapeutic agents for cancer treatment. Special attention is given to the concept of theranostics, where SPIONs are utilized for both therapy and diagnosis within a single system. We comprehensively summarize recent advances in the use of SPIONs for cancer theranostics over the past decade while briefly addressing their toxicity and biodegradability. Finally, the review discusses the current challenges and future prospects of SPIONs in theranostic applications including its explorations in ongoing clinical trials. The current study addresses the challenges and future perspectives in applying SPIONs in oncology, providing a roadmap for future research and development. Furthermore, considering the potential of SPION-based therapeutic platforms to achieve targeted anticancer efficacy, this article is expected to make a significant contribution to the existing body of knowledge and inspire further advancements in this rapidly evolving field.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"260 ","pages":"Article 115372"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0