Colloids and Surfaces B: Biointerfaces最新文献

{"title":"CD-44 targeted nanoparticles for combination therapy in an in vitro model of triple-negative breast cancer: Targeting the tumour inside out","authors":"Silvia Gómez-Pastor ,&nbsp;Auréane Maugard ,&nbsp;Harriet R. Walker ,&nbsp;Jacobo Elies ,&nbsp;Kaja E. Børsum ,&nbsp;Giulia Grimaldi ,&nbsp;Giacomo Reina ,&nbsp;Amalia Ruiz","doi":"10.1016/j.colsurfb.2025.114504","DOIUrl":"10.1016/j.colsurfb.2025.114504","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer defined by the lack of three key receptors: estrogen, progesterone, and HER2. This lack of receptors makes TNBC difficult to treat with hormone therapy or drugs, and so it is characterised by a poor prognosis compared to other kinds of breast cancer. This study explores photoactive Poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a potential therapeutic strategy for TNBC. The nanoparticles are functionalised with hyaluronic acid (HA) for targeted delivery to CD-44 receptors overexpressed in TNBC cells, especially under hypoxic conditions. Additionally, we co-loaded the nanoparticles with Doxorubicin (Dox) and Indocyanine Green (ICG) to enable combinatorial chemo-photothermal therapy. After carefully optimising the formulation, we propose an effortless and reproducible preparation of the nanodrugs. We demonstrate that HA-conjugated nanoparticles effectively target TNBC cells and inhibit their proliferation while the treatment efficiency is enhanced during near-infrared light irradiation. We also prove that our treatment is effective in a 3D cell culture model, highlighting the importance of tumour architecture and the metabolic stage of the cells in the tumour microenvironment. This approach is promising for a tumour-targeted theragnostic for TNBC with improved efficacy in hypoxic microenvironments.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114504"},"PeriodicalIF":5.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the biological characteristics of aminolysis surface-modified 3D printed nanocomposite polycaprolactone/nanohydroxyapatite scaffold via gelatin biomacromolecule immobilization: An in vitro and in vivo study","authors":"Mohammadhasan Farnaghi ,&nbsp;Seyed Ali Poursamar ,&nbsp;Mahour Farzan ,&nbsp;Mahan Farzan ,&nbsp;Monireh Kouhi ,&nbsp;Mohammad Rafienia","doi":"10.1016/j.colsurfb.2025.114505","DOIUrl":"10.1016/j.colsurfb.2025.114505","url":null,"abstract":"<div><div>The surface characteristics of scaffolds utilized in bone tissue engineering profoundly influence subsequent cellular response. This study investigated the efficacy of applying a gelatin coat to the surface of aminolysis surface-modified scaffolds fabricated through 3D printing with a polycaprolactone/hydroxyapatite nanocomposite, employing the hot-melt extrusion FDM technique. Initially, aminolysis surface modification using hexamethylenediamine enhanced surface hydrophilicity by introducing amine functional groups. Subsequently, gelatin solutions were applied to the scaffolds, and crosslinking with EDC/NHS was performed to increase coating strength. Contact angle measurements revealed a significantly increased surface hydrophilicity post-aminolysis. Aminolysis facilitated uniform gelatin coating formation and distribution. Subsequently, crosslinking enhanced coating durability. The addition of gelatin coating resulted in a notable 20 % increase in scaffold mechanical strength and more than 50 % rise in Young's modulus and exhibited enhancement of biodegradability and bioactivity. Gelatin coated scaffolds also demonstrated improved cell viability and adhesion and over two times higher expression of OPN and ALP genes, suggesting improved biological properties. In addition, <em>in vivo</em> bone formation studies verified the biological enhancement of scaffolds. Utilizing an immobilized crosslinked gelatin biomacromolecule coating effectively enhanced the biological characteristics of 3D printed scaffolds and their potential applications as bone tissue engineering scaffolds.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114505"},"PeriodicalIF":5.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone","authors":"Mariam Zewail ,&nbsp;Passent M.E. Gaafar ,&nbsp;Haidy Abbas ,&nbsp;Manal A Elsheikh","doi":"10.1016/j.colsurfb.2025.114497","DOIUrl":"10.1016/j.colsurfb.2025.114497","url":null,"abstract":"<div><div>Rheumatoid arthritis is a highly prevalent debilitating condition linked to inflammation. The effectiveness of the present therapeutic techniques is constrained; so, there is an urgent requirement for a novel nanoplatform entailing drugs with proven efficacy. The current work highlighted the development of dexamethasone and luteolin co-encapsulated hyalurosomes (LUT-DEX hyalurosomes). High entrapment efficiency of 92.79 % and 81.21 % for DEX and LUT, respectively in addition to sustained release of both drugs were attained, where only 45 % DEX and 75.87 % LUT were released after 24 h indicating the possibility of a persistent therapeutic impact. A spherical nano-system with smooth edges and a characteristic layer of hyaluronic acid surrounding the core of the particles was evidenced by a transmission electron microscope. The efficacy of LUT-DEX hyalurosomes was evaluated <em>in-vision vivo</em> using a rat model of rheumatoid arthritis initiated by Complete Freund's Adjuvant (CFA). Histological examination and serum concentrations of malondialdehyde (MDA), interleukin 1ß (IL1ß), tumour necrosis factor-alpha (TNF-α), interleukin 3 (MMP-3), and nuclear factor (erythroid-derived) Like 2 NRF2) were also evaluated. The dual drug-loaded hyalurosomes demonstrated 2.9-, 3.2-, 2.5- and 2.7-fold decreases in MMP3, TNF-α, MDA and IL1, respectively, compared with the positive control group. Conversely, the negative control group demonstrated the highest NRF2 level followed by LUT-DEX hyalurosomes, comparison compared to the positive control group which demonstrated the lowest NRF2 level. The histological examination of the joints confirmed the superior effect of the dual drug encapsulated nano delivery system in reducing joint swelling and inflammation achieving similar results as the negative control group. Ultimately, the developed hyalurosomes co-encapsulating dexamethasone and luteolin, possess the potential to serve as a highly auspicious innovative strategy for managing rheumatoid arthritis.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114497"},"PeriodicalIF":5.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ-on-a-chip: Quo vademus? Applications and regulatory status","authors":"Maria Mendes ,&nbsp;Ana Sofia Morais ,&nbsp;Ana Carlos ,&nbsp;João José Sousa ,&nbsp;Alberto Canelas Pais ,&nbsp;Silvia M. Mihăilă ,&nbsp;Carla Vitorino","doi":"10.1016/j.colsurfb.2025.114507","DOIUrl":"10.1016/j.colsurfb.2025.114507","url":null,"abstract":"<div><div>Organ-on-a-chip systems, also referred to as microphysiological systems (MPS), represent an advance in bioengineering microsystems designed to mimic key aspects of human organ physiology and function. Drawing inspiration from the intricate and hierarchical architecture of the human body, these innovative platforms have emerged as invaluable <em>in vitro</em> tools with wide-ranging applications in drug discovery and development, as well as in enhancing our understanding of disease physiology. The facility to replicate human tissues within physiologically relevant three-dimensional multicellular environments empowers organ-on-a-chip systems with versatility throughout different stages of the drug development process. Moreover, these systems can be tailored to mimic specific disease states, facilitating the investigation of disease progression, drug responses, and potential therapeutic interventions. In particular, they can demonstrate, in early-phase pre-clinical studies, the safety and toxicity profiles of potential therapeutic compounds. Furthermore, they play a pivotal role in the <em>in vitro</em> evaluation of drug efficacy and the modeling of human diseases. One of the most promising prospects of organ-on-a-chip technology is to simulate the pathophysiology of specific subpopulations and even individual patients, thereby being used in personalized medicine. By mimicking the physiological responses of diverse patient groups, these systems hold the promise of revolutionizing therapeutic strategies, guiding them towards tailored intervention to the unique needs of each patient. This review presents the development status and evolution of microfluidic platforms that have facilitated the transition from cells to organs recreated on chips and some of the opportunities and applications offered by organ-on-a-chip technology. Additionally, the current potential and future perspectives of these microphysiological systems and the challenges this technology still faces are discussed.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114507"},"PeriodicalIF":5.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear-induced rotation enhances protein adsorption","authors":"Zhengfu Zhang ,&nbsp;Kaixuan Lyu ,&nbsp;Bo Peng ,&nbsp;Hongbo Chen ,&nbsp;Quan Chen ,&nbsp;Chuanfu Luo ,&nbsp;Dapeng Wang","doi":"10.1016/j.colsurfb.2025.114508","DOIUrl":"10.1016/j.colsurfb.2025.114508","url":null,"abstract":"<div><div>Theories predicted that shear promotes desorption, but due to the presence of factors such as aggregation effects, it is difficult to observe how shear influences the adsorption and desorption of individual protein molecules. In this study, we employed high-throughput single-molecule tracking and molecular dynamics simulations to investigate how shear flow affects the adsorption kinetics of plasma proteins (including human serum albumin, immunoglobulin G, and fibrinogen) at solid-liquid interfaces. Over the studied shear rate range of 0 – 10³ s⁻¹, shear stress did not trigger the protein desorption. Notably, we observed a significant increase, up to two orders of magnitude, in the adsorption rate constants <em>k</em>_a, in the dilute limit at solid-liquid interfaces. However, this shear-induced increase in <em>k</em>_a diminished with increasing the protein concentrations. At least in the scenarios studied, these trends were consistent across all three types of proteins and two types of surfaces investigated. Through a systematic analysis combining control experiments, coarse-grained, and all-atom molecular dynamics simulations, we identified that the shear-induced increase in <em>k</em>_a could be attributed to enhanced protein rotational diffusion, thereby increasing the likelihood of favorable surface proximity for adsorption.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114508"},"PeriodicalIF":5.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal pH-sensitive Pickering emulsions stabilized by glycosylated zein conjugates ferulic acid nanoparticles: Improving oral bioaccessibility of Coenzyme Q10","authors":"Tongliang Yang,&nbsp;Yaqing Bian,&nbsp;Zihan Qu,&nbsp;Yifu Zhang,&nbsp;Shuhong Li,&nbsp;Guiyun Chen,&nbsp;Ye Chen","doi":"10.1016/j.colsurfb.2025.114502","DOIUrl":"10.1016/j.colsurfb.2025.114502","url":null,"abstract":"<div><div>Pickering emulsion stabilized by food grade nanoparticles with stimulus response as a targeted delivery system for lipophilic bioactive compounds has attracted people's attention. In this study, ferulic acid was used to modify saccharified zein to prepare pH-sensitive nanoparticles for stabilizing Pickering emulsion. The structure, interface behavior, stability of Pickering emulsion and gastrointestinal digestion characteristics of nanoparticles <em>in vitro</em> were studied. The results showed that covalent embedding of ferulic acid (ZGF-con) effectively improved the surface properties of zein nanoparticles based on glycosylation modification of zein, further regulating their behavior at the oil-water interface. In addition, the particle size of ZGF-con was small (92.93 nm), the wettability was moderate (89.85 °), and it was spherical, with orderly transition of secondary structure, which was conducive to the formation of stable emulsion at the oil-water interface. The stable Pickering emulsion formed by ZGF-con showed ideal emulsification performance, and the electrostatic repulsion between droplets and the formation of a robust spatial network structure promoted the stability of the emulsion. In addition, the encapsulation efficiency of CoQ10 in ZGF-con stabilized Pickering emulsion reached 96.11 %. <em>In vitro</em> simulated digestion, ZGF-con stabilized Pickering emulsion was relatively stable in the gastric acid environment, and slowly released in the small intestine, realizing the small intestine targeted release of CoQ10, which increased its bioaccessibility from 10.57 % to 56.42 %. This study provides an effective strategy for the preparation of pH-sensitive Pickering emulsion to improve the bioaccessibility of hydrophobic active ingredients.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114502"},"PeriodicalIF":5.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upconverting/magnetic Janus-like nanoparticles integrated into spiropyran micelle-like nanocarriers for NIR light- and pH- responsive drug delivery, photothermal therapy and biomedical imaging","authors":"Fernando Espinola-Portilla ,&nbsp;Fanny d’Orlyé ,&nbsp;Jorge A. Molina González ,&nbsp;Laura Trapiella-Alfonso ,&nbsp;Silvia Gutiérrez-Granados ,&nbsp;Anne Varenne ,&nbsp;Gonzalo Ramírez-García","doi":"10.1016/j.colsurfb.2025.114501","DOIUrl":"10.1016/j.colsurfb.2025.114501","url":null,"abstract":"<div><div>The integration of multiple functionalities into single theranostic platforms offers new opportunities for personalized and minimally invasive clinical interventions, positioning these materials as highly promising tools in modern medicine. Thereby, magneto-luminescent Janus-like nanoparticles (JNPs) were developed herein, and encapsulated into near-infrared (NIR) light- and pH- responsive micelle-like aggregates (Mic) for simultaneous magnetic targeting, biomedical imaging, photothermal therapy, and pH- NIR-light activated drug delivery. The JNPs consisted of NaYF₄:Yb,Tm upconverting nanoparticles (UCNPs) on which a well-differentiated magnetite structure (MNPs) grew epitaxially. JNPs were encapsulated together with doxorubicin (Dox) into micelle-like aggregates formed with the stimuli-responsive Poly(NIPAM-co-Spiropyran) copolymer, which responds to UV light, temperature changes, and pH variations, so as to form the JNP-Dox@Mic nanocarrier. Based on physicochemical characterizations, the mechanism for the NIR-activated release of Dox from the JNP-Dox@Mic aggregates is suggested: i) activation of the upconverting emissions with 975 nm light, ii) energy transfer to the material's lattice via nonradiative relaxation, inducing a local temperature increase, iii) resonance energy transfer (RET) from the UV-emission bands to the micelle-like aggregates, and iv) reversible isomerization of the hydrophobic Spiropyran (SP) moiety to a hydrophilic zwitterionic merocyanine (MC) form, leading to Dox delivery. Furthermore, the strong light-to-heat conversion ability of the JNPs was demonstrated through thermal imaging analysis, reaching temperatures up to 108 °C upon irradiation for 60 seconds. The efficacy of these nanocomposites for pH- and NIR-light-induced controlled release was demonstrated using electrophoretic separations and tested against MCF-7 breast cancer cells. While non-irradiated samples of JNP-Dox@Mic were innocuous up to 200 μg.mL⁻¹, irradiation with 975 nm light for 5 minutes reduced cell viability to 26 %. These findings highlight the effective synergy between JNPs and micelle-like aggregates, resulting in versatile heterostructures that could be evaluated for multimodal therapy and imaging strategies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114501"},"PeriodicalIF":5.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MoS2 nanoflowers surface decorated with CuS nanorods and carbon dots for fluorescent and ultrasound imaging in cancer therapy","authors":"Nishakavya Saravanan ,&nbsp;Anandhakumar Sundaramurthy ,&nbsp;Sukho Park","doi":"10.1016/j.colsurfb.2025.114503","DOIUrl":"10.1016/j.colsurfb.2025.114503","url":null,"abstract":"<div><div>In recent years, the design of various ultrasound responsive echogenic nanomaterials offers many advantages such as deep tissue penetration, high signal intensity, colloidal stability, biocompatibility and less expensive for ultrasound-based cancer cell imaging while providing the option to monitor the progress of tumor volume during the treatment. Further, the ability of nanomaterials to combine photo-thermal therapy (PTT) and chemotherapy has opened a new avenue in the development of cancer theranostics for synergistic cancer therapy. Herein, we report MoS₂ nanoflowers (NFs) surface decorated with CuS nanorods (NRs) and folic acid-derived carbon dots (FACDs) using cystine-polyethyleneimine (PEI) linker for PTT-chemotherapy. The size of NFs was found to be 350 ± 50 nm which increased to 500 ± 50 nm after surface decoration. The morphology of MoS₂ NFs before and after surface decoration was investigated using scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and UV-Vis-NIR spectroscopy. The photo-thermal heat generation was found to be increasing as a function of the concentration of NFs. The encapsulation efficiency of doxorubicin (DOX) and photo-thermal conversion efficiency (PCE) for surface-decorated MoS₂ NFs (MoS₂@CuS/FACDs NFs) was estimated to be 42 and 44 %, respectively. The surface decoration of CuS NRs and FACDs on MoS₂ NFs not only improved the anticancer activity but also increased the signal intensity in ultrasound and fluorescence imaging of cancer cells. The MoS₂@CuS/FACDs NFs exhibited excellent cytotoxicity against MDA-MB-231 cancer cells. Hence, the hybrid system demonstrated here showed high potential for use as a combined probe for non-invasive ultrasound imaging and fluorescence imaging for PTT-chemotherapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114503"},"PeriodicalIF":5.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The latest applications of exosome-mediated drug delivery in anticancer therapies","authors":"Zhiwei Wen ,&nbsp;Wei Zhang ,&nbsp;Wei Wu","doi":"10.1016/j.colsurfb.2025.114500","DOIUrl":"10.1016/j.colsurfb.2025.114500","url":null,"abstract":"<div><div>In recent years, the significant role of anticancer drugs in cancer treatment has garnered considerable attention. However, the application of these drugs is largely limited by their short half-life in blood circulation, low cellular uptake efficiency, and off-target effects. Exosomes, which serve as crucial messengers in intercellular communication, exhibit unique advantages in molecular delivery compared to traditional synthetic carriers, thereby offering new possibilities for modern drug delivery systems. Exosomes possess organotropic functions and are naturally produced by cells, making them promising candidates for natural drug delivery systems with organotropic properties and minimal side effects. These naturally derived carriers can achieve stable, efficient, and selective delivery of anticancer drugs, thereby enhancing the efficacy and potential of anticancer agents in cancer immunotherapy. This review provides a concise overview of the unique characteristics of exosomes related to anticancer drug delivery, strategies for utilizing exosomes as carriers in cancer therapy, and the latest advancements in the field.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114500"},"PeriodicalIF":5.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on surface modification and coating technologies of biomedical NiTi alloys","authors":"Xiang Li ,&nbsp;Ying Yang ,&nbsp;Hui Shen ,&nbsp;Meng Zhou ,&nbsp;Bingmin Huang ,&nbsp;Lishan Cui ,&nbsp;Shijie Hao","doi":"10.1016/j.colsurfb.2025.114496","DOIUrl":"10.1016/j.colsurfb.2025.114496","url":null,"abstract":"<div><div>NiTi alloys are an important class of biomaterials with extensive clinical applications such as cardiovascular stents, orthodontic arch-wires, esophageal stents, orthopedic implants and more. However, the long-term implantation of NiTi alloys presents significant challenges due to their susceptibility to wear, corrosion and the excessive release of harmful nickel ions. These factors can severely compromise both the biocompatibility and the overall service life of the implants. To better meet the demands for safety, durability and superior biological performance after implantation, surface modification of NiTi alloys has become a focal point of current research. Based on the fundamental properties of the NiTi alloys and the challenges encountered in their practical applications, this article provides a focused review of recent advances in improving their corrosion resistance, wear resistance, antibacterial properties and biological performance through surface modification and coating techniques. In addition, the paper outlines current research challenges and proposes recommendations for future development directions.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"249 ","pages":"Article 114496"},"PeriodicalIF":5.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}