Zhirong Yang , Lingli Deng , Zhenhong Pan , Xiaoyang Wang , Li Lin , Yaqi Fang , Yinxing Huang , Xianquan Feng , Xi Chen
{"title":"氧增强纳米药物用于放大铁凋亡-光动力免疫疗法联合PD-1检查点阻断治疗三阴性乳腺癌","authors":"Zhirong Yang , Lingli Deng , Zhenhong Pan , Xiaoyang Wang , Li Lin , Yaqi Fang , Yinxing Huang , Xianquan Feng , Xi Chen","doi":"10.1016/j.colsurfb.2025.114963","DOIUrl":null,"url":null,"abstract":"<div><div>While photodynamic therapy (PDT) may augment immune checkpoint blockade in triple-negative breast cancer (TNBC), its effectiveness is constrained by tumor hypoxia and suboptimal immune activation. To address these challenges, an innovative nanodrug (HV NPs) has been developed for the targeted delivery of the photosensitizer verteporfin and hemin, utilizing human serum albumin as a delivery vehicle. The catalase-like activity of hemin alleviates the hypoxic conditions in the tumor microenvironment and boosts PDT. The HV NPs, when activated by a 635 nm laser, induce apoptosis and ferroptosis in tumor cells and facilitate the release of tumor-associated debris, which triggers immunogenic cell death and enhance tumor immunogenicity. Meanwhile, modulation of the hypoxic tumor microenvironment attenuates immunosuppressive cell infiltration, thereby enhancing antitumor immunity. This systemic immune response can be further enhanced by PD-1 blockade, thereby inhibiting both primary tumors and lung metastasis. Collectively, our study indicates that HV NPs-mediated oxygen-boosted PDT represents a promising strategy to enhance the efficacy of PD-1 checkpoint blockade immunotherapies in TNBC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114963"},"PeriodicalIF":5.4000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxygen-boosted nanodrug for amplified ferroptosis-photodynamic immunotherapy together with PD-1 checkpoint blockade against triple-negative breast cancer\",\"authors\":\"Zhirong Yang , Lingli Deng , Zhenhong Pan , Xiaoyang Wang , Li Lin , Yaqi Fang , Yinxing Huang , Xianquan Feng , Xi Chen\",\"doi\":\"10.1016/j.colsurfb.2025.114963\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>While photodynamic therapy (PDT) may augment immune checkpoint blockade in triple-negative breast cancer (TNBC), its effectiveness is constrained by tumor hypoxia and suboptimal immune activation. To address these challenges, an innovative nanodrug (HV NPs) has been developed for the targeted delivery of the photosensitizer verteporfin and hemin, utilizing human serum albumin as a delivery vehicle. The catalase-like activity of hemin alleviates the hypoxic conditions in the tumor microenvironment and boosts PDT. The HV NPs, when activated by a 635 nm laser, induce apoptosis and ferroptosis in tumor cells and facilitate the release of tumor-associated debris, which triggers immunogenic cell death and enhance tumor immunogenicity. Meanwhile, modulation of the hypoxic tumor microenvironment attenuates immunosuppressive cell infiltration, thereby enhancing antitumor immunity. This systemic immune response can be further enhanced by PD-1 blockade, thereby inhibiting both primary tumors and lung metastasis. Collectively, our study indicates that HV NPs-mediated oxygen-boosted PDT represents a promising strategy to enhance the efficacy of PD-1 checkpoint blockade immunotherapies in TNBC.</div></div>\",\"PeriodicalId\":279,\"journal\":{\"name\":\"Colloids and Surfaces B: Biointerfaces\",\"volume\":\"255 \",\"pages\":\"Article 114963\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloids and Surfaces B: Biointerfaces\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927776525004709\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces B: Biointerfaces","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927776525004709","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Oxygen-boosted nanodrug for amplified ferroptosis-photodynamic immunotherapy together with PD-1 checkpoint blockade against triple-negative breast cancer
While photodynamic therapy (PDT) may augment immune checkpoint blockade in triple-negative breast cancer (TNBC), its effectiveness is constrained by tumor hypoxia and suboptimal immune activation. To address these challenges, an innovative nanodrug (HV NPs) has been developed for the targeted delivery of the photosensitizer verteporfin and hemin, utilizing human serum albumin as a delivery vehicle. The catalase-like activity of hemin alleviates the hypoxic conditions in the tumor microenvironment and boosts PDT. The HV NPs, when activated by a 635 nm laser, induce apoptosis and ferroptosis in tumor cells and facilitate the release of tumor-associated debris, which triggers immunogenic cell death and enhance tumor immunogenicity. Meanwhile, modulation of the hypoxic tumor microenvironment attenuates immunosuppressive cell infiltration, thereby enhancing antitumor immunity. This systemic immune response can be further enhanced by PD-1 blockade, thereby inhibiting both primary tumors and lung metastasis. Collectively, our study indicates that HV NPs-mediated oxygen-boosted PDT represents a promising strategy to enhance the efficacy of PD-1 checkpoint blockade immunotherapies in TNBC.
期刊介绍:
Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.
Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication.
The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.