化学•材料最新文献

{"title":"","authors":"Xinran Zhang, Shuxin Yang, Jiaxing Lv, Wanpeng Lu, Yi Bi and Xianhe Fang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 25","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Miguel Mellado-Hidalgo, Joan Conejos-Jalencas, Saúl F. Teloxa, Andrea Suárez-Herrera, Luke McCall, Anna M. Costa*, Pedro Romea*, Fèlix Urpí*, Gabriel Aullón and Cristina Puigjaner, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 25","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partially substituting whey protein by rice protein hydrolysate to fabricate emulsions: Physicochemical properties, stability and digestion behavior","authors":"Wen Wang ,&nbsp;Yaxuan Liu ,&nbsp;Meijun Liu,&nbsp;Feng Gao,&nbsp;Boxue Xia,&nbsp;Ru Zhao,&nbsp;Xinxin Yin,&nbsp;Cuina Wang","doi":"10.1016/j.colsurfb.2025.114917","DOIUrl":"10.1016/j.colsurfb.2025.114917","url":null,"abstract":"<div><div>The partial substitution of whey protein with plant-derived proteins in the formulation of new products has garnered significant attention. This study investigated emulsions stabilized by varying blends of whey protein concentrate (WPC) and rice protein hydrolysate (RPH) in mass ratios ranging from 100:0–0:100, focusing on their physicochemical properties, stability, and digestive characteristics. RPH was obtained via trypsin hydrolysis, achieving a solubility of up to 92.4 % across pH values of 3–9. Increasing the ratio of RPH in blend led to a reduction in particle size, an increase in surface charge, a decrease in surface hydrophobicity, and a more flexible secondary structure. The emulsions exhibited particle sizes below 325 nm with a narrow size distribution and high surface charge. The gradual replacement of WPC with RPH resulted in decreased physical stability of the emulsions under varying pH and ionic strength conditions. Emulsions composed of 75 % WPC and 25 % RPH demonstrated the highest stability against lipid oxidation. The incorporation of RPH into WPC formulations enhanced the fatty acid release rate of the emulsions compared to those stabilized by individual emulsifiers. These findings may offer a robust theoretical foundation for the selection and utilization of blended animal and plant proteins in emulsion technology.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114917"},"PeriodicalIF":5.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Range Destabilizing Effects of Mutations at the <i><i>Escherichia coli</i></i> β Clamp Dimer Interface.","authors":"Melissa L Liriano, Madison B Berger, Kenny Nguyen, Dmitry M Korzhnev, G Andrés Cisneros, Penny J Beuning","doi":"10.1021/acs.biochem.5c00135","DOIUrl":"https://doi.org/10.1021/acs.biochem.5c00135","url":null,"abstract":"<p><p>The bacterial processivity factor, the β sliding clamp, endows Pol III DNA polymerase α with efficiency and processivity during DNA replication by tethering α to DNA. The dimeric β clamp is loaded onto primer:template DNA junctions by a five-subunit clamp loader complex. We previously showed that tuning the stability of the β dimer interface affected clamp opening dynamics and function. The L82D clamp mutation destabilized the dimer interface due to altered hydrophobic interactions and β L82D exhibited lower thermostability, a change in dimerization state, and a decrease in loading activity. Molecular modeling revealed a rearrangement of the local hydrogen-bond network near L82D in Domain 1, leading to new, non-native interactions involving residues Q265 and R269 in Domain 3 of the partner protomer. We hypothesize that altering this newly formed network in the context of the β L82D variant may stabilize the dimer interface and rescue clamp activity. To test these hypotheses, Q265 and R269 were mutated in WT β and in the L82D variant. The β R269 residue is essential for maintaining a stable dimer interface, functional oligomeric state, and efficient DNA loading, while Q265 is not, as Q265A is tolerated. Disrupting native interactions of R269 with the formation of an alternate bonding network in L82D seems to be the primary driver for the lower thermostability, altered dimerization state, and loss of clamp activity previously observed in β L82D. Our observations show that a complex balance of noncovalent interactions contributes to the stability of the β clamp dimer interface.</p>","PeriodicalId":28,"journal":{"name":"Biochemistry Biochemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Evolution of Boron Clusters upon Copper Doping in CuB_<i>x</i>^- (<i>x</i> = 4-6).","authors":"Anton S Pozdeev, Hyun Wook Choi, Wei-Jia Chen, Lai-Sheng Wang, Ivan A Popov","doi":"10.1021/acs.jpca.5c02881","DOIUrl":"https://doi.org/10.1021/acs.jpca.5c02881","url":null,"abstract":"<p><p>Photoelectron spectroscopy and theoretical calculations are combined to elucidate the structures and chemical bonding of small boron clusters doped with a copper atom, CuB_<i>x</i>^- (<i>x</i> = 4-6). Relatively complex spectral features are observed and are interpreted by comparison with the theoretical results. Predicted global minimum structures of CuB_<i>x</i>^- (<i>x</i> = 4-6) evince that the Cu atom binds to an apex B atom in each cluster and does not significantly alter the planar boron framework of the corresponding B_<i>x</i>^- clusters. Multielectronic transitions (shakeup processes) are observed in all three systems, a manifestation of strong electron correlation effects. Chemical bonding analyses show that the copper atom preferentially binds to the apex sites with the highest electron localization to form a Cu-B covalent bond. The structures and bonding of CuB_<i>x</i>^- (<i>x</i> = 4-6) are compared with those of the bare B_<i>x</i>^- and the Cu₂B_<i>x</i>^- clusters, providing new insights into the structural and electronic evolution of Cu-doped boron clusters and the transition from Cu-B covalent bonding to ionic bonding.</p>","PeriodicalId":59,"journal":{"name":"The Journal of Physical Chemistry A","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Sooah Shin,&nbsp;Subin Lee and Seewon Joung*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 25","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Jayaveerapandiyan Barathkumar,&nbsp;Rebaka Vara Prasad and Subbiah Nagarajan*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 25","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Evgeniya E. Ivanova,&nbsp;Svetlana V. Martynovskaya,&nbsp;Igor’ A. Ushakov,&nbsp;Alexander V. Vashchenko,&nbsp;Alexander S. Bobkov,&nbsp;Nikita V. Teplyashin,&nbsp;Olesya P. Vitovskaya and Andrey V. Ivanov*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 25","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Wenlong Ren,&nbsp;Yang Liu,&nbsp;Jintao Ou,&nbsp;Jinzi Huang,&nbsp;Xujian Sheng and Yian Shi*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 25","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A smart ultra-small near infrared persistent luminescence nanoprobe for non-invasive detection of early rheumatoid arthritis","authors":"Yanping Xie ,&nbsp;Qiong Zou ,&nbsp;Yunfei Zhu ,&nbsp;Ya Wen ,&nbsp;Siqi Hu ,&nbsp;Jing Wang ,&nbsp;Chenyang Lu ,&nbsp;Rui Zou ,&nbsp;Ju Jiao","doi":"10.1016/j.colsurfb.2025.114915","DOIUrl":"10.1016/j.colsurfb.2025.114915","url":null,"abstract":"<div><div>Early detection of rheumatoid arthritis (E-RA) is crucial for long-term patient health, but current methods lack precision. Overproduced reactive oxygen species (ROS) in hypoxic and inflammatory synovium are early markers of RA, appearing years before significant radiological findings, making them attractive biomarkers for early detection. Here, an ultrasensitive ROS-responsive nanoprobe are developed based on glutathione (GSH) modified Cr^3 + doped ZnGa₂O₄ ultra-small near-infrared (NIR) persistent luminescence nanoparticles (denoted as ZnGa₂O₄:Cr³⁺-GSH). The well-designed ZnGa₂O₄:Cr³⁺-GSH responds to ROS and cross-link by forming disulfide bonds, enabling autofluorescence-free NIR persistent luminescence (NIR-PL) imaging in vivo with a 1.9-fold signal to noise ratio (SNR) increase in collagen-induced arthritis mice paws compared to healthy control. Leveraging its ROS-responsive crosslinking and superior SNR performance, ZnGa₂O₄:Cr³⁺-GSH achieves ultrasensitive E-RA lesion detection through NIR-PL imaging. In addition, pharmacokinetic analysis shows that ultra-small ZnGa₂O₄:Cr³⁺-GSH has an elimination half-life of 19.85 min, with 3.45 % ID and 20.43 % ID excreted via urine and feces at 2 days post-injection, confirming its excellent biosafety. The study demonstrates the clinical promise of ZnGa₂O₄:Cr³⁺-GSH for precise diagnosis of E-RA, which might also offer an alternative basis for existing diagnostic procedures of RA.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114915"},"PeriodicalIF":5.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}