Polymer Science, Series A最新文献

Research Progress on Biodegradable Polymer Materials for Oral Insulin Delivery 口服胰岛素可降解高分子材料的研究进展

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-09-28 DOI: 10.1134/S0965545X24601333

Yu Xuan Su, Zi Ling Li, Hong Xia Gao, Xiang Yuan Xiong

{"title":"Research Progress on Biodegradable Polymer Materials for Oral Insulin Delivery","authors":"Yu Xuan Su, Zi Ling Li, Hong Xia Gao, Xiang Yuan Xiong","doi":"10.1134/S0965545X24601333","DOIUrl":"10.1134/S0965545X24601333","url":null,"abstract":"One of the main treatment methods for diabetes is the subcutaneous injection of insulin. However, frequent subcutaneous injections can lead to adverse reactions, such as swelling and inflammation at the injection site, resulting in poor patient compliance. In contrast, non-invasive insulin delivery methods, particularly oral administration, offer advantages in terms of improved patient compliance, convenience, and cost-effectiveness. Nevertheless, the multiple physiological barriers in the gastrointestinal tract pose significant challenges to the oral delivery of protein or peptide drugs. Biodegradable polymer materials are now widely used in the research of oral insulin delivery due to their excellent properties, including good biocompatibility, biodegradability, and low toxicity. These materials are capable of protecting insulin from degradation in the harsh environments of the stomach and intestinal lumen, thus enhancing the oral bioavailability of insulin. This paper has described the various physiological barriers of oral insulin delivery and summarized the types and properties of biodegradable polymeric materials that have been used for oral insulin delivery in recent years.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"67 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sorption and Mechanical Characteristics of a Polymer Composite Based on Acrylic Hydrogel and Detonation Nanodiamonds and the Kinetics of Metronidazole Release from It 丙烯酸水凝胶-爆轰纳米金刚石聚合物复合材料的吸附力学特性及甲硝唑释放动力学

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-09-28 DOI: 10.1134/S0965545X25600693

D. V. Grigoriev, A. V. Gudkin, E. V. Sivtsov, A. V. Kalinin, M. V. Uspenskaya

引用次数: 0

Synthesis, Characterization and Cytotoxicity Analyzes of Novel ABA–Type PNIPAM-b-PLLA-b-PNIPAM Amphiphilic Block Copolymer 新型aba型PNIPAM-b-PLLA-b-PNIPAM两亲嵌段共聚物的合成、表征及细胞毒性分析

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-09-28 DOI: 10.1134/S0965545X24600698

Murat Mısır, Serap Yalçın Azarkan, Ahmet Bilgin

{"title":"Synthesis, Characterization and Cytotoxicity Analyzes of Novel ABA–Type PNIPAM-b-PLLA-b-PNIPAM Amphiphilic Block Copolymer","authors":"Murat Mısır, Serap Yalçın Azarkan, Ahmet Bilgin","doi":"10.1134/S0965545X24600698","DOIUrl":"10.1134/S0965545X24600698","url":null,"abstract":"ABA–type amphiphilic poly(N-isopropylacrylamide)-block-poly(L-lactide)-block-poly(N-isopropylacrylamide) (PNIPAM-b-PLLA-b-PNIPAM) was synthesized via combination of ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) using the novel bifunctional PLLA–based ATRP macroinitiator bearing 1,2-bis[(3-oxapropyl)oxa]benzene core. For this purpose, at first bifunctional diol initiator, o-bis[(3-hydroxypropyl)oxy]benzene (1), was synthesized by the reaction of catechol and 3-chloro-1-propanol in the presence of sodium hydroxide (NaOH) in ethanol. Secondly, PLLA-diol (HO-PLLA-OH) was prepared by Sn(Oct)2 -catalyzed (ROP) of (L-LA) at 120°C using (1) as initiator in toluene. Thirdly, dibromoester end-functionalized PLLA-based ATRP macroinitiator (Br-PLLA-Br) was synthesized by esterification of hydroxyl end groups of PLLA-diol. Finally ABA-type block copolymer, (PNIPAM-b-PLLA-b-PNIPAM), was synthesized by (ATRP) of NIPAM as monomer using PLLA-based ATRP macroinitiator in presence of copper(I) chloride/tris[2-(dimethylamino)ethyl]amine (CuCl/Me6TREN) as catalyst system in DMF/water at 25°C. Characterization of the molecular structures for synthesized novel macroinitiator and the block copolymer were made by spectroscopic (FTIR and 1H NMR) and chromatographic (GPC) methods. In the application phase of this study, the effectiveness of polymers was examined on cancer cells. Cytotoxicity and metastatic effects were evaluated in vitro on MDA-MB-231 cell lines. As a result, novel ABA-Type PNIPAM-b-PLLA-b-PNIPAM amphiphilic block copolymer, which has been successfully developed, characterized and determined to be non-toxic, can be used as a promising drug delivery system in many areas such as tumor treatments.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"67 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Electrospinning of Fibers from Polyaminonaphthoyleneimide Solutions to Prepare Superheat-Resistant Nonwoven Fibrous Materials 聚酰胺亚胺溶液静电纺丝制备耐热非织造纤维材料

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X25600498

L. A. Varfolomeeva, Ya. V. Golubev, A. F. Vashchenko, A. V. Mityukov, I. I. Ponomarev, V. G. Kulichikhin

引用次数: 0

Preparation and Properties of Superhydrophobic Composite Microspheres with Fluorescent Mosquito-Like Compound Eyes 具有荧光蚊样复眼的超疏水复合微球的制备及性能研究

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X25600516

Deyu Yu, Liangjiong Yang, Qingsheng Deng, Haipeng Zou, Xinmei Yan, Zichen Zhang, Yan Jiang, Hongwen Zhang

{"title":"Preparation and Properties of Superhydrophobic Composite Microspheres with Fluorescent Mosquito-Like Compound Eyes","authors":"Deyu Yu, Liangjiong Yang, Qingsheng Deng, Haipeng Zou, Xinmei Yan, Zichen Zhang, Yan Jiang, Hongwen Zhang","doi":"10.1134/S0965545X25600516","DOIUrl":"10.1134/S0965545X25600516","url":null,"abstract":"In this study, polysiloxane microspheres were prepared by silane hydrolysis condensation method, and polysiloxane microspheres with fluorescent properties were obtained after calcination. SiO2 nanoparticles were synthesized by the template method and composited with fluorescent polysiloxane microspheres through surface modification, and superhydrophobic composite microspheres with fluorescent properties were successfully prepared. The composites constructed multi-scale micro-nanostructures with morphology and structure similar to mosquito compound eyes. The structure and properties of the composite microspheres were investigated using characterization tools such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and contact angle tester. The results showed that the SiO2 nanoparticles were successfully compounded with polysiloxane microspheres and formed a stable structure; the surface of the composite microspheres showed superhydrophobicity while retaining the fluorescent properties of the polysiloxane matrix. This fluorescent superhydrophobic composite with a bionic compound eye structure has broad application prospects in the fields of optical devices and functional coatings, etc.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 6","pages":"730 - 738"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tunable Optical and Electrical Properties of Poly(meta-aminophenol) via Doping with FeCl3 and I2 for Advanced Applications 通过FeCl3和I2掺杂聚间氨基苯酚的可调光学和电学性质在高级应用中的应用

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X25600528

Bouabdallah Daho, Abdelkader Dehbi, Ali Alsalme, Massimo Messori

{"title":"Tunable Optical and Electrical Properties of Poly(meta-aminophenol) via Doping with FeCl3 and I2 for Advanced Applications","authors":"Bouabdallah Daho, Abdelkader Dehbi, Ali Alsalme, Massimo Messori","doi":"10.1134/S0965545X25600528","DOIUrl":"10.1134/S0965545X25600528","url":null,"abstract":"Conjugated conductive organic polymers, such as polyacetylene, polythiophene, polypyrrole, and polyaniline, are among the most widely studied materials due to their unique properties and diverse applications. To explore their potential for advanced technologies, poly(meta-aminophenol) was synthesized and characterized using FTIR, XRD, UV–Vis spectroscopy, TGA, and electrical measurements. The optical properties of the doped polymer were investigated through oxidation-reduction reactions using FeCl3 and I2 to analyze its redox behavior. Upon doping, the energy gap of the polymers decreased, influenced by the oxidation potential of the dopants. The undoped polymer exhibited an energy gap of 3.4 eV, which reduced to 1.8 eV for the I2-doped polymer and 2.05 eV for the FeCl3-doped polymer. This reduction in energy gap correlated with an increase in electrical conductivity, from 8.85 × 10−4 S/m for the undoped polymer to 7.28 × 10–3 S/m for the I2-doped polymer and 4.22 × 10−3 S/m for the FeCl3-doped polymer.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 6","pages":"696 - 702"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Rheological Behavior of Solutions of Some Polysaccharides in Order to Optimize the Concentration of the Polymer in the Solution Used for the Preparation of Soft Dosage Forms in the Form of Protective Wound Coatings 分析一些多糖溶液的流变行为，以优化用于制备保护性伤口涂层软剂型的溶液中聚合物的浓度

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X25600188

A. S. Shurshina, M. A. Afanasyeva, R. Yu. Lazdin, E. I. Kulish

{"title":"Analysis of the Rheological Behavior of Solutions of Some Polysaccharides in Order to Optimize the Concentration of the Polymer in the Solution Used for the Preparation of Soft Dosage Forms in the Form of Protective Wound Coatings","authors":"A. S. Shurshina, M. A. Afanasyeva, R. Yu. Lazdin, E. I. Kulish","doi":"10.1134/S0965545X25600188","DOIUrl":"10.1134/S0965545X25600188","url":null,"abstract":"The work is devoted to the analysis of solutions of some polymers in order to optimize the concentration, which ensures the production of protective film materials with the necessary characteristics. The polysaccharides such as pectin, chitosan, the sodium salt of chitosan succinyl and the sodium salt of carboxymethylcellulose were used as the basis for the creation of materials in this work. The conducted rheological studies suggest that solutions of polysaccharides, depending on the polymer concentrations, have different degrees of structure and fluidity. Solutions with concentrations up to Ce behave like Newtonian liquids. Solutions with concentrations between Ce and Cgel are like pseudoplastic liquids. Solutions with higher concentrations behave like elastic-viscous gels. The polymer concentration in solution used in the process of forming a film coating fundamentally affects a number of physicochemical and physicomechanical characteristics of films. In order for film coatings to be characterized by maximum strength and elasticity, good sorption capacity and controlled drug yield, they must be formed from a semi-diluted solution with a concentration of Се < С < Сgel.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 6","pages":"685 - 695"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Filling Effects of BaSO4 and CaF2 on Non-linear Rheological Behaviours and Mechanical Performances in Fluoroelastomer BaSO4和CaF2填充对氟弹性体非线性流变行为和力学性能的影响

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X24601023

Ronghao Song, Rui Yang, Chen Wang, Zhengtao Su

{"title":"Filling Effects of BaSO4 and CaF2 on Non-linear Rheological Behaviours and Mechanical Performances in Fluoroelastomer","authors":"Ronghao Song, Rui Yang, Chen Wang, Zhengtao Su","doi":"10.1134/S0965545X24601023","DOIUrl":"10.1134/S0965545X24601023","url":null,"abstract":"Correlations between filling amount and effects in FKM of two fillers, BaSO4 and CaF2, were investigated to clarify differences in dispersion, binding, and reinforcement. Rheological behaviors of FKM mixtures were first explored via LAOS tests, indicating that the increase in filling content of BaSO4 had relatively monotonous impacts on the non-linear viscoelasticity responses, while those of CaF2 presented a complex three-stage alteration pattern. It was hypothesized that an approximate CaF2-FKM “mesophase” was formed with filler content up to the 25–30 phr range due to the specific binding properties of CaF2 to the FKM matrix. Next, investigations on FKM vulcanizate corroborated the conjecture provided by the LAOS test, where differences in filler aggregation morphology under SEM images and G ' from DMA measurements were observed. Engineering tests were then conducted for FKM vulcanizates, with which the discrepancies of BaSO4 and CaF2 in the filling effects on FKM were further discussed. Results illustrated that BaSO4 had poor dispersion and binding in FKM, while CaF2 possessed more significant reinforcing effects due to its good wetting and dispersion, and the difference in performances of vulcanizate with two types of filler was most prominent in the filling range of 20–30 phr.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 6","pages":"714 - 729"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoroelastomer-Induced Microcellular Structure in Polyolefin Elastomer Foams: a Pathway to Reduced Shrinkage and Enhanced Mechanical Properties 聚烯烃弹性体泡沫中氟弹性体诱导的微孔结构：减少收缩和增强机械性能的途径

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X24601266

Yueming Wang, Xiaoyang Du, Li Zhang, Jinbiao Bao

{"title":"Fluoroelastomer-Induced Microcellular Structure in Polyolefin Elastomer Foams: a Pathway to Reduced Shrinkage and Enhanced Mechanical Properties","authors":"Yueming Wang, Xiaoyang Du, Li Zhang, Jinbiao Bao","doi":"10.1134/S0965545X24601266","DOIUrl":"10.1134/S0965545X24601266","url":null,"abstract":"Polyolefin elastomer (POE) is widely used in automotive components, footwear materials, and other applications due to its excellent elasticity and thermoplastic processability. However, POE foams prepared via supercritical carbon dioxide (scCO2) foaming often face significant shrinkage issues, severely limiting their practical applications. Enhancing the rigidity of cell walls through irreversible chemical crosslinking is the prevailing strategy for suppressing shrinkage. However, this compromises recyclability. Balancing anti-shrinkage, high foaming ratio and recyclability remains a critical challenge. In this study, we propose a novel approach to fabricate POE/FKM (fluoroelastomer) foams with high open-cell content by introducing FKM as a modifier. The results show that with 10 wt % FKM, the foams attain an open-cell content of 95.1% and a foaming ratio of 27.5 times, while the shrinkage ratio is significantly reduced from 64.6% (for pure POE foams) to 12.1%. These performance improvements are attributed to the high CO2 affinity and heterogeneous nucleation effect of FKM, which promote the uniform cell refinement and the formation of a highly open-cell structure. This structure effectively reduces the negative pressure within the cells, thereby improving dimensional stability. This study proposes a high-performance POE/FKM foam, offering a feasible approach for developing polyolefin foams with excellent anti-shrinkage properties, recyclability, and outstanding mechanical performance.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 6","pages":"703 - 713"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-isothermal Crystallization Kinetics Behavior of Ethylene-vinyl Acetate Copolymer and Ethylene-vinyl Acetate Copolymer/Nitrile Butadiene Rubber/Liquid Nitrile Butadiene Rubber Thermoplastic Vulcanizates Crosslinked with a Coordination System 配位体系交联的乙烯-醋酸乙烯共聚物和乙烯-醋酸乙烯共聚物/丁腈橡胶/液态丁腈橡胶热塑性硫化胶的非等温结晶动力学行为

IF 1.1 4区化学

Polymer Science, Series A Pub Date : 2025-07-15 DOI: 10.1134/S0965545X2560053X

Jianqiang Chu, Yongheng Sun, Zhiyuan Gong, Mengran Li, Zhaobo Wang

{"title":"Non-isothermal Crystallization Kinetics Behavior of Ethylene-vinyl Acetate Copolymer and Ethylene-vinyl Acetate Copolymer/Nitrile Butadiene Rubber/Liquid Nitrile Butadiene Rubber Thermoplastic Vulcanizates Crosslinked with a Coordination System","authors":"Jianqiang Chu, Yongheng Sun, Zhiyuan Gong, Mengran Li, Zhaobo Wang","doi":"10.1134/S0965545X2560053X","DOIUrl":"10.1134/S0965545X2560053X","url":null,"abstract":"Thermoplastic vulcanizates (TPVs) based on ethylene-vinyl acetate copolymer (EVA)/nitrile butadiene rubber (NBR)/liquid nitrile rubber (LNBR) were prepared using a dynamic vulcanization method with a copper sulfate (CuSO4) coordination cross-linking system. The microstructures of EVA/NBR TPV and EVA/NBR/LNBR TPV were analyzed using field emission scanning electron microscopy (FE-SEM). The mechanical properties and non-isothermal crystallization kinetics of EVA/NBR/LNBR TPV, EVA/NBR TPV and pure EVA were investigated using a universal testing machine and differential scanning calorimetry (DSC), respectively. The experimental results demonstrated that the incorporation of LNBR enhanced the mechanical properties of the EVA/NBR TPV significantly. The size of the crosslinked NBR particles were refined with the incorporation of LNBR in TPV, which influenced the non-isothermal crystallization behavior of the EVA phase. Data analysis revealed that the crystallization behavior could be characterized by the Jeziorny and Mo methods effectively. The NBR phase was found to promote nucleation of the EVA matrix while simultaneously inhibiting the growth of EVA crystals. The existence of LNBR in TPV further enhanced the nucleation-promoting effect, while the influence on weakening the inhibition of crystal growth was limited.","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 6","pages":"673 - 684"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0