Sorption and Mechanical Characteristics of a Polymer Composite Based on Acrylic Hydrogel and Detonation Nanodiamonds and the Kinetics of Metronidazole Release from It
D. V. Grigoriev, A. V. Gudkin, E. V. Sivtsov, A. V. Kalinin, M. V. Uspenskaya
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Abstract
A polymer composite material for medical applications based on acrylic hydrogels and detonation nanodiamonds containing the medicinal substance metronidazole has been synthesized. The kinetics of gel swelling in media of different ionic strengths and pH values and the kinetics of metronidazole release from it have been studied. It has been shown that detonation nanodiamonds affect the completeness of metronidazole release. Mathematical models that best describe the process of metronidazole desorption and swelling kinetics have been proposed. The mechanical properties of the hydrogels and the frequency dependences of their dynamic moduli have been studied using oscillation rheometry methods. The effect of detonation nanodiamonds and metronidazole on the dynamic moduli, the mechanical loss tangent, and the parameters of the polymer matrix network has been shown.
期刊介绍：
Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.
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