Trends in Analytical Chemistry最新文献

Recent advances in smartphone-integrated laser-scribed graphene-based electrochemical sensing platforms for personalized health management 基于个性化健康管理的智能手机集成激光书写石墨烯电化学传感平台的最新进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-24 DOI: 10.1016/j.trac.2025.118357

Sirui Wu , Lican He , Jian Shu , Dianping Tang

{"title":"Recent advances in smartphone-integrated laser-scribed graphene-based electrochemical sensing platforms for personalized health management","authors":"Sirui Wu , Lican He , Jian Shu , Dianping Tang","doi":"10.1016/j.trac.2025.118357","DOIUrl":"10.1016/j.trac.2025.118357","url":null,"abstract":"<div><div>Laser-scribed graphene (LSG), with its high electrical conductivity, tunable surface chemistry, and facile fabrication, has emerged as a key material for developing advanced electrochemical sensors. This review presents recent advancements in LSG electrodes for portable and wearable electrochemical biosensing, focusing on both electrode materials functionalization and their integration with smartphone-based electrochemical sensing systems. It briefly introduces the design and working principles of smartphone-based electrochemical sensing system, followed by an analysis of the physicochemical properties and advantages of LSG electrodes. The advances of LSG electrodes are systematically discussed through various surface functionalization strategies, including the integration of metal nanoparticles, polymers, metal complexes, and biomolecules. Furthermore, the review examines the practical applications of smartphone-integrated LSG-based electrochemical sensing platforms for detecting physiological fluids such as blood, sweat, and saliva, demonstrating their potential for personalized healthcare and disease management. Finally, the challenges associated with LSG electrodes in portable and wearable sensing applications are addressed, along with future research directions. Recommendations are provided to promote the commercialization and widespread adoption of this technology. Smartphone-integrated LSG-based electrochemical sensing platforms is expected to play an increasingly crucial role in the future of healthcare.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118357"},"PeriodicalIF":11.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanohybrid approaches for precise analytical screening of trace contaminants in complex environmental and biological matrices 复杂环境和生物基质中痕量污染物精确分析筛选的纳米混合方法

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-24 DOI: 10.1016/j.trac.2025.118358

V.C. Deivayanai, S. Karishma, Pavithra Swaminaathan, A. Saravanan, A.S. Vickram, K. Anbarasu, P.R. Yaashikaa

{"title":"Nanohybrid approaches for precise analytical screening of trace contaminants in complex environmental and biological matrices","authors":"V.C. Deivayanai, S. Karishma, Pavithra Swaminaathan, A. Saravanan, A.S. Vickram, K. Anbarasu, P.R. Yaashikaa","doi":"10.1016/j.trac.2025.118358","DOIUrl":"10.1016/j.trac.2025.118358","url":null,"abstract":"<div><div>In complex biological and environmental matrices, nanohybrid technologies have become effective instruments for the accurate analytical screening of trace contaminants. By combining organic and inorganic components, these hybrid materials provide improved pollutant detection sensitivity, selectivity, and multifunctionality. Their uses include pharmaceutical residue screening, microbial contamination detection, and environmental monitoring. Highly accurate real-time analysis is made possible by sophisticated nanohybrid sensors, such as metal-doped electrochemical sensors and nano-quantum dot sensors. Furthermore, contamination analysis is being advanced by AI-driven optimization and multimodal detection techniques. Notwithstanding their potential, issues like environmental impact, reproducibility, and stability need to be resolved before they can be widely used. To increase productivity and reduce environmental hazards, future advancements should concentrate on AI-assisted detection models and sustainable synthesis techniques.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118358"},"PeriodicalIF":11.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-enhanced Raman scattering detection of antibiotics 表面增强拉曼散射检测抗生素

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-22 DOI: 10.1016/j.trac.2025.118352

Waqas Ahmad , Muhammad Zareef , Min Chen , Yi Xu , Jingjing Wang , Quansheng Chen

{"title":"Surface-enhanced Raman scattering detection of antibiotics","authors":"Waqas Ahmad , Muhammad Zareef , Min Chen , Yi Xu , Jingjing Wang , Quansheng Chen","doi":"10.1016/j.trac.2025.118352","DOIUrl":"10.1016/j.trac.2025.118352","url":null,"abstract":"<div><div>The extensive use of antibiotics has led to residues seeping into the food chain and water supplies, creating a hidden yet pervasive threat. To control antibiotic residues and prevent the silent spread of resistance, it is essential to use modern technologies for their detection. Surface-enhanced Raman scattering (SERS)-based detection offers molecular fingerprint signatures enabling differentiation among structurally related antibiotics. Thus, the current review oversees an up-to-date coverage of the advances in SERS-antibiotics detection in foodstuffs, water, and biological matrices. The study systematically <strong>(i)</strong> categorizes all groups of antibiotics (quinolones, tetracyclines, sulfonamides, aminoglycoside, amphenicols, β-lactams, nitrofuran, macrolides and nitroimidazoles); <strong>(ii)</strong> evaluates nanosubstrate design, novelty, detection (label/label-free) modes, experimental bands assignment, mechanism, orientation on the substrate, and other routine SERS metrics; and finally <strong>(iii)</strong> highlight limitations and future trends in antibiotic-SERS detection. The review will be applicable in diverse fields of chemical (bio)sensors, analytical chemistry, materials science, food science, and environmental monitoring.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118352"},"PeriodicalIF":11.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Application of microneedle patch in food and medical analysis 微针贴片在食品和医学分析中的应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-20 DOI: 10.1016/j.trac.2025.118351

Hui Jiang , Qing Tang , Donglei Jiang , Xinmei Liu , Wei Shen , Qiushi Feng , Bin Di , Jun Yang

引用次数: 0

Aptamer-based biosensors: from SELEX to biomedical diagnostics 基于适配体的生物传感器：从SELEX到生物医学诊断

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-20 DOI: 10.1016/j.trac.2025.118349

Stefen Stangherlin , Nathania Lui , Jung Heon Lee , Juewen Liu

{"title":"Aptamer-based biosensors: from SELEX to biomedical diagnostics","authors":"Stefen Stangherlin , Nathania Lui , Jung Heon Lee , Juewen Liu","doi":"10.1016/j.trac.2025.118349","DOIUrl":"10.1016/j.trac.2025.118349","url":null,"abstract":"<div><div>With excellent binding properties, stability, programmable structures, and ease of modification, DNA aptamers are promising for developing biosensors for both point-of-care and continuous monitoring applications. Over the last few years, significant progress has been made in the selection of high-quality aptamers for important target molecules, fundamental understanding of aptamer binding, and biosensor development, especially in the form of portable sensors, continuous in vivo monitoring and wearable devices. For small molecule targets, library-immobilization-based selection has yielded over 100 high-quality short aptamers with well-defined secondary structures. For protein targets, engineering polyvalent aptamers and slow off-rate aptamers can better mimic the binding properties of antibodies allowing extensive washing and binding in complex sample matrices. New methods in cell-SELEX have also provided insights into the isolation of aptamers against rare surface biomarkers. This review aims to capture these developments, which will build a solid foundation for future research and development in aptamer-based biosensors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118349"},"PeriodicalIF":11.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, properties and applications of DNA-templated copper nanoclusters in chemical and biological sensing dna模板铜纳米团簇的合成、性质及其在化学和生物传感中的应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-20 DOI: 10.1016/j.trac.2025.118347

Fabio Spiaggia , Pasquale Palladino , Corinne Ravelet , Maria Minunni

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Molecularly imprinted polymers for the sensing of hazardous chemicals: Mechanisms and applications 用于危险化学品传感的分子印迹聚合物：机制和应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-20 DOI: 10.1016/j.trac.2025.118348

Dan Wu , Zhibin Xu , Yifei Wang , Jiong Guo , Wenxin Zhang , Lili Qiu , Zihui Meng

{"title":"Molecularly imprinted polymers for the sensing of hazardous chemicals: Mechanisms and applications","authors":"Dan Wu , Zhibin Xu , Yifei Wang , Jiong Guo , Wenxin Zhang , Lili Qiu , Zihui Meng","doi":"10.1016/j.trac.2025.118348","DOIUrl":"10.1016/j.trac.2025.118348","url":null,"abstract":"<div><div>Hazardous chemicals, characterized by their diverse origins and significant toxicity, pose systemic threats to global public safety, ecological environments, and human health. These chemicals primarily include explosives, chemical warfare agents, organophosphorus pesticides, biotoxins, and illicit drugs. While conventional detection technologies exhibit high sensitivity, their reliance on bulky instruments and specialized expertise impedes rapid on-site response capabilities. The development of novel detection methodologies featuring efficient identification, real-time monitoring, and anti-interference capabilities has become an urgent demand to avoid threats from hazardous chemicals. As synthetic biomimetic recognition materials, molecularly imprinted polymers (MIPs) have demonstrated significant potential due to their high specificity, stability, and customizable recognition sites. MIPs achieve selective target binding through pre-designed cavities that are complementary to analytes in terms of size, shape, and functional groups. Recent advances demonstrate that MIPs integrated with optical, electrochemical, and mass-sensitive sensing principles exhibit remarkable advantages in detection sensitivity, anti-interference capability, and environmental adaptability, making them suitable for rapid on-site detection and real-time monitoring scenarios. This review systematically summarizes recent progress in MIP-based hazardous chemical detection, focusing on biomimetic recognition mechanisms and technical superiority, while exploring the potential for multi-scenario applications. Current challenges and future perspectives of MIP-based detection strategies are critically examined, providing a theoretical foundation for the development of efficient and portable detection platforms.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"192 ","pages":"Article 118348"},"PeriodicalIF":11.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging metal-organic framework (MOF)-based biosensors with high potential for point-of-care determination of biomarkers: Mechanisms and applications 新兴的基于金属有机框架（MOF）的生物传感器具有很高的护理点生物标志物测定潜力：机制和应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-19 DOI: 10.1016/j.trac.2025.118345

Mohammad Ali Farzin , Seyed Morteza Naghib , Navid Rabiee

{"title":"Emerging metal-organic framework (MOF)-based biosensors with high potential for point-of-care determination of biomarkers: Mechanisms and applications","authors":"Mohammad Ali Farzin , Seyed Morteza Naghib , Navid Rabiee","doi":"10.1016/j.trac.2025.118345","DOIUrl":"10.1016/j.trac.2025.118345","url":null,"abstract":"<div><div>Emerging research in real-time and in-situ biosensors has attracted much attention worldwide, especially in response to outbreaks of deadly epidemics and incurable chronic diseases. However, the initiation of research in this field is still challenging for researchers in selecting sensing platforms, probes, sensing strategies and other aspects to realize clinical goals. The selection of these options should be such that in addition to improving the figures of merit of analytical tools such as sensitivity, selectivity, limit of detection (LOD) and dynamic linear range (DLR), clinical requirements such as biocompatibility, stability and the absence of foreign-body response (FBR) in complex matrices are also met. This review article emphasizes the use of metal organic frameworks (MOFs) as electrochemical platforms, fluorescent probes and nanozymes as well as luminophores. As a group of porous crystalline materials, MOFs show high potential for the fabrication of biosensors integrated with the Internet of Things (IoT), logic gates or smartphones that have a significant impact on the modern medical and healthcare systems. To the best of our knowledge, this review article is the first comprehensive study focusing on different types of MOF-based real-time and in-situ biosensors, including optical, electrochemical, dual-mode photoelectrochemical, and electrochemical-luminescence biosensors, as well as specific standards that affect their biological applications. Despite the large number of research studies in this field, the lack of personalized implantable/wearable biosensors, as well as MOF-based neuromorphic biosensors, is evident.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118345"},"PeriodicalIF":11.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular recognition on glycans interaction in cell membrane by atomic force microscopy 细胞膜聚糖相互作用的原子力显微镜分子识别

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-17 DOI: 10.1016/j.trac.2025.118344

Wenfeng Xu , Xuan Zhang , Shaoping Li , Jing Zhao

{"title":"Molecular recognition on glycans interaction in cell membrane by atomic force microscopy","authors":"Wenfeng Xu , Xuan Zhang , Shaoping Li , Jing Zhao","doi":"10.1016/j.trac.2025.118344","DOIUrl":"10.1016/j.trac.2025.118344","url":null,"abstract":"<div><div>Glycans, also known as polysaccharides/saccharides/carbohydrates, commonly found in biological cell membrane/wall, and play important biological functions. Biomolecular recognition on the cell surface is governed by molecular interactions, making direct measurement essential for understanding biological processes. Atomic force microscopy (AFM) is the only microscopy technique that provides images in aqueous media with nanometer resolution, which greatly facilitates the specific recognition of macromolecules on the cell surface. Moreover, single-molecule force spectroscopy (SMFS) based on AFM has been commonly employed to investigate interactions between proteins and other molecules. However, there are fewer reviews on glycan molecular recognition. Therefore, this review focuses on the molecular recognition between glycans and cell membranes using AFM, covering glycans-receptor interactions and the important roles of glycans on the cell membrane. Finally, strategies for enhancing the study of molecular recognition between glycans and cell membranes through AFM are prospected and with the aims to address biomedical challenges and discover novel biomolecules.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118344"},"PeriodicalIF":11.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in sample preparation techniques combined with analytical methods for the determination of antiepileptic drugs (AEDs) 抗癫痫药物样品制备技术与分析方法的结合研究进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-06-13 DOI: 10.1016/j.trac.2025.118340

Mürüvvet Begüm Özen , Hassan Elzain Hassan Ahmed , Mustafa Soylak

引用次数: 0