Trends in Analytical Chemistry最新文献

Advances in DNA damage detection: Current progress, challenges, and future directions

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-27 DOI: 10.1016/j.trac.2025.118246

Heeseok Kang , Hyung Joon Park , Jieun Kang , Yuna Hwang , YongJin Lee , Sang-Uk Park , Jeongkyu Kim , Kwan Hyi Lee , Sunbok Jang

{"title":"Advances in DNA damage detection: Current progress, challenges, and future directions","authors":"Heeseok Kang , Hyung Joon Park , Jieun Kang , Yuna Hwang , YongJin Lee , Sang-Uk Park , Jeongkyu Kim , Kwan Hyi Lee , Sunbok Jang","doi":"10.1016/j.trac.2025.118246","DOIUrl":"10.1016/j.trac.2025.118246","url":null,"abstract":"<div><div>DNA is much continuously exposed to endogenous and exogenous agents that induce damage, potentially leading to genomic instability, disease development, and aging. Detecting DNA damage and understanding associated repair mechanisms are essential for advancing diagnostic techniques, biosensors, and therapeutic interventions. Since DNA damage varies, the desired measurement approach differs, highlighting the need for an unbiased exploration of DNA damage biomarkers, along with a critical analysis of various quantification methods. Therefore, this review aims to provide a comprehensive overview of current methodologies for measuring DNA damage, focusing on direct detection of DNA lesions and indirect measurement of repair enzymes. We discuss various analytical, biochemical, and imaging techniques, identify the limitations in existing technologies and suggest future directions. This review emphasizes the growing need for advanced tools to measure DNA damage, which is set to play a transformative role in early disease detection, optimizing treatments, and supporting safe human space exploration.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118246"},"PeriodicalIF":11.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Halloysite-based sorbents: Synthesis, characterization, and applications in sample preparation

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-22 DOI: 10.1016/j.trac.2025.118241

Omid Mazloumi, Fatemeh Zahra Biabanpour, Saeed Nojavan

{"title":"Halloysite-based sorbents: Synthesis, characterization, and applications in sample preparation","authors":"Omid Mazloumi, Fatemeh Zahra Biabanpour, Saeed Nojavan","doi":"10.1016/j.trac.2025.118241","DOIUrl":"10.1016/j.trac.2025.118241","url":null,"abstract":"<div><div>Halloysite nanotubes (HNTs), naturally occurring aluminosilicate clay minerals, possess unique structural and physicochemical properties that make them highly promising sorbents for solid-based extraction methods. Their tubular structure, high surface area, and inherent adsorption capacity enable efficient capture of analytes from complex matrices. This review comprehensively examines the application of HNTs in solid-phase extraction (SPE) and its miniaturized variants, such as solid-phase microextraction (SPME) or micro SPE (μ-SPE), focusing on their use in isolating analytes from environmental, beverage, food, and biological samples. Key aspects covered include the synthesis and modification of HNT-based composites to enhance extraction selectivity and efficiency, the assessment of the environmental impact and greenness of the extraction methodologies, and the characterization techniques used to elucidate the structure-property relationships of the HNT-based materials. The review highlights the significant potential of HNTs to advance sample preparation technologies by offering sustainable and efficient extraction processes across a broad range of analytical disciplines.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118241"},"PeriodicalIF":11.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxyapatite-based composites as efficient sorbents: Fabrication and application in sample preparation techniques

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-22 DOI: 10.1016/j.trac.2025.118242

Ali Firoozichahak , Saber Alizadeh , Razzagh Rahimpoor , Danial Soleymani-ghoozhdi

{"title":"Hydroxyapatite-based composites as efficient sorbents: Fabrication and application in sample preparation techniques","authors":"Ali Firoozichahak , Saber Alizadeh , Razzagh Rahimpoor , Danial Soleymani-ghoozhdi","doi":"10.1016/j.trac.2025.118242","DOIUrl":"10.1016/j.trac.2025.118242","url":null,"abstract":"<div><div>Hydroxyapatite (HAP) and its composites, especially in nano-scale forms, have garnered significant interest among researchers owing to their remarkable characteristics. These features include a flexible pore structure, substantial specific surface area, high porosity, robust stability, and alterable surface properties. Recently, HAP and its composites extensively utilized in various interdisciplinary fields such as environmental science, biomedical, and materials science. In this way, novel sample preparation methods based on nano-HAP (n-HAP) have been developed. This article provides an overview of the different synthesis methods of the n-HAP materials, the commonly used techniques for their characterization, the types and properties of their nanocomposites, green and sustainability aspects of them, and their applications in sample preparation techniques including; Solid Phase Extraction (SPE), Dispersive Solid Phase Extraction (DSPE), Magnetic Solid Phase Extraction (MSPE), Solid Phase Microextraction (SPME), Needle Trap Devices (NTDs), and Microextraction by Packed Sorbent (MEPS). This review covers published documents since 2000 in the field of HAP-based adsorbents for sample preparation techniques. Additionally, the article discusses future prospects for these procedures.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118242"},"PeriodicalIF":11.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viscoelastic microfluidics: Fundamentals, technological development and applications

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-20 DOI: 10.1016/j.trac.2025.118240

Xiaoyue Kang , Haotian Cha , Nam-Trung Nguyen , Weihua Li , Alexander Klimenko , Jun Zhang , Dan Yuan

{"title":"Viscoelastic microfluidics: Fundamentals, technological development and applications","authors":"Xiaoyue Kang , Haotian Cha , Nam-Trung Nguyen , Weihua Li , Alexander Klimenko , Jun Zhang , Dan Yuan","doi":"10.1016/j.trac.2025.118240","DOIUrl":"10.1016/j.trac.2025.118240","url":null,"abstract":"<div><div>Microfluidics has significantly advanced research in environmental science, biomedicine, and chemical analysis. Many natural and synthetic fluids, such as saliva, blood and polymer solution, are non-Newtonian. These fluids can exhibit viscoelastic and shear-thinning properties, which profoundly affect particle behaviour in microchannels. Understanding particle migration in these fluids is essential for accurate and effective particle manipulation. This paper reviews the current viscoelastic microfluidics research. We first explain the fundamental theory of hydrodynamic forces on particles in viscoelastic fluids. Next, we describe particle viscoelastic migration in channels of different geometries and cross-sectional shapes. Subsequently, we review the state of the art of multi-stage and multi-physics integration with viscoelastic microfluidics. We also provide a summary of the applications of viscoelastic microfluidics in manipulating micro and nano bioparticles. Finally, we discuss the limitations of current research and propose future research directions. This review aims to provide insights into viscoelastic microfluidics' further development and applications.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118240"},"PeriodicalIF":11.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-edge MoS2-Based biosensing platforms for detecting contaminants in food samples

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-18 DOI: 10.1016/j.trac.2025.118239

Joydip Sengupta , Chaudhery Mustansar Hussain

{"title":"Cutting-edge MoS2-Based biosensing platforms for detecting contaminants in food samples","authors":"Joydip Sengupta , Chaudhery Mustansar Hussain","doi":"10.1016/j.trac.2025.118239","DOIUrl":"10.1016/j.trac.2025.118239","url":null,"abstract":"<div><div>Cutting-edge advancements in sensing technologies have positioned molybdenum disulfide (MoS<sub>2</sub>) as a transformative material for detecting contaminants in food samples. Leveraging its exceptional electrical, optical, and catalytic properties, MoS<sub>2</sub>-based sensing platforms have demonstrated remarkable potential in identifying a wide range of foodborne hazards, including pathogens, pesticides, and allergens. This review explores the latest developments in MoS<sub>2</sub>-enabled sensing systems, emphasizing their ability to synergistically combine electrochemical sensitivity and optical responsiveness for unparalleled detection accuracy and efficiency. The unique two-dimensional structure of MoS<sub>2</sub>, with its high surface area and tunable properties, enhances sensor specificity and sensitivity, enabling rapid and reliable contaminant detection in complex food matrices. While challenges such as long-term stability, scalability, and signal interference remain, emerging strategies like hybrid nanocomposite engineering and machine learning-assisted data analysis offer promising solutions. This review underlines the transformative potential of MoS<sub>2</sub>-based sensing platforms in revolutionizing food safety monitoring, ensuring public health protection, and paving the way for sustainable and cost-effective detection technologies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118239"},"PeriodicalIF":11.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanomaterials-derived colorimetric signaling strategies for immunosensing and food safety

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-17 DOI: 10.1016/j.trac.2025.118238

Rui Shu , Sijie Liu , Ibrahim A. Darwish , Jianlong Wang , Daohong Zhang

{"title":"Gold nanomaterials-derived colorimetric signaling strategies for immunosensing and food safety","authors":"Rui Shu , Sijie Liu , Ibrahim A. Darwish , Jianlong Wang , Daohong Zhang","doi":"10.1016/j.trac.2025.118238","DOIUrl":"10.1016/j.trac.2025.118238","url":null,"abstract":"<div><h3>Background</h3><div>The food industry faces significant challenges from spoilage and contamination, leading to frequent food safety incidents and substantial economic losses. As a result, the development of sensors capable of detecting foodborne contaminants has become increasingly critical.</div></div><div><h3>Scope and approach</h3><div>Colorimetric immunosensors are particularly favored for their specificity, cost-effectiveness, portability, and ease of signal interpretation. Gold nanomaterials (AuNMs) are widely employed in colorimetric immunosensors owing to their superior optical properties, affinity, and catalytic activity, which enable accurate and reliable detection. However, achieving accurate and reliable detection remains a significant challenge for traditional colloidal gold. To address this issue, researchers have proposed various effective improvement strategies while preserving the inherent advantages of AuNMs. This study investigates both intrinsic and activated colorimetric immunosensing methods based on AuNMs, with an emphasis on their application in food safety monitoring. Specifically, this review first categorizes and summarizes signal strategies derived directly from the nanolabels themselves, followed by a detailed introduction of catalytic reactions.</div></div><div><h3>Key findings and conclusions</h3><div>This review offers valuable insights into enhancing current colorimetric detection methods and establishes a solid foundation for the development of diversified “colorimetric + other signals\" immunoassays. Furthermore, it addresses the challenges encountered in AuNMs-based colorimetric immunoassays and outlines future development directions, providing a novel approach to designing sensing modes tailored to the specific needs of the food industry.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118238"},"PeriodicalIF":11.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent nanozymes: Emerging versatile materials advancing analytical chemistry

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-17 DOI: 10.1016/j.trac.2025.118237

Qiaoqiao Diao , Zheng Tang , Jinjin Liu, Xiangheng Niu

{"title":"Fluorescent nanozymes: Emerging versatile materials advancing analytical chemistry","authors":"Qiaoqiao Diao , Zheng Tang , Jinjin Liu, Xiangheng Niu","doi":"10.1016/j.trac.2025.118237","DOIUrl":"10.1016/j.trac.2025.118237","url":null,"abstract":"<div><div>Since the revelation of Fe<sub>3</sub>O<sub>4</sub> nanoparticles with enzyme-like characteristics, nanozymes present a promising alternative to traditional bio-enzymes due to their straightforward preparation, good robustness, and adjustable performance. In addition to enzyme-mimetic catalysis, these materials also tend to show optical, electrical, thermal, and magnetic properties. Integrating nanozyme catalysis with these properties into an entity can offer fascinating merits to biochemical sensing. Especially, fluorescent nanozymes, a class of materials combining enzyme-mimicking activity and fluorescence, have been drawing growing interest in the analytical chemistry community in the past five years. To highlight the achievements and progress made in this emerging area, here we, for the first time, present a comprehensive summary on fluorescent nanozymes and their roles in advancing analytical detection. First, a definition of fluorescent nanozymes is given, and their bifunctional features are discussed. Then, common strategies employed to develop different material types of fluorescent nanozymes are introduced. Emphatically, their unique contributions to biochemical analysis are clarified in detail, along with various applications in environmental monitoring, food safety analysis, and biomedical detection. Finally, substantial potential of fluorescent nanozymes in realizing advanced detection as well as existing challenges is spotlighted. Our review provides a comprehensive and up-to-date reference on fluorescent nanozymes, which will attract more attention and guide future efforts to further promote the promising field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118237"},"PeriodicalIF":11.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micropumps and microvalves for biomedical applications

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-16 DOI: 10.1016/j.trac.2025.118236

Yun Zheng , Huanhuan Shi , Zhongjian Tan , Weizheng Xu , Rui Zhao , Zhengxian Dan , Zhiying Dai , Jiacong Liao , Hongwen Wu

{"title":"Micropumps and microvalves for biomedical applications","authors":"Yun Zheng , Huanhuan Shi , Zhongjian Tan , Weizheng Xu , Rui Zhao , Zhengxian Dan , Zhiying Dai , Jiacong Liao , Hongwen Wu","doi":"10.1016/j.trac.2025.118236","DOIUrl":"10.1016/j.trac.2025.118236","url":null,"abstract":"<div><div>This review focuses on the recent microfluidic technologies for fine manipulation of trace liquids based on functional components constructed by micropumps and microvalves and its biomedical applications. The working principle and importance of micropumps and microvalves as key components are expounded, and functional components such as enrichment, separation, mixing, extraction, purification and screening based on them are introduced. The wide applications of these functional components in wearable devices and point-of-care (POCT) devices were discussed, including real-time monitoring of human physiological indicators, rapid diagnosis of infectious diseases, early screening of cancer, etc. The significant advantages of microfluidic chips containing micropumps and microvalves in improving detection sensitivity, accuracy and efficiency are analyzed, and their important roles in personalized medicine and precision medicine are emphasized. The technical bottlenecks, limitations and possible solutions of existing microfluidic chips are discussed, and future development trends and potential breakthroughs in the biomedical field are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118236"},"PeriodicalIF":11.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviewing the fundamentals and best practices to characterize microplastics using state–of–the-art quantum-cascade laser reflectance-absorbance spectroscopy

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-13 DOI: 10.1016/j.trac.2025.118229

Adrián López-Rosales , Borja Ferreiro , Jose M. Andrade , Andreas Kerstan , Darren Robey , Soledad Muniategui

{"title":"Reviewing the fundamentals and best practices to characterize microplastics using state–of–the-art quantum-cascade laser reflectance-absorbance spectroscopy","authors":"Adrián López-Rosales , Borja Ferreiro , Jose M. Andrade , Andreas Kerstan , Darren Robey , Soledad Muniategui","doi":"10.1016/j.trac.2025.118229","DOIUrl":"10.1016/j.trac.2025.118229","url":null,"abstract":"<div><div>Microplastic pollution studies depend on reliable identification of the suspicious particles. Out of the various analytical techniques available to characterize them, infrared transflectance using a tuneable mid-IR quantum cascade laser is a high-throughput state-of-the-art imaging option, specifically Agilent's QCL-LDIR (Quantum Cascade Laser Direct Infrared imaging). Its conceptual grounds are reviewed, instrumental developments are discussed, along with a review of applications and best practices to overcome obstacles/difficulties in routine measurements, namely: the spectral range, the variation of some peak intensities with the particles size, processing speed, and avoiding the use of measurement aliquots. Objective procedures to avoid too many false positives when identifying spectra and to distinguish fibers and fragments are given. These practices open a path to QCL-LDIR measurement standardization and potential use for microplastics monitoring, as requested by many governmental bodies in charge of setting environmental protection rules.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118229"},"PeriodicalIF":11.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating extracellular vesicles with advanced fluorescence biosensing technologies

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-03-08 DOI: 10.1016/j.trac.2025.118228

Yeonju Lee , Kyung-Min Kim , Joonseok Lee , Young-Pil Kim

{"title":"Illuminating extracellular vesicles with advanced fluorescence biosensing technologies","authors":"Yeonju Lee , Kyung-Min Kim , Joonseok Lee , Young-Pil Kim","doi":"10.1016/j.trac.2025.118228","DOIUrl":"10.1016/j.trac.2025.118228","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) are the enigmatic messengers of intercellular communications and vital biological processes, including immune regulation, tissue regeneration, and disease progression. Despite their immense values as clinical diagnosis, the analysis of EVs poses significant challenges due to their small size and heterogeneity. This review focuses on the rapid evolution of fluorescence (FL) biosensing technologies. The convergence of FL biosensing technologies with advancements in biotechnology and nanotechnology has elaborated EV analysis, providing unprecedented sensitivity, specificity, and multiplexing capabilities. Here we overview three key areas of FL analyses of EVs: FL signal amplification technologies, Förster resonance energy transfer-based technologies, and innovative FL technologies. These cutting-edge methods, utilizing fluorescent dyes, enable precise visualization and simultaneous analysis of multiple EVs, offering insights into their diverse subpopulations and potential implications for biological processes, paving the way for novel diagnostic and therapeutic strategies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"188 ","pages":"Article 118228"},"PeriodicalIF":11.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0