Zhehao Zhang , Lijia Zhang , Yulin Li , Kun Song , Yunhui Meng , Xiaobai Li , Shilong Yang , Hongwei Ma
{"title":"化学战剂探测技术的研究现状","authors":"Zhehao Zhang , Lijia Zhang , Yulin Li , Kun Song , Yunhui Meng , Xiaobai Li , Shilong Yang , Hongwei Ma","doi":"10.1016/j.trac.2025.118474","DOIUrl":null,"url":null,"abstract":"<div><div>Chemical warfare agents (CWAs) are a class of highly toxic chemicals. They are often classified into different categories because of distinctions in their toxic effects. Although the Chemical Weapons Convention of 1993 banned the use of chemical weapons, the ease of manufacture and lethality of CWAs make them still a threat. Therefore, the development of rapid, accurate and sensitive detection techniques for CWAs is essential. This paper reviews the types of CWAs and their mechanisms of toxicity, introduces the use of CWAs mimics, and discusses in detail the mainstream CWAs detection techniques in recent years, including detection by Chemical Analysis Instrument, Ion Mobility Spectrometry (IMS), Electrochemistry, Fluorescence, Colorimetry, and Chemiresistor. Each of these technologies has its own advantages and disadvantages in terms of sensitivity, selectivity, portability and detection speed, etc. Meanwhile, this paper lists as well as analyzes the condition of CWAs detection equipment that have been put into commercial application in recent years. Finally, this paper provides an outlook on the future development of the application of CWAs detection technology in public safety.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118474"},"PeriodicalIF":12.0000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current status of research on chemical warfare agent detection technology\",\"authors\":\"Zhehao Zhang , Lijia Zhang , Yulin Li , Kun Song , Yunhui Meng , Xiaobai Li , Shilong Yang , Hongwei Ma\",\"doi\":\"10.1016/j.trac.2025.118474\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Chemical warfare agents (CWAs) are a class of highly toxic chemicals. They are often classified into different categories because of distinctions in their toxic effects. Although the Chemical Weapons Convention of 1993 banned the use of chemical weapons, the ease of manufacture and lethality of CWAs make them still a threat. Therefore, the development of rapid, accurate and sensitive detection techniques for CWAs is essential. This paper reviews the types of CWAs and their mechanisms of toxicity, introduces the use of CWAs mimics, and discusses in detail the mainstream CWAs detection techniques in recent years, including detection by Chemical Analysis Instrument, Ion Mobility Spectrometry (IMS), Electrochemistry, Fluorescence, Colorimetry, and Chemiresistor. Each of these technologies has its own advantages and disadvantages in terms of sensitivity, selectivity, portability and detection speed, etc. Meanwhile, this paper lists as well as analyzes the condition of CWAs detection equipment that have been put into commercial application in recent years. Finally, this paper provides an outlook on the future development of the application of CWAs detection technology in public safety.</div></div>\",\"PeriodicalId\":439,\"journal\":{\"name\":\"Trends in Analytical Chemistry\",\"volume\":\"193 \",\"pages\":\"Article 118474\"},\"PeriodicalIF\":12.0000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Analytical Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165993625003425\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993625003425","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Current status of research on chemical warfare agent detection technology
Chemical warfare agents (CWAs) are a class of highly toxic chemicals. They are often classified into different categories because of distinctions in their toxic effects. Although the Chemical Weapons Convention of 1993 banned the use of chemical weapons, the ease of manufacture and lethality of CWAs make them still a threat. Therefore, the development of rapid, accurate and sensitive detection techniques for CWAs is essential. This paper reviews the types of CWAs and their mechanisms of toxicity, introduces the use of CWAs mimics, and discusses in detail the mainstream CWAs detection techniques in recent years, including detection by Chemical Analysis Instrument, Ion Mobility Spectrometry (IMS), Electrochemistry, Fluorescence, Colorimetry, and Chemiresistor. Each of these technologies has its own advantages and disadvantages in terms of sensitivity, selectivity, portability and detection speed, etc. Meanwhile, this paper lists as well as analyzes the condition of CWAs detection equipment that have been put into commercial application in recent years. Finally, this paper provides an outlook on the future development of the application of CWAs detection technology in public safety.
期刊介绍:
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.