Trends in Analytical Chemistry最新文献

{"title":"Application of fluorescent tracing technology for investigating the effect of microplastics and nanoplastics on biological organisms","authors":"Xueyi Li ,&nbsp;Jun Liu ,&nbsp;Haifeng Meng ,&nbsp;Yiting Huang ,&nbsp;Wucheng Xie ,&nbsp;Yong Liang ,&nbsp;Jun Wang","doi":"10.1016/j.trac.2024.118039","DOIUrl":"10.1016/j.trac.2024.118039","url":null,"abstract":"<div><div>As the plastic industry rapidly develops, the resultant pollution from microplastics (MPs) and nanoplastics (NPs) has become widespread, significantly affecting human health and the ecological environment by their transmission and enrichment in the food chain. This article reviews an effective technique used for analysing the toxicological and metabolic mechanisms of MPs and NPs within organisms, namely the fluorescent tracing technology. This technology facilitates the qualitative and quantitative detection of MPs and NPs within organisms, enabling the monitoring of the behaviour and effect of MPs and NPs within biological systems. The paper explores the principles, advantages and disadvantages of various currently employed fluorescent tracers; summarises the equipment and technology currently utilised for MPs and NPs detection and tracing within organisms and discusses the application of the technology in studying MPs and NPs effects on organisms. Finally, it prospects the application prospect of in vivo fluorescence tracer technology for the detection of MPs and NPs, and points out the limitations and development directions of this method in subsequent research.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118039"},"PeriodicalIF":11.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latest trends in biosensors powered by nucleic acid isothermal amplification for the diagnosis of joint infections: From sampling to identification towards the point-of-care","authors":"Mariarita De Felice ,&nbsp;Mariarosaria De Falco ,&nbsp;Amina Antonacci ,&nbsp;Sara Colella ,&nbsp;Vincenzo Vedi ,&nbsp;Rachele Isticato ,&nbsp;Alfonso Maria Romano ,&nbsp;Valeria Nocerino ,&nbsp;Bruno Miranda ,&nbsp;Luca De Stefano ,&nbsp;Viviana Scognamiglio","doi":"10.1016/j.trac.2024.118036","DOIUrl":"10.1016/j.trac.2024.118036","url":null,"abstract":"<div><div>As the number of joint arthroplasties continues to increase, joint infections have emerged as a significant and devastating complication associated with total joint arthroplasty. The formation and persistence of bacterial biofilms create a formidable barrier against both the host immune system and antibiotics, contributing to the pathogenesis of joint infections, antibiotic resistance, and treatment failures. This review examines the latest trends on biosensors powered by isothermal nucleic acid amplification technologies designed to manage joint infections, highlighting their advantages and disadvantages, with a particular attention on their integration into point-of-care testing. In detail, a special focus on such innovative approaches for rapid and specific identification of pathogenic nucleic acids will cover the entire process from sampling to extraction, amplification, and detection methods.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118036"},"PeriodicalIF":11.8,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embarking on a journey through Micro-RNA and Circular-RNA detection methods","authors":"Zhaleh Asadi Fakhr ,&nbsp;Xinlan Zhu ,&nbsp;Hechen Wang ,&nbsp;Ruiyang Ma ,&nbsp;Ziwei Lin ,&nbsp;Xudan Shen ,&nbsp;Jiatong Liu ,&nbsp;Su Zeng ,&nbsp;Sheng Cai","doi":"10.1016/j.trac.2024.118035","DOIUrl":"10.1016/j.trac.2024.118035","url":null,"abstract":"<div><div>Micro-RNAs (miRNAs) and circular-RNAs (circRNAs) are attracting attention as biomarkers for cancer diagnosis due to their distinct biological characteristics. MiRNAs, known for their critical role in gene regulation and tissue specificity, face challenges in detection due to their small size and low abundance in clinical samples. CircRNAs, on the other hand, offer advantages in stability based on their circular structure and are emerging as robust biomarkers. Traditional detection methods have limitations in sensitivity and specificity. Recent developments in isothermal amplification methods promise improved detection capabilities. This review focuses on the innovative primer/probe designs, which enhanced the efficiency of miRNA and circRNA detection in real samples.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118035"},"PeriodicalIF":11.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical methods for identification, characterization, and quantification of metal-containing nanoparticles in biological and biomedical samples, food and personal care products","authors":"Dominik Blaimer,&nbsp;Kerstin Leopold","doi":"10.1016/j.trac.2024.118031","DOIUrl":"10.1016/j.trac.2024.118031","url":null,"abstract":"<div><div>Analytical methods for the identification, characterization, and quantification of metal-containing nanoparticles (MNPs) are required for quality control and toxicological assessment in a variety of complex sample matrices. This review provides a comprehensive overview of the available methods for the speciation, sizing, and quantification of MNPs in biological and biomedical samples, food and personal care products. Sample preparation, separation and fractionation approaches combined or directly coupled to different detection techniques are discussed in detail, along with their main analytical figures of merit. A detailed table summarizes the analytical approaches in this field reported over the past five years, listing the analytical steps and techniques, as well as their reported detection and quantification limits in terms of size and concentration of MNPs. A broad spectrum of analytical approaches and performance levels is observed. New developments that offer promising solutions to previously unsolved problems are also discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118031"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecularly imprinted polymers meet sensors: Insights and prospects for pollutants analysis","authors":"Dandan Han ,&nbsp;Niao Zhao ,&nbsp;Yahan Cui ,&nbsp;Hongyuan Yan","doi":"10.1016/j.trac.2024.118032","DOIUrl":"10.1016/j.trac.2024.118032","url":null,"abstract":"<div><div>Sensors offer several outstanding properties, including ease of operation, rapid response times, portability, and the ability to perform real-time analysis, driving their rapid development and broad applications. Among these, molecularly imprinted polymers (MIPs)-based sensors stand out due to their unique capability to modify sensor surfaces by creating recognition cavities in the polymer matrix. This approach offers a versatile methodology for imprinting various pollutants, providing a fast, sensitive, user-friendly, and highly selective sensing platform. MIPs-based sensors are especially attractive due to their excellent physicochemical stability, low cost, and reusability. Currently, a variety of sensors integrated with MIPs—such as fluorescent sensors and electrochemical sensors-have been developed for the detection and identification of trace biological macromolecules, organic pollutants, and heavy metal ions. This review explores the different types of MIPs-based sensors, their latest applications in pollutant detection, and highlights the challenges, limitations, and future directions for the development of these advanced sensing technologies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118032"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations, trends and analytical strategies applied for biological samples collection (sampling) and storage in forensic toxicology of volatile poisons (inorganic and organic)","authors":"Kamil Jurowski ,&nbsp;Maciej Noga ,&nbsp;Alicja Krośniak ,&nbsp;Paweł Papierz ,&nbsp;Łukasz Niżnik ,&nbsp;Damian Kobylarz","doi":"10.1016/j.trac.2024.118033","DOIUrl":"10.1016/j.trac.2024.118033","url":null,"abstract":"<div><div>The forensic analysis of volatile poisons, including volatile inorganic (VIP) and organic poisons (VOP), is crucial in forensic toxicology. These substances are challenging to analyse due to their instability and tendency to dissipate, requiring careful handling from sample collection to analysis. Despite their importance in public health and criminal justice, standardised guidelines for collecting and storing biological samples to detect VIP and VOP are lacking. This study reviews existing literature, identifies trends, and develops advanced strategies for effective sample collection and storage. Biological samples like blood, urine, serum, hair, saliva, and nails need customised approaches to preserve volatile analytes. Innovative techniques such as the PENVOC system and rolling stir bar sampling offer significant improvements in volatile organic compounds (VOC) analysis. The study also addresses post-mortem microbial production, complicating forensic ethanol analysis, and evaluates advanced storage methods like hydrophobic coatings, membrane-based preservation, supercritical fluid extraction, and cryogenic storage.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118033"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and limitations of the analytical methods currently employed for the assessment of inorganic pollutants in indoor and outdoor air","authors":"Mila Ródenas ,&nbsp;Teresa Vera ,&nbsp;Amalia Muñoz ,&nbsp;Florentina Villanueva","doi":"10.1016/j.trac.2024.118034","DOIUrl":"10.1016/j.trac.2024.118034","url":null,"abstract":"<div><div>Inorganic air pollutants comprise a broad class of substances, including acids, nitrogen and carbon oxides, ozone, ammonia, chlorine, and other halogenated compounds and ionic species. These types of pollutants can be emitted or produced naturally or anthropogenically outdoors but also can be emitted or generated by indoor activities.</div><div>Due to the diverse typology of inorganic compounds, the measurement techniques are also very different. Notwithstanding, there is no comprehensive review that comprises the different instruments and technologies currently existing in the market to design an air quality (AQ) monitoring strategy. Our paper aims at filling this gap by providing an overview and compendium of the most used measurement techniques and methods for the determination of inorganic pollutants in the air, including online and discontinuous methods in terms of advantages and disadvantages, and taking into account specifications such as detection limits, potential artifacts, temporal resolution and costs. Well-established methods, together with innovative instrumentation and methodology have been critically discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118034"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics of volatile organic compounds (VOCs) in infectious diseases","authors":"Kyrilos Sadaka ,&nbsp;Bahram Dalvand ,&nbsp;Zoya Faruqui ,&nbsp;Saman Aqeel ,&nbsp;Marzieh Ghoohestani ,&nbsp;Mohammad Goodarzi","doi":"10.1016/j.trac.2024.118024","DOIUrl":"10.1016/j.trac.2024.118024","url":null,"abstract":"<div><div>The metabolic profile, a direct indicator of phenotype and biochemical activity in infectious diseases, comprises diverse small molecules in biological systems, including natural products and drug components with variable expression. Metabolomics provides insights into novel drugs, drug scaffolds, and promising targets, contributing to suggesting binding partners and exploring natural products crucial in combating infections. Leveraging metabolomics amplifies the discovery of therapeutic agents, revealing anticipated and unforeseen drug effects. In infectious diseases, it contributes to prognostic and diagnostic aspects, employing NMR or mass spectrometry to identify disease-specific biomarkers. Metabolomics also uncovers potential targets among metabolic enzymes, utilizing advanced flux analysis techniques. This comprehensive review emphasizes metabolomics' significance in screening biomarkers, identifying drug targets for infections, and exploring immunometabolomics. Additionally, it focuses on advanced analytical techniques for volatile organic compound (VOC) analysis, addressing the application of chemometrics and the use of different analytical instruments, emphasizing the need for future research in this field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118024"},"PeriodicalIF":11.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal probes for the detection of bone cancer-related disease in biological systems: Recent advances and future prospects","authors":"Xiao-Lin Wen ,&nbsp;Xu-Yang Chen ,&nbsp;Yu-long Jin ,&nbsp;Zhi-Gang Sun ,&nbsp;Ai-Guo Zhang ,&nbsp;Kai Wang","doi":"10.1016/j.trac.2024.118030","DOIUrl":"10.1016/j.trac.2024.118030","url":null,"abstract":"<div><div>Bone cancer can be broadly categorized into primary bone cancer and metastatic bone cancer. Primary bone cancer, such as osteosarcoma and Ewing's sarcoma, is not only highly malignant but also tends to occur in younger age groups. Metastatic bone cancer typically originates from highly malignant diseases like prostate cancer, breast cancer, and lung cancer. The presence of bone metastasis usually indicates a poor prognosis. Therefore, early detection and treatment of bone lesions are crucial for improving patient prognosis and quality of life. Commonly used conventional detection methods, such as bone imaging, computed tomography (CT), and magnetic resonance imaging (MRI), suffer from limitations in resolution or penetration depth. As a result, the detection rate for small early bone metastases is often poor. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) utilize radionuclide-labeled imaging agents to perform functional imaging. These techniques improve the specificity of detection and provide information about tissue metabolism based on the concentration of different components in various tissues. However, PET and SPECT are susceptible to interference from factors like infection and necrosis, which may lead to false-positive results. Chemical probes have largely compensated for the lack of specificity and sensitivity of conventional methods, especially Near-Infrared (NIR) and photoacoustic (PA) imaging, which not only increase the depth of detection but also do not have radiological hazards. In this review, we will discuss the importance of probes for the early detection of bone-associated cancers. Specifically, we will examine probe-associated markers, recognition modalities, and imaging modalities in the context of probes used for metastatic bone cancers originating from breast and prostate cancers, as well as for primary osteosarcoma. The use of targeted probes enables the identification of cancerous lesions in bone through binding to biomarkers expressed in cancer cells. Different probe designs allow for various recognition strategies and imaging techniques to visualize the probes after they have bound to cancer cells. Understanding current probe technologies is critical for improving early diagnosis and treatment of bone cancers.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118030"},"PeriodicalIF":11.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical methods for protein kinase and inhibitor screening including kinetic evaluation","authors":"Viola Wurster ,&nbsp;Peter Fechner ,&nbsp;Günther Proll ,&nbsp;Carolin Huhn","doi":"10.1016/j.trac.2024.118025","DOIUrl":"10.1016/j.trac.2024.118025","url":null,"abstract":"<div><div>Protein kinases promote cell processes such as cell growth and proliferation similarly in tumor cells and healthy cells. Pharmaceutical research aims at developing small molecules that inhibit tumor growth binding in the ATP-binding pocket of specific protein kinases. To understand the specificity of the inhibitor, thermodynamic and kinetic data of the kinase-inhibitor binding process are important. A broad range of analytical methods may investigate the interactions between protein kinases and inhibitors. Today, however, there is no comprehensive strategy to provide information on both specificity screening and binding kinetics. The purpose of this review is to summarize analytical methods used not only to monitor the protein kinase inhibition, but also to provide kinetic and thermodynamic data on the basis of screening applications. A focus is set on optical biosensing as the most promising techniques. We discuss, that intelligent combinations of methods can provide comprehensive information on protein kinases interacting with inhibitors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118025"},"PeriodicalIF":11.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}