Trends in Analytical Chemistry最新文献_第2页

Label-free electrochemical immunosensors: A practical guide 无标记电化学免疫传感器：实用指南

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117949

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The golden age of colorimetry in diagnostics and drug analysis: Focus on the rising star of metabolite-based assays 诊断和药物分析领域的比色法黄金时代：聚焦基于代谢物检测的后起之秀

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117947

{"title":"The golden age of colorimetry in diagnostics and drug analysis: Focus on the rising star of metabolite-based assays","authors":"","doi":"10.1016/j.trac.2024.117947","DOIUrl":"10.1016/j.trac.2024.117947","url":null,"abstract":"<div><p>Optical spectroscopy has gained increasing significance over time, offering an impressive revival of this analytical approach for qualitative and quantitative applications. This resurgence spans from homemade test kits to official high-throughput methods employing automatic analyzers in pharmacopoeias and forensic science. This primary methodology is once again poised to provide suitable solutions to contemporary analytical problems through the new possibilities offered by the digital revolution and biocompatible materials, fostering the development of self-standing biosensing and wearable analytical devices. This review begins with the principles of optical-based analysis, rooted in the classical correlation among analyte structural features, well-established chemical reactions, and optical properties. It concludes with applicative examples of assays built under the emerging field of metabolite-based assays, incorporating natural derivatizing molecules and metabolite-derived nanomaterials. Data suggest that a comprehensive exploration of the colorimetric research field, integrated with next-generation technologies, could lead to significant improvements in pharmaceutical analysis and molecular clinical diagnosis.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advances and trends in optical devices and sensors for hydrogen peroxide detection 过氧化氢检测光学设备和传感器的最新进展和趋势

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117948

{"title":"Recent advances and trends in optical devices and sensors for hydrogen peroxide detection","authors":"","doi":"10.1016/j.trac.2024.117948","DOIUrl":"10.1016/j.trac.2024.117948","url":null,"abstract":"<div><p>Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a critically important, vital biomarker and hence a highly relevant analyte in a broad range of bioanalytical applications. The most recent trends furthering the ability of its reliable, reproducible, and sensitive quantification include the development of non-biological enzyme mimics, the investigation of smartphone cameras as transducers and detectors, and the continued development of semi-reversible and reversible detection strategies. While the non-biological catalysts offer stability-related advantages over enzymes while providing equally good limits of detection, critical questions regarding toxicity, persistence, (bio)accumulation, and overall environmental footprint need to be answered. In the case of heavy metal-based strategies a replacement by non-toxic, renewable alternatives should be an obvious research need. Signal recording has seen a dramatic change toward smartphones, with their ever-improving computing and image-acquisition abilities. Yet, with the sheer number of different camera and phone models progress can be difficult to assess, as reproducibility and comparability of results and experimental set-ups are too often elusive. In the area of semi-reversible sensors flow injection analysis (FIA) coupled with chemiluminescence (CL) remains the most advanced system. In the case of fully reversible sensors, research points toward oxygen-based sensing to be the most reliable. Analyzing publications from 2018 to 2024, it is not surprising that the important analytical figures of merit of low limits of detection (LODs), broad quantitation ranges, faster response and regeneration times combined with novel (reversible) probes continue to be and should remain central focus of future developments.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016599362400431X/pdfft?md5=481bc0b9cf9383130f3ce5ed3da66dda&pid=1-s2.0-S016599362400431X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics 基于 LC-MS 的代谢组学中固相（微）萃取的新型材料和方法

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-30 DOI: 10.1016/j.trac.2024.117941

{"title":"Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics","authors":"","doi":"10.1016/j.trac.2024.117941","DOIUrl":"10.1016/j.trac.2024.117941","url":null,"abstract":"<div><p>Metabolomics offers a unique approach to study biological systems. Liquid chromatography coupled to mass spectrometry serves as a powerful analytical tool to analyze complex mixtures of metabolites. However, successful metabolomic analysis relies on sample preparation. While untargeted analysis traditionally favors non-selective procedures like liquid-liquid extraction (LLE), these methods can compromise analytical performance due to limited analyte enrichment and potential matrix interferences. Solid-phase extraction (SPE) has emerged as a well-established and versatile technique for this purpose, offering advantages over other traditional methods like LLE. This review explores the applications of SPE and solid-phase microextraction (SPME) in LC-MS-based metabolomics. We discuss various modes of SPE, ranging from conventional flow-through cartridges and plates to approaches involving the dispersion of sorbent in a sample, as well as sorbents, their properties, and the diverse geometries of support materials employed in SPME. This review underscores the potential of emerging extraction protocols to further accelerate metabolomics research.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165993624004242/pdfft?md5=d89be50ff621326d3a49573d77f783bd&pid=1-s2.0-S0165993624004242-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tips and tricks for LC–MS-based metabolomics and lipidomics analysis 基于 LC-MS 的代谢组学和脂质组学分析的技巧和窍门

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-29 DOI: 10.1016/j.trac.2024.117940

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Recent advances of artificial intelligence in quantitative analysis of food quality and safety indicators: A review 人工智能在食品质量和安全指标定量分析方面的最新进展：综述

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-29 DOI: 10.1016/j.trac.2024.117944

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Advancing breast cancer diagnosis in 3D: The transformative power of X-ray phase-contrast microtomography for virtual histology 推进乳腺癌的三维诊断：X 射线相位对比显微层析技术在虚拟组织学中的变革力量

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-29 DOI: 10.1016/j.trac.2024.117943

{"title":"Advancing breast cancer diagnosis in 3D: The transformative power of X-ray phase-contrast microtomography for virtual histology","authors":"","doi":"10.1016/j.trac.2024.117943","DOIUrl":"10.1016/j.trac.2024.117943","url":null,"abstract":"<div><p>Breast cancer, a prevalent global malignancy in women, demands accurate tissue alteration detection for effective diagnosis and treatment. Histology, pivotal in diagnosis, faces challenges like time, limited tissue, and lacking comprehensive three-dimensional views. This review explores X-ray microtomography virtual histology as a complementary tool to address histology's limitations. Particularly, phase-contrast techniques offer non-destructive, high-resolution 3D imaging, surpassing traditional histology constraints. Phase-contrast microtomography provides valuable insights into breast tissue alterations, aiding early cancer detection and enhancing diagnostic precision. The role of synchrotron facilities and alternative validation approaches for clinical settings are discussed. Another significant aspect covered in this review is the global shortage of pathologists, which poses a major challenge in the timely and accurate diagnosis of breast cancer. Phase-contrast microtomography can support pathologists by offering digital imaging capabilities, which enable remote consultation and reduce the dependency on physical tissue sections.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Challenges and possibilities for the qualitative and quantitative analysis of phosphate metabolites 磷酸盐代谢物定性和定量分析的挑战与机遇

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-29 DOI: 10.1016/j.trac.2024.117934

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Exploring the potential of carbon quantum dots (CQDs) as an advanced nanomaterial for effective sensing and extraction of toxic pollutants 探索碳量子点（CQDs）作为先进纳米材料在有效传感和提取有毒污染物方面的潜力

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-28 DOI: 10.1016/j.trac.2024.117939

{"title":"Exploring the potential of carbon quantum dots (CQDs) as an advanced nanomaterial for effective sensing and extraction of toxic pollutants","authors":"","doi":"10.1016/j.trac.2024.117939","DOIUrl":"10.1016/j.trac.2024.117939","url":null,"abstract":"<div><p>Both organic and inorganic pollutants seriously impact the environment, human health, and ecosystems. Carbon quantum dots (CQDs) and their composites have emerged as promising materials for addressing these environmental issues due to their adaptability, efficiency, and environmentally friendly nature. This study aims to discuss the most recent developments in CQDs-based nanomaterials, focusing on their distinctive structures, synthesis methodologies, characterizations, and applications in environmental science as pollutants extractors and sensors. It studies the potential of nanomaterials based on CQDs for identifying and absorbing contaminants, focusing on their effectiveness in detecting and absorbing hazardous organic chemicals and heavy metals from different environments. The key results include the recognition of distinctive surface characteristics of CQDs-based nanomaterials, which facilitate effective interactions with various pollutants. This enhances their effectiveness in sensor applications and as constituents of extraction materials. This review emphasizes the potential of CQDs-based nanomaterials to transform pollution detection and extraction practices by providing an extensive overview of their utility in environmental science.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Unveiling bee pollen's contamination with pesticides and mycotoxins: Current analytical procedures, results and regulation 揭开蜂花粉受农药和霉菌毒素污染的真相：当前的分析程序、结果和监管

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-28 DOI: 10.1016/j.trac.2024.117935

引用次数: 0