Trends in Analytical Chemistry最新文献

{"title":"Bio-based gold nanoparticles for environmental and forensic samples: State of the art with a sustainable way forward","authors":"Asmaa Kamal El-Deen ,&nbsp;Chaudhery Mustansar Hussain","doi":"10.1016/j.trac.2024.118113","DOIUrl":"10.1016/j.trac.2024.118113","url":null,"abstract":"<div><div>The global emphasis on green nanotechnology has resulted in the ecological and physiological safe uses of nanomaterials. Several works have been performed on the biological, chemical, and physical production of metal nanoparticles. The safety and ease of synthesis of biological techniques make them the best choice. Gold nanoparticles (AuNPs) are powerful, biodegradable, and ecologically friendly nanoparticles that have recently acquired popularity. This study highlights the current state of the art in this subject, with an emphasis on the synthesis, characterization, and applications of bio-based AuNPs. It emphasizes their usage in forensic science, air pollution monitoring, and environmental sample analysis. The challenges and restrictions of this growing discipline are discussed, as well as its future prospects. Finally, this review highlights the enormous potential of bio-based AuNPs as a sustainable solution for environmental and forensic applications, paving the path for a greener, more ecologically friendly future.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118113"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years","authors":"Yingxue Jin ,&nbsp;Jingjing Yan ,&nbsp;Zongwei Cai ,&nbsp;Zian Lin","doi":"10.1016/j.trac.2024.118102","DOIUrl":"10.1016/j.trac.2024.118102","url":null,"abstract":"<div><div>Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has been regarded as one of the prominent techniques in small molecule analysis, which employs nanostructured materials as substrates to replace conventional organic matrices for laser absorption and analyte desorption/ionization. The rational design and development of nanostructured substrates, particularly metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs), are crucial for enhancing SALDI-MS performance. This review aims to cover the latest developments (within 5 years) in nanostructured substrates in SALDI-MS, including carbon- and silicon-based materials, metals and their oxide materials, MOFs, COFs, and other materials. The key design parameters that affect the SALDI-MS efficiency of these nanomaterials in small molecule analysis, such as pore size, surface area, and functional groups, are also discussed. Furthermore, the applications of SALDI-MS in various fields are reviewed. Lastly, the challenges and prospects for future research on the design of nanostructured substrates for SALDI-MS in small molecule analysis are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118102"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine specialized metabolites: Unveiling Nature's chemical treasures from the deep blue","authors":"Thilina U. Jayawardena ,&nbsp;Natacha Merindol ,&nbsp;Nuwan Sameera Liyanage ,&nbsp;Fatima Awwad ,&nbsp;Isabel Desgagné-Penix","doi":"10.1016/j.trac.2024.118097","DOIUrl":"10.1016/j.trac.2024.118097","url":null,"abstract":"<div><div>Marine specialized metabolites (MSM) represent a fascinating realm of chemical diversity with multifaceted functions across the spectrum of life on Earth. These metabolites serve as weapons, metal transporters, regulatory agents, and more. The conservation of genes responsible for their production over extensive evolutionary timescales underscores their selective advantage. Recent decades have witnessed an upsurge in MSM studies, driven by advancements in analytical techniques and the ever-growing accessibility of the aquatic environment. Marine macro and microorganisms offer a rich tapestry of specialized metabolites, some exhibiting potent activities in diverse domains, including medicine. The study of MSM presents several challenges, reflecting the need to separate complex mixtures into individual bioactive metabolites and utilize state-of-the-art extraction methods. Comprehensive structural analysis relies on advanced spectroscopic approaches, including nuclear magnetic resonance and mass spectrometry. These tools are instrumental in unravelling the chemical diversity of MSM and understanding their potential applications. While bioprospecting offers enormous potential, it raises critical challenges concerning sustainability, conservation, and equitable benefit-sharing. International protocols like the Nagoya Protocol seeks to regulate access to and share benefits from genetic resources, with considerable implications for marine bioprospecting. The convergence of advanced metabolomics, metagenomics, and synthetic biology offers promising avenues for accelerating the discovery and sustainable production of MSM, shaping the future of this field. This comprehensive review provides a deep dive into the challenges, methodologies, and emerging trends in studying marine-derived natural products, underscoring the immense potential of MSM for advancing chemical sciences and their transformative applications in diverse areas such as food, medicine, biotechnology, and environmental conservation. By bridging multiple disciplines, the continued exploration and sustainable utilization of these metabolites hold the promise of unlocking new innovations for society's benefit.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118097"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of degradable microplastics, biochar and their coexistence on soil organic matter decomposition: A critical review","authors":"Junjie Lin ,&nbsp;Qitai Cheng ,&nbsp;Amit Kumar ,&nbsp;Wenling Zhang ,&nbsp;Zhiguo Yu ,&nbsp;Dafeng Hui ,&nbsp;Changai Zhang ,&nbsp;Shengdao Shan","doi":"10.1016/j.trac.2024.118082","DOIUrl":"10.1016/j.trac.2024.118082","url":null,"abstract":"<div><div>Biodegradable plastics often degrade into microplastics within the natural environment, where they interact with soil organic matter (SOM). Concurrently, biochar is applied to soil as a photosynthesis-derived negative carbon technology. However, the efficacy of biochar in carbon sequestration may be compromised by the priming effect triggered by the presence of degradable microplastics. This review critically examines the interaction between degradable microplastics and soil organisms and their collective impact on SOM dynamics. It synthesizes current knowledge on the influence of biochar and degradable agricultural films on SOM, the mineralization processes of degradable microplastics, and the resulting stability of SOM. Special attention is given to the priming effect induced by microplastics and the implications of their coexistence with biochar on SOM decomposition. The review underscores the need for further research to elucidate the long-term carbon budget implications of biochar application and the fate of microplastics on carbon pools within biochar-amended soils.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118082"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The applications of bio-orthogonal Raman labels for visualizing lipids in eukaryotic cells","authors":"Ning Xu ,&nbsp;Damei Sun ,&nbsp;Hongwei Sun ,&nbsp;Qiaoling Ding ,&nbsp;Jiangyu Zong ,&nbsp;Yuchan Qu ,&nbsp;Man Hong ,&nbsp;Ke Tong","doi":"10.1016/j.trac.2024.118099","DOIUrl":"10.1016/j.trac.2024.118099","url":null,"abstract":"<div><div>Lipid metabolism is closely associated with atherosclerosis, obesity, diabetes, and many other metabolic diseases. Visualizing the distribution and kinetics of lipids are critical for understanding the role of lipids. Compared with fluorophores, bio-orthogonal Raman labels, such as deuterium and alkynes, are smaller and have unique Raman vibrations in the silent region of the cell. They've been widely used as tags for the cellular lipid metabolism tracking. For Raman tags of deuterium, the molecular mechanisms involved in atherosclerosis formation, lipid droplet doping, lipid storage capacity, and the physical properties of lipids are reviewed. For Raman tags of alkynes, multiple design strategies, including conjugation with multiple aromatic hydrocarbons and isotope labeling, are summarized for stronger signals and multiple imaging. The novel bio-orthogonal Raman tags of nitriles and astaxanthin is also described. The unique advantages of Raman spectroscopy combined with bio-orthogonal Raman labeling have been demonstrated in lipid imaging, and these applications provide new biological insights into lipid metabolism.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118099"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent trends in the multi-target electrochemical rapid detection of co-contaminated mycotoxins in foodstuffs","authors":"Kornautchaya Veenuttranon ,&nbsp;Xianbo Lu ,&nbsp;Ningbo Geng ,&nbsp;Jiping Chen","doi":"10.1016/j.trac.2024.118108","DOIUrl":"10.1016/j.trac.2024.118108","url":null,"abstract":"<div><div>Mycotoxin contamination in food and feed is a widespread issue with serious economic and public health consequences. Current detection methods often fail to meet quality standards due to the presence of multiple mycotoxins. This review presents recent advancements in the electrochemical detection of co-contaminated mycotoxins in food, emphasizing multi-target and rapid detection approaches. Key mycotoxins, including ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZEN), fumonisin (FB1), and aflatoxin B1 (AFB1), are discussed, along with their toxicological effects and relevant regulatory standards. The review explores electrochemical methods, including simultaneous and multi-target detection, highlighting both biomolecule-free techniques for potential-resolved selectivity and biomolecule-based approaches, such as immunosensors and aptasensors. Additionally, challenges in on-site application and future trends like screen-printing, miniaturization, smartphone integration, and cloud computing are examined. By providing a comprehensive analysis, this review underscores the potential of electrochemical sensors for enhancing food monitoring and identifies key directions for further research.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118108"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One class classification (class modelling): State of the art and perspectives","authors":"Lorenzo Strani ,&nbsp;Marina Cocchi ,&nbsp;Daniele Tanzilli ,&nbsp;Alessandra Biancolillo ,&nbsp;Federico Marini ,&nbsp;Raffaele Vitale","doi":"10.1016/j.trac.2024.118117","DOIUrl":"10.1016/j.trac.2024.118117","url":null,"abstract":"<div><div>Classification, i.e., the prediction of one or more qualitative attributes of samples based on the measured data, is ubiquitous in chemistry, and, more specifically, in analytical chemistry. Among the possible classification strategies, class modelling techniques, which aim at describing one category at a time, present several advantages over discriminant ones, especially when dealing with asymmetric problems featuring one category of interest being well characterized and representatively sampled and another (made of everything that is not belonging to the first specific group) being under-represented by definition and highly heterogeneous.</div><div>In this review, the fundamentals of class modelling are illustrated, together with an overview of the main techniques of this kind proposed in the literature, namely Soft Independent Modelling of Class Analogy (SIMCA), Unequal Class Spaces (UNEQ), Potential Functions (PF), Partial Least Squares (PLS)-based algorithms, One Class-Support Vector Machines (OC-SVM) or Neural Networks (NN)-based strategies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118117"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements of prokaryotic Argonautes in molecular diagnostics and future perspectives","authors":"Yuting Shang ,&nbsp;Xiang Gao ,&nbsp;Hongqin Wei ,&nbsp;Zhengzheng Wang ,&nbsp;Liqing Xi ,&nbsp;Yantao Wang ,&nbsp;Meijing Liu ,&nbsp;Ying Feng ,&nbsp;Juan Wang ,&nbsp;Qingping Wu ,&nbsp;Moutong Chen ,&nbsp;Yu Ding","doi":"10.1016/j.trac.2024.118122","DOIUrl":"10.1016/j.trac.2024.118122","url":null,"abstract":"<div><div>Due to the notable biological advantages, programmable nucleases have become a groundbreaking class of tools in the field of nucleic acid testing (NAT). Prokaryotic Argonautes (pAgos), a subclass of Argonaute proteins, represent an emerging class of nucleases that offer greater flexibility compared to conventional CRISPR/Cas systems and hold tremendous biotechnological potential. Recent advancements in pAgo-mediated NAT have opened new avenues for the development of rapid and highly sensitive nucleic acid detection methods. In this review, we first undertake a comprehensive exploration of pAgos in structural diversity and the molecular mechanisms of guide and target binding by pAgos. Further, a comparison analysis of pAgos and CRISPR/Cas nucleases is conducted, focusing on their similarities, differences, and complementarities, with the understanding of what is crucial for the rational design of novel NAT. Afterward, the recent progress of the different pAgo-mediated biosensor platforms is summarized, and the associated challenges and perspectives are discussed. With comprehensive illustration, the goal of this review is to provide new insights and perspectives for developing next-generation nucleic acid detection platforms.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118122"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in electrochemical sensors and biosensors for food additives determination: Principle and application","authors":"Gözde Aydoğdu Tığ ,&nbsp;Giovanna Marrazza ,&nbsp;Kübra Turan ,&nbsp;Niran Öykü Erdoğan ,&nbsp;Nazlı Şimşek","doi":"10.1016/j.trac.2024.118127","DOIUrl":"10.1016/j.trac.2024.118127","url":null,"abstract":"<div><div>Food additives (FAs) are natural or synthetic compounds added to food products to preserve flavor or improve taste. FAs can be classified into many groups, including sweeteners, preservatives, antioxidants, stabilizers and thickeners, emulsifiers and emulsifying salts, and color and color retention agents. To ensure the safety and quality of food products, it is essential to develop accurate and reliable methods for detecting and quantifying FAs. Electrochemical sensors have emerged as promising tools, as they can be designed to detect various FAs. Various materials are employed to modify the sensitivity and selectivity of electrochemical sensors for FAs. This review provides a comprehensive overview of the classification of FAs and recently developed electrochemical sensors/biosensors for their detection, highlighting their advantages, limitations, and food safety applications. Finally, future aspects are discussed by referencing recent critical studies, aiming to advance research in developing novel functional electrochemical (bio)sensors for food safety and contamination detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118127"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell spatial (scs) omics: Recent developments in data analysis","authors":"José Camacho ,&nbsp;Michael Sorochan Armstrong ,&nbsp;Luz García-Martínez ,&nbsp;Caridad Díaz ,&nbsp;Carolina Gómez-Llorente","doi":"10.1016/j.trac.2024.118109","DOIUrl":"10.1016/j.trac.2024.118109","url":null,"abstract":"<div><div>Over the past few years, technological advances have allowed for measurement of omics data at the cell level, creating a new type of data generally referred to as single-cell (sc) omics. On the other hand, the so-called spatial omics are a family of techniques that generate biological information in a spatial domain, for instance, in the volume of a tissue. In this survey, we are mostly interested in the intersection between sc and spatial (scs) omics and in the challenges and opportunities that this new type of data pose for downstream data analysis methodologies. Our goal is to cover all major omics modalities, including transcriptomics, genomics, epigenomics, proteomics and metabolomics.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118109"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}