Advances in lateral flow assays for sensitive detection of antibiotic residues: An intelligent tool for food safety monitoring

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-09-15 DOI:10.1016/j.trac.2025.118462

Peifang Chen , Imran Mahmood Khan , Mingwei Qin , Yu Li , Ali Raza , Shuo Qi , Zhouping Wang

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引用次数: 0

Abstract

Antibiotics are widely used in livestock and aquaculture to promote growth and prevent disease. However, antibiotic residues in animal-derived food pose serious risks to human health and the global antibiotic resistance. Thus, there is an urgent need for point-of-care testing strategies to ensure food safety. This review provides a comprehensive overview of recent advancements in lateral flow assay (LFA) platforms for sensitive antibiotic detection. We critically assess the integration of biorecognition elements, advanced nanomaterials, innovative optical systems, and intelligent devices including smartphone-assisted platforms and artificial intelligence (AI)-enhanced analysis. Special focus is given to novel signal amplification strategies and multiplexing techniques that enable simultaneous detection of multiple antibiotics. Furthermore, we discuss current limitations and outline future directions. This review highlights the transformative potential of intelligent LFA tools in establishing digitalized, automated, and scalable solutions for end-to-end monitoring of antibiotics throughout the food supply chain.

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横向流动法敏感检测抗生素残留的研究进展：食品安全监测的智能工具

抗生素广泛用于牲畜和水产养殖，以促进生长和预防疾病。然而，动物源性食品中的抗生素残留对人类健康和全球抗生素耐药性构成严重威胁。因此，迫切需要即时检测策略来确保食品安全。本文综述了用于敏感抗生素检测的横向流动试验（LFA）平台的最新进展。我们批判性地评估了生物识别元素、先进纳米材料、创新光学系统和智能设备（包括智能手机辅助平台和人工智能（AI）增强分析）的整合。特别关注的是新的信号放大策略和复用技术，能够同时检测多种抗生素。此外，我们还讨论了当前的局限性并概述了未来的发展方向。这篇综述强调了智能LFA工具在为整个食品供应链的抗生素端到端监测建立数字化、自动化和可扩展的解决方案方面的变革潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.