Trends in Analytical Chemistry最新文献

{"title":"Triboelectric nanogenerator-enabled self-powered strategies for sensing applications","authors":"Xiaolin Qu ,&nbsp;Xiaoshi Liu ,&nbsp;Yuyan Yue ,&nbsp;Yuguo Tang ,&nbsp;Peng Miao","doi":"10.1016/j.trac.2025.118191","DOIUrl":"10.1016/j.trac.2025.118191","url":null,"abstract":"<div><div>Triboelectric nanogenerator (TENG) is able to efficiently convert mechanical energy from the environment into useable electrical energy. Most <em>in vitro</em> sensors applied in biomedical field require external power supplies and complex material preparation processes. The emergence of TENG may provide a possible solution. Measurements of signals like open-circuit voltage, short-circuit current, and charge are involved, which are much facile compared with commonly applied optical signals. According to operating mechanisms, TENG-based sensors can be constructed with different modes: contact-separation TENG for active sensing, solid-liquid TENG for active sensing, and TENG deployed as power source for sensing and gas discharge. A wide range of substances can be accurately determined with TENG sensing strategies. TENG offers significant advantages including high energy conversion efficiency, scalability, cost-effective materials and maintenances. In addition, the ability to integrate flexible and wearable materials makes TENG ideal for the development of adaptable, lightweight and portable <em>in vitro</em> sensors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118191"},"PeriodicalIF":11.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoluminescent assay and imaging for effective modulation of photothermal events on enhanced cancer therapy developed via analytical techniques","authors":"Tianyou Wang ,&nbsp;Hang Zhang ,&nbsp;Zhaoyin Wang ,&nbsp;Wenwen Tu ,&nbsp;Zhihui Dai","doi":"10.1016/j.trac.2025.118188","DOIUrl":"10.1016/j.trac.2025.118188","url":null,"abstract":"<div><div>With rapid development of analytical techniques, photoluminescent assay and imaging are popularly applied to explore the effect of photothermal therapy, encompassing precise therapeutic guidance and evaluation of therapeutic efficacy. Photothermal therapy as an emerging and evolving technology for tumor treatment is a non-invasive and low-toxic modality. However, photothermal therapy process triggers physiological activities in tumor and surrounding tissues, leading to a series of side effects and poor prognosis. Therefore, the modulation of photothermal therapy-related events is crucial for reducing side effects and amplifying therapeutic effect. In this work, we summarize some recent researches on modulating photothermal therapy-related events to improve therapeutic efficacy, including reducing inflammation, overcoming tumor heat tolerance, and immune activation under photoluminescent assay and imaging guidance. We also highlight the impacts of photothermal therapy-related events and provide promising perspectives on future research directions, prompting us to further explore the mechanisms using photoluminescent techniques developed via analytical chemistry.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118188"},"PeriodicalIF":11.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass spectrometric methods for the analysis of electrochemical transformation products","authors":"Valentin Göldner ,&nbsp;Jens Fangmeyer ,&nbsp;Uwe Karst","doi":"10.1016/j.trac.2025.118178","DOIUrl":"10.1016/j.trac.2025.118178","url":null,"abstract":"<div><div>Electrochemical transformation is relevant in fields like synthesis, energy storage, analytical detection, and mimicking metabolic and environmental conversion processes. Mass spectrometry aids in understanding and optimizing these systems by providing information about intermediates and final transformation products. This review critically discusses applications of mass spectrometry and hyphenated techniques for identifying electrochemical transformation products, focusing on non-volatile products in solution or precipitated on/adsorbed to electrode surfaces. Detailed discussions cover the simulation of biotransformation processes during metabolic and environmental conversion. A comprehensive summary of xenobiotics studied by electrochemistry-mass spectrometry, grouped by the observed biomimetic reactions, is provided. Surface-sensitive mass spectrometry is discussed for analyzing precipitated and adsorbed products on electrodes, relevant to energy storage and electro-synthesis. This review emphasizes the advantages of combining mass spectrometric analysis with electrochemical systems, aiming to make electrochemistry accessible to analytical chemists and demonstrate the capabilities of mass spectrometry to experienced electrochemists.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118178"},"PeriodicalIF":11.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics in animal-derived products and their potential risks to human health","authors":"Hainuo Zeng ,&nbsp;Yuling Cui ,&nbsp;Runlin Shao ,&nbsp;Tong Li ,&nbsp;Yanhao Zhao ,&nbsp;Ruiheng Liu ,&nbsp;Zhenkai Dai ,&nbsp;Yuanjia Liu ,&nbsp;Jun Wang ,&nbsp;Qingmei Xie ,&nbsp;Xinheng Zhang","doi":"10.1016/j.trac.2025.118187","DOIUrl":"10.1016/j.trac.2025.118187","url":null,"abstract":"<div><div>Microplastics, a new type of pollutant widely present in aquatic, terrestrial, and atmospheric environments, have attracted global attention due to their accumulation in organisms and potential toxicity. In recent years, animal products, as an important source of human daily diet and consumer goods, have increasingly faced the risk of microplastic contamination. These microplastics can enter the human body through food consumption or the use of daily products, posing a threat to health. However, there is currently a lack of comprehensive reviews on the impact of microplastic contamination in animal products on human health. This review begins with the sources, migration, and accumulation mechanisms of microplastics, systematically elaborates on the routes through which microplastics enter the human body via animal products and their harmful effects on the body, and summarizes the detection and elimination technologies for microplastics in the environment to ensure the safety of animal products and human health. In summary, microplastics can enter animals through ingestion, gas exchange, and contact, and can remain in animal products, posing potential risks to the human respiratory, digestive, and immune systems. Although existing detection and removal technologies for microplastics have played a role in ensuring the safety of animal products, further optimization is needed to develop more efficient and environmentally friendly methods. In the future, efforts should be strengthened to research pollution prevention and purification technologies for microplastics, reduce their residues in animal products, and thereby effectively safeguard food safety and public health.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118187"},"PeriodicalIF":11.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive approaches to expanding CRISPR biosensor applications beyond nucleic acid targets","authors":"Indrani Nandi ,&nbsp;Jyoti Verma ,&nbsp;Rajendra Prasad ,&nbsp;Sumit K. Singh ,&nbsp;Pranjal Chandra","doi":"10.1016/j.trac.2025.118179","DOIUrl":"10.1016/j.trac.2025.118179","url":null,"abstract":"<div><div>The CRISPR/Cas system has transformed molecular diagnostics due to its exceptional specificity and programmability. Initially designed for detecting nucleic acids, recent progress has expanded its use to include non-nucleic acid targets. This review offers an in-depth examination of recent innovations in CRISPR-based biosensing, focusing on proteins, heavy metals, toxins, and other metabolites. It highlights novel methods that incorporate antibodies, aptamers, and DNAzymes for detection. Key CRISPR biosensing techniques, such as target recognition, signal conversion, and amplification, are discussed within the context of biosensor design principles. The review also addresses the future potential and challenges of CRISPR-powered biosensors, suggesting areas for further development and improvement in biosensing technologies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118179"},"PeriodicalIF":11.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key insights into microplastic pollution in agricultural soils: A comprehensive review of worldwide trends, sources, distribution, characteristics and analytical approaches","authors":"Harshit Sahai ,&nbsp;Ana M. Aguilera del Real ,&nbsp;Alfredo Alcayde ,&nbsp;M.J. Martínez Bueno ,&nbsp;Chen Wang ,&nbsp;María Dolores Hernando ,&nbsp;Amadeo R. Fernández- Alba","doi":"10.1016/j.trac.2025.118176","DOIUrl":"10.1016/j.trac.2025.118176","url":null,"abstract":"<div><div>Microplastics in agricultural ecosystems have gained recent attention due to their widespread prevalence and the reported impacts. The current study reviews close to 90 relevant publications. Seventy studies were selected using ResNetBot, a tool designed to identify key works based on their significance to other studies matching the search criteria. The selection focused on global occurrence of microplastics within agricultural landscapes, emphasizing their distribution, origins, concentrations, morphology, color, polymer types, dimensions, vertical distribution, and the implications of land use. Furthermore, this study included predominant methodologies for extracting, identifying, and characterizing microplastics. Plastic mulch films represent the primary source of input, accompanied by sewage sludge, biosolids, irrigation water (notably wastewater), atmospheric deposition, and polymer-coated fertilizers, among others. Concentrations exhibit considerable variability, ranging from a few particles/kg in low-input regions to exceeding 80,000 particles/kg in areas subjected to prolonged mulching practices. Polyethylene and polypropylene are the most frequently encountered polymers, while fragments, fibers, and films are predominant forms, with films strongly linked to mulching and fibers typically associated with biosolid applications. Transparent/white and black particles are predominant, reflecting the materials commonly utilized in film applications. Microplastic concentrations generally decrease with soil depth; however, smaller particles penetrate deeper soil layers. Intensive agricultural practices demonstrate significantly elevated microplastic loads in comparison to less intensive or natural ecosystems. Density separation methods (commonly utilizing NaCl) followed by digestion processes (often employing H₂O₂) are standard practices for isolating microplastics while spectroscopic methodologies (including FTIR/μ-FTIR and Raman spectroscopy) are essential for verifying polymer composition and ensuring precise identification.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118176"},"PeriodicalIF":11.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond single-analyte detection: Advancing molecularly imprinted polymers for simultaneous multi-target sensing","authors":"Fatah Ben Moussa ,&nbsp;Tutku Beduk ,&nbsp;Amadeo Sena-Torralba ,&nbsp;Duygu Beduk ,&nbsp;Abdellatif Ait Lahcen ,&nbsp;Wlodzimierz Kutner ,&nbsp;Ajeet Kaushik","doi":"10.1016/j.trac.2025.118177","DOIUrl":"10.1016/j.trac.2025.118177","url":null,"abstract":"<div><div>Molecular imprinting in polymers is one of the most rapidly growing trends in chemical sensing, offering high stability and selectivity for target analytes. Delving into the synthesis methods and highlighting innovations that enable the simultaneous determination of multiple analytes, we extensively and critically reviewed herein the advancements in multi-analyte molecularly imprinted polymer (MIP) sensors applied in various fields. The fundamentals of MIP-based electrochemical and optical sensors featuring hybrid recognition systems, as well as the challenges related to removing templates from MIPs, separation of detection signals, and upscaling for commercialization, are deeply discussed. Moreover, considering the potential of MIPs as efficient platforms for multi-target sensing, we provide insight into the critical aspects that hinder the MIP sensors from crossing laboratory borders. By identifying recent progress and persistent challenges, the current review serves as a guide for advancing MIP-based sensing platforms for multiple target analytes recognizing across medical, pharmaceutical, and environmental domains.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118177"},"PeriodicalIF":11.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in sustainable strategies for the integration of nanostructured sensing surfaces in electroanalytical devices","authors":"Filippo Silveri,&nbsp;Flavio Della Pelle,&nbsp;Dario Compagnone","doi":"10.1016/j.trac.2025.118175","DOIUrl":"10.1016/j.trac.2025.118175","url":null,"abstract":"<div><div>Nanomaterials (NMs) integration in electrochemical devices as conductive nanostructured freestanding transducers and sensing surfaces has emerged in the analytical scenario, toward on-demand device manufacturing and fully exploiting NMs' features.</div><div>This review reports the advances in developing electroanalytical devices based on nanostructured sensing films/surfaces obtained via accessible/sustainable strategies. Various manufacturing approaches are discussed including emerging nanostructured film-transfer technologies and nanofilms' direct generation onto low-cost substrates. Additive manufacturing and printed electronics are also treated, focusing on straightforward strategies for printed device nano-structuring. Post-production nano-modifications of preexisting transducers/electrodes are not considered.</div><div>This review outlines a critical overview concerning technological novelties to obtain nanofilm-based sensors, biosensors, and electroanalytical devices, and related analytical advancements. In particular, attention is paid to nanofilms 'manufacturing strategies' based on user-friendly technologies, focusing on approaches devoted to improving sustainability. The topics will be covered describing noteworthy advancements, giving technical/practical advice, pointing out limitations, and outlining future perspectives.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118175"},"PeriodicalIF":11.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR-Cas technology for rapid detection of pathogens","authors":"Hossein Daneshgar ,&nbsp;Moein Safarkhani ,&nbsp;Soheil Sojdeh ,&nbsp;Mojtaba Bagherzadeh ,&nbsp;Navid Rabiee","doi":"10.1016/j.trac.2025.118174","DOIUrl":"10.1016/j.trac.2025.118174","url":null,"abstract":"<div><div>In battling global pathogens like SARS-CoV-2, salmonella, and malaria, rapid and precise detection methods are vital. Traditional approaches often face cost and accessibility challenges, especially in resource-limited areas. Integrating CRISPR-Cas technology into detection processes is a game-changer, offering unparalleled specificity and speed for point-of-care use. This method aligns with Green Biomaterials principles, emphasizing eco-friendliness and resource efficiency. By incorporating green biomaterials, the CRISPR-Cas system becomes more sustainable, efficient, and environmentally sensitive. This integration revolutionizes pathogen detection while promoting environmental stewardship. It not only advances rapid detection but also underscores a commitment to ecological consciousness and sustainability in diagnostics, offering promise for global health.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118174"},"PeriodicalIF":11.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional proteomics in plants: The role of chemical tools and applications","authors":"Lijun Chen ,&nbsp;Zhengao Di ,&nbsp;Zhangshuang Deng ,&nbsp;Yiqing Zhou","doi":"10.1016/j.trac.2025.118160","DOIUrl":"10.1016/j.trac.2025.118160","url":null,"abstract":"<div><div>With the significant advances in “-omics” technologies, various biological approaches and analytical platforms have been developed to uncover the functions and involved biological processes of proteins in plants. However, in-depth characterization of protein functions at the molecular level, such as protein activities, interactions and post-translational modifications (PTMs), remains one of the most challenging tasks in plant science. As an alternative, chemical proteomics has emerged as a precise and dynamic analytical method that employs chemical tools to explore the functional states of proteins within complex proteomes. This review highlights the contributions of chemical tools in plant functional proteomics studies, with focus on their applications in evaluating enzyme activity, identifying receptors or targets of bioactive small molecules, elucidating biosynthetic pathways of plant natural products, and profiling PTMs in plant-derived biological systems.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"185 ","pages":"Article 118160"},"PeriodicalIF":11.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}