Trends in Analytical Chemistry最新文献_第9页

Boron nitride nanosheets for biosensors and biomedicine 用于生物传感器和生物医学的氮化硼纳米片

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-17 DOI: 10.1016/j.trac.2025.118379

Guohai Yang , Luqing Chen , Jihan Liu , Yan Liu , Lulu Qu , Chengzhou Zhu , Jun-Jie Zhu , Yuehe Lin , Xiaochen Dong

{"title":"Boron nitride nanosheets for biosensors and biomedicine","authors":"Guohai Yang , Luqing Chen , Jihan Liu , Yan Liu , Lulu Qu , Chengzhou Zhu , Jun-Jie Zhu , Yuehe Lin , Xiaochen Dong","doi":"10.1016/j.trac.2025.118379","DOIUrl":"10.1016/j.trac.2025.118379","url":null,"abstract":"<div><div>The rapid development of advanced functional nanomaterials offers a robust foundation for exploring high-performance biosensing and biomedicine platforms. Boron nitride nanosheets (BNNS), atomically thin hexagonal boron nitride, have attracted significant attention due to outstanding chemical and thermal stability, excellent biocompatibility, and fascinating catalytic properties. Integrating doping and functionalization give BNNS-based materials significant potential in the fields of biosensors and biomedicine. This review firstly describes the structural features and overview of the prevailing preparation methods of BNNS. The following sections focus on the BNNS-based nanomaterials applications in biosensors. Additionally, the review addresses key biomedical applications of BNNS-based nanomaterials in drug delivery, boron neutron capture therapy (BNCT), and antibacterial treatments. Finally, the challenges faced by BNNS in these areas and potential pathways for future explorations are discussed. This review is expected to stimulate strategic advances in the use of BNNS for biosensors and biomedicine, thereby providing promising avenues for practical implementation.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118379"},"PeriodicalIF":11.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in solid-phase microextraction for detecting endocrine disrupting compounds in environmental and biological matrices 固相微萃取法检测环境和生物基质中内分泌干扰物的研究进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-16 DOI: 10.1016/j.trac.2025.118372

Shaohan Wang , Jiaxing Yu , Yuemei Chen , Nan Li , Jiajia Han , Yang Yu , Yueru Shi , Guosheng Chen , Junlang Qiu , Fang Zhu , Gangfeng Ouyang

{"title":"Advances in solid-phase microextraction for detecting endocrine disrupting compounds in environmental and biological matrices","authors":"Shaohan Wang , Jiaxing Yu , Yuemei Chen , Nan Li , Jiajia Han , Yang Yu , Yueru Shi , Guosheng Chen , Junlang Qiu , Fang Zhu , Gangfeng Ouyang","doi":"10.1016/j.trac.2025.118372","DOIUrl":"10.1016/j.trac.2025.118372","url":null,"abstract":"<div><div>The widespread occurrences and adverse effects of endocrine disrupting compounds (EDCs) pose significant threats to the environment. Due to their persistence, bioaccumulation, and toxicity, EDCs migrate through environmental compartments and accumulate in organisms, resulting in health risks to humans. This concerning paradigm necessitates robust detecting strategies for EDCs across both environmental and biological matrices. Solid-phase microextraction (SPME) has emerged as a powerful analytical technique, particularly effective for complex matrix analysis. The miniaturization and non-exhaustive extraction characteristics of SPME make it uniquely suitable for both on-site and <em>in vivo</em> implementations. This review critically evaluates recent advances (2020–2025) in SPME applications for EDC detection in environmental and biological matrices. The discussion encompasses in-lab and on-site SPME approaches for environmental detecting, while also addressing <em>in vitro</em> and <em>in vivo</em> SPME methodologies in biological specimens. Finally, the future emerging trends and research directions in this field are proposed based on the recent achievements.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118372"},"PeriodicalIF":11.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Towards sustainable analytical chemistry 走向可持续分析化学

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-16 DOI: 10.1016/j.trac.2025.118371

Elefteria Psillakis

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Advanced deep learning algorithms in food quality and authenticity 先进的深度学习算法在食品质量和真实性

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-16 DOI: 10.1016/j.trac.2025.118374

Che Shen, Qi Jin, Ganghua Zhou, Ran Wang, Zhenwei Wang, Di Liu, Kezhou Cai, Baocai Xu

{"title":"Advanced deep learning algorithms in food quality and authenticity","authors":"Che Shen, Qi Jin, Ganghua Zhou, Ran Wang, Zhenwei Wang, Di Liu, Kezhou Cai, Baocai Xu","doi":"10.1016/j.trac.2025.118374","DOIUrl":"10.1016/j.trac.2025.118374","url":null,"abstract":"<div><div>Ensuring food quality and authenticity is critical to the food industry and consumers. With the advancements in Industry 4.0 and Artificial Intelligence (AI) technologies, deep learning (DL) offers unparalleled opportunities to extract information and make decisions on complex or large datasets. However, conventional convolutional neural networks (CNN) and recurrent neural networks (RNN) have limitations. The development of advanced DL algorithms can accommodate the growing demand for complex tasks and herald revolutionary breakthroughs in the field of food quality and authenticity identification, which will continue to be driven by the ongoing development of advanced DL. This review provides a comprehensive overview of various advanced DL algorithms for food quality identification and food authenticity analysis, including advanced variants of CNN, lightweight DL, sequential neural networks, graph neural networks (GNN), deep generative models (DGM), and target detection algorithms. It also surveys recent applications of advanced DL algorithms for Food quality inspection and authenticity analysis. This review discusses the challenges associated with advanced DL and the future trends, offering new insights into the development of advanced DL algorithms in food quality and authenticity. Challenges such as overfitting, scalability, interpretability, accessibility, data privacy, algorithmic bias, and the creation of large databases must be addressed in the application of advanced DL algorithms to drive their further iterations.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118374"},"PeriodicalIF":11.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From extraction to detection: An analytical journey of plastic additives and their migrations 从提取到检测：塑料添加剂及其迁移的分析之旅

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-16 DOI: 10.1016/j.trac.2025.118373

Benjamin Caux , Clément De Saint Jores , Ramy Abou-Naccoul , Caroline West

{"title":"From extraction to detection: An analytical journey of plastic additives and their migrations","authors":"Benjamin Caux , Clément De Saint Jores , Ramy Abou-Naccoul , Caroline West","doi":"10.1016/j.trac.2025.118373","DOIUrl":"10.1016/j.trac.2025.118373","url":null,"abstract":"<div><div>Plastic materials, which are massively produced for a large variety of applications, require small organic molecules called additives to improve their physico-chemical properties. Plastic additives set health and environment issues, because they can migrate from the plastic material to contact matrices, which is a significant concern for food packaging, medical devices, toys, environmental compartments etc. Here we describe the different families of plastic additives, which come with different chemical structures and polarities, and the way they migrate from plastic material to contact matrices. Then the extraction and analysis methods to determine plastic additives in materials and contact matrices are detailed. Many examples are presented to explain the particularities of extraction and analysis methods, comprising spectroscopic, chromatographic and thermal analyses. Comparison tables are provided to guide researchers looking for extraction or analysis methods, depending on the type of matrices examined. Finally, the areas where further research is necessary are detailed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118373"},"PeriodicalIF":11.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra- and inter-individual variation of the human lipidome 人类脂质组的个体内和个体间变异

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-12 DOI: 10.1016/j.trac.2025.118368

Anh Hoang Nguyen , Habtamu B. Beyene , Gabriele Mocciaro , Lisa Hahnefeld , Santosh Lamichhane , Mikael Fabritius , Henri Avela , Yuqin Wang , Alex M. Dickens , Robert Gurke , Baoru Yang , William J. Griffiths , Tuulia Hyötyläinen , Peter J. Meikle , Matej Orešič

{"title":"Intra- and inter-individual variation of the human lipidome","authors":"Anh Hoang Nguyen , Habtamu B. Beyene , Gabriele Mocciaro , Lisa Hahnefeld , Santosh Lamichhane , Mikael Fabritius , Henri Avela , Yuqin Wang , Alex M. Dickens , Robert Gurke , Baoru Yang , William J. Griffiths , Tuulia Hyötyläinen , Peter J. Meikle , Matej Orešič","doi":"10.1016/j.trac.2025.118368","DOIUrl":"10.1016/j.trac.2025.118368","url":null,"abstract":"<div><div>Lipids play essential roles in cellular functions such as membrane structure, signaling, and energy storage. Lipidomics—global study of lipids in cells and tissues—seeks to identify biomarkers and uncover underlying metabolic pathways. Human lipid concentrations in cells and biofluids can fluctuate at multiple temporal scales, reflecting normal biochemical and physiological variation, or responses to various internal and external stimuli. Understanding both intra- and inter-individual lipid variability is crucial for accurate lipidomics study design and interpretation. This knowledge also supports personalized healthcare, moving beyond static reference ranges. Here, we review key drivers of intra-individual variation, including diet, circadian rhythms, sleep, environmental exposures, and physiological states. We also examine inter-individual factors such as genetics, age, sex, microbiome composition, and medications. Finally, we discuss how these variables interact and influence lipidomics outcomes, aiming to enhance reproducibility and guide future research.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118368"},"PeriodicalIF":11.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Destructive Spectral Systems (NDSS) for modern inspection systems in real-time: challenges and industrial perspectives 用于现代实时检测系统的无损光谱系统（NDSS）：挑战和工业前景

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-12 DOI: 10.1016/j.trac.2025.118369

Jose Blasco , Giulia Gorla , Sandra Munera , Raffaele Vitale , Jose Manuel Amigo

{"title":"Non-Destructive Spectral Systems (NDSS) for modern inspection systems in real-time: challenges and industrial perspectives","authors":"Jose Blasco , Giulia Gorla , Sandra Munera , Raffaele Vitale , Jose Manuel Amigo","doi":"10.1016/j.trac.2025.118369","DOIUrl":"10.1016/j.trac.2025.118369","url":null,"abstract":"<div><div>The demand for efficient, accurate, and non-invasive inspection methodologies has led to the emergence of Non-Destructive Spectral Systems (NDSS) as transformative tools. NDSS, in combination with chemometrics, enables rapid and precise analyses without damaging the sample, revolutionising traditional inspection approaches and offering accurate quantification and classification, process optimisation, and cost reduction capabilities. This review highlights the principles, advancements, and real-time applications of NDSS in product inspection and quality assurance. Recent technological innovations, data acquisition, computational algorithms, and their applications in the agri-food, pharmaceutical, and environmental monitoring sectors are explored. Furthermore, the challenges associated with their adoption for real-time implementations, including computational demands, calibration complexities, and environmental variability, are discussed. Case studies and emerging research directions provide a comprehensive outlook on the potential of NDSS to address evolving industrial needs. This review underscores the pivotal role of NDSS in enhancing operational efficiency, ensuring product quality, and driving future advancements in analytical instrumentation.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118369"},"PeriodicalIF":11.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Molecular recognition polymer microspheres and nanoparticles for nonseparation assays: the Mosbach imprint 用于非分离分析的分子识别聚合物微球和纳米颗粒：莫斯巴赫印记

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-12 DOI: 10.1016/j.trac.2025.118370

Lei Ye, Tong Zhang, Qicheng Zhang

{"title":"Molecular recognition polymer microspheres and nanoparticles for nonseparation assays: the Mosbach imprint","authors":"Lei Ye, Tong Zhang, Qicheng Zhang","doi":"10.1016/j.trac.2025.118370","DOIUrl":"10.1016/j.trac.2025.118370","url":null,"abstract":"<div><div>Synthesis of molecularly imprinted polymer microspheres using precipitation polymerization was first reported in 1999 in Lund. The synthetic approach attracted great interest for molecular imprinters worldwide due to its simplicity. Following the initial demonstration of feasibility for material synthesis, imprinted polymer microspheres were found to exhibit good colloidal stability qualifying for use as antibody substitutes in a proximity scintillation assay. In the following years, other types of nonseparation assays using imprinted polymer microspheres started to be developed. Molecular detection based on fluorescence measurements eventually became the method of choice to avoid radioactive tracers. Many of the research ideas have been inspired by the earlier contributions from Professor Klaus Mosbach. This manuscript provides a historic review on molecularly imprinted polymer microspheres and nanoparticles designed for nonseparation assays. While the main thread is the research evolvement of the authors’ laboratory till the present time, important contributions from other groups are also discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118370"},"PeriodicalIF":11.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering positive feedback in nucleic acid circuit Biosensors: Design and applications 工程正反馈的核酸电路生物传感器：设计与应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-10 DOI: 10.1016/j.trac.2025.118367

Shuang Zhao , Xuesong Wang , Meilin Gong , Zuowei Xie , Jingsen Cao , Ming Chen , Kai Chang

{"title":"Engineering positive feedback in nucleic acid circuit Biosensors: Design and applications","authors":"Shuang Zhao , Xuesong Wang , Meilin Gong , Zuowei Xie , Jingsen Cao , Ming Chen , Kai Chang","doi":"10.1016/j.trac.2025.118367","DOIUrl":"10.1016/j.trac.2025.118367","url":null,"abstract":"<div><div>Positive feedback refers to a process in which a system's output signal redirected to its input and superimposed in the same direction, causing progressive amplification. Integrating positive feedback loops into biosensor design has become a powerful strategy for efficient sensitivity improvement, enabling trace biomarkers detection. Recent advancements have applied cutting-edge technologies, such as DNAzymes, nucleic acid-modifying enzymes, and CRISPR/Cas systems, to engineer positive feedback loop in nucleic acid circuit biosensors with exceptional detection capability, cost-effectiveness, and robustness. This review first explained the mechanism of positive feedback-driven signal amplification and deconstructs the design principles of positive feedback nucleic acid circuit biosensors. It then systematically reviews representative studies, highlighting design innovations and comparing their performance. Finally, the current challenges and future directions were discussed. This review aims to clarify the design logic of positive feedback biosensors and inspire the development of next-generation biosensors with enhanced detection performance.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118367"},"PeriodicalIF":11.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring 比率余辉发光：可靠定量生物成像和疾病监测的新兴范例

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-07-09 DOI: 10.1016/j.trac.2025.118366

Meng Yuan , Shuaiming Bao , Kejun Wu , Zixin Deng , Huanghao Yang , Jiangtao Gao

{"title":"Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring","authors":"Meng Yuan , Shuaiming Bao , Kejun Wu , Zixin Deng , Huanghao Yang , Jiangtao Gao","doi":"10.1016/j.trac.2025.118366","DOIUrl":"10.1016/j.trac.2025.118366","url":null,"abstract":"<div><div>Ratiometric afterglow luminescence has emerged as a transformative approach for quantitative bio-imaging and disease monitoring, addressing fundamental limitations in conventional imaging techniques. This review examines recent advancements in ratiometric afterglow probes, concentrating on their design principles, energy transfer mechanisms, and applications in disease detection. The integration of dual-emission capabilities with prolonged luminescence enables reliable quantification by eliminating background interference and providing internal calibration. Recent advances have demonstrated exceptional performance in monitoring cancer immunotherapy, arthritis progression, and brain tumor development through the detection of specific biomarkers. Despite significant progress, challenges remain in material design, signal stability, and clinical translation. The review examines current engineering solutions and emerging opportunities, particularly in the integration of artificial intelligence, multiplexed sensing, and the development of point-of-care diagnostics. These advances establish ratiometric afterglow luminescence as a powerful platform for next-generation biomedical imaging and disease monitoring systems.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118366"},"PeriodicalIF":11.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0