Trends in Analytical Chemistry最新文献_第9页

Recent progress and challenges in biosensing of carcinoembryonic antigen 癌胚抗原生物传感技术的最新进展与挑战

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-07 DOI: 10.1016/j.trac.2024.117964

Mojtaba Afshari Babazad , Amin Foroozandeh , Majid Abdouss , Hossein SalarAmoli , Reyhaneh Afshari Babazad , Mohammad Hasanzadeh

{"title":"Recent progress and challenges in biosensing of carcinoembryonic antigen","authors":"Mojtaba Afshari Babazad , Amin Foroozandeh , Majid Abdouss , Hossein SalarAmoli , Reyhaneh Afshari Babazad , Mohammad Hasanzadeh","doi":"10.1016/j.trac.2024.117964","DOIUrl":"10.1016/j.trac.2024.117964","url":null,"abstract":"<div><p>Carcinoembryonic antigen (CEA) is a multifunctional glycoprotein that belongs to the immunoglobulin superfamily and plays dual regulatory roles in cancer and fetal development. Due to its crucial biological functions in cancer regulation, CEA levels elevate abnormally in colorectal, breast, lung, gastric, medullary thyroid, and pancreatic cancers. Furthermore, conditions unrelated to neoplasms, such as ulcerative pancreatitis, chronic obstructive pulmonary disease (COPD), cirrhosis, colitis, hypothyroidism, Crohn's disease, and smoking are associated with increased CEA levels. Therefore, developing precise and sensitive strategies for monitoring CEA holds significant importance. This study emphasizes the successful creating of detection methods through surface modification, bio-functionalization, and nano-fabrication to enable effective detection of CEA at trace levels (with a threshold of 20 ng mL<sup>−1</sup>). It explores various optical and electrochemical (EC) sensors, including electrochemiluminescence (ECL), fluorometric, surface-enhanced Raman scattering (SERS), photoelectrochemical (PEC), and colorimetric methods. The study highlights the integrating of innovative nanomaterials with a range of bioreceptor elements, including peptides, aptamers (Apt), DNA, enzymes, and antibodies (Abs), to enhance the effectiveness of CEA tracking and quantification, which are essential for analytical methods. Additionally, the research identifies gaps, challenges, and areas for improvement in CEA biosensing methods, research, and technology. This review represents an unprecedented assessment of CEA tracking through the application of biosensor technology.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"180 ","pages":"Article 117964"},"PeriodicalIF":11.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165993624004473/pdfft?md5=5efc7be29603bad230fbeb65324203d3&pid=1-s2.0-S0165993624004473-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advances in single-nucleotide variant assay: From in vitro detection to in vivo imaging 单核苷酸变异检测的最新进展：从体外检测到体内成像

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-07 DOI: 10.1016/j.trac.2024.117963

Huimin Yuan , Wen-jing Liu , Juan Hu, Chun-yang Zhang

引用次数: 0

Electronic nose for the detection and discrimination of volatile organic compounds: Application, challenges, and perspectives 用于检测和鉴别挥发性有机化合物的电子鼻：应用、挑战和前景

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-05 DOI: 10.1016/j.trac.2024.117958

Yanchen Li , Zike Wang , Tianning Zhao , Hua Li , Jingkun Jiang , Jianhuai Ye

{"title":"Electronic nose for the detection and discrimination of volatile organic compounds: Application, challenges, and perspectives","authors":"Yanchen Li , Zike Wang , Tianning Zhao , Hua Li , Jingkun Jiang , Jianhuai Ye","doi":"10.1016/j.trac.2024.117958","DOIUrl":"10.1016/j.trac.2024.117958","url":null,"abstract":"<div><p>The electronic nose, commonly referred to as e-nose, has become an essential tool for the detection of volatile organic compounds (VOCs) which play critical roles in air quality, climate change, and human health. Inspired from the human olfactory system, e-noses offer key advantages in portability and cost-effectiveness, making them indispensable for identifying a series of VOCs. This review explores advancements in e-nose technology for VOC detection, detailing the operational principles of various sensors, and assessing their strengths and weaknesses. It also examines the conventional and novel algorithms for VOC pattern recognition, highlighting their role in enhancing detection accuracy and application robustness. Moreover, the review discusses the diverse applications of e-noses, ranging from environmental monitoring to critical sectors such as food processing and medical diagnostics. Finally, the review addresses current challenges in e-nose applications, such as selectivity and sensitivity, and offers insights into emerging trends and future perspectives in e-nose development.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"180 ","pages":"Article 117958"},"PeriodicalIF":11.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data fusion strategies for the integration of diverse non-destructive spectral sensors (NDSS) in food analysis 在食品分析中整合多种无损光谱传感器（NDSS）的数据融合策略

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-04 DOI: 10.1016/j.trac.2024.117957

Lorenzo Strani , Caterina Durante , Marina Cocchi , Federico Marini , Ingrid Måge , Alessandra Biancolillo

{"title":"Data fusion strategies for the integration of diverse non-destructive spectral sensors (NDSS) in food analysis","authors":"Lorenzo Strani , Caterina Durante , Marina Cocchi , Federico Marini , Ingrid Måge , Alessandra Biancolillo","doi":"10.1016/j.trac.2024.117957","DOIUrl":"10.1016/j.trac.2024.117957","url":null,"abstract":"<div><p>The evolving landscape of agri-food systems, driven by climate change and population growth, necessitates innovative approaches to ensure food integrity, safety, and sustainability. This review explores the role of data fusion strategies, particularly focusing on non-destructive spectroscopic sensors (NDSS) in three key application contexts: in-field monitoring, on/in-line food processing, and food quality authentication. Various data fusion scenarios, including fusing spectra from different spectroscopic platforms, integrating images and spectra, and combining non-spectroscopic sensor data with spectroscopic ones are reviewed. Focus is set on practical considerations, such as selecting the level of data fusion, defining blocks, variable selection, and validation methods, highlighting the importance of tailored approaches based on research aims and data characteristics.</p><p>While combining information from diverse sensors generally enhances information extraction and modelling performance, their implementation in routine applications is still limited and especially studies focused on data fusion models’ performance over time and their maintenance are lacking.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"180 ","pages":"Article 117957"},"PeriodicalIF":11.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165993624004400/pdfft?md5=ba7b79557644151f18b5756a5babbdd0&pid=1-s2.0-S0165993624004400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation-induced emission-based luminescent porous materials as cutting-edge tools for food safety monitoring 基于聚集诱导发射的多孔发光材料是食品安全监控的尖端工具

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117945

Yuanyuan Cheng , Xuechi Yin , Deepak Kukkar , Jianlong Wang , Ki-Hyun Kim , Daohong Zhang

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Label-free electrochemical immunosensors: A practical guide 无标记电化学免疫传感器：实用指南

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117949

R. Cancelliere, E. Paialunga, A. Grattagliano, L. Micheli

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The golden age of colorimetry in diagnostics and drug analysis: Focus on the rising star of metabolite-based assays 诊断和药物分析领域的比色法黄金时代：聚焦基于代谢物检测的后起之秀

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117947

Pasquale Palladino , Mariagrazia Lettieri , Simona Scarano , Maria Minunni

{"title":"The golden age of colorimetry in diagnostics and drug analysis: Focus on the rising star of metabolite-based assays","authors":"Pasquale Palladino , Mariagrazia Lettieri , Simona Scarano , Maria Minunni","doi":"10.1016/j.trac.2024.117947","DOIUrl":"10.1016/j.trac.2024.117947","url":null,"abstract":"<div><p>Optical spectroscopy has gained increasing significance over time, offering an impressive revival of this analytical approach for qualitative and quantitative applications. This resurgence spans from homemade test kits to official high-throughput methods employing automatic analyzers in pharmacopoeias and forensic science. This primary methodology is once again poised to provide suitable solutions to contemporary analytical problems through the new possibilities offered by the digital revolution and biocompatible materials, fostering the development of self-standing biosensing and wearable analytical devices. This review begins with the principles of optical-based analysis, rooted in the classical correlation among analyte structural features, well-established chemical reactions, and optical properties. It concludes with applicative examples of assays built under the emerging field of metabolite-based assays, incorporating natural derivatizing molecules and metabolite-derived nanomaterials. Data suggest that a comprehensive exploration of the colorimetric research field, integrated with next-generation technologies, could lead to significant improvements in pharmaceutical analysis and molecular clinical diagnosis.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"180 ","pages":"Article 117947"},"PeriodicalIF":11.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances and trends in optical devices and sensors for hydrogen peroxide detection 过氧化氢检测光学设备和传感器的最新进展和趋势

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-09-03 DOI: 10.1016/j.trac.2024.117948

John J. Galligan, Antje J. Baeumner, Axel Duerkop

{"title":"Recent advances and trends in optical devices and sensors for hydrogen peroxide detection","authors":"John J. Galligan, Antje J. Baeumner, Axel Duerkop","doi":"10.1016/j.trac.2024.117948","DOIUrl":"10.1016/j.trac.2024.117948","url":null,"abstract":"<div><p>Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a critically important, vital biomarker and hence a highly relevant analyte in a broad range of bioanalytical applications. The most recent trends furthering the ability of its reliable, reproducible, and sensitive quantification include the development of non-biological enzyme mimics, the investigation of smartphone cameras as transducers and detectors, and the continued development of semi-reversible and reversible detection strategies. While the non-biological catalysts offer stability-related advantages over enzymes while providing equally good limits of detection, critical questions regarding toxicity, persistence, (bio)accumulation, and overall environmental footprint need to be answered. In the case of heavy metal-based strategies a replacement by non-toxic, renewable alternatives should be an obvious research need. Signal recording has seen a dramatic change toward smartphones, with their ever-improving computing and image-acquisition abilities. Yet, with the sheer number of different camera and phone models progress can be difficult to assess, as reproducibility and comparability of results and experimental set-ups are too often elusive. In the area of semi-reversible sensors flow injection analysis (FIA) coupled with chemiluminescence (CL) remains the most advanced system. In the case of fully reversible sensors, research points toward oxygen-based sensing to be the most reliable. Analyzing publications from 2018 to 2024, it is not surprising that the important analytical figures of merit of low limits of detection (LODs), broad quantitation ranges, faster response and regeneration times combined with novel (reversible) probes continue to be and should remain central focus of future developments.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"180 ","pages":"Article 117948"},"PeriodicalIF":11.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016599362400431X/pdfft?md5=481bc0b9cf9383130f3ce5ed3da66dda&pid=1-s2.0-S016599362400431X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics 基于 LC-MS 的代谢组学中固相（微）萃取的新型材料和方法

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-30 DOI: 10.1016/j.trac.2024.117941

Michał Młynarczyk , Mariusz Belka , Weronika Hewelt-Belka

{"title":"Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics","authors":"Michał Młynarczyk , Mariusz Belka , Weronika Hewelt-Belka","doi":"10.1016/j.trac.2024.117941","DOIUrl":"10.1016/j.trac.2024.117941","url":null,"abstract":"<div><p>Metabolomics offers a unique approach to study biological systems. Liquid chromatography coupled to mass spectrometry serves as a powerful analytical tool to analyze complex mixtures of metabolites. However, successful metabolomic analysis relies on sample preparation. While untargeted analysis traditionally favors non-selective procedures like liquid-liquid extraction (LLE), these methods can compromise analytical performance due to limited analyte enrichment and potential matrix interferences. Solid-phase extraction (SPE) has emerged as a well-established and versatile technique for this purpose, offering advantages over other traditional methods like LLE. This review explores the applications of SPE and solid-phase microextraction (SPME) in LC-MS-based metabolomics. We discuss various modes of SPE, ranging from conventional flow-through cartridges and plates to approaches involving the dispersion of sorbent in a sample, as well as sorbents, their properties, and the diverse geometries of support materials employed in SPME. This review underscores the potential of emerging extraction protocols to further accelerate metabolomics research.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"180 ","pages":"Article 117941"},"PeriodicalIF":11.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165993624004242/pdfft?md5=d89be50ff621326d3a49573d77f783bd&pid=1-s2.0-S0165993624004242-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tips and tricks for LC–MS-based metabolomics and lipidomics analysis 基于 LC-MS 的代谢组学和脂质组学分析的技巧和窍门

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-08-29 DOI: 10.1016/j.trac.2024.117940

Stanislava Rakusanova, Tomas Cajka

引用次数: 0