Trends in Analytical Chemistry最新文献

{"title":"Chelating agent-assisted extraction of toxic elements towards ensuring food and beverage safety: Advances and challenges","authors":"Marzieh Fallahi Nezhad ,&nbsp;Amin Foroozandeh ,&nbsp;Hossein Salar Amoli ,&nbsp;Mohammad Hasanzadeh","doi":"10.1016/j.trac.2024.118104","DOIUrl":"10.1016/j.trac.2024.118104","url":null,"abstract":"<div><div>Heavy metals (HMs) pose significant health risks when consumed, necessitating accurate detection and removal strategies. This review surveyed the recent advancements in detecting and extracting HMs from food and beverage matrices, focusing on preconcentration methods and the effectiveness of various chelating agents. Next, several preconcentration methods were discussed, including dispersive liquid-liquid microextraction (DLLME) and solid phase extraction (SPE), highlighting their efficiency in isolating metal ions from complex food matrices. Then, the application of various chelating agents, such as dithiocarbamates, phenanthrolines, hydroxyquinolines, and pyridylazo, in the extraction of HMs were discussed based on their selectivity and binding capabilities. By evaluating the mechanisms of action, efficacy, and limitations of various chelating agents, this review surveyed to identify the most effective agents and highlighted areas for extraction of HMs. The review emphasizes recent advances and challenges (advantages, limitations, and research gaps) in the chelating agent-assisted extraction of HMs to ensure food and beverage safety. Finally, future perspectives on applying chelating compounds to remove hazardous metals were evaluated.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118104"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in electrochemical sensors and biosensors for food additives determination: Principle and application","authors":"Gözde Aydoğdu Tığ ,&nbsp;Giovanna Marrazza ,&nbsp;Kübra Turan ,&nbsp;Niran Öykü Erdoğan ,&nbsp;Nazlı Şimşek","doi":"10.1016/j.trac.2024.118127","DOIUrl":"10.1016/j.trac.2024.118127","url":null,"abstract":"<div><div>Food additives (FAs) are natural or synthetic compounds added to food products to preserve flavor or improve taste. FAs can be classified into many groups, including sweeteners, preservatives, antioxidants, stabilizers and thickeners, emulsifiers and emulsifying salts, and color and color retention agents. To ensure the safety and quality of food products, it is essential to develop accurate and reliable methods for detecting and quantifying FAs. Electrochemical sensors have emerged as promising tools, as they can be designed to detect various FAs. Various materials are employed to modify the sensitivity and selectivity of electrochemical sensors for FAs. This review provides a comprehensive overview of the classification of FAs and recently developed electrochemical sensors/biosensors for their detection, highlighting their advantages, limitations, and food safety applications. Finally, future aspects are discussed by referencing recent critical studies, aiming to advance research in developing novel functional electrochemical (bio)sensors for food safety and contamination detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118127"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in Arduino- and smartphone-based sensors for biochemical and environmental analysis","authors":"Mirkomil Sharipov ,&nbsp;Shakhzodjon Uzokboev ,&nbsp;Nguyen Ngoc Nghia ,&nbsp;Shavkatjon Azizov ,&nbsp;WonHyoung Ryu ,&nbsp;Salah M. Tawfik ,&nbsp;Yong-Ill Lee","doi":"10.1016/j.trac.2024.118103","DOIUrl":"10.1016/j.trac.2024.118103","url":null,"abstract":"<div><div>Recent SARS-CoV-2 pandemic and environmental disasters have emphasized the importance of rapid and efficient sensing platforms. Scientists have focused on developing portable sensing platforms to avoid using bulky and high-cost analytical equipment. Smartphones are the most accessible gadgets with integrated sensors to perform analytical analysis. However, the constant advances and competition in smartphones result in upgrades to smartphones, including their sensors, every year. Moreover, differences in smartphones’ sensor and image processing algorithms that vary from model to model complicate the standardization of readers. Arduino microcontroller-based readers have been investigated as an alternative to the smartphone data reader. Although Arduino-based sensors are not as portable as smartphones and cannot perform other tasks than they are developed and programmed for, they are usually built from a limited number of components, thus simplifying their standardization. In this review, we outline the different approaches used to develop smartphone-based analytical sensors and the development of Arduino-based sensors. These approaches will mainly focus on developing novel sensing platforms, the choice of smartphone sensors, and data processing methods. We also discuss the application of smartphone- and Arduino-based sensors for biochemical and environmental monitoring.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118103"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in microplastic characterization: Spectroscopic techniques and heavy metal adsorption insights","authors":"M. Vasudeva ,&nbsp;Anish Kumar Warrier ,&nbsp;V.B. Kartha ,&nbsp;V.K. Unnikrishnan","doi":"10.1016/j.trac.2024.118111","DOIUrl":"10.1016/j.trac.2024.118111","url":null,"abstract":"<div><div>Microplastics (MPs) have become a matter of very serious concern as environmental pollutants nowadays because of the humongous increased production, use-and-discard nature associated with them, and the contamination of the environment with micro- and nano-plastics and other pollutants carried over by them, like many heavy metals, organic species, etc. Researchers have employed various techniques for detecting and classifying microplastics, mainly based on their optical or mass spectra or specific mass. This article discusses the various techniques used to characterize microplastics and surface-adsorbed heavy metals. Conventional techniques like Fourier Transform Infrared (FTIR) spectroscopy and Raman spectroscopy are widely used to identify the class of MPs and provide details about the extent of pollution. Heavy metals are one of the other environmental contaminants that can cause severe health issues. The microplastics act as a vector for transporting heavy metals from different locations and induce a potentiating effect. To identify the heavy metals adsorbed onto the MPs, various techniques such as Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Energy Dispersive X-ray Spectroscopy (SEM-EDS), and others are used. After a review of the current identification approaches, which require the utilization of multiple resources and expertise for microplastic characterization and their surface-adsorbed heavy metal detection, the recent development of a single multi-modal spectroscopy system, capable of identifying both molecular and elemental information, which serve the purpose of microplastics and surface-adsorbed heavy metal identification in short times, enabling rapid screening and classification of samples, is discussed. Novel methods using such multi-modal systems-containing Laser-Induced Breakdown Spectroscopy (LIBS)/and Raman/fluorescence spectroscopy-under a single platform will come in handy in the future for the complete analysis of the microplastic samples for plastic classification and heavy metal detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118111"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive nanozyme sensors for urinalysis","authors":"Sanjana Naveen Prasad,&nbsp;Vipul Bansal,&nbsp;Rajesh Ramanathan","doi":"10.1016/j.trac.2024.118100","DOIUrl":"10.1016/j.trac.2024.118100","url":null,"abstract":"<div><div>Biomolecules in body fluids serve as biomarkers or early indicators of diseases while offering opportunities to monitor disease progression and track the effectiveness of treatments. Urinalysis can potentially detect early signs of disease, as the body eliminates harmful substances and molecules because of its homeostasis mechanism. This would mean that the relevant concentrations of such markers remain unchanged in the blood while manifesting themselves first in the urine. This highlights the need to improve sensor capabilities for urinalysis. Although urinalysis sensors (typically enzyme-based or a combination of antibody and enzymes) have seen limited commercial success, there is a critical need for new sensing technologies to improve sensor sensitivity, selectivity, and accuracy. To this end, nanozymes, nanomaterials mimicking the catalytic activity of enzymes (a large majority mimicking oxidoreductase enzymes), can detect clinically significant urinary biomarkers with minimal interference from the sample matrix and demonstrate superior sensor performance across a wide range of pH and temperature conditions, making them ideal for the development of portable point-of-care testing devices. This review attempts to critically evaluate the strategies used in nanozyme sensors, recognise if the strategy is capable of detecting urinary biomarkers in the physiologically relevant range, and finally identify the key challenges that need to be addressed before nanozyme-based sensors can be used in clinical settings.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118100"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic-based microextraction systems for the determination of emerging contaminants in environmental liquid samples","authors":"Tanausú Vega-Morales ,&nbsp;Zoraida Sosa-Ferrera ,&nbsp;José Juan Santana-Rodríguez ,&nbsp;Sarah Montesdeoca-Esponda","doi":"10.1016/j.trac.2024.118116","DOIUrl":"10.1016/j.trac.2024.118116","url":null,"abstract":"<div><div>The development of novel methodologies for the extraction of emerging contaminants (ECs) based on functionalized magnetic nanoparticles (MNPs) has increased over the past decade. The properties of these materials permit rapid and efficient separation of the adsorbents and/or solvents used as extractants by the application of a magnetic field, avoiding the use of time-consuming and expensive processes. Due to their high surface areas, ease of modification with different materials, and integration with conventional solid-phase extraction systems, such nanoadsorbents are candidates for developing efficient microextraction methods. Furthermore, they can be easily automated and aligned with green chemistry principles, reducing the environmental impact generated in the synthesis of the nanoparticles and their subsequent application. This critical review focuses on the use of MNPs composites in microextraction systems employed for the determination of ECs in liquid environmental matrices over the past 10 years, including pharmaceuticals, personal care products, plasticizers and industrial chemicals and microplastics.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118116"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oxygen isotopic composition of tooth enamel carbonate: A review of measurement methods & forensic applications","authors":"Daniel L. Johnson ,&nbsp;Thuan H. Chau ,&nbsp;Lesley A. Chesson","doi":"10.1016/j.trac.2024.118084","DOIUrl":"10.1016/j.trac.2024.118084","url":null,"abstract":"<div><div>Oxygen isotopes in tooth enamel carbonate are commonly measured in studies of ecology, paleoclimate, and provenance; however, methods for sample pretreatment and mass spectrometric analysis widely vary. Here, we advocate for the development of a standardized protocol for oxygen isotope ratio analysis of tooth enamel carbonate that would be particularly suited for forensic applications. To do this, we review primarily the archaeological literature and highlight applications of tooth enamel carbonate data explored in previous studies; we also examine potential challenges for using these data in forensic contexts. Despite the demonstrated utility of oxygen isotopic data for tooth enamel carbonate, we find that variations in sample preparation and measurement methodologies can dramatically hinder the development of robust forensic applications. We encourage adoption of a standardized approach to facilitate the routine generation of oxygen isotopic data for forensic identification purposes and to improve data comparability among analytical facilities moving forward.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118084"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in porous organic framework-based aptasensors for diagnosis of cancer diseases","authors":"Abdelmonaim Azzouz ,&nbsp;Lamia Hejji ,&nbsp;Ki-Hyun Kim","doi":"10.1016/j.trac.2024.118106","DOIUrl":"10.1016/j.trac.2024.118106","url":null,"abstract":"<div><div>The detection of biomarkers present in biological fluids (e.g., serum, blood, saliva, and urine) is the primary step for the early diagnosis of associated diseases. In this context, the great utility of porous organic frameworks (POFs), including metal, covalent, and hydrogen-bonding organic frameworks, is recognized. These frameworks in combination with aptamers can be utilized in diagnostic sensing against a range of biomarkers such as prostate-specific antigens, carcinoembryonic antigens, alpha-fetoprotein, mucin 1, human epidermal growth factor receptor 2, and exosomes. This article outlines the recent breakthroughs in advancing aptamer-functionalized POFs for the sensing of cancer biomarkers with respect to sensing principles, sensing mechanisms (including POFs directly as signal probes or as carriers for loading signal probes), and performance (with a focus on sensitivity). Finally, the challenges and prospects related to the development of aptamer-functionalized POFs are discussed for their upscaled sensing application toward cancer biomarkers in real biological samples.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118106"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmon-enhanced fluorescence (bio)sensors and other bioanalytical technologies","authors":"Dario Cattozzo Mor ,&nbsp;Gizem Aktug ,&nbsp;Katharina Schmidt ,&nbsp;Prasanth Asokan ,&nbsp;Naoto Asai ,&nbsp;Chun-Jen Huang ,&nbsp;Jakub Dostalek","doi":"10.1016/j.trac.2024.118060","DOIUrl":"10.1016/j.trac.2024.118060","url":null,"abstract":"<div><div>Advances in the plasmon-enhanced fluorescence method and its implementations in optical sensors, biosensors, and other types of bioanalytical technologies are discussed in this paper. In particular, the focus is given to the results that have been achieved over the last ten years concerning the design and preparation of metallic nanostructures tailored for the amplification of weak fluorescence signals and their utilization in the field of ultrasensitive detection and identification of chemical and biological species. Applications and performance characteristics of plasmon-enhanced fluorescence in the areas of analysis of biomarkers for disease diagnostics, cell imaging, environmental monitoring of harmful compounds, and single molecule analysis are critically reviewed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118060"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconductive polymer-based biosensors for early cancer detection via liquid biopsy: Advances, challenges, and future prospects","authors":"Babak Mikaeeli Kangarshahi ,&nbsp;Soheil Sojdeh ,&nbsp;Hossein Daneshgar ,&nbsp;Mojtaba Bagherzadeh ,&nbsp;Seyed Morteza Naghib ,&nbsp;Navid Rabiee","doi":"10.1016/j.trac.2024.118062","DOIUrl":"10.1016/j.trac.2024.118062","url":null,"abstract":"<div><div>Early detection and treatment significantly improve the survival rates and overall health outcomes of cancer patients, making them critical factors in reducing the global mortality rate. Electrochemical biosensors have the capability to detect a wide range of cancer biomarkers—including DNA, RNA, proteins, enzymes, and cells—in biological samples. Conductive polymers, which possess unique electrical and optical properties, can enhance the performance of these biosensors. They provide a biocompatible surface for biomolecule attachment, facilitate electron transport between the electrode and analyte, and amplify signals through their electroactive properties or by integrating functional nanomaterials. This review offers a comprehensive overview of recent advances in the development of electrochemical biosensors utilizing conductive polymers and their composites for cancer biomarker detection. It explores the benefits and challenges associated with various conductive polymers, such as polyaniline, polypyrrole, polythiophene, and poly (3,4-ethylenedioxythiophene) (PEDOT), alongside their fabrication techniques, including electrodeposition, chemical polymerization, and spin coating. Additionally, strategies to enhance the sensitivity, selectivity, stability, and reproducibility of these biosensors—such as the use of aptamers, nanoparticles, nanocomposites, and multiplexing—are discussed. The review also considers the future potential and challenges of employing electrochemical biosensors based on conductive polymers in cancer detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118062"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}