Trends in Analytical Chemistry最新文献_第8页

Stimulus-responsive smart solvents and their application in analytical liquid-liquid (micro)extraction techniques 刺激响应智能溶剂及其在液-液（微）萃取分析技术中的应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-14 DOI: 10.1016/j.trac.2025.118267

Miguel Ángel Aguirre , Lorena Vidal , Mazaher Ahmadi , Antonio Canals

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Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications 中药代谢研究进展：样品前处理、质谱分析策略及典型应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-14 DOI: 10.1016/j.trac.2025.118269

Li-li Hong , Dian-xin Cui , Hong-da Wang , Qi Jing , Xue Li , Ying Hu , Yi-qing Yao , Xiu-mei Gao , De-an Guo , Wen-zhi Yang

{"title":"Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications","authors":"Li-li Hong , Dian-xin Cui , Hong-da Wang , Qi Jing , Xue Li , Ying Hu , Yi-qing Yao , Xiu-mei Gao , De-an Guo , Wen-zhi Yang","doi":"10.1016/j.trac.2025.118269","DOIUrl":"10.1016/j.trac.2025.118269","url":null,"abstract":"<div><div>Understanding of how complex traditional Chinese medicine (TCM) components are absorbed, distributed, metabolized, and eliminated is crucial to determine the impacts of the exogenous chemicals (prototypes and metabolites) to the organism (humans and animals). Mass spectrometry (MS)-oriented analytical strategies, combined with versatile analysis tools, have been predominantly utilized to comprehensively decipher TCM metabolism. Among the entire workflows involved in TCM metabolism occurring in the last decade, great advances are gained regarding the bio-samples pre-treatment, MS data acquisition, and data processing. By focusing on the biological samples pre-treatment, state-of-the-art data acquisition and data processing strategies relying on MS, we comparatively outline the basic principles and characteristics of the developed analytical techniques reported from 2015 to 2024, and the typical applications in various scenarios of TCM metabolism, based on 964 related publications. It is expected to offer a methodological reference to the researchers in metabolism studies of TCM and its various components.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118269"},"PeriodicalIF":11.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances and challenges in the determination of micro- and nano-plastics by pyrolysis-gas chromatography-mass spectrometry 热解-气相色谱-质谱法测定微、纳米塑料的研究进展与挑战

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-14 DOI: 10.1016/j.trac.2025.118270

Qingcun Li , Qingsheng Bai , Sujuan Yu , Rui Liu , Jingfu Liu

{"title":"Advances and challenges in the determination of micro- and nano-plastics by pyrolysis-gas chromatography-mass spectrometry","authors":"Qingcun Li , Qingsheng Bai , Sujuan Yu , Rui Liu , Jingfu Liu","doi":"10.1016/j.trac.2025.118270","DOIUrl":"10.1016/j.trac.2025.118270","url":null,"abstract":"<div><div>Global attention on micro- and nano-plastics (MNPs) has increased due to their widespread presence and potential risks. Accurate detection of MNPs is critical for understanding their environmental fate, transformation processes, and potential toxicity. Pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) has emerged as a highly effective method for MNP detection, which has been applied to the identification and quantization of MNPs in different matrices, including atmosphere, aquatic environments, soils and sediments, organisms and human tissues. This review provides a comprehensive overview of the development, principles, and applications of Py-GC-MS in MNP research, highlighting its versatility and efficacy across different matrices. It also proposes current challenges in MNP quantification, such as strong destructive nature, limited injection volume, background interference, and the lack of standardized protocols. In conclusion, this review aims to understand the role of Py-GC-MS in advancing MNP research, thereby establishing the foundation for future research on the health risk of MNPs.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118270"},"PeriodicalIF":11.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Strategies for acquiring electrochemiluminescence spectra and their applications in mechanism studies and multi-analyte determination 获取电化学发光光谱的策略及其在机理研究和多分析物测定中的应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-14 DOI: 10.1016/j.trac.2025.118259

Lixin Zang , Haiyan Song , Huimin Zhao , Qiao Zhang , Qi Kang , Dazhong Shen

{"title":"Strategies for acquiring electrochemiluminescence spectra and their applications in mechanism studies and multi-analyte determination","authors":"Lixin Zang , Haiyan Song , Huimin Zhao , Qiao Zhang , Qi Kang , Dazhong Shen","doi":"10.1016/j.trac.2025.118259","DOIUrl":"10.1016/j.trac.2025.118259","url":null,"abstract":"<div><div>Owing to its high sensitivity and close-to-zero background, the electrochemiluminescence (ECL) technique is widely used in biological analysis, environmental detection, and other fields. ECL spectra can provide molecular-level information useful for elucidating ECL mechanisms and expanding the scope of ECL applications. However, acquiring ECL spectra is challenging, as the ECL intensity changes over measurement time. Herein, we review three strategies for ECL spectrum acquisition, namely, the combinations of (i) a photomultiplier tube detector used in single-wavelength mode with repeated ECL excitation, (ii) a charge-coupled device detector array and monochromator with a single ECL excitation scan, and (iii) a photomultiplier tube detector and band-pass filter array turntable with a single ECL excitation scan based on ECL intensity correction. Subsequently, we discuss the applications of ECL spectroscopy, including luminescence mechanism investigations, spectrum-resolved multianalyte determination, and ratiometric ECL sensors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118259"},"PeriodicalIF":11.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nucleic acid-based reference materials: A “ruler” for precision molecular diagnostics 基于核酸的标准物质：精密分子诊断的“标尺”

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-13 DOI: 10.1016/j.trac.2025.118268

Kai Li , Yaning Guo , Xin Qi , Fukai Li , Xinran Li , Mengrui Yang , Jian Zhou , Haiwei Zhou , Gang Liu , Liang Li

{"title":"Nucleic acid-based reference materials: A “ruler” for precision molecular diagnostics","authors":"Kai Li , Yaning Guo , Xin Qi , Fukai Li , Xinran Li , Mengrui Yang , Jian Zhou , Haiwei Zhou , Gang Liu , Liang Li","doi":"10.1016/j.trac.2025.118268","DOIUrl":"10.1016/j.trac.2025.118268","url":null,"abstract":"<div><div>Analytical chemistry is experiencing a growing demand for reliable and traceable results, which have significant implications for public health and food safety. The COVID-19 pandemic further underscores the need for accurate and dependable molecular diagnostics. Nucleic acid-based reference materials (NARMs) play a crucial role in ensuring the quality of results. Notably, NARMs have gained increased attention following the outbreak of COVID-19. While previous reviews introduced NARMs but overlooked their applications in different fields. Moreover, the integration of multiple methods represents a new trend in the preparation of NARMs, but these have not appeared in previous reviews. Therefore, this review delineates NARMs classification, synthesizes characterization techniques, reviews their applications in virus diagnosis, animal diseases, pathogenic microorganisms, genetic diseases and genetically modified organism detection, and provides a perspective on NARMs’ development and current challenges. In-depth study of NARMs will be significant for precise molecular diagnostics in biology, agriculture and public health.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118268"},"PeriodicalIF":11.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Functional nucleic acid-based liposome engineering strategies for bioanalytical applications 基于功能核酸的脂质体工程策略在生物分析中的应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-10 DOI: 10.1016/j.trac.2025.118258

Chuancheng Wu , Lili Zhang , Sai Bi

{"title":"Functional nucleic acid-based liposome engineering strategies for bioanalytical applications","authors":"Chuancheng Wu , Lili Zhang , Sai Bi","doi":"10.1016/j.trac.2025.118258","DOIUrl":"10.1016/j.trac.2025.118258","url":null,"abstract":"<div><div>As for resembling biological membranes structures, liposomes have emerged as safe, biocompatible and biodegradable vehicles for understanding, sensing and manipulating fundamental biological processes using natural or synthetic lipids. Engineering with other functional elements makes a versatile liposome. In contrast, functional nucleic acid (FNA) can interface with liposomes to direct their assembly, disassembly and vesicle fusion in a programmable manner. Because of the above merits, engineering of liposome using FNA has provided an attractive strategy to study and manipulate liposome behaviours and functionalities for the development and biological application of liposome. This review summarizes the latest advances in functional nucleic acid-based liposome engineering. The strategies for anchoring FNA to liposomes are first comprehensively elucidated. Then, the applications of FNA-based liposome engineering in cellular behavior mimicry, bioanalysis, drug delivery, and disease treatment are reviewed. Finally, the current challenges and the prospects for future development of FNA-engineered liposomes are discussed in the field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118258"},"PeriodicalIF":11.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mercury isotopes in the atmosphere: Synthesis, perspectives and analytical considerations 大气中的汞同位素：合成、观点和分析考虑

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-08 DOI: 10.1016/j.trac.2025.118257

Jan Gačnik , Igor Živković , Milena Horvat

{"title":"Mercury isotopes in the atmosphere: Synthesis, perspectives and analytical considerations","authors":"Jan Gačnik , Igor Živković , Milena Horvat","doi":"10.1016/j.trac.2025.118257","DOIUrl":"10.1016/j.trac.2025.118257","url":null,"abstract":"<div><div>Mercury (Hg) transport in the atmosphere plays a critical role in its global distribution, although it is not yet fully understood. The use of Hg stable isotopes in atmospheric studies has gained significant attention due to advances in technology, enabling precise isotope measurements even at low concentrations. Isotopic analysis is key to identifying Hg sources and understanding processes crucial for implementing the Minamata Convention. Our review synthesizes published data on atmospheric Hg isotopes, showing that mass-dependent fractionation (δ<sup>202</sup>Hg) is effective at differentiating between sampling sites, while mass-independent fractionation (Δ<sup>199</sup>Hg) reflects photochemical transformations. Natural and anthropogenic emissions can be distinguished by isotope composition (natural: δ<sup>202</sup>Hg = −0.1 ‰, Δ<sup>199</sup>Hg = −0.1 ‰; anthropogenic: δ<sup>202</sup>Hg = −1.6 ‰, Δ<sup>199</sup>Hg = −0.3 ‰). Some preconcentration methods, however, may introduce biases and complicate the interpretation of Hg isotopic fingerprints. We offer recommendations to address these challenges and improve future studies of atmospheric Hg isotopes for more reliable analysis.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118257"},"PeriodicalIF":11.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Chiral analysis by capillary electromigration techniques 毛细管电迁移技术手性分析

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-08 DOI: 10.1016/j.trac.2025.118256

Samuel Bernardo-Bermejo , Sandra Adámez-Rodríguez , María Castro-Puyana , María Luisa Marina

{"title":"Chiral analysis by capillary electromigration techniques","authors":"Samuel Bernardo-Bermejo , Sandra Adámez-Rodríguez , María Castro-Puyana , María Luisa Marina","doi":"10.1016/j.trac.2025.118256","DOIUrl":"10.1016/j.trac.2025.118256","url":null,"abstract":"<div><div>The big impact that chirality presents in different scientific disciplines is illustrated by the high number of analytical methodologies developed to achieve the separation and determination of the enantiomers of chiral compounds. Capillary Electromigration (CE) techniques have demonstrated to be very powerful tools for chiral separations due to their inherent characteristics such as high separation efficiency and resolution, and the possibility of discriminating enantiomers by adding a chiral selector to the separation medium as in Electrokinetic Chromatography. This review describes the most relevant contributions of CE techniques to chiral analysis from 2020 to the present. The main advances reported in the last years are presented together with the most representative applications of chiral CE techniques to the analysis of pharmaceutical/cosmetic formulations, and biological, food, or agrochemical/environmental samples. The characteristics of the developed methodologies are grouped in tables and critically discussed together with the future trends expected in this topic.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118256"},"PeriodicalIF":11.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nanomaterial-based advanced sensors for rapid marine biotoxin detection: An ethical and promising alternative 基于纳米材料的海洋生物毒素快速检测先进传感器：一种道德和有前途的替代方案

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-07 DOI: 10.1016/j.trac.2025.118255

Ruth Stephanie , Xinyue Ruan , Suresh Kumar Kailasa , Jong Pil Park , Chan Yeong Park , Tae Jung Park

{"title":"Nanomaterial-based advanced sensors for rapid marine biotoxin detection: An ethical and promising alternative","authors":"Ruth Stephanie , Xinyue Ruan , Suresh Kumar Kailasa , Jong Pil Park , Chan Yeong Park , Tae Jung Park","doi":"10.1016/j.trac.2025.118255","DOIUrl":"10.1016/j.trac.2025.118255","url":null,"abstract":"<div><div>Marine toxins are naturally occurring chemicals produced by harmful algal blooms, which produce toxic substances through their metabolic processes. These toxins may accumulate in various marine species such as fish, crabs, or filter-feeding bivalves. Some marine toxins are poisonous enough to classify them as neurotoxins and/or poisoning toxins. Unfortunately, the standardized method for marine toxin detection is still conducted in complicated, expensive, and rather unethical ways. Nanomaterial-based biosensors can serve as a promising alternative detection for marine toxins as rapid and practical, in addition to having adequate sensitivity and selectivity. We present the most advanced studies to engineer various platforms promising new standards for marine toxin detection, which describe the fundamentals and the need for nanobiosensors for marine biotoxins. This review will conclusively provide a critical perspective and insights into the major challenges for marine biotoxin detections that must be overcome for these systems to have real impacts on society.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118255"},"PeriodicalIF":11.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent progress and challenges in ECL biosensors for the identification of small extracellular vesicle and clinical diagnosis ECL生物传感器在细胞外小泡识别和临床诊断中的最新进展和挑战

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-04 DOI: 10.1016/j.trac.2025.118253

Shijie Li , Peilin Wang , Qiang Ma

{"title":"Recent progress and challenges in ECL biosensors for the identification of small extracellular vesicle and clinical diagnosis","authors":"Shijie Li , Peilin Wang , Qiang Ma","doi":"10.1016/j.trac.2025.118253","DOIUrl":"10.1016/j.trac.2025.118253","url":null,"abstract":"<div><div>Small extracellular vesicle (sEV) also known as exosome carries of intercellular information and genetic material transfer, e.g., DNA, RNA, proteins, lipids, and other active substances. However, conventional detection techniques do not meet the requirements of sEVs analysis. Recently, electrochemiluminescence (ECL) biosensors have become powerful tools in the detection of sEVs owing to their attractive properties with identification strategies and unique potential- and spatial-controlled ability. Therefore, in this review, the latest advances and principal issues in the ECL biosensors for sEV detection are systematically discussed. Especially, the sensing mechanisms and signal transduction strategies involved in sEV identification are discussed in detail to provide insights into the design and construction of ECL biosensors, such as DNA logical computation, proximity labeling, proximity ligation assay, mediated-membrane fusion strategy, lab-on-a-chip systems, as well as artificial intelligence. Subsequently, the recent application of ECL biosensors for clinic sEV diagnosis is further emphatically introduced, including tumorous sEV identification, peritoneal metastasis diagnosis, tumor microenvironment monitoring, phenotypic profiling, and asthma evaluation. Finally, the potential challenges and future directions of sEV sensing systems are highlighted. It provides a distinct perspective for researchers to construct ECL biosensors and enlightens the fast development of sEV detection in biological research, clinical use, and commercialization.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118253"},"PeriodicalIF":11.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143790873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0