Towards the development of SERS-based immunosensors for detection of biotoxins: Advances and challenges

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-07-31 DOI:10.1016/j.trac.2025.118402

Xin Gao , Sihang Zhang , Wei Zeng , Yu Han , Yiping Chen , Long Wu

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Abstract

Biotoxins, which are diverse in type and potent in toxicity, are prevalent in food and pose a serious threat to human health. Surface-enhanced Raman scattering (SERS) technology has attracted considerable attention in the field of biosensing due to its ultra-high sensitivity and specificity. When combined with immunoassay models, SERS immunosensors demonstrate significant potential for trace amounts detection of biotoxins. In this review, we first introduce the principles of SERS technology, then discuss the design principles of SERS immunosensors. In addition, we summarize several typical cases of SERS-based immunosensors for biotoxin detection. Finally, we outline the future challenges and trends in the field, emphasizing the importance of SERS stability and reproducibility, and reducing costs to advance the real applications. This review provides crucial insights and valuable information for researchers in food safety and points the way forward for the development of future biotoxins detection technologies.

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基于sers的生物毒素检测免疫传感器的研究进展与挑战

生物毒素种类繁多，毒性强，普遍存在于食品中，对人类健康构成严重威胁。表面增强拉曼散射（SERS）技术以其超高的灵敏度和特异性在生物传感领域备受关注。当与免疫分析模型相结合时，SERS免疫传感器显示出痕量生物毒素检测的巨大潜力。本文首先介绍了SERS技术的原理，然后讨论了SERS免疫传感器的设计原则。此外，我们还总结了几种基于sers的生物毒素检测免疫传感器的典型案例。最后，我们概述了该领域未来的挑战和趋势，强调了SERS稳定性和可重复性的重要性，以及降低成本以推进实际应用。本综述为食品安全研究人员提供了重要的见解和有价值的信息，并为未来生物毒素检测技术的发展指明了方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.