Trends in Analytical Chemistry最新文献_第7页

How to enhance the recognition activity of molecularly imprinted polymer sites: a review 如何提高分子印迹聚合物位点的识别活性

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-25 DOI: 10.1016/j.trac.2025.118278

Pan Wang , Lihong Zhang , Lu Liu , Danqing Shen , Kai Yu , Yuhong Jiang , Yongquan Zhou , Yanan Huang , Jianming Pan

{"title":"How to enhance the recognition activity of molecularly imprinted polymer sites: a review","authors":"Pan Wang , Lihong Zhang , Lu Liu , Danqing Shen , Kai Yu , Yuhong Jiang , Yongquan Zhou , Yanan Huang , Jianming Pan","doi":"10.1016/j.trac.2025.118278","DOIUrl":"10.1016/j.trac.2025.118278","url":null,"abstract":"<div><div>Molecularly imprinted polymers (MIPs) have emerged as significant tools in various domains, including fine chemistry and biomedicine, owing to their capacity for selective recognition of target molecules. While substantial progress has been made in MIP preparation techniques and application development, a systematic understanding of strategies to enhance their recognition activity remains underexplored. This review provides a comprehensive overview of the strategies for precisely regulating the imprinting process and improving the recognition separation efficacy. The role of theoretical modeling and experimental titration in designing functional monomers with precise molecular matching has been emphasized. Enhancing site-specific interactions by increasing the quality and density of recognition sites. The review further investigates adsorption and desorption mechanisms in efficient recognition processes, highlighting their significance in practical applications. This review aims to serve as a critical resource for advancing MIP synthesis, optimizing active site functionality, and achieving superior separation performance in complex sample matrices.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118278"},"PeriodicalIF":11.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-dimensional materials in bioelectronics 生物电子学中的二维材料

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-23 DOI: 10.1016/j.trac.2025.118279

Navid Rabiee

{"title":"Two-dimensional materials in bioelectronics","authors":"Navid Rabiee","doi":"10.1016/j.trac.2025.118279","DOIUrl":"10.1016/j.trac.2025.118279","url":null,"abstract":"<div><div>Two-dimensional (2D) materials have emerged as transformative building blocks in bioelectronics, enabling seamless interfaces between electronic systems and living tissues. Their exceptional electrical conductivity, mechanical flexibility, optical tunability, and environmental resilience make them uniquely suited for next-generation biomedical devices. This perspective highlights recent advances in the use of 2D materials for bioelectronic applications, including skin-conformal wearables and implantable interfaces for dynamic organs such as the heart, brain, and gastrointestinal tract. We examine cutting-edge fabrication techniques, including transfer printing, layer-by-layer assembly, and hybrid integration with three-dimensional architectures, with an emphasis on scalability and clinical translation. The manuscript also addresses critical challenges—ranging from long-term biocompatibility and environmental stability to regulatory hurdles—and presents current solutions including the design of biodegradable platforms and multilayered heterostructures with multimodal capabilities. By bridging materials science, bioengineering, and medicine, 2D materials hold the promise of revolutionizing healthcare through smart, minimally invasive, and adaptive bioelectronic systems capable of real-time monitoring, diagnosis, and therapeutic intervention.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118279"},"PeriodicalIF":11.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of HSP and COSMO-RS for computational green solvent screening: Applications in biomass valorization 计算绿色溶剂筛选的HSP和cosmos - rs综述：在生物质增值中的应用

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-22 DOI: 10.1016/j.trac.2025.118272

Felipe Sanchez Bragagnolo , Sebastián Ormazábal-Latorre , Roberto I. Canales , Maurício Ariel Rostagno , Jesús Esteban , González-Miquel María

{"title":"An overview of HSP and COSMO-RS for computational green solvent screening: Applications in biomass valorization","authors":"Felipe Sanchez Bragagnolo , Sebastián Ormazábal-Latorre , Roberto I. Canales , Maurício Ariel Rostagno , Jesús Esteban , González-Miquel María","doi":"10.1016/j.trac.2025.118272","DOIUrl":"10.1016/j.trac.2025.118272","url":null,"abstract":"<div><div>Valorizing biomass by-products and reducing their accumulation are critical current issues. Nevertheless, the large volume of such materials requires continuous and enhanced strategies to mitigate potential environmental problems. The valorization of biomass through the recovery of valuable compounds must be sustainable and optimized, emphasizing the selection of optimal and greener solvents for this purpose. In this context, to reduce experimental efforts, material resources, and energy expenses, predictive <em>in silico</em> tools enable efficient preliminary screening, highlighting the tools based on Hansen Solubility Parameters (HSP) and COnductor-like Screening MOdel for Real Solvents (COSMO-RS). Considering their widespread application, this review critically analyzes both computational methods, highlighting their main concepts, applications, and limitations. Finally, we propose a simplified guide from solvent selection to the purified (or not) fraction.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118272"},"PeriodicalIF":11.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in MOF-modified electrochemical sensor for point-of-care detecting cardiac biomarkers mof修饰电化学传感器在护理点检测心脏生物标志物的研究进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-22 DOI: 10.1016/j.trac.2025.118277

Md Maruf Ahmed , Jingyi Bai , Liming Kong , Jianping Du , Seitkhan Azat , Qin Xu

{"title":"Recent advances in MOF-modified electrochemical sensor for point-of-care detecting cardiac biomarkers","authors":"Md Maruf Ahmed , Jingyi Bai , Liming Kong , Jianping Du , Seitkhan Azat , Qin Xu","doi":"10.1016/j.trac.2025.118277","DOIUrl":"10.1016/j.trac.2025.118277","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) has become a major concern all over the world due to the elevated morbidity and mortality rates. The rapid identification and treatment of CVDs has become a crucial challenge in saving life. In the past decade, electrochemical sensing technology has established a novel domain for the accurate detection of CVDs due to their simplicity, rapidity, sensitivity, and low cost. To achieve optimal sensing performance, the creation of functional electrode materials with high electron transfer efficiency, large surface area, and excellent electrocatalytic activities is required. Metal-organic frameworks (MOFs) are attractive options for the identification of cardiac biomarkers due to their multifunctional properties. MOFs exhibit large surface areas, structural tunability and porous architectures, fulfilling all requirements for use as sensing materials for the accurate identification of cardiac biomarkers. This work provides a brief discussion about several cardiac biomarkers and their association with disease severity. Then, the properties, fabrication processes, parameters, and functionalization strategies of MOFs have been emphasized. The review summarizes the latest advancement of MOF-based electrochemical/hybrid electrochemical sensors for the ultrasensitive detection of cardiac biomarkers. Furthermore, this review explores current obstacles, highlights the prospects, and discusses the opportunities of point-of-care (POC) technologies for the detection of cardiac biomarkers.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118277"},"PeriodicalIF":11.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in MXene-based electrochemical sensors for healthcare applications 医疗保健应用中基于mxene的电化学传感器的最新进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-21 DOI: 10.1016/j.trac.2025.118276

Harini Loganathan , Durgalakshmi Dhinasekaran , Ajay Rakkesh Rajendran

{"title":"Recent advances in MXene-based electrochemical sensors for healthcare applications","authors":"Harini Loganathan , Durgalakshmi Dhinasekaran , Ajay Rakkesh Rajendran","doi":"10.1016/j.trac.2025.118276","DOIUrl":"10.1016/j.trac.2025.118276","url":null,"abstract":"<div><div>MXenes, a class of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides, have garnered substantial attention due to their remarkable electrochemical properties synthesized via top-down and bottom-up approaches. The rapid advancement of electrochemical sensing technology inspires the development of innovative sensing platforms for healthcare applications. This review focuses on recent breakthroughs in MXene based electrochemical sensors, imposing their exceptional conductivity and surface area. We highlight scalable key synthesis methods, properties, and unique features of MXenes that make them promising materials for sensing applications. We discuss fabrication techniques and functionalization strategies for sensor optimization as MXene sensors provide versatile healthcare applications, including diagnostics and real-time monitoring. This review also emphasizes on the development of point of care devices integrated with machine learning for prompt accurate results. This review concludes by discussing current challenges and future prospects for advancing MXene-based electrochemical sensors for healthcare applications using machine learning aspects.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118276"},"PeriodicalIF":11.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR biosensing with lateral flow assays for point of care Diagnostics: Overcoming commercial development challenges CRISPR生物传感与护理点诊断的横向流动分析：克服商业发展挑战

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-21 DOI: 10.1016/j.trac.2025.118275

Tim Hall , Sneha Gulati , Rui Sang , Zhengyang Jia , Flyn Mckinnirey , Graham Vesey , Ewa Goldys , Fei Deng

{"title":"CRISPR biosensing with lateral flow assays for point of care Diagnostics: Overcoming commercial development challenges","authors":"Tim Hall , Sneha Gulati , Rui Sang , Zhengyang Jia , Flyn Mckinnirey , Graham Vesey , Ewa Goldys , Fei Deng","doi":"10.1016/j.trac.2025.118275","DOIUrl":"10.1016/j.trac.2025.118275","url":null,"abstract":"<div><div>The combination of lateral flow assays (LFAs) with CRISPR biosensing technologies offers a new frontier in point-of-care (POC) diagnostics. LFAs are widely used for their simplicity, rapid results, and ease of use, enabling detection of various targets including proteins and nucleic acids. However, traditional LFAs often struggle with sensitivity, especially in detecting viral nucleic acids like SARS-CoV-2. CRISPR biosensing systems, particularly those using Cas12 and Cas13 effectors, enhance LFA performance by providing highly sensitive and specific detection of nucleic acids. These effectors, upon recognizing a target sequence, trigger collateral cleavage activity, amplifying the detection signal. This approach has been used in diagnostic tools such as DETECTR (Cas12a) and SHERLOCK (Cas13a), which have shown PCR-level sensitivity and specificity for detecting viral RNA, including SARS-CoV-2, with faster and more cost-effective results. By integrating CRISPR technologies into LFAs, these hybrid systems are poised to offer powerful solutions for sensitive, low-cost, and user-friendly diagnostics, especially in resource-limited settings. This review summarizes the recent advancements in CRISPR-based LFAs, exploring their mechanisms, advantages, and limitations. In addition, this review also outlines the commercial development challenges and discussed the future prospects.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118275"},"PeriodicalIF":11.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assay formats and target recognition strategies in lateral flow assays for the detection of mycotoxins 检测真菌毒素的横向流动试验的检测格式和目标识别策略

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-19 DOI: 10.1016/j.trac.2025.118273

Monika Conrad, Maria C. DeRosa

引用次数: 0

Cutting-edge RNA quantitative detection methods for rapid and on-site analysis 尖端的RNA定量检测方法，用于快速和现场分析

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-19 DOI: 10.1016/j.trac.2025.118274

Tao Dong , Chenghui Yu , Feng Han , Qi Mao , Weixuan Jing , Zhaochu Yang , Nuno Miguel Matos Pires , José Higino Correia , Qijing Lin , Fei Hu , Honghong Yao , Kui Hu , Tao Xu , Zhuangde Jiang

{"title":"Cutting-edge RNA quantitative detection methods for rapid and on-site analysis","authors":"Tao Dong , Chenghui Yu , Feng Han , Qi Mao , Weixuan Jing , Zhaochu Yang , Nuno Miguel Matos Pires , José Higino Correia , Qijing Lin , Fei Hu , Honghong Yao , Kui Hu , Tao Xu , Zhuangde Jiang","doi":"10.1016/j.trac.2025.118274","DOIUrl":"10.1016/j.trac.2025.118274","url":null,"abstract":"<div><div>RNA, a vital biomarker, is crucial for molecular diagnostics, encompassing pathogen detection, gene expression, tumor diagnosis, prognosis, and drug efficacy. Since the COVID-19 outbreak, its role in clinical settings has grown. This review examines established RNA detection methods like qPCR, sequencing, Nanostring, and fluorescence in situ hybridization (FISH), highlighting recent progress and trends. It also focuses on new Point-of-Care Testing (POCT) methods developed over the last five years, categorizing them by the necessity for reverse transcription and nucleic acid amplification. The review emphasizes advances in multiplex detection tailored for POCT, aiming to update researchers and clinicians on the latest RNA detection technologies. Among various RNA detection methods, the amplification-free approach is preferable for POCT applications compared to those requiring reverse transcription and sequence-dependent amplification, as they simplify the detection process by reducing technical complexity while retaining high sensitivity.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118274"},"PeriodicalIF":11.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent trends in molecularly imprinted photoelectrochemical sensors 分子印迹光电化学传感器的最新进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-15 DOI: 10.1016/j.trac.2025.118271

Kheibar Dashtian , Forough Zahedpour , Amin Foroozandeh , Rezvan Karimi , Majid Abdouss , Shaaker Hajati

{"title":"Recent trends in molecularly imprinted photoelectrochemical sensors","authors":"Kheibar Dashtian , Forough Zahedpour , Amin Foroozandeh , Rezvan Karimi , Majid Abdouss , Shaaker Hajati","doi":"10.1016/j.trac.2025.118271","DOIUrl":"10.1016/j.trac.2025.118271","url":null,"abstract":"<div><div>Molecularly imprinted photoelectrochemical sensors (MIPECSs) represent an advanced analytical platform with remarkable selectivity and sensitivity for detecting a broad spectrum of molecular targets, including Microcystin-LR, Aflatoxin B1, Fumonisin B1, Oxytetracycline, Salicylic acid, Dioctyl phthalate, and Bisphenol A, across diverse matrices. This review provides a comprehensive analysis of recent advancements in the design and application of MIPECSs, focusing on the underlying principles of PEC-responsive MIPs such as poly-phenylenediamine, polydopamine, polypyrrole, and MI-titania/silica, as well as their integration with PEC techniques. A key emphasis is placed on the incorporation of MIPs with narrow-bandgap semiconductors (SCs), including covalent organic frameworks (COFs), metal-organic frameworks (MOFs), metal oxides, metal chalcogenides, and carbon nitrides, both in their pristine states and as heterojunctions. Additionally, this review critically evaluates strategies aimed at improving selective molecular recognition, signal sensitivity, operational stability, and overall technological robustness. These approaches encompass the utilization of novel SCs, surface engineering methodologies, and signal amplification techniques. Furthermore, the review explores the diverse applications of MIPECSs across various fields, including environmental monitoring, food safety assessment, clinical diagnostics, point-of-care testing, and non-invasive biological fluid analysis. By offering an in-depth examination of current research trends and emerging technologies, this work identifies existing challenges and outlines future directions. The insights presented contribute to the ongoing development of next-generation biosensing technologies, advancing the field of molecularly imprinted PEC sensors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118271"},"PeriodicalIF":11.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretability in near-infrared (NIR) spectroscopy: Current pathways to the long-standing challenge 近红外（NIR）光谱的可解释性：解决长期挑战的当前途径

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-04-14 DOI: 10.1016/j.trac.2025.118254

Krzysztof B. Beć, Justyna Grabska, Christian W. Huck

{"title":"Interpretability in near-infrared (NIR) spectroscopy: Current pathways to the long-standing challenge","authors":"Krzysztof B. Beć, Justyna Grabska, Christian W. Huck","doi":"10.1016/j.trac.2025.118254","DOIUrl":"10.1016/j.trac.2025.118254","url":null,"abstract":"<div><div>Near-infrared (NIR) spectroscopy holds a unique position in analytical chemistry, contrasting excellent utility with intrinsic spectral complexity. Challenges arise from high dimensionality and limited interpretability of its spectral data. Applied NIR analysis evolved to rely on multivariate data analysis, with various statistical parameters providing information sufficient to control and maintain the calibration process, ultimately delivering reliable predictions. However, in NIR spectroscopic analysis the key analytical insights derive from well-defined molecular vibrations, a factor often not fully explored in the routine. Recent advancements have tackled many of these persistent issues through refined chemometric approaches, theoretical simulations of NIR absorption bands, or novel approaches to deal with physical footprint of the sample. At the same time, trending data science approaches such as deep chemometrics introduce own challenges in model transparency. These developments dynamically alter the outlook on interpretability in NIR spectroscopy; the review critically examines the emerging potential at their intersection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"189 ","pages":"Article 118254"},"PeriodicalIF":11.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0