Trends in Analytical Chemistry最新文献

{"title":"Recent progress in mass spectrometry-based liquid biopsy for cancer detection and analysis: A comprehensive review","authors":"Yingjun Lu ,&nbsp;Yonghao Ma ,&nbsp;Quan Liu ,&nbsp;Dixian Luo","doi":"10.1016/j.trac.2025.118291","DOIUrl":"10.1016/j.trac.2025.118291","url":null,"abstract":"<div><div>Cancer, being highly variable and heterogeneous, necessitates innovative strategies in its analysis and diagnosis. Within this landscape, mass spectrometry-based liquid biopsy has emerged as a promising tool for managing cancer. This approach presents a non-invasive means to capture and scrutinize tumour-derived proteins, metabolites, and nucleic acids from bodily fluids. By leveraging this technology, the detection of cancer biomarkers is augmented, shedding light on tumour heterogeneity and facilitating real-time monitoring of disease progression and treatment efficacy. Here, we discuss the challenge of detecting early cancer markers through mass spectrometry-based liquid biopsy. We review the latest developments in mass spectrometry technology for cancer detection and propose its complementarity with traditional liquid biopsy and the potential for future technological advancements to maximize the advantages of such technology in personalized early detection of cancer.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118291"},"PeriodicalIF":11.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weathering of plastics in terrestrial environments","authors":"Max Groß ,&nbsp;Matthias Mail ,&nbsp;Rafaela Debastiani ,&nbsp;Torsten Scherer ,&nbsp;Melanie Braun","doi":"10.1016/j.trac.2025.118281","DOIUrl":"10.1016/j.trac.2025.118281","url":null,"abstract":"<div><div>When plastics accumulate in the terrestrial environment, they undergo weathering, which alters their properties and causes them to fragment into micro- and submicron plastics. Although various analytical methods exist to study these processes, a comprehensive overview of their application and the alterations of plastics under field conditions across different terrestrial systems is missing. This review summarises analytical approaches for assessing surface, structural, chemical and mechanical changes in weathered plastics, focusing on scanning electron microscopy. We examine plastic alterations in short-term (e.g., composting, wastewater treatment) and long-term (e.g., landfills, soils) systems. As sample treatment can substantially alter analyses, we provide recommendations for assessing these changes. Plastic weathering leads to significant, but comparable, changes across terrestrial systems, with plastic properties as key influencing factors. While most data come from landfill studies, research in soils remains limited. Understanding long-term weathering is essential for evaluating the environmental fate of plastics, emphasizing the need for extended studies in diverse terrestrial environments.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118281"},"PeriodicalIF":11.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in small-molecule probes for lipid droplets","authors":"Yaochen Tu ,&nbsp;Wenjie Zhang ,&nbsp;Jiaqian Yan ,&nbsp;Miaomiao Wang ,&nbsp;Bubin Xu ,&nbsp;Yusheng Xie","doi":"10.1016/j.trac.2025.118287","DOIUrl":"10.1016/j.trac.2025.118287","url":null,"abstract":"<div><div>Lipid droplets (LDs) are highly dynamic organelles, which are present in most eukaryotic and some prokaryotic cells. It has been long known that lipid droplets play crucial roles in lipid metabolism, membrane biosynthesis, cellular energy balance, and signaling pathways, etc. Dysfunction of LDs has been associated with many diseases, such as obesity, non-alcoholic fatty liver disease, atherosclerosis, and cancer. In recent years, small-molecule probes have become instrumental in inquiring the dynamics of LDs and targeted therapies. Herein, we describe recent key advances of LD-targeted chemical probes for studying organelle interactions, super-resolution imaging, and their application in diseases (2021–2024). We further discuss the potential of LD-targeted photodynamic photosensitizers and degraders for disease treatment. Next, we discuss the general design principles and challenges of current small-molecule probes. Finally, we recommend future research directions of LDs from our perspectives.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118287"},"PeriodicalIF":11.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in surface chemical modifications of paper-based analytical platforms","authors":"Abderrahman Lamaoui ,&nbsp;Narjiss Seddaoui ,&nbsp;Abdellatif Ait Lahcen ,&nbsp;Fabiana Arduini ,&nbsp;Aziz Amine ,&nbsp;Youssef Habibi","doi":"10.1016/j.trac.2025.118290","DOIUrl":"10.1016/j.trac.2025.118290","url":null,"abstract":"<div><div>Recently, paper-based analytical devices (PADs) have gained significant interest in the fields of analytical and bioanalytical chemistry. Being able to meet the criteria for smart and sustainable analytical devices, particularly cost-effectiveness, user-friendliness, fast analysis, and portability, PADs have proven valuable for point-of-care diagnostics, environmental monitoring, food safety inspection, and illicit drug detection. The main reason for the popularity of PADs is that they are based on papers as smart solid substrates, which exhibit unique chemical and physical properties. The PADs' flexibility allows for easy sample loading and surface modifications, enabling tailored performance. Various approaches have been developed to modify the surfaces of PADs to endow them with specific properties. The overreaching goal of this review is to provide, after a brief introduction to the types, chemistry, and properties of paper, a comprehensive examination of the most successful approaches used to modify PADs with organic, inorganic, organic-inorganic hybrid, and biological materials for a variety of (bio)chemical analytes. Furthermore, it offers a deep understanding of the interface between PADs and the (nano)materials. It elucidates how incorporating different materials onto the paper substrate influences the performance and sensitivity of PADs in detecting target analytes. It discusses the sustainability criteria fulfilled during the preparation of PADs and the current challenges related to their commercialization potential. Finally, it outlines future research directions, highlighting the need to address current challenges and suggesting avenues for further advancements in the field of PADs.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118290"},"PeriodicalIF":11.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface molecularly imprinted polymer nanocatalytic probes for scattering spectral analysis","authors":"Jingjing Li ,&nbsp;Zhiqiang Wang ,&nbsp;Guiqing Wen ,&nbsp;Aihui Liang ,&nbsp;Zhiliang Jiang","doi":"10.1016/j.trac.2025.118283","DOIUrl":"10.1016/j.trac.2025.118283","url":null,"abstract":"<div><div>Surface molecularly imprinted polymers (SMIPs) offer efficient capture and specific recognition of target molecules by creating three-dimensional recognition sites on the polymer surface. SMIPs in solution can be combined with resonance Rayleigh scattering (RRS) and surface-enhanced Raman scattering (SERS) techniques for selective, sensitive analysis. SMIP-based nanocatalytic probes (SMIPNCPs) integrate recognition with catalytic amplification, enhancing spectral signals and improving sensitivity. This article introduces the design and synthesis of stable SMIP nanoprobes and SMIPNCPs, including the selection of template molecules, optimization of functional monomers, and the development of nanozymes and nanocatalytic indicator reactions. Drawing on the research work of the authors' group, the review highlights recent advances in SMIPs probe-based RRS/SERS and SMIPNCPs-based RRS/SERS spectral analysis. Finally, the challenges and future directions for the practical application of SMIPNCPs are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118283"},"PeriodicalIF":11.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in paper microfluidics for blood analysis and diagnostics","authors":"Zhiyuan Yang ,&nbsp;Yafei Lou ,&nbsp;Linan Sun ,&nbsp;Siyu Chen ,&nbsp;Miaosi Li ,&nbsp;Zhuoxuan Lu ,&nbsp;Liming Zhang ,&nbsp;Rong Cao ,&nbsp;Junfei Tian","doi":"10.1016/j.trac.2025.118289","DOIUrl":"10.1016/j.trac.2025.118289","url":null,"abstract":"<div><div>Paper microfluidics has emerged as a transformative technology in blood analysis and diagnostics, offering a portable, cost-effective, and user-friendly alternative to traditional laboratory tests. This review discusses the progress in paper microfluidics for blood tests over the past five years, focusing on their potential to revolutionize point-of-care testing in resource-limited settings. After providing an overview of blood composition and the evolution of blood testing technologies, the review explores innovative advances in emerging microfluidic paper-based analytical devices for blood detection. It categorizes their applications based on the type of blood sample used and whether pretreatment techniques are required, enabling developers to efficiently identify suitable methodologies aligned with the intended sample state and accelerate the prototyping of devices. In addition, this review summarizes how paper substrate, is innovatively repurposed into auxiliary tools to enhance blood detection processes through its adaptability. Challenges in commercialization and promising directions for future development are also discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118289"},"PeriodicalIF":11.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New microextraction techniques in exposome Research: Bridging environmental exposures and human health","authors":"Hasan Javanmardi ,&nbsp;Anna Roszkowska ,&nbsp;Janusz Pawliszyn","doi":"10.1016/j.trac.2025.118284","DOIUrl":"10.1016/j.trac.2025.118284","url":null,"abstract":"<div><div>Exposome studies encompass comprehensive investigations into the various exposures individual living organisms encounter from exogenous factors throughout their lifetime, and how these exposures may affect their health status. These studies may focus on health risks associated with single chemical exposures or the cumulative effect of multiple chemicals, aiming to elucidate dose−response relationships. Numerous analytical methods are available for measuring contaminants and/or their endogenous metabolites across various matrices, including biofluids, food, air, water, and soil. In recent years, microextraction techniques have gained increasing relevance in exposome research due to their ability to enhance analytical throughput while minimizing invasion to the systems under study. Among these techniques, solid phase microextraction (SPME), a well-established sample preparation method in environmental and toxicological studies, has gained particular attention for its ability to extract a wide range of compounds, including short-lived and unstable compounds, directly from living organisms (<em>in vivo</em> SPME). As a result, SPME is gaining traction in exposome studies for its ability to both detect exogenous compounds in environmental matrices and track the fate of these contaminants, including their metabolism, accumulation, and metabolic effects in living systems. This review explores recent applications of microextraction in exposome research, highlighting the advantages of different coatings, adsorbent chemistries, and geometric designs— such as fiber SPME, thin film SPME (TFME), needle trap devices (NTDs), coated tips (arrow-SPME), blade SPME, and the newly introduced swab-SPME—for the analysis of exogenous and endogenous compounds in environmental samples and in biological matrices. We also examine the emerging applications of direct-MS coupled with SPME in exposome research and provide an overview of the significant potential of SPME in both targeted and untargeted screening of low molecular weight molecules within exposomics and metabolomics applications.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118284"},"PeriodicalIF":11.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denoising for single-cell resolution highly multiplexed imaging: Deep learning safeguards cell spatial heterogeneity analysis","authors":"Yinjie Zhang ,&nbsp;Jing Zhao ,&nbsp;Yaquan Liu ,&nbsp;Hua Qin ,&nbsp;Yun Ding ,&nbsp;Haijiang Tian ,&nbsp;Guangxuan Wang ,&nbsp;Jingtai Yao ,&nbsp;Jie Gao ,&nbsp;Mingli Chen ,&nbsp;Liqun Chen ,&nbsp;Runzeng Liu ,&nbsp;Jianbo Shi ,&nbsp;Yang Song ,&nbsp;Guangbo Qu ,&nbsp;Guibin Jiang","doi":"10.1016/j.trac.2025.118282","DOIUrl":"10.1016/j.trac.2025.118282","url":null,"abstract":"<div><div>High-dimensional single-cell techniques enable exploring the heterogeneous cell populations at single-cell resolution unveiling deep biological insight into various diseases. Single-cell resolution highly multiplexed imaging is one of the cutting-edge techniques for high-dimensional single-cell analysis, preserving spatial context while creating high-dimensional biomarker catalogs of cells. As a part and parcel of highly multiplexed imaging data processing, visualization preprocessing aims to remove noise from original signal, a process achieved through the use of denoising algorithms. While highly multiplexed imaging become more widely adopted, denoising optimizations are critical for advancing future research. In this paper, we summarize the feature of different highly multiplexed imaging techniques and reviews the principles, characteristics, development, and applications of denoising algorithms. Furthermore, we discussed the technical requirements and development prospects, offering assistance for domain researches and technology developers.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118282"},"PeriodicalIF":11.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly nanomaterials in white analytical chemistry: Design, role and implications","authors":"Ghazanfar Hussain ,&nbsp;Rüstem Keçili ,&nbsp;Chaudhery Mustansar Hussain","doi":"10.1016/j.trac.2025.118285","DOIUrl":"10.1016/j.trac.2025.118285","url":null,"abstract":"<div><div>The integration of eco-friendly nanomaterials (NMs) into white analytical chemistry (WAC) emerged as a pivotal progress for promoting efficiency and sustainability and in analytical and bioanalytical applications. This review paper explores the design principles, development, critical roles and implications of eco-friendly NMs considering the main principles of WAC approach. For this purpose, the rationale behind material selection and environmentally benign synthesis techniques that minimize resource use and hazardous by-products are carefully discussed throughout the manuscript. The crucial role of these NMs in enhancing analytical performance, including sensitivity and selectivity while ensuring environmental safety is also discussed. Furthermore, this review outlines the potential and recent applications of eco-friendly NMs in diverse areas such biological applications, environmental analysis and food safety. The broader implications including scalability and the impact on environmental health, are also addressed. Overall, this study provides a comprehensive overview of how the incorporation of sustainable NMs into WAC can revolutionize the field and contribute to the global pursuit of greener scientific practices.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118285"},"PeriodicalIF":11.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in DNA-empowered membrane surface engineering for artificial manipulation and visual analysis of cell-cell communication","authors":"Tian Zhang,&nbsp;Xun Guo,&nbsp;Jiao Zheng,&nbsp;Sai Bi","doi":"10.1016/j.trac.2025.118280","DOIUrl":"10.1016/j.trac.2025.118280","url":null,"abstract":"<div><div>The artificial manipulation of cell-cell communication is essential for exploring the key physiological processes, which facilitate insights into the signal transduction pathways that ensure intercellular interactions. Benefiting from the controllable topology and precise self-assembly abilities of DNA nanostructures, the developed nanoplatforms have demonstrated the predictable spatial structures and customized functions. Once anchored to the cell surface, DNA-based nanoplatforms can programmatically modulate cell-cell assembly, offering a modular tool for exploring intercellular interactions. More importantly, by interfacing with cell-surface receptors, the engineered manipulation strategies have both basic and applied research in the controllable regulation of intercellular communication. Focusing on the key signaling pathways involved in the natural cell-cell communication, we will highlight the design principles of artificial regulation and visual analysis of cell-cell communication through DNA-based membrane surface engineering, and summarize the latest advancements in the potential for precision treatment of diseases. Finally, the challenges and outlook on using DNA nanotechnology to manipulate cellular interactions are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118280"},"PeriodicalIF":11.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}