Trends in Analytical Chemistry最新文献

{"title":"A comprehensive review of wearable devices for non-invasive biosensing","authors":"Wei-Ting Hsueh ,&nbsp;Cheng-Xue Yu ,&nbsp;Hung-Chi Cheng ,&nbsp;Mu-Yen Chen ,&nbsp;Hsing-Meng Wang ,&nbsp;Lung-Ming Fu","doi":"10.1016/j.trac.2025.118425","DOIUrl":"10.1016/j.trac.2025.118425","url":null,"abstract":"<div><div>Wearable biosensors have emerged as powerful tools for non-invasive, continuous health monitoring, enabling the real-time analysis of physiological and biochemical markers in body fluids such as sweat, saliva, tears, and exhaled breath. This review provides a comprehensive overview of the advancements in wearable biosensing platforms over the past five years, with a particular focus on device-level innovations, diverse sensing modalities, clinical applications, commercialization efforts, and future prospects including AI integration. The key technologies discussed include electrochemical and optical sensors embedded in patches, mouthguards, contact lenses, and smart masks, all of which are tailored to specific biofluids and diagnostic needs. The review highlights innovations in antifouling coatings, self-healing materials, and microfluidic control systems that improve device durability and accuracy under dynamic physiological conditions. The review also provides a critical analysis of the key challenges, including biofluid variability, environmental interference, and power supply limitations. It further explores potential directions for future research, such as the transition from laboratory prototypes to commercial products, the integration of edge AI computing, and the development of standardized data workflows. Importantly, it also highlights regulatory hurdles and the need for standardization to facilitate clinical translation and ensure interoperability. The considered applications range from glucose, lactate, cortisol, and electrolyte testing to monitoring infectious pathogens and vital signs. Challenges such as biofluid variability, environmental interference, and sensor biocompatibility are critically reviewed. The review also explores the transition of wearable devices from laboratory prototypes to commercial products, discussing current market offerings and regulatory considerations. Looking ahead, the integration of multifunctional sensor arrays and AI-driven data analytics will revolutionize health diagnostics, paving the way for the development of smart, user-adaptive, and clinically reliable wearable biosensing platforms for revolutionizing personal health monitoring and disease monitoring.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118425"},"PeriodicalIF":12.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ monitoring nucleation and growth of metal organic frameworks: device, mechanism and application","authors":"Xiaohui Wen ,&nbsp;Juan He ,&nbsp;Xiaoying Huang ,&nbsp;Zhengjun Gong ,&nbsp;Xiandeng Hou","doi":"10.1016/j.trac.2025.118430","DOIUrl":"10.1016/j.trac.2025.118430","url":null,"abstract":"<div><div>Comprehending the mechanisms of metal-organic frameworks (MOFs) nucleation and growth is crucial for designing rational synthesis schemes to achieve controllable construction of materials with desired properties. Nucleation and growth are greatly influenced by various reaction parameters, and it is often challenging to determine the optimal strategy by adjusting the reaction parameters for preparing a desired material. In situ approaches are well-suited for acquiring the missing knowledge about the mechanisms that occur under reaction conditions, which can provide valuable insights into solid-state transformation, the presence of short-lived intermediates or precursors, and the impact of reaction parameters on chemical reactions. Therefore, this review particularly emphasizes recent advances in situ approaches, ranging from optical scattering, spectroscopy, to microscopy, and explores their main applications of these instruments for MOFs, revealing important new insights into the mechanisms of nucleation and growth, as well as the relationship between reaction parameters and synthesis products. Finally, the review delves into the future trends in this exciting area of research.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118430"},"PeriodicalIF":12.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular recognition-driven detection of β-Lactoglobulin: Mechanisms, progress and future prospects","authors":"Yanlin Zeng ,&nbsp;Yangzi Zhang ,&nbsp;Yifan Wu ,&nbsp;Xuan Ma ,&nbsp;Longjiao Zhu ,&nbsp;Wentao Xu","doi":"10.1016/j.trac.2025.118427","DOIUrl":"10.1016/j.trac.2025.118427","url":null,"abstract":"<div><div>β-Lactoglobulin (BLG), the principal allergen in bovine milk, exhibits strong immunogenicity and structural stability, posing notable challenges to food safety. Accurate detection of BLG is critical for allergen labeling and consumer protection. This review systematically summarizes molecular recognition strategies for BLG detection. It defines eight recognition modes and three binding sites, and categorizes seven recognition elements, including antibodies, aptamers, specific binding peptides, molecularly imprinted polymers, fluorogenic probes, metal nanozymes, and primers, based on binding mechanisms. Additionally, direct strategies utilizing BLG's intrinsic signatures, such as mass spectrometry and spectroscopy, are reviewed. Detection platforms are evaluated in terms of sensitivity, specificity, and applicability. Future perspectives highlight advances in intelligent sensing technologies, including integration with nanomaterials, microfluidics, and digital analysis. Emphasis is placed on achieving high performance under complex food conditions. This review provides a concise reference for developing next-generation BLG biosensors with improved accuracy, portability, and suitability for real-world allergen monitoring.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118427"},"PeriodicalIF":12.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplexed optical sensors driven by nanomaterials for food and agriculture safety detection: From sensing strategies to practical challenges","authors":"Wenhui Wang ,&nbsp;Limei Yin ,&nbsp;Heera Jayan ,&nbsp;Chanjun Sun ,&nbsp;Chifang Peng ,&nbsp;Xiaobo Zou ,&nbsp;Zhiming Guo","doi":"10.1016/j.trac.2025.118428","DOIUrl":"10.1016/j.trac.2025.118428","url":null,"abstract":"<div><div>In recent years, the presence of hazardous contaminants in food and agricultural products has posed a significant risk to public health. Therefore, it is critical to develop rapid, accurate, and broad-spectrum food hazard detection techniques. Optical sensing has the advantages of rapid and high sensitivity, it will play an unparalleled role in ensuring food safety. This review provides a comprehensive overview of the fundamentals of optical systems based on fluorescence, surface-enhanced Raman scatting (SERS), surface plasmon resonance (SPR) and colorimetry. The ability of nanomaterials (metal, semiconductor, carbon-based) enhanced optical sensors to detect pesticides, heavy metals, biotoxins, and foodborne pathogens is summarized. In addition, this paper discusses the limitations and prospects of optical sensors, and particularly emphasizes the main findings: 1) AI-optimized nanomaterial design, 2) smartphone-integrated portable detection systems, 3) self-validating dual-mode sensors. This work aims to promote strategic advances in high-precision sensing methods that ultimately safeguard food safety.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118428"},"PeriodicalIF":12.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical sensing with terahertz microfluidics: Recent progress and future prospects","authors":"Lin Chen ,&nbsp;Yifei Song ,&nbsp;Darren Chin Yao Lim ,&nbsp;Yiming Zhu ,&nbsp;Songlin Zhuang ,&nbsp;Ranjan Singh","doi":"10.1016/j.trac.2025.118416","DOIUrl":"10.1016/j.trac.2025.118416","url":null,"abstract":"<div><div>The terahertz spectral region has garnered significant attention for label-free chemical and biological sensing due to its molecular fingerprints, low energy characteristics, and remote sensing capabilities. Microfluidic platforms are particularly attractive because microchannels are made from inexpensive biocompatible materials, preventing environmental contamination, and require only micro to nanolitre sample volumes for manipulation. These platforms offer the advantages of simple design, easy fabrication, lightweight prototypes, and real-time measurements. In this manuscript, we review state-of-the-art terahertz microfluidic technology with a focus on liquid-based high sensitivity terahertz microfluidic devices and systems. This includes material platforms, the physical mechanisms underlying their characterization methods, and fabrication methodologies. Next, we explore further applications of microfluidics, such as the optoacoustic effect, particle capture, active amplitude control, frequency-agile multiplexing, imaging, and signal processing. Finally, the future prospects of terahertz microfluidic in biochemical sensing applications are also discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118416"},"PeriodicalIF":12.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cas13-mediated liquid biopsy: A comprehensive review of cancer diagnostic applications","authors":"Menglu Gao ,&nbsp;Si Wu ,&nbsp;Xin Hu ,&nbsp;Lihan Zhu ,&nbsp;Yue Hu ,&nbsp;Xin He ,&nbsp;Jiurong He ,&nbsp;Rong Yuan ,&nbsp;Yinhua Zhang ,&nbsp;Cheng Liu ,&nbsp;Fu-Bing Wang","doi":"10.1016/j.trac.2025.118411","DOIUrl":"10.1016/j.trac.2025.118411","url":null,"abstract":"<div><div>Over the past decade, CRISPR-based molecular editing technologies have found extensive applications across various disease domains. Among them, CRISPR Cas13, a significant member of the CRISPR family, has been employed in a non-invasive diagnostic method that analyzes circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), microRNAs (miRNAs), and extracellular vehicles (EVs) isolated from biological fluids such as blood, urine, saliva, cerebrospinal fluid, and pleural effusion. This has established CRISPR Cas13 as a crucial tool in tumor liquid biopsies. We have reviewed the structural compositions of different CRISPR Cas13 members and optimization strategies for the Cas13 reaction system, including guiding RNA (gRNA) design, integration of nanomaterials, electrochemical sensors, and microfluidic chips. By examining Cas13 applications in both <em>in vivo</em> and <em>in vitro</em> tumor detection, we delve into the innovative and practical potential of these approaches and highlight their promise as transformative tools in cancer diagnostics.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118411"},"PeriodicalIF":12.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocellulose functional materials for advanced adsorption and removal of emerging Contaminants: Green strategies and analytical perspectives","authors":"Yan Liu ,&nbsp;Miao He ,&nbsp;Luyao Zhao ,&nbsp;Charles Q. Jia ,&nbsp;Donald W. Kirk ,&nbsp;Dianwei Zhang ,&nbsp;Huilin Liu ,&nbsp;Baoguo Sun","doi":"10.1016/j.trac.2025.118424","DOIUrl":"10.1016/j.trac.2025.118424","url":null,"abstract":"<div><div>The proliferation of emerging contaminants (ECs) from intensified industrial and social activities poses significant threats to global ecosystems and public health. In response to this worldwide challenge, cellulose-based functional materials are gaining traction. Their unique biocompatibility and tunable functionality position them as a crucial link between sustainable development and the circular economy. Strategically hybridizing cellulose with next-generation nanomaterials (carbon nanomaterials, MXene, metal organic frameworks, and covalent organic frameworks) is driving innovation toward sustainable, cost-effective, and low-carbon solutions for ECs detection, capture, and removal. This review systematically investigates cellulose composites for ECs management, covering cellulose synthesis, functionalization strategies, and mechanisms of ECs analysis and removal. Finally, we critically evaluate persistent challenges pertaining to limitation of materials, scalable manufacturing, and the balance between durability and controlled degradation, while proposing strategic research directions for future intelligent monitoring and remediation systems.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"192 ","pages":"Article 118424"},"PeriodicalIF":12.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in epitope-imprinted polymers for disease diagnosis and treatment","authors":"Rongrong Xing ,&nbsp;Huiqin Chai ,&nbsp;Bin Liu ,&nbsp;Runqin Wang ,&nbsp;Shuang Hu","doi":"10.1016/j.trac.2025.118423","DOIUrl":"10.1016/j.trac.2025.118423","url":null,"abstract":"<div><div>Molecularly imprinted polymers face challenges in protein imprinting due to the scarcity and instability of protein templates. Epitope-imprinted polymers (EIPs) address these limitations by employing short peptide epitopes as templates, thereby enabling the precise and efficient recognition of target proteins. With these advantages, EIPs have demonstrated promising potential in disease diagnosis and treatment, attracting substantial research attention in recent years. This review summarizes the latest progress in EIP applications across these domains. First, we categorize epitope imprinting strategies based on the number and structural features of epitope templates. Subsequently, in the context of disease diagnosis, we systematically evaluate the applications of EIPs in cancer, cardiovascular diseases, infectious diseases, and immune diseases. For disease treatment, we introduce the roles of EIPs in signal pathway regulation, enzyme activity regulation, drug delivery, and photothermal therapy. Finally, we briefly discuss current challenges and future perspectives for EIPs in advancing disease diagnosis and treatment.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118423"},"PeriodicalIF":12.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interdiscipline rendezvous of aptamers and radionuclides: Advances, challenges and prospects","authors":"Liping Zhao ,&nbsp;Yi Zhao ,&nbsp;Linsen Li ,&nbsp;Xianyu Zhu ,&nbsp;Ruixue Liu ,&nbsp;Qi Sun ,&nbsp;Ge Yang ,&nbsp;Jigang Yang ,&nbsp;Feng Qu","doi":"10.1016/j.trac.2025.118421","DOIUrl":"10.1016/j.trac.2025.118421","url":null,"abstract":"<div><div>Aptamers have emerged as versatile tools in biomedical applications spanning biosensing, medical imaging, and therapeutic interventions. Radionuclides as the therapeutic and diagnostic agents, with simple molecular structures and good safety profile, represent one of the most mature theranostics technologies. Under the overarching trend of interdisciplinary and cross-integrated research, radionuclide-labeled aptamers have garnered significant scientific interest as dual-functional agents offering precise diagnostic and therapeutic potential. In this review, the latest progresses of aptamer selection and the different modification strategies for aptamer performance enhancement for <em>in vivo</em> applications are summarized. Radionuclides, strategies for aptamer radiolabeling, and their applications in disease diagnosis, treatment, and pharmacokinetic studies are emphasized. Although there are still obstacles of radiolabeled aptamers for clinical translation, we envision that more precise and efficient molecular drugs and tools will be developed in the near future against the backdrop of cross-collaboration between the two major fields of nucleic acid aptamers and radionuclides.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"192 ","pages":"Article 118421"},"PeriodicalIF":12.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular imprinting using biopolymers as building Blocks: Sustainable and biocompatible metamaterials for smart recognition and selective biointerfaces","authors":"Todd Cowen ,&nbsp;Devid Maniglio ,&nbsp;Alessandra Maria Bossi","doi":"10.1016/j.trac.2025.118422","DOIUrl":"10.1016/j.trac.2025.118422","url":null,"abstract":"<div><div>The present review provides a comprehensive analysis of the development and application of molecularly imprinted polymers (MIPs) derived from natural biopolymers, covering literature from the early 1980s onward. The discussion is organized based on the chemical nature of the biopolymers utilized, covering glucans, chitosan, alginates, proteins, and nucleic acids. Each section offers a description of the respective biopolymer, reports synthetic approaches and applications, and attempt a critical evaluation of its effectiveness in molecular imprinting. The use of biopolymers in MIP technology is a promising approach for producing highly selective and sustainable recognition systems. The review underscores the potential of biopolymer-based MIPs in advancing molecular imprinting technology and their impactful contributions to future applications.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"193 ","pages":"Article 118422"},"PeriodicalIF":12.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}