Trends in Analytical Chemistry最新文献_第5页

Development of chamber-based digital polymerase chain reaction: From chip to device 基于腔室的数字聚合酶链反应的发展：从芯片到设备

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-13 DOI: 10.1016/j.trac.2025.118299

Jizhi Tong , Fangfang Yin , Mengda Liang , Wen Zong , Yu Wang , Duo Xiao , Juxin Yin , Ying Mu

引用次数: 0

Engineering CRISPR/Cas12-based biosensors: Recent advances and future perspectives 基于CRISPR/ cas12的生物传感器工程：最新进展和未来展望

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Trends in Analytical Chemistry Pub Date : 2025-05-13 DOI: 10.1016/j.trac.2025.118296

Lijuan Yin , Caihong Zhou , Baoxue Gao , Fufeng Liu , Long Ma , Fei Guo

{"title":"Engineering CRISPR/Cas12-based biosensors: Recent advances and future perspectives","authors":"Lijuan Yin , Caihong Zhou , Baoxue Gao , Fufeng Liu , Long Ma , Fei Guo","doi":"10.1016/j.trac.2025.118296","DOIUrl":"10.1016/j.trac.2025.118296","url":null,"abstract":"<div><div>Rapid, sensitive, and accurate biosensing is instrumental for clinical diagnostics, food safety, and environmental monitoring. The CRISPR/Cas12 system has emerged as a robust biosensing tool, leveraging its biocompatibility, distinctive cleavage activity, and user-friendly design. In recent years, numerous CRISPR/Cas-based biosensing strategies have been developed to enhance detection sensitivity, specificity, and portability, significantly advanced the molecular diagnostics field. This review systematically discusses recent advances in various engineering strategies aimed at improving the performance of CRISPR/Cas12-based biosensors, with emphasis on their practical applications. Specifically, progresses are highlighted in optimizing Cas effector proteins, CRISPR RNAs, and reaction buffer formulations. Diverse signal output methodologies are compared including fluorescence, colorimetry, electrochemical sensing, surface-enhanced Raman spectroscopy, and deep-learning-assisted detection techniques. Finally, challenges and future prospectives of CRISPR/Cas12-based biosensing technologies are discussed to help the development of optimal biosensing tools.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118296"},"PeriodicalIF":11.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Spatial metabolomics boost understanding the molecular targets and pathways of active components of traditional Chinese medicine in situ and in vivo 空间代谢组学有助于了解中药活性成分在体内和体内的分子靶点和途径

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-13 DOI: 10.1016/j.trac.2025.118288

Kunshuang Shen , Le Yang , Hui Sun , Ye Sun , Guangli Yan , Ying Han , Xijun Wang

{"title":"Spatial metabolomics boost understanding the molecular targets and pathways of active components of traditional Chinese medicine in situ and in vivo","authors":"Kunshuang Shen , Le Yang , Hui Sun , Ye Sun , Guangli Yan , Ying Han , Xijun Wang","doi":"10.1016/j.trac.2025.118288","DOIUrl":"10.1016/j.trac.2025.118288","url":null,"abstract":"<div><div>Traditional Chinese medicine (TCM), despite its therapeutic potential, faces challenges in mechanistic validation due to phytochemical complexity. Recent advances in spatial metabolomics, leveraging high-resolution mass spectrometry imaging (MSI), have provided exceptional spatial resolution and molecular specificity. This label-free technique enables the <em>in situ</em> spatial mapping of molecular production and localization, providing profound insights into the metabolic heterogeneity and mechanisms of TCM's active components. This review comprehensively explores the applications of spatial metabolomics in TCM research, focusing on biosynthesis, spatial distribution, pharmacodynamic mechanisms, safety evaluations, and pharmacokinetics. It also underscores the technological advancements and methodological improvements in spatial metabolomics in terms of sensitivity, spatial resolution, multimodal integration, and artificial intelligence (AI)-driven analytics. These applications reveal the spatial distribution and molecular targets of bioactive components, fostering TCM's broader acceptance in global healthcare systems.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118288"},"PeriodicalIF":11.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advancing cancer diagnosis through surface plasmon resonance detection of extracellular vesicles 通过细胞外囊泡表面等离子体共振检测推进癌症诊断

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-12 DOI: 10.1016/j.trac.2025.118298

Ziyang Zhou, Qiaoqiao Tang, Bo Yao, Guangzhong Ma

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Smart analytical chemistry: Integrating green, sustainable, white and AI-driven approaches in modern analysis 智能分析化学：在现代分析中整合绿色、可持续、白色和人工智能驱动的方法

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-11 DOI: 10.1016/j.trac.2025.118295

Chaudhery Mustansar Hussain , Ghazanfar Hussain , Rüstem Keçili

{"title":"Smart analytical chemistry: Integrating green, sustainable, white and AI-driven approaches in modern analysis","authors":"Chaudhery Mustansar Hussain , Ghazanfar Hussain , Rüstem Keçili","doi":"10.1016/j.trac.2025.118295","DOIUrl":"10.1016/j.trac.2025.118295","url":null,"abstract":"<div><div>Smart Analytical Chemistry is an emerging and powerful multidisciplinary approach which combines the key features and principles of Green Analytical Chemistry, Sustainable Analytical Chemistry as well as White Analytical Chemistry together with number of emerging technologies including artificial intelligence, automation and miniaturized platforms. This review paper presents how Smart Analytical Chemistry transforms conventional analytical techniques and processes into smart, sustainable, effective, sensitive, portable and powerful platforms which are appropriate for modern scientific and industrial needs. By integrating eco-friendly and sustainable practices with the help of advanced data-driven approaches, Smart Analytical Chemistry provides significant enhancements in analytical performance, decreases resource and energy consumption and also promotes sustainability across diverse application fields of science (i.e. environmental monitoring, food safety, biomedical diagnostic platforms and forensic science). This paper also presents the current drawbacks and challenges related to scalability, ethical considerations, regulatory compliance as well as interdisciplinary collaboration.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118295"},"PeriodicalIF":11.8,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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CRISPR-enabled genetic logic circuits for biosensing 用于生物传感的crispr基因逻辑电路

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-11 DOI: 10.1016/j.trac.2025.118297

Xiyan Wang , Yuanli Gao , Nan Zhou , Zhugen Yang , Jonathan M. Cooper , Baojun Wang

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Various eco-friendly and green approaches in thin film microextraction techniques for sample analysis – a review 各种环保和绿色的薄膜微萃取技术在样品分析中的应用综述

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-10 DOI: 10.1016/j.trac.2025.118292

Wajid Ali Khan , Muhammad Balal Arain , Suniya Shahzad , Mustafa Soylak

{"title":"Various eco-friendly and green approaches in thin film microextraction techniques for sample analysis – a review","authors":"Wajid Ali Khan , Muhammad Balal Arain , Suniya Shahzad , Mustafa Soylak","doi":"10.1016/j.trac.2025.118292","DOIUrl":"10.1016/j.trac.2025.118292","url":null,"abstract":"<div><div>Thin film microextraction (TFME) has received much attention because of its high surface area to volume ratio in the extraction phase, short extraction time, high adsorption ability, and minimal solvent use. Thin film microextraction is used for preconcentration of a wide range of analytes in different matrices, including pharmaceutical, pesticide, food, biological, and environmental. The extraction phase is extremely important among the various influencing parameters in TFME. The use of an effective green extraction phase in TFME improves extraction performance. This review briefly evaluates various green approaches in the TFME technique, including ionic liquid-based, deep eutectic solvent-based, biopolymer-based, and biochar-based extraction phases. The discussed approaches were more green and effective than traditional TFME because of the sorbents' relative biodegradability, sustainability, cost-effectiveness, and environmental friendliness. Each TFME approach has been discussed in light of recent research in order to explore its benefits fully.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118292"},"PeriodicalIF":11.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances on constructing functional reticular materials for efficient determination of radionuclides

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-09 DOI: 10.1016/j.trac.2025.118294

Yuan-Jun Tong , Xinying Gong , Dongmei Wang , Lu-Dan Yu , Zhengjun Gong

{"title":"Advances on constructing functional reticular materials for efficient determination of radionuclides","authors":"Yuan-Jun Tong , Xinying Gong , Dongmei Wang , Lu-Dan Yu , Zhengjun Gong","doi":"10.1016/j.trac.2025.118294","DOIUrl":"10.1016/j.trac.2025.118294","url":null,"abstract":"<div><div>The accurate and rapid determination of radionuclides has become an imperative requirement in environmental monitoring and nuclear safety management, driven by their chemical and radiotoxic threats to ecosystems. Luminescent reticular materials have emerged as promising sensing platforms owing to their ordered porous architectures and precisely tailorable host-guest interaction dynamics. Nevertheless, unmodified reticular frameworks frequently suffer from insufficient recognition specificity toward target radionuclides, resulting in compromised detection sensitivity and selectivity. To address these limitations, intensive research efforts have been dedicated to engineering functionalized reticular systems through rational design principles. This review systematically examines cutting-edge strategies for constructing high-performance luminescent materials, commencing with an analysis of radionuclide contamination mechanisms and the fundamental advantages of reticular scaffolds in photoluminescent sensing applications. Subsequently, we critically evaluate three predominant functionalization methodologies of ligand tailoring, post-synthetic modification and blending method. Throughout the discussion, we emphasize the structure-performance correlations in achieving selective recognition and environmental stability enhancement.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"190 ","pages":"Article 118294"},"PeriodicalIF":11.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advances in graphene quantum dots: Chemistry of synthesis, surface modifications, and improved properties for biomedical applications 石墨烯量子点的最新进展：合成化学、表面修饰和生物医学应用性能的改进

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-09 DOI: 10.1016/j.trac.2025.118293

Soumyanti Panda , K.S. Shalini Devi , Seiya Tsujimura , Saroj Kumar , Jaroon Jakmunee , Jai Prakash

{"title":"Recent advances in graphene quantum dots: Chemistry of synthesis, surface modifications, and improved properties for biomedical applications","authors":"Soumyanti Panda , K.S. Shalini Devi , Seiya Tsujimura , Saroj Kumar , Jaroon Jakmunee , Jai Prakash","doi":"10.1016/j.trac.2025.118293","DOIUrl":"10.1016/j.trac.2025.118293","url":null,"abstract":"<div><div>Graphene quantum dots (GQDs) emerged as a focal point of researchers owing to their expceptional properties such as quantum confinement, pronounced edge effect, inherent biocompatibility, minimal toxicity, tunable photoluminescence, and excellent dispersibility. These properties make them highly suitable for a range of applications including promising biomedical applications, allowing for the exploration of biological processes at the cellular level. In this review, the recent advances in the synthesis of GQDs encompassing both top-down and bottom-up approaches have been discussed such as hydrothermal, microwave, electrochemical, ultrasonic, pyrolysis etc. along with green synthesis method with emphasis on how to improve their properties for biomedical applications. Various synthesis parameters and their optimizations of good biocompatible GQDs along with various surface modifications and other physio-chemical properties have been discussed in detail with their biomedical applications. Thereafter, review focuses on recent advances in biomedical applications using GQDs such as biosensing, bioimaging, drug delivery, tissue engineering, photothermal/photodynamic therapy etc. with emphasis on mechanism of action of GQDs. Eventually, the review delves into the multifaceted challenges associated with the integration of GQDs into biomedical applications.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118293"},"PeriodicalIF":11.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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On the road to automation: a comparative review on chemometric strategies for GC-MS data analysis 在自动化的道路上：气相色谱-质谱数据分析化学计量策略的比较综述

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2025-05-09 DOI: 10.1016/j.trac.2025.118286

Agnieszka Smolinska , Samuele Pellacani , Michal Skawinski , Caterina Durante

引用次数: 0