Trends in Analytical Chemistry最新文献

{"title":"Laser-induced breakdown spectroscopy (LIBS) in biomedical analysis","authors":"Rongling Zhang ,&nbsp;Shunfan Hu ,&nbsp;Changfei Ma ,&nbsp;Tianlong Zhang ,&nbsp;Hua Li","doi":"10.1016/j.trac.2024.117992","DOIUrl":"10.1016/j.trac.2024.117992","url":null,"abstract":"<div><div>The subtle changes in elements within a biological system can directly impact metabolism and physiological processes. Rapid and accurate analysis of elements in the body is essential for clinical disease diagnosis. Laser-induced breakdown spectroscopy (LIBS) has been widely used because it is rapid, in-situ, and micro-damage. This review summarizes the research status of LIBS in biomedical analysis in 2017–2024. The basic research of LIBS is introduced initially. Based on the different research subjects, biomedical applications of LIBS are divided into three categories, namely, microorganisms, biological tissues, and medicinal plants. LIBS plays a crucial role in enhancing the accuracy of pathogen identification in microorganisms. In biological tissues, it reveals elemental compositions that are vital for physiological analysis and pathological diagnosis. For medicinal plants, it focuses on the detection of heavy metals and adulteration to ensure safety and authenticity of medicines. Finally, the future prospects of LIBS in biomedicine are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 117992"},"PeriodicalIF":11.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in nanomaterials based electrochemical sensors for rapid detection of food additives: A comprehensive review","authors":"Harish Kumar ,&nbsp;Rajni Kumari ,&nbsp;Devender Singh ,&nbsp;Bindu Mangla","doi":"10.1016/j.trac.2024.118011","DOIUrl":"10.1016/j.trac.2024.118011","url":null,"abstract":"<div><div>Foodborne illness caused by additives and toxins like nitrites, Vannilin, Atrazine, Nitronezene, etc., poses a significant risk to the food industry. To address public health concerns, it is essential to have a safe, cost-effective, efficient, and rapid method for analyzing food additives and contaminants. During the last decade, the application of nanotechnology-derived materials in developing electrochemical sensors has significantly increased. Nanoparticles and nanostructures have played a vital role in nanotechnology-based sensing approaches to enhance sensitivity and selectivity, improve sample preparation, create innovative designs, and increase portability. This review highlights the recent advancements in the design, fabrication, and characterization of the most common categories of electrochemical sensing materials. These include graphene-based materials, metal nanoparticles, metal oxide nanocomposites, and conducting polymer nanocomposites, all focused on enhancing food safety evaluation. The discussion on the interaction and synergistic effects of metal oxide/graphene/conducting polymer-based nanocomposites, along with the analytical performance of modified sensors is the salient feature. It covers the current standards for the development of sensitive, cost-effective, and compact nanomaterial-based electrochemical sensors for rapid evaluation of food/beverage safety and quality control, as well as the challenges associated with practical implementation.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118011"},"PeriodicalIF":11.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative and cutting-edge approaches in microfluidic paper-based analytical devices for detection of food adulteration","authors":"Waleed Alahmad ,&nbsp;Ahmet Cetinkaya ,&nbsp;S. Irem Kaya ,&nbsp;Sibel A. Ozkan","doi":"10.1016/j.trac.2024.118012","DOIUrl":"10.1016/j.trac.2024.118012","url":null,"abstract":"<div><div>Food adulterants are substances added to food products to improve their weight and appearance and reduce costs. However, the use of these substances deteriorates the quality of food products and results in a decrease in nutritional value. For this reason, situations that negatively affect the health of consumers occur. Microfluidic paper-based analytical devices (μPADs) have gained popularity as miniaturized, portable, highly sensitive, accurate, and affordable detection platforms. μPADs are preferred as advantageous platforms for the determination of food adulterants in foods, thanks to their on-site analysis and simultaneous determination of multiple analytes features. Therefore, μPADs provide fast and reliable results in food safety. In this review, the selection of paper and method for the fabrication of μPADs, as well as the determination of the signal readout mode, are briefly mentioned. In addition, the sample preparation process before the use of PADs is also mentioned. The most current applications of μPADs in determining food adulteration are applied sample, method, linear range, LOD, etc., evaluated in terms of parameters. This review also sheds light on commercial practices by discussing the most prominent studies in the last three years.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118012"},"PeriodicalIF":11.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in exponential amplification reaction-enabled biosensors","authors":"Wentao Zhao ,&nbsp;Fengli Su ,&nbsp;Shulin Wang ,&nbsp;Yujie Ma ,&nbsp;Bingzhi Li ,&nbsp;Xing Zhang","doi":"10.1016/j.trac.2024.118006","DOIUrl":"10.1016/j.trac.2024.118006","url":null,"abstract":"<div><div>Exponential amplification reaction (EXPAR) is a synthetic biological circuit that can rapidly amplify short nucleic acid strands in an isothermal and exponential manner. EXPAR-enabled biosensors, developed through the integration of aptamers, nanomaterials, antibodies, and programmable nucleases, are widely applied in detecting both nucleic acid and non-nucleic acid targets critical in medical, environmental, and agricultural domains. This review summarizes recent advances in understanding and suppressing non-specific amplification in EXPAR, which is the most significant issue hampering the performance improvement of EXPAR-enabled biosensors. Subsequently, we introduce the application of EXPAR-enabled biosensors in detecting a broad range of analytes, with an emphasis on the strategies and their relevance to performance enhancement. Additionally, the trends in this area and the solutions associated with their challenges are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118006"},"PeriodicalIF":11.8,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142438232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microextraction techniques for antibiotics surveillance in the food chain and environment","authors":"Joanna Antos ,&nbsp;Laura García-Cansino ,&nbsp;María Ángeles García ,&nbsp;Dobrochna Ginter-Kramarczyk ,&nbsp;María Luisa Marina ,&nbsp;Joanna Zembrzuska ,&nbsp;José Sousa Câmara ,&nbsp;Jorge A.M. Pereira","doi":"10.1016/j.trac.2024.118009","DOIUrl":"10.1016/j.trac.2024.118009","url":null,"abstract":"<div><div>Antibiotics are commonly used to prevent and treat infections in human medicine, animal farming, and aquaculture. However, their excessive use can result in the development of antibiotic resistance and the presence of antibiotic residues in the food and environment. Therefore, it is essential to monitor antibiotic use and assess resistance, but the lack of standardisation and long-term quantitative data on antibiotic usage in different animal species is very challenging. Sample preparation techniques, such as solid-phase extraction (SPE) and liquid-liquid extraction (LLE), have been widely used, but they have limitations, including the need for large sample volumes, organic solvents, and complex and labourious protocols. Microextraction techniques (μExT) that align with the principles of Green Analytical Chemistry have gained attention in recent decades. Depending on the type of μExT used and the target analytes, the amounts of solvents, reagents, and samples used can be reduced by up to ten times or more. Often, the extraction time is also shortened by several orders of magnitude, labware requirements are much lower, and the analytical hardware can be simplified without compromising acceptable analytical performance. Notably, this includes the substitution of expensive LC-MS configurations with LC-UV or FLR cheaper equipment and detection systems. Greener solvents, such as ionic liquids (IL), supramolecular solvents (SUPRAS), and deep eutectic solvents (DES), have also been reported, further contributing to the development of more sustainable and environmentally friendly antibiotic extraction and analytical procedures. The AGREE tool metrics shows that substitution of conventional extraction approaches with μExT enables a greener profile for any methodology developed to analyse antibiotics in different food and environmental samples. This article provides a detailed overview of the advantages of using different μExT to monitor antibiotic usage in the food industry and environment and discusses the challenges and opportunities in this field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118009"},"PeriodicalIF":11.8,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and opportunities in the development of planar potentiometric sensors for point-of-care analysis","authors":"Eliza J. Herrero,&nbsp;Philippe Bühlmann","doi":"10.1016/j.trac.2024.118002","DOIUrl":"10.1016/j.trac.2024.118002","url":null,"abstract":"<div><div>Despite decades of interest in the development of electrochemical point-of-care sensors, commercial applications are still hindered by unfulfilled needs. This review analyzes work in the field of miniaturized potentiometric devices, with a particular emphasis on reports from the past ten years. Research in this field has focused in particular on the types of underlying substrates to support these sensors, the degree to which sensing components are integrated into the substrate, the use of solid-contact materials to improve performance, and testing in real-life applications. This article highlights challenges in the design and performance of potentiometric point-of-care sensors that are preventing their wider use. Following an overview of differences in the layout of strip-type, sandwich-type, fully integrated, and fiber- and yarn-based sensors, the discussion focuses on the effects of materials and substrates on response slopes, potential reproducibility, and limits of detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118002"},"PeriodicalIF":11.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of NMR in heparin and low molecular weight heparins","authors":"Yiwen Xu,&nbsp;Yadan Wang,&nbsp;Feiyu Gao,&nbsp;Qing Wang,&nbsp;Huiying Yang,&nbsp;Huimin Sun,&nbsp;Yong Lu,&nbsp;Xianfu Wu","doi":"10.1016/j.trac.2024.118010","DOIUrl":"10.1016/j.trac.2024.118010","url":null,"abstract":"<div><div>Nuclear magnetic resonance (NMR) is a powerful tool for qualitative and quantitative analysis in the pharmaceutical field. Animal-derived heparin and low molecular weight heparins (LMWHs) are mixtures of polysaccharides widely used as anticoagulants. In this review, studies mainly regarding the application of NMR in heparin and LMWHs in recent years are grouped and discussed. The first part presents an overview of the NMR applications in identification of heparin and LMWHs. Our team participated in the drafting of three LMWHs monographs (enoxaparin, nadroparin and dalteparin), including NMR as identification method, which may promote the revision of the 2025 edition of the Chinese Pharmacopeia. The second part presents the quantification of heparin and LMWHs by NMR. The third part describes the application of NMR combination with multivariate analysis in the distinguishment of different animal origins of heparin, the distinguishment of heparin from different manufacturers, and the determination of the average molecular weight of heparin. The fourth part deals with the determination of the binding interface of the heparin-protein complex by NMR. With the global epidemic COVID-19, proper clinical use of heparin and LMWHs have contributed to reducing the spread and mortality of COVID-19. The fifth part presents the NMR application in the study of the role of heparin in the prevention and treatment of COVID-19. The sixth part reports some examples of NMR applications in heparin-related drug development. Our review has shown that NMR is a versatile tool that not only provides holistic quality control of heparin and LMWHs but is also a promising tool that provides numerous valuable information for potential use. The discussed approaches are recommended to be implemented during the development, production, and quality control process of heparin and LMWHs.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118010"},"PeriodicalIF":11.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current materials applied in analytical extraction techniques for the determination of bioactive compounds and chemical contaminants in wine: Recent advances and future trends","authors":"Marina Pereira-Coelho ,&nbsp;Isabel Cristina da Silva Haas ,&nbsp;Luciano Vitali ,&nbsp;Luiz Augusto dos Santos Madureira","doi":"10.1016/j.trac.2024.118008","DOIUrl":"10.1016/j.trac.2024.118008","url":null,"abstract":"<div><div>Wine is a globally appreciated beverage with a remarkably complex chemical composition, including sugars, organic acids, minerals, aromatic compounds, and polyphenols that contribute to the diversity of flavors in wines. Furthermore, it is essential to consider the presence of contaminants such as pesticides, and biogenic amines, among others, which can compromise the safety and authenticity of the wine. Concern for the quality and safety of wines has led analytical chemists to develop advanced sample preparation methods, aligned with green chemistry criteria. The development of materials for the extraction of a wide range of organic compounds in wine is essential to advance the quality and efficiency of analyses, providing greater sensitivity, selectivity, and accuracy in the detection of target compounds. This review offers an updated and comprehensive overview of innovative materials and solid supports, highlighting their applicability and benefits in the analysis of organic compounds, including bioactive compounds and chemical contaminants in wine.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118008"},"PeriodicalIF":11.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of green chemistry in reversed-phase liquid chromatography: A review of sustainable solvents","authors":"Oktawia Kalisz ,&nbsp;Marek Tobiszewski ,&nbsp;Alicja Nowaczyk ,&nbsp;Szymon Bocian","doi":"10.1016/j.trac.2024.118007","DOIUrl":"10.1016/j.trac.2024.118007","url":null,"abstract":"<div><div>This article delves into the growing field of green analytical chemistry, focusing on sustainable solvents for reversed-phase liquid chromatography (RP LC). RP LC is a widely applied technique in the pharmaceutical, food, and environmental analysis industries, consuming vast quantities of toxic and non-renewable solvents that pose serious environmental and health risks. In response to the urgent need for greener alternatives, this review discusses organic solvents such as ethanol, innovative options such as Cyrene and dimethyl carbonate, and surfactants in micellar liquid chromatography (MLC). In addition, the potential of pure water, ionic liquids (ILs), and deep eutectic solvents (DESs) was evaluated. By analyzing the efficacy, environmental impact, and feasibility of green solvents, the review highlights their potential to replace conventional solvents, supporting safer and more sustainable analytical practices. This comprehensive and critical analysis of recent reports aims to guide future research and promote the use of green solvents in RP LC.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118007"},"PeriodicalIF":11.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-induced breakdown spectroscopy in space applications: Review and prospects","authors":"H. Saeidfirozeh ,&nbsp;P. Kubelík ,&nbsp;V. Laitl ,&nbsp;A. Křivková ,&nbsp;J. Vrábel ,&nbsp;K. Rammelkamp ,&nbsp;S. Schröder ,&nbsp;I.B. Gornushkin ,&nbsp;E. Képeš ,&nbsp;J. Žabka ,&nbsp;M. Ferus ,&nbsp;P. Pořízka ,&nbsp;J. Kaiser","doi":"10.1016/j.trac.2024.117991","DOIUrl":"10.1016/j.trac.2024.117991","url":null,"abstract":"<div><div>This review describes the principles and summarizes the challenges of analytical methods based on optical emission spectroscopy (OES) in space applications, with a particular focus on Laser-Induced Breakdown Spectroscopy (LIBS). Over the past decade, LIBS has emerged as a powerful analytical technique for space exploration and In-Situ Resource Utilization (ISRU) of celestial bodies. Its implementation has been suggested for various segments of the Space Resources Value Chain, including prospecting, mining, and beneficiation. Current missions to Mars, including the ChemCam instrument on the Curiosity rover, the SuperCam on the Perseverance rover, and the MarSCoDe on the Zhurong rover, are considered flagship applications of LIBS. Despite neither the Pragyan rover nor the Vikram lander waking from the lunar night, the success of the Chandrayaan-3 mission marks another milestone in the development of LIBS instruments, with further missions, including commercial ones, anticipated.</div><div>This paper reviews the deployment of LIBS payloads on Mars rovers, upcoming missions prospecting the Moon and asteroids, and LIBS analysis of meteorites. Additionally, it highlights the importance of data processing specific to space applications, emphasizing recent trends in transfer learning. Furthermore, LIBS combined with other spectroscopic techniques (e.g., Raman Spectroscopy, Mass Spectrometry, and Fourier-Transform Infrared Spectroscopy) represents an intriguing platform with comprehensive analytical capabilities. The review concludes by emphasizing the significance of LIBS-based contributions in advancing our understanding of celestial bodies and paving the way for future space exploration endeavors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 117991"},"PeriodicalIF":11.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}