发布求助
文献互助 智能选刊 最新文献

Trends in Analytical Chemistry最新文献

筛选
英文 中文
Microneedle wearables in advanced microsystems: Unlocking next-generation biosensing with AI
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-27 DOI: 10.1016/j.trac.2025.118208
Ghazala Ashraf , Khalil Ahmed , Ayesha Aziz , Muhammad Asif , Jilie Kong , Xueen Fang
{"title":"Microneedle wearables in advanced microsystems: Unlocking next-generation biosensing with AI","authors":"Ghazala Ashraf ,&nbsp;Khalil Ahmed ,&nbsp;Ayesha Aziz ,&nbsp;Muhammad Asif ,&nbsp;Jilie Kong ,&nbsp;Xueen Fang","doi":"10.1016/j.trac.2025.118208","DOIUrl":"10.1016/j.trac.2025.118208","url":null,"abstract":"<div><div>Wearable electronics have transformed health monitoring, but the non-invasive, real-time extraction of biomarkers from interstitial fluid (ISF) remains a complex challenge. Microneedle (MN) technologies, integrated with bioelectronics and artificial intelligence (AI), provide a promising solution for continuous health monitoring and personalized therapy. This review explores the design of MN platforms and key sampling mediums, highlighting their role in advanced biosensing applications. It delves into conventional and emerging sensing modalities detailing their integration strategies. Additionally, MN-based assays for biomarkers including glucose, lactate, pH, electrolytes, nucleic acids, and proteins are examined, emphasizing their potential in early disease diagnostics. The review highlights key challenges in the clinical translation of MN-based devices and the integration of AI for improved biomarker calibration. Emerging materials and AI-driven MN platforms show promise for advancing personalized, real-time diagnostics and therapies. However, overcoming issues with ISF biomarker variability, data reliability, and scalability is crucial for their broader clinical adoption.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118208"},"PeriodicalIF":11.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in chemiresistive gas sensor for acetone detection: Focus on room temperature
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-27 DOI: 10.1016/j.trac.2025.118213
Lu Zhang , Mingyue Zhou , Fanxing Meng , Jinyu Bai , Dong Wang , Mingcong Tang , Zhaofeng Wu
{"title":"Recent advances in chemiresistive gas sensor for acetone detection: Focus on room temperature","authors":"Lu Zhang ,&nbsp;Mingyue Zhou ,&nbsp;Fanxing Meng ,&nbsp;Jinyu Bai ,&nbsp;Dong Wang ,&nbsp;Mingcong Tang ,&nbsp;Zhaofeng Wu","doi":"10.1016/j.trac.2025.118213","DOIUrl":"10.1016/j.trac.2025.118213","url":null,"abstract":"<div><div>Acetone is a harmful volatile organic compound and a key biomarker for metabolic health. Room temperature (RT) gas sensors have the characteristics of low power consumption, high safety, and easy integration, making them an ideal choice for building non-invasive acetone monitoring. With AI and Internet of Things advancements, RT acetone sensors, especially those with miniaturized and wearable features, are expected to gain significant future interest. This review systematically summarizes the possible sensing mechanisms (oxygen species adsorption, direct electron transfer and electron scattering effects) and internal/external influencing factors of acetone sensors at RT. The different types of materials for RT acetone detection are classified. Besides, the state-of-the-art portable/wearable sensing devices for RT acetone detection are presented. Finally, the challenges that must be solved in the move to the continuous development of RT gas sensors are clearly discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118213"},"PeriodicalIF":11.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergizing Machine Learning and fluorescent biomolecules: A new era in sensing platforms
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-27 DOI: 10.1016/j.trac.2025.118196
Navjot Saini , Kriti , Ankita Thakur , Sanjeev Saini , Navneet Kaur , Narinder Singh
{"title":"Synergizing Machine Learning and fluorescent biomolecules: A new era in sensing platforms","authors":"Navjot Saini ,&nbsp;Kriti ,&nbsp;Ankita Thakur ,&nbsp;Sanjeev Saini ,&nbsp;Navneet Kaur ,&nbsp;Narinder Singh","doi":"10.1016/j.trac.2025.118196","DOIUrl":"10.1016/j.trac.2025.118196","url":null,"abstract":"<div><div>Machine Learning (ML) algorithms offer significant advantages over traditional methods, enabling the identification of complex correlations and hidden patterns within data, which enhances efficiency, reduces costs, and improves decision-making. This article provides a comprehensive overview of recent advances in ML-assisted fluorescent peptide and protein-based sensors. Notably, a supervised ML-assisted peptide-based sensor has been developed for the identification of water-soluble polymers, improving environmental and industrial monitoring. ML-assisted sulfonamido-oxine (SOX)-labeled peptides facilitate the quantitation of mitogen-activated protein kinases, advancing sensitive biomarker analysis. An array-based detection system using green fluorescent protein conjugates enables high-throughput protein screening. A deep learning (DL)-assisted fluorophore-labeled peptide sensor array shows promise for non-invasive breast cancer diagnosis with high accuracy. Additionally, a ML-aided sensor array combining antimicrobial peptides and fluorescent proteins enables the discrimination of top clinical isolates, enhancing antimicrobial resistance diagnostics. These innovations in peptide sensor design and ML integration highlight their transformative impact in biological research, disease diagnostics, and environmental monitoring, offering improved sensitivity, selectivity, and performance. This review provides valuable insights for researchers and practitioners in the field of fluorescence-based sensing, ML, and their interdisciplinary applications.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118196"},"PeriodicalIF":11.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenolic compounds detection and quantification in whole grains: A comprehensive review of recent advancements in analytical methods
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-26 DOI: 10.1016/j.trac.2025.118215
Huanhuan Li , Xorlali Nunekpeku , Selorm Yao-Say Solomon Adade , Wei Sheng , Bridget Ama Kwadzokpui , Efakor Beloved Ahlivia , Quansheng Chen
{"title":"Phenolic compounds detection and quantification in whole grains: A comprehensive review of recent advancements in analytical methods","authors":"Huanhuan Li ,&nbsp;Xorlali Nunekpeku ,&nbsp;Selorm Yao-Say Solomon Adade ,&nbsp;Wei Sheng ,&nbsp;Bridget Ama Kwadzokpui ,&nbsp;Efakor Beloved Ahlivia ,&nbsp;Quansheng Chen","doi":"10.1016/j.trac.2025.118215","DOIUrl":"10.1016/j.trac.2025.118215","url":null,"abstract":"<div><div>Phenolic compounds are the most abundant antioxidants in the daily diet and are extensively distributed in plants and plant-derived food sources, including whole grains. Over the past decades, there has been a growing scientific focus on their diverse contributions to human health, given their array of bioactivities encompassing antioxidant, anti-inflammatory, anti-cancer, neuroprotective properties, among others. Hence, the quantification and examination of these compounds stand as fundamental basis of natural product exploration. Many efforts have been undertaken to provide highly sensitive and selective analytical approaches for their identification and characterization. To furnish novel perspectives for future advancement, the present review describes and discusses recent advancements in analytical methodologies for phenolic compound analysis in whole grains, spanning from traditional solvent-based to more robust modern and green extraction methodologies, spectrophotometry, and chromatography, non-destructive spectroscopic methods, and emergent technologies such as biosensors, while exploring into their current challenges and future prospects.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118215"},"PeriodicalIF":11.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-26 DOI: 10.1016/j.trac.2025.118212
Tao Bo , Feng Yang , Bo Yan , David A. Michels , Tiemin Huang , Janusz Pawliszyn
{"title":"Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization","authors":"Tao Bo ,&nbsp;Feng Yang ,&nbsp;Bo Yan ,&nbsp;David A. Michels ,&nbsp;Tiemin Huang ,&nbsp;Janusz Pawliszyn","doi":"10.1016/j.trac.2025.118212","DOIUrl":"10.1016/j.trac.2025.118212","url":null,"abstract":"<div><div>Imaged capillary isoelectric focusing (icIEF) has made remarkable strides in recent years, presenting the biopharmaceutical industry with a range of innovative solutions to characterize protein charge heterogeneity and streamline the development and manufacturing of biologics. This review highlights the latest advancements in icIEF technology for comprehensive biopharmaceutical characterization. Key innovations, including the development of critical reagents and capillary coatings, advanced icIEF fractionation, cutting-edge icIEF-MS online coupling, and novel applications for protein bio-interactions, are redefining icIEF analytical methodologies and broadening their applicability. These breakthroughs significantly enhance the characterization of complex therapeutic proteins, aiding researchers in mitigating challenges and setbacks during drug development and manufacturing. In describing these advances, we delve into multidisciplinary concepts spanning biology, chemistry, instrument design, and workflow optimization, aiming to inspire further innovations and insights in this dynamic, rapidly evolving field. Furthermore, this review traces the origins and 30-year evolution of icIEF technology by illustrating its continuous progression and expanding impact over time.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118212"},"PeriodicalIF":11.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress of black phosphorus quantum dots: Synthesis method, biological characteristics, and biomedical applications
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-26 DOI: 10.1016/j.trac.2025.118214
Yi He , Fangyang Shi , Yaoling Han , Runze Li , Jie Wu , Wei Zhao , Dongsheng Yu
{"title":"Recent progress of black phosphorus quantum dots: Synthesis method, biological characteristics, and biomedical applications","authors":"Yi He ,&nbsp;Fangyang Shi ,&nbsp;Yaoling Han ,&nbsp;Runze Li ,&nbsp;Jie Wu ,&nbsp;Wei Zhao ,&nbsp;Dongsheng Yu","doi":"10.1016/j.trac.2025.118214","DOIUrl":"10.1016/j.trac.2025.118214","url":null,"abstract":"<div><div>Zero-dimensional (0D) black phosphorus quantum dots (BPQDs), a novel manifestation of black phosphorus (BP), have garnered significant attention due to their exceptional properties and vast potential across various applications, positioning them as a promising functional nanomaterial in the biomedical field. Notable for their ease of functionalization, distinctive optical and electrical properties, excellent biocompatibility, and large specific surface area, BPQDs have been extensively investigated in bioimaging, biosensing, drug delivery, and cancer therapy. This review focuses on the synthesis methods, optical and electrical properties, biocompatibility, and biomedical applications of BPQDs, while also addressing future opportunities and challenges.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118214"},"PeriodicalIF":11.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role and choice of molecular descriptors for predicting retention times in HPLC: A comprehensive review
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-25 DOI: 10.1016/j.trac.2025.118207
Elena Bandini , Ardiana Kajtazi , Roman Szucs , Frédéric Lynen
{"title":"The role and choice of molecular descriptors for predicting retention times in HPLC: A comprehensive review","authors":"Elena Bandini ,&nbsp;Ardiana Kajtazi ,&nbsp;Roman Szucs ,&nbsp;Frédéric Lynen","doi":"10.1016/j.trac.2025.118207","DOIUrl":"10.1016/j.trac.2025.118207","url":null,"abstract":"<div><div>This review explores the essential role of molecular descriptors (MDs) and their selection for prediction modelling in the domain of high-performance liquid chromatography (HPLC). Currently, there are no standardized methods for selecting MDs, and there is a general lack of understanding about their impact on chromatography, which is more challenging given the multitude of available descriptors. This review aims to provide a comprehensive overview of the role of feature selection methods and an aid for the reader to navigate through MDs in the field of HPLC. It critically assesses the advantages and limitations of the methodologies used since the understanding of more advanced machine learning models. Furthermore, it evaluates the most influential MDs in HPLC and their relationship to retention time, advocating for pursuing innovative descriptor research, using cutting-edge approaches, and interdisciplinary collaboration to surmount challenges and enhance the quality of predictive models in the field of liquid chromatography.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118207"},"PeriodicalIF":11.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing hydrogen-bonded organic frameworks and metal-organic frameworks for biosensor applications
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-24 DOI: 10.1016/j.trac.2025.118211
Navid Rabiee
{"title":"Comparing hydrogen-bonded organic frameworks and metal-organic frameworks for biosensor applications","authors":"Navid Rabiee","doi":"10.1016/j.trac.2025.118211","DOIUrl":"10.1016/j.trac.2025.118211","url":null,"abstract":"<div><div>This paper presents a comparative perspective on the use of hydrogen-bonded organic frameworks (HOFs) and metal-organic frameworks (MOFs) in the development of biosensors. Both HOFs and MOFs have gained significant attention due to their tunable structures, high surface areas, and potential for a wide range of applications, including environmental monitoring, medical diagnostics, and biosensing. HOFs, with their non-metallic nature and reliance on hydrogen bonds, offer unique advantages such as easier synthesis, biocompatibility, and enhanced stability in certain environments. In contrast, MOFs, which incorporate metal centers, exhibit superior mechanical strength, higher stability, and versatility in sensing a broader range of analytes. This paper reviews the key features, advantages, and limitations of HOFs and MOFs in the context of biosensor development. It highlights recent advancements in their applications for detecting biological targets, and exploring their sensitivity, selectivity, and response times. Additionally, the paper discusses the challenges in integrating these materials into functional biosensors and provides insights into their future potential for improving diagnostic tools, environmental monitoring, and healthcare applications. Also, the paper offers a critical evaluation of how HOFs and MOFs can complement each other in advancing biosensor technology.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118211"},"PeriodicalIF":11.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smart polymers advance analytical chemistry
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-22 DOI: 10.1016/j.trac.2025.118198
Yahui Zhang , Xinjia Zhao , Guangyan Qing
{"title":"Smart polymers advance analytical chemistry","authors":"Yahui Zhang ,&nbsp;Xinjia Zhao ,&nbsp;Guangyan Qing","doi":"10.1016/j.trac.2025.118198","DOIUrl":"10.1016/j.trac.2025.118198","url":null,"abstract":"<div><div>The “precision medicine” project put forward higher requirements for analytical chemistry, centering on new material development. Given the increasing diversity of complex samples and rising demands on analytical methods, breakthroughs in the creation of analytical materials that offer selectivity, sensitivity, speed, and specificity are required. As a star system in material science, smart polymers can respond to subtle changes in external stimuli, leading to significant conformational changes in their polymer chains, and further translating, transferring, and amplifying the stimulus signals into macroscopic properties of the material. Their excellent controllability and adjustability in both structures and functions inject fresh energy into the advancement of analytic methods. This review concisely presents the latest research regarding the advancements of smart polymers in analytical chemistry, and furthermore proposes the challenges and feasible solutions that smart polymers encounter during design and application. These materials will accelerate the arrival of a new era of precision medicine.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"187 ","pages":"Article 118198"},"PeriodicalIF":11.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences” [TrAC Trends Anal. Chem. 185 (2025) 118170]
IF 11.8 1区 化学
Trends in Analytical Chemistry Pub Date : 2025-02-22 DOI: 10.1016/j.trac.2025.118197
Boyang Zhang , Xinyue Lan , Siyuan Tan , Zehu Xie , Longjiao Zhu , Xiaoyun Gong , Xinhua Dai , Xiang Fang , Wentao Xu
{"title":"Corrigendum to “Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences” [TrAC Trends Anal. Chem. 185 (2025) 118170]","authors":"Boyang Zhang ,&nbsp;Xinyue Lan ,&nbsp;Siyuan Tan ,&nbsp;Zehu Xie ,&nbsp;Longjiao Zhu ,&nbsp;Xiaoyun Gong ,&nbsp;Xinhua Dai ,&nbsp;Xiang Fang ,&nbsp;Wentao Xu","doi":"10.1016/j.trac.2025.118197","DOIUrl":"10.1016/j.trac.2025.118197","url":null,"abstract":"","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"186 ","pages":"Article 118197"},"PeriodicalIF":11.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信