Trends in Analytical Chemistry最新文献

{"title":"Molecularly imprinted polymers meet sensors: Insights and prospects for pollutants analysis","authors":"Dandan Han ,&nbsp;Niao Zhao ,&nbsp;Yahan Cui ,&nbsp;Hongyuan Yan","doi":"10.1016/j.trac.2024.118032","DOIUrl":"10.1016/j.trac.2024.118032","url":null,"abstract":"<div><div>Sensors offer several outstanding properties, including ease of operation, rapid response times, portability, and the ability to perform real-time analysis, driving their rapid development and broad applications. Among these, molecularly imprinted polymers (MIPs)-based sensors stand out due to their unique capability to modify sensor surfaces by creating recognition cavities in the polymer matrix. This approach offers a versatile methodology for imprinting various pollutants, providing a fast, sensitive, user-friendly, and highly selective sensing platform. MIPs-based sensors are especially attractive due to their excellent physicochemical stability, low cost, and reusability. Currently, a variety of sensors integrated with MIPs—such as fluorescent sensors and electrochemical sensors-have been developed for the detection and identification of trace biological macromolecules, organic pollutants, and heavy metal ions. This review explores the different types of MIPs-based sensors, their latest applications in pollutant detection, and highlights the challenges, limitations, and future directions for the development of these advanced sensing technologies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118032"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations, trends and analytical strategies applied for biological samples collection (sampling) and storage in forensic toxicology of volatile poisons (inorganic and organic)","authors":"Kamil Jurowski ,&nbsp;Maciej Noga ,&nbsp;Alicja Krośniak ,&nbsp;Paweł Papierz ,&nbsp;Łukasz Niżnik ,&nbsp;Damian Kobylarz","doi":"10.1016/j.trac.2024.118033","DOIUrl":"10.1016/j.trac.2024.118033","url":null,"abstract":"<div><div>The forensic analysis of volatile poisons, including volatile inorganic (VIP) and organic poisons (VOP), is crucial in forensic toxicology. These substances are challenging to analyse due to their instability and tendency to dissipate, requiring careful handling from sample collection to analysis. Despite their importance in public health and criminal justice, standardised guidelines for collecting and storing biological samples to detect VIP and VOP are lacking. This study reviews existing literature, identifies trends, and develops advanced strategies for effective sample collection and storage. Biological samples like blood, urine, serum, hair, saliva, and nails need customised approaches to preserve volatile analytes. Innovative techniques such as the PENVOC system and rolling stir bar sampling offer significant improvements in volatile organic compounds (VOC) analysis. The study also addresses post-mortem microbial production, complicating forensic ethanol analysis, and evaluates advanced storage methods like hydrophobic coatings, membrane-based preservation, supercritical fluid extraction, and cryogenic storage.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118033"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and limitations of the analytical methods currently employed for the assessment of inorganic pollutants in indoor and outdoor air","authors":"Mila Ródenas ,&nbsp;Teresa Vera ,&nbsp;Amalia Muñoz ,&nbsp;Florentina Villanueva","doi":"10.1016/j.trac.2024.118034","DOIUrl":"10.1016/j.trac.2024.118034","url":null,"abstract":"<div><div>Inorganic air pollutants comprise a broad class of substances, including acids, nitrogen and carbon oxides, ozone, ammonia, chlorine, and other halogenated compounds and ionic species. These types of pollutants can be emitted or produced naturally or anthropogenically outdoors but also can be emitted or generated by indoor activities.</div><div>Due to the diverse typology of inorganic compounds, the measurement techniques are also very different. Notwithstanding, there is no comprehensive review that comprises the different instruments and technologies currently existing in the market to design an air quality (AQ) monitoring strategy. Our paper aims at filling this gap by providing an overview and compendium of the most used measurement techniques and methods for the determination of inorganic pollutants in the air, including online and discontinuous methods in terms of advantages and disadvantages, and taking into account specifications such as detection limits, potential artifacts, temporal resolution and costs. Well-established methods, together with innovative instrumentation and methodology have been critically discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118034"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics of volatile organic compounds (VOCs) in infectious diseases","authors":"Kyrilos Sadaka ,&nbsp;Bahram Dalvand ,&nbsp;Zoya Faruqui ,&nbsp;Saman Aqeel ,&nbsp;Marzieh Ghoohestani ,&nbsp;Mohammad Goodarzi","doi":"10.1016/j.trac.2024.118024","DOIUrl":"10.1016/j.trac.2024.118024","url":null,"abstract":"<div><div>The metabolic profile, a direct indicator of phenotype and biochemical activity in infectious diseases, comprises diverse small molecules in biological systems, including natural products and drug components with variable expression. Metabolomics provides insights into novel drugs, drug scaffolds, and promising targets, contributing to suggesting binding partners and exploring natural products crucial in combating infections. Leveraging metabolomics amplifies the discovery of therapeutic agents, revealing anticipated and unforeseen drug effects. In infectious diseases, it contributes to prognostic and diagnostic aspects, employing NMR or mass spectrometry to identify disease-specific biomarkers. Metabolomics also uncovers potential targets among metabolic enzymes, utilizing advanced flux analysis techniques. This comprehensive review emphasizes metabolomics' significance in screening biomarkers, identifying drug targets for infections, and exploring immunometabolomics. Additionally, it focuses on advanced analytical techniques for volatile organic compound (VOC) analysis, addressing the application of chemometrics and the use of different analytical instruments, emphasizing the need for future research in this field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118024"},"PeriodicalIF":11.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal probes for the detection of bone cancer-related disease in biological systems: Recent advances and future prospects","authors":"Xiao-Lin Wen ,&nbsp;Xu-Yang Chen ,&nbsp;Yu-long Jin ,&nbsp;Zhi-Gang Sun ,&nbsp;Ai-Guo Zhang ,&nbsp;Kai Wang","doi":"10.1016/j.trac.2024.118030","DOIUrl":"10.1016/j.trac.2024.118030","url":null,"abstract":"<div><div>Bone cancer can be broadly categorized into primary bone cancer and metastatic bone cancer. Primary bone cancer, such as osteosarcoma and Ewing's sarcoma, is not only highly malignant but also tends to occur in younger age groups. Metastatic bone cancer typically originates from highly malignant diseases like prostate cancer, breast cancer, and lung cancer. The presence of bone metastasis usually indicates a poor prognosis. Therefore, early detection and treatment of bone lesions are crucial for improving patient prognosis and quality of life. Commonly used conventional detection methods, such as bone imaging, computed tomography (CT), and magnetic resonance imaging (MRI), suffer from limitations in resolution or penetration depth. As a result, the detection rate for small early bone metastases is often poor. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) utilize radionuclide-labeled imaging agents to perform functional imaging. These techniques improve the specificity of detection and provide information about tissue metabolism based on the concentration of different components in various tissues. However, PET and SPECT are susceptible to interference from factors like infection and necrosis, which may lead to false-positive results. Chemical probes have largely compensated for the lack of specificity and sensitivity of conventional methods, especially Near-Infrared (NIR) and photoacoustic (PA) imaging, which not only increase the depth of detection but also do not have radiological hazards. In this review, we will discuss the importance of probes for the early detection of bone-associated cancers. Specifically, we will examine probe-associated markers, recognition modalities, and imaging modalities in the context of probes used for metastatic bone cancers originating from breast and prostate cancers, as well as for primary osteosarcoma. The use of targeted probes enables the identification of cancerous lesions in bone through binding to biomarkers expressed in cancer cells. Different probe designs allow for various recognition strategies and imaging techniques to visualize the probes after they have bound to cancer cells. Understanding current probe technologies is critical for improving early diagnosis and treatment of bone cancers.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118030"},"PeriodicalIF":11.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical methods for protein kinase and inhibitor screening including kinetic evaluation","authors":"Viola Wurster ,&nbsp;Peter Fechner ,&nbsp;Günther Proll ,&nbsp;Carolin Huhn","doi":"10.1016/j.trac.2024.118025","DOIUrl":"10.1016/j.trac.2024.118025","url":null,"abstract":"<div><div>Protein kinases promote cell processes such as cell growth and proliferation similarly in tumor cells and healthy cells. Pharmaceutical research aims at developing small molecules that inhibit tumor growth binding in the ATP-binding pocket of specific protein kinases. To understand the specificity of the inhibitor, thermodynamic and kinetic data of the kinase-inhibitor binding process are important. A broad range of analytical methods may investigate the interactions between protein kinases and inhibitors. Today, however, there is no comprehensive strategy to provide information on both specificity screening and binding kinetics. The purpose of this review is to summarize analytical methods used not only to monitor the protein kinase inhibition, but also to provide kinetic and thermodynamic data on the basis of screening applications. A focus is set on optical biosensing as the most promising techniques. We discuss, that intelligent combinations of methods can provide comprehensive information on protein kinases interacting with inhibitors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118025"},"PeriodicalIF":11.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virgin olive oil authentication using mass spectrometry-based approaches: A review","authors":"Irene Caño-Carrillo ,&nbsp;Bienvenida Gilbert-López ,&nbsp;Cristina Ruiz-Samblás ,&nbsp;Antonio Molina-Díaz ,&nbsp;Juan F. García-Reyes","doi":"10.1016/j.trac.2024.118029","DOIUrl":"10.1016/j.trac.2024.118029","url":null,"abstract":"<div><div>Virgin olive oil (VOO) is one of the most valuable vegetable oils due to its excellent nutritional value and health benefits. However, its high cost and demand make it one of the most vulnerable products to food fraud. Hence, providing rapid and effective analytical methods is essential for the quality and authenticity assessment of olive oils. Mass spectrometry (MS) has been crucial for the detection of fraudulent activities in VOO, mainly related to the verification of geographical origin or cultivar variety, the correct discrimination between different commercial categories, and adulteration with other vegetable oils or lower-quality olive oils. An ample range of MS approaches have been reported, including chromatographic systems coupled to MS, direct MS using different ionization sources, analysis with minor or even no sample preparation by ambient MS methods, and MS-based elemental analysis techniques. This review aims to provide an overview of these MS-based methods, which, often combined with suitable chemometric techniques, constitute a resourceful tool for ensuring olive oil authenticity.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118029"},"PeriodicalIF":11.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in flexible sensors: From sensing materials to detection modes","authors":"Jiao Qin ,&nbsp;Yuxin Tang ,&nbsp;Yongyi Zeng ,&nbsp;Xiaolong Liu ,&nbsp;Dianping Tang","doi":"10.1016/j.trac.2024.118027","DOIUrl":"10.1016/j.trac.2024.118027","url":null,"abstract":"<div><div>Flexible sensors have recently garnered extensive public attention owing to their flexibility, wearability, and tunable mechanical properties, enabling real-time, non-invasive detection of various stimulations. Sensing materials are crucial for flexible sensors. To better enhance the performance, flexible sensors need to be integrated with multiple functional sensing materials to fulfill different detection demands. Herein, this paper reviews the latest advancements in sensing material and detection modes for flexible sensor applications. This review begins with an introduction to the development of different types of sensing materials. Then, it comprehensively summarizes different detection modes of flexible sensors. Furthermore, flexible sensors for various applications based on these advanced sensing materials and detection modes are concluded as well. The challenges of flexible sensors in practical application and promising solutions are finally presented. By summarizing recent advances in flexible sensing technology, this review intends to emphasize the potential of flexible sensors and stimulate innovation in this field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118027"},"PeriodicalIF":11.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial colonization of microplastic (MP) in aquatic environments: MP toxicity, microbial degradation potential and their interactions","authors":"Xiaoyong Zhang ,&nbsp;Xinye Chen ,&nbsp;Zhuolin Liu ,&nbsp;Xinfeng Pan ,&nbsp;Xiaoning Zheng ,&nbsp;Yaozu Li ,&nbsp;Xingyu Liao ,&nbsp;Jun Wang","doi":"10.1016/j.trac.2024.118028","DOIUrl":"10.1016/j.trac.2024.118028","url":null,"abstract":"<div><div>Microbial plastic biodegradation is one sustainable approach in reducing the accumulated plastic wastes in the environments, but specific interactions between microplastic (MP) and microorganism are still lacking. This study systematically reviews the influences of MP on cell functions and community structures of microorganisms, as well as the microbial impacts on the fate of MP within aquatic environments. Detailed examinations of their distinctive interactions within various aquatic ecosystems are also presented. While MP are commonly toxic to most microorganisms, they could also enrich specific microbial groups such as pathogens and hydrocarbon-degrading bacteria due to the chemotaxis and easier nutrition access of microorganisms. On the other hand, microorganisms are capable of secreting extracellular enzymes that biodegrade MPs into oligomers, dimers, and monomers, hereby changing the density, crystallinity, and surface roughness of MPs, consequently influencing the MP distribution patterns in aquatic environments. Additionally, we discuss current study limitations and future prospects, providing a comprehensive foundational overview for further investigations.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118028"},"PeriodicalIF":11.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Fluorescence detection setups in capillary electrophoresis and microscale liquid chromatography: Developments over the past decade” [Trends Anal. Chem. 181 (2024) 118001]","authors":"Jozef Šesták ,&nbsp;Andras Guttman ,&nbsp;Jana Lavická","doi":"10.1016/j.trac.2024.118014","DOIUrl":"10.1016/j.trac.2024.118014","url":null,"abstract":"","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118014"},"PeriodicalIF":11.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}