Trends in Analytical Chemistry最新文献_第3页

Recent advancements in polyaniline-based biosensors for diagnosis of cancers: A comprehensive review 用于诊断癌症的聚苯胺基生物传感器的最新进展：综述

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-08 DOI: 10.1016/j.trac.2024.118040

Mojtaba Hosseine , Ali Bakhshi , Seyed Morteza Naghib , Navid Rabiee

{"title":"Recent advancements in polyaniline-based biosensors for diagnosis of cancers: A comprehensive review","authors":"Mojtaba Hosseine , Ali Bakhshi , Seyed Morteza Naghib , Navid Rabiee","doi":"10.1016/j.trac.2024.118040","DOIUrl":"10.1016/j.trac.2024.118040","url":null,"abstract":"<div><div>Recent advances in biosensor and bioelectronics technologies have revolutionized cancer diagnosis, providing more accessible, sensitive, and specific methods for early detection. This review focuses on polyaniline (PANI)-based biosensors, which demonstrate significant potential in detecting cancer biomarkers due to their tunable properties, cost-effectiveness, and ease of synthesis. Various PANI synthesis techniques, including chemical, electrochemical, enzyme-catalyzed, vapor-phase, and template-assisted polymerization, are examined, along with the development of multidimensional PANI nanostructures to enhance biosensor performance. Advanced 3D printing techniques have enabled the precise fabrication of PANI-based devices, such as flexible sensors, high-performance supercapacitors, and electroactive scaffolds, showcasing PANI's versatility and potential in biomedical and biosensor applications. The application of PANI-based biosensors in detecting lung, liver, breast, and prostate cancers is discussed, highlighting the detection principles, limits, and specificity for each cancer type. Furthermore, the role of PANI in signal amplification through nanocomposite (NC) integration, which improves diagnostic accuracy, is explored. This comprehensive review also addresses the current challenges and future opportunities for advancements in PANI-based biosensor technology, emphasizing its critical importance in the next generation of cancer diagnostics. By overcoming the limitations of conventional diagnostic methods, these biosensors are positioned to play a pivotal role in improving early cancer detection and patient outcomes.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118040"},"PeriodicalIF":11.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating excitation-emission matrix for characterization of dissolved organic matter in natural and engineered water systems: Unlocking submerged secrets 评估自然和工程水系统中溶解有机物特征的激发-发射矩阵：揭开水下的秘密

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-08 DOI: 10.1016/j.trac.2024.118045

Bo Gong , Wei Chen , Chen Qian , Han-Qing Yu

{"title":"Evaluating excitation-emission matrix for characterization of dissolved organic matter in natural and engineered water systems: Unlocking submerged secrets","authors":"Bo Gong , Wei Chen , Chen Qian , Han-Qing Yu","doi":"10.1016/j.trac.2024.118045","DOIUrl":"10.1016/j.trac.2024.118045","url":null,"abstract":"<div><div>Dissolved organic matter (DOM) is ubiquitous in waters and plays a fundamental role. The examination of DOM properties and their environmental effects, including intrinsic biogeochemical processes and the impact of DOM on the transformation and fate of other contaminants, is of paramount significance. Among the techniques available for DOM characterization, the fluorescent excitation-emission matrix (EEM) stands out as one of the most powerful methods, due to its speed, high sensitivity, and wealth of molecular information provided. This review encapsulates the principles of EEM-based methodologies for DOM interpretation, then critically summarizes DOM characterization in natural waters, and wastewater, as well as the water and wastewater treatment processes. Various scientific issues related to DOM, such as its physicochemical and biochemical properties, spatial and temporal distribution, transformation, removal, and environmental implications, can be discerned using EEM. Finally, the limitations and challenges, as well as the potential advancements and perspectives on EEM collection and analytical tools are discussed, broadening the application scope and utilizing theoretical simulation for mechanism investigation. This review serves as a beneficial guide to selecting suitable EEM-related strategies, facilitating an in-depth understanding and forecasting of the environmental behaviors of DOM in both natural and engineered water systems.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118045"},"PeriodicalIF":11.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compound-specific isotope analysis of amino acids for aquatic systems – Problems, challenges, solutions: A review 水生系统氨基酸的特定化合物同位素分析--问题、挑战和解决方案：综述

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-07 DOI: 10.1016/j.trac.2024.118038

Shaista Khaliq , Maik A. Jochmann , Tobias Hesse , Milen Nachev , Bernd Sures , Philip M. Riekenberg , Marcel T.J. van der Meer , Torsten C. Schmidt

{"title":"Compound-specific isotope analysis of amino acids for aquatic systems – Problems, challenges, solutions: A review","authors":"Shaista Khaliq , Maik A. Jochmann , Tobias Hesse , Milen Nachev , Bernd Sures , Philip M. Riekenberg , Marcel T.J. van der Meer , Torsten C. Schmidt","doi":"10.1016/j.trac.2024.118038","DOIUrl":"10.1016/j.trac.2024.118038","url":null,"abstract":"<div><div>Compound-specific isotope analysis of individual amino acids (AAs) is a promising method for characterizing resource flow and transformation in aquatic systems, encompassing microbial domains to macroscopic consumers. This review delves into two key areas of research concerning AAs in aquatic ecosystems. Firstly, carbon isotope analysis is employed to explore carbon sources assimilated for AAs synthesis, and secondly, nitrogen isotope analysis is used to clarify ecosystem baselines and trophic dynamics of organisms. Surprisingly, literature provides limited discussions on the limitations or critical challenges faced during AAs isotope analysis over the past decade. To address this gap, this review focuses on challenges encountered in method development, sample preparation, and technical aspects, including instrumental design, and δ<sup>13</sup>C and δ<sup>15</sup>N analysis of AAs. Recommendations are provided to increase the accuracy and reliability. The review also highlights the significance of comprehensive understanding and detailed methodology to address challenges during AA isotope analysis in aquatic systems.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118038"},"PeriodicalIF":11.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microextraction by packed sorbents (MEPS): Fundamental principles and nanomaterial-based adsorbents 填料吸附剂微萃取（MEPS）：基本原理和基于纳米材料的吸附剂

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-07 DOI: 10.1016/j.trac.2024.118043

Ali Firoozichahak , Danial Soleymani-ghoozhdi , Saber Alizadeh , Razzagh Rahimpoor

{"title":"Microextraction by packed sorbents (MEPS): Fundamental principles and nanomaterial-based adsorbents","authors":"Ali Firoozichahak , Danial Soleymani-ghoozhdi , Saber Alizadeh , Razzagh Rahimpoor","doi":"10.1016/j.trac.2024.118043","DOIUrl":"10.1016/j.trac.2024.118043","url":null,"abstract":"<div><div>Sample preparation is a crucial aspect of analytical methods, particularly when dealing with complex matrices and/or low concentrations of analytes. Recent advancements in analytical methods have focused on minimizing sample preparation devices, evolving towards extraction techniques that utilize solvent-free or green solvents, or minimal amounts of solvents. Microextraction by Packed Sorbent (MEPS) is a miniaturized version of the conventional Solid-phase extraction (SPE) technique. The MEPS has been recognized as a modern technique in sample preparation due to the minimal use of solid adsorbent, organic solvent, and liquid sample. This innovative technique allows for the recovery of the adsorbents and contributes to sustainability. Furthermore, MEPS can be seamlessly integrated with chromatographic systems in an automated manner to enhance both efficiency and reproducibility. This review tries to have comprehensive insight into the various MEPS technique, advancements, and emerging trends with emphasis on the wide range of employed nanomaterials as adsorbents.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118043"},"PeriodicalIF":11.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Metabolite Annotation through Stable Isotope Labeling 通过稳定同位素标记进行代谢物注释

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-07 DOI: 10.1016/j.trac.2024.118037

Yonghui Dong , Liron Feldberg , Asaph Aharoni , Uwe Heinig

引用次数: 0

Recent advances in bioactivity-guided drug screening strategies for pre-clinical and clinical drug discovery 用于临床前和临床药物发现的生物活性指导药物筛选策略的最新进展

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-05 DOI: 10.1016/j.trac.2024.118042

Simin Chen , Chenxiao Shen , Wanyu Li , Yu Fan , Dong-Hua Yang , Yitao Wang , Ruibing Feng , Guodong Li , Zhangfeng Zhong

{"title":"Recent advances in bioactivity-guided drug screening strategies for pre-clinical and clinical drug discovery","authors":"Simin Chen , Chenxiao Shen , Wanyu Li , Yu Fan , Dong-Hua Yang , Yitao Wang , Ruibing Feng , Guodong Li , Zhangfeng Zhong","doi":"10.1016/j.trac.2024.118042","DOIUrl":"10.1016/j.trac.2024.118042","url":null,"abstract":"<div><div>Over the past two decades, bioactivity-guided drug screening has become a pivotal approach in drug discovery, which could identify potential drug candidates with desirable therapeutic effects against specific disease phenotypes or targets. This strategy has led to the discovery of many clinical medications such as natural products, peptides, and antibody drugs, and become a mainstream method. Herein, we first systematically summarize the principles and applications of recent bioactivity-guided drug screening strategies through technological advances in <em>in silico</em> screening, cell model systems, organoid model systems, and animal model systems. We then provide an overview on the representative active compounds, pre-clinical drugs, and marketed drugs, and discuss the present challenges and future directions of bioactivity-guided drug screening methods for clinical drug development. Based on the research advancements, it is anticipated that more disease-relevant screening models and efficient methods can be developed to identify drugs with ideal therapeutic effects and favorable pharmacological properties.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118042"},"PeriodicalIF":11.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Application of fluorescent tracing technology for investigating the effect of microplastics and nanoplastics on biological organisms 应用荧光追踪技术研究微塑料和纳米塑料对生物有机体的影响

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-05 DOI: 10.1016/j.trac.2024.118039

Xueyi Li , Jun Liu , Haifeng Meng , Yiting Huang , Wucheng Xie , Yong Liang , Jun Wang

{"title":"Application of fluorescent tracing technology for investigating the effect of microplastics and nanoplastics on biological organisms","authors":"Xueyi Li , Jun Liu , Haifeng Meng , Yiting Huang , Wucheng Xie , Yong Liang , Jun Wang","doi":"10.1016/j.trac.2024.118039","DOIUrl":"10.1016/j.trac.2024.118039","url":null,"abstract":"<div><div>As the plastic industry rapidly develops, the resultant pollution from microplastics (MPs) and nanoplastics (NPs) has become widespread, significantly affecting human health and the ecological environment by their transmission and enrichment in the food chain. This article reviews an effective technique used for analysing the toxicological and metabolic mechanisms of MPs and NPs within organisms, namely the fluorescent tracing technology. This technology facilitates the qualitative and quantitative detection of MPs and NPs within organisms, enabling the monitoring of the behaviour and effect of MPs and NPs within biological systems. The paper explores the principles, advantages and disadvantages of various currently employed fluorescent tracers; summarises the equipment and technology currently utilised for MPs and NPs detection and tracing within organisms and discusses the application of the technology in studying MPs and NPs effects on organisms. Finally, it prospects the application prospect of in vivo fluorescence tracer technology for the detection of MPs and NPs, and points out the limitations and development directions of this method in subsequent research.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118039"},"PeriodicalIF":11.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latest trends in biosensors powered by nucleic acid isothermal amplification for the diagnosis of joint infections: From sampling to identification towards the point-of-care 利用核酸等温扩增技术诊断关节感染的生物传感器的最新发展趋势：从采样到鉴定，迈向护理点

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-03 DOI: 10.1016/j.trac.2024.118036

Mariarita De Felice , Mariarosaria De Falco , Amina Antonacci , Sara Colella , Vincenzo Vedi , Rachele Isticato , Alfonso Maria Romano , Valeria Nocerino , Bruno Miranda , Luca De Stefano , Viviana Scognamiglio

{"title":"Latest trends in biosensors powered by nucleic acid isothermal amplification for the diagnosis of joint infections: From sampling to identification towards the point-of-care","authors":"Mariarita De Felice , Mariarosaria De Falco , Amina Antonacci , Sara Colella , Vincenzo Vedi , Rachele Isticato , Alfonso Maria Romano , Valeria Nocerino , Bruno Miranda , Luca De Stefano , Viviana Scognamiglio","doi":"10.1016/j.trac.2024.118036","DOIUrl":"10.1016/j.trac.2024.118036","url":null,"abstract":"<div><div>As the number of joint arthroplasties continues to increase, joint infections have emerged as a significant and devastating complication associated with total joint arthroplasty. The formation and persistence of bacterial biofilms create a formidable barrier against both the host immune system and antibiotics, contributing to the pathogenesis of joint infections, antibiotic resistance, and treatment failures. This review examines the latest trends on biosensors powered by isothermal nucleic acid amplification technologies designed to manage joint infections, highlighting their advantages and disadvantages, with a particular attention on their integration into point-of-care testing. In detail, a special focus on such innovative approaches for rapid and specific identification of pathogenic nucleic acids will cover the entire process from sampling to extraction, amplification, and detection methods.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118036"},"PeriodicalIF":11.8,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Embarking on a journey through Micro-RNA and Circular-RNA detection methods 开启微型 RNA 和环状 RNA 检测方法之旅

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-02 DOI: 10.1016/j.trac.2024.118035

Zhaleh Asadi Fakhr , Xinlan Zhu , Hechen Wang , Ruiyang Ma , Ziwei Lin , Xudan Shen , Jiatong Liu , Su Zeng , Sheng Cai

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Analytical methods for identification, characterization, and quantification of metal-containing nanoparticles in biological and biomedical samples, food and personal care products 生物和生物医学样品、食品和个人护理产品中含金属纳米颗粒的鉴定、表征和定量分析方法

IF 11.8 1区化学

Trends in Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.trac.2024.118031

Dominik Blaimer, Kerstin Leopold

{"title":"Analytical methods for identification, characterization, and quantification of metal-containing nanoparticles in biological and biomedical samples, food and personal care products","authors":"Dominik Blaimer, Kerstin Leopold","doi":"10.1016/j.trac.2024.118031","DOIUrl":"10.1016/j.trac.2024.118031","url":null,"abstract":"<div><div>Analytical methods for the identification, characterization, and quantification of metal-containing nanoparticles (MNPs) are required for quality control and toxicological assessment in a variety of complex sample matrices. This review provides a comprehensive overview of the available methods for the speciation, sizing, and quantification of MNPs in biological and biomedical samples, food and personal care products. Sample preparation, separation and fractionation approaches combined or directly coupled to different detection techniques are discussed in detail, along with their main analytical figures of merit. A detailed table summarizes the analytical approaches in this field reported over the past five years, listing the analytical steps and techniques, as well as their reported detection and quantification limits in terms of size and concentration of MNPs. A broad spectrum of analytical approaches and performance levels is observed. New developments that offer promising solutions to previously unsolved problems are also discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"181 ","pages":"Article 118031"},"PeriodicalIF":11.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0